UniProtKB - Q96ME1 (FXL18_HUMAN)
Protein
F-box/LRR-repeat protein 18
Gene
FBXL18
Organism
Homo sapiens (Human)
Status
Functioni
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity
GO - Biological processi
- post-translational protein modification Source: Reactome
- protein polyubiquitination Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q96ME1 |
Reactomei | R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: F-box/LRR-repeat protein 18Alternative name(s): F-box and leucine-rich repeat protein 18 |
Gene namesi | Name:FBXL18 Synonyms:FBL18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21874, FBXL18 |
MIMi | 609084, gene |
neXtProti | NX_Q96ME1 |
VEuPathDBi | HostDB:ENSG00000155034.18 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Other locations
- SCF ubiquitin ligase complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000155034 |
PharmGKBi | PA134949446 |
Miscellaneous databases
Pharosi | Q96ME1, Tdark |
Genetic variation databases
BioMutai | FBXL18 |
DMDMi | 61213731 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119867 | 1 – 805 | F-box/LRR-repeat protein 18Add BLAST | 805 |
Proteomic databases
EPDi | Q96ME1 |
jPOSTi | Q96ME1 |
MassIVEi | Q96ME1 |
MaxQBi | Q96ME1 |
PaxDbi | Q96ME1 |
PeptideAtlasi | Q96ME1 |
PRIDEi | Q96ME1 |
ProteomicsDBi | 77339 [Q96ME1-1] 77340 [Q96ME1-2] 77341 [Q96ME1-3] 77342 [Q96ME1-4] |
PTM databases
iPTMneti | Q96ME1 |
MetOSitei | Q96ME1 |
PhosphoSitePlusi | Q96ME1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000155034, Expressed in subthalamic nucleus and 181 other tissues |
ExpressionAtlasi | Q96ME1, baseline and differential |
Genevisiblei | Q96ME1, HS |
Organism-specific databases
HPAi | ENSG00000155034, Low tissue specificity |
Interactioni
Subunit structurei
Directly interacts with SKP1 and CUL1.
By similarityProtein-protein interaction databases
BioGRIDi | 123080, 48 interactors |
IntActi | Q96ME1, 16 interactors |
MINTi | Q96ME1 |
STRINGi | 9606.ENSP00000371805 |
Miscellaneous databases
RNActi | Q96ME1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 72 | F-boxPROSITE-ProRule annotationAdd BLAST | 48 | |
Repeati | 77 – 103 | LRR 1Add BLAST | 27 | |
Repeati | 104 – 128 | LRR 2Add BLAST | 25 | |
Repeati | 129 – 153 | LRR 3Add BLAST | 25 | |
Repeati | 177 – 201 | LRR 4Add BLAST | 25 | |
Repeati | 324 – 352 | LRR 5Add BLAST | 29 | |
Repeati | 367 – 392 | LRR 6Add BLAST | 26 | |
Repeati | 393 – 422 | LRR 7Add BLAST | 30 | |
Repeati | 468 – 492 | LRR 8Add BLAST | 25 | |
Repeati | 516 – 540 | LRR 9Add BLAST | 25 | |
Repeati | 542 – 567 | LRR 10Add BLAST | 26 | |
Repeati | 572 – 597 | LRR 11Add BLAST | 26 | |
Repeati | 599 – 623 | LRR 12Add BLAST | 25 |
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502QVW9, Eukaryota |
GeneTreei | ENSGT00390000015109 |
HOGENOMi | CLU_758549_0_0_1 |
InParanoidi | Q96ME1 |
OMAi | PNPAHWP |
PhylomeDBi | Q96ME1 |
TreeFami | TF331865 |
Family and domain databases
Gene3Di | 3.80.10.10, 3 hits |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF00646, F-box, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96ME1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL
60 70 80 90 100
NVRRTCRKLA ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS
110 120 130 140 150
MAGCYWLPGS TVEHVARCRS LVKVNLSGCH LTSLRLSKML SALQHLRSLA
160 170 180 190 200
IDVSPGFDAS QLSSECKATL SRVRELKQTL FTPSYGVVPC CTSLEKLLLY
210 220 230 240 250
FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG YINQEVVRLY
260 270 280 290 300
LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS
310 320 330 340 350
WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL
360 370 380 390 400
SGCVHCLSPD SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG
410 420 430 440 450
LGRHLCQLLA RLRHLRSLSL PVCSVADSAP RADRAPAQPA MHAVPRGFGK
460 470 480 490 500
KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK NLPFLEHLEL IGSNFSSAMP
510 520 530 540 550
RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ LPSVLTGSGL
560 570 580 590 600
VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF
610 620 630 640 650
SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT
660 670 680 690 700
GESLATCKSL QQSLLRRWGE VTGRRPQLFT ELREEPSART SRATGRRQPC
710 720 730 740 750
LPDSGVVCCP CGRPLAVSGI ILVGVSPSLV VKTTCVYRVL FKNLDYASIF
760 770 780 790 800
FLVCLFETES HSVVQAGVQW RDLSSLQPLL SGLQPQPPEQ LENELEIGFS
YCFVI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96D16 | Q96D16_HUMAN | F-box/LRR-repeat protein 18 | FBXL18 | 259 | Annotation score: | ||
H0Y6I6 | H0Y6I6_HUMAN | F-box/LRR-repeat protein 18 | FBXL18 | 685 | Annotation score: |
Sequence cautioni
The sequence BAB13838 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 555 | L → P in BAB13838 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055800 | 552 | N → K. Corresponds to variant dbSNP:rs33941092Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013009 | 364 – 365 | RK → CR in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_013010 | 366 – 805 | Missing in isoform 3. 1 PublicationAdd BLAST | 440 | |
Alternative sequenceiVSP_013011 | 667 – 718 | RWGEV…PLAVS → SFQAERPALNVVIFPLLHEG LTDVIRDVPLVHLDEITLFK SRVAEEPPNLWW in isoform 4. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_013012 | 667 – 668 | RW → SR in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_013013 | 669 – 805 | Missing in isoform 2. 1 PublicationAdd BLAST | 137 | |
Alternative sequenceiVSP_013014 | 719 – 805 | Missing in isoform 4. 1 PublicationAdd BLAST | 87 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK021529 mRNA Translation: BAB13838.1 Different initiation. AK057042 mRNA Translation: BAB71354.1 BC004228 mRNA Translation: AAH04228.1 BC006426 mRNA Translation: AAH06426.2 BC024256 mRNA Translation: AAH24256.1 |
CCDSi | CCDS43546.1 [Q96ME1-4] |
Genome annotation databases
Ensembli | ENST00000382368; ENSP00000371805; ENSG00000155034 [Q96ME1-4] ENST00000415009; ENSP00000415064; ENSG00000155034 [Q96ME1-2] ENST00000453700; ENSP00000444797; ENSG00000155034 [Q96ME1-3] |
UCSCi | uc003son.5, human [Q96ME1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK021529 mRNA Translation: BAB13838.1 Different initiation. AK057042 mRNA Translation: BAB71354.1 BC004228 mRNA Translation: AAH04228.1 BC006426 mRNA Translation: AAH06426.2 BC024256 mRNA Translation: AAH24256.1 |
CCDSi | CCDS43546.1 [Q96ME1-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123080, 48 interactors |
IntActi | Q96ME1, 16 interactors |
MINTi | Q96ME1 |
STRINGi | 9606.ENSP00000371805 |
PTM databases
iPTMneti | Q96ME1 |
MetOSitei | Q96ME1 |
PhosphoSitePlusi | Q96ME1 |
Genetic variation databases
BioMutai | FBXL18 |
DMDMi | 61213731 |
Proteomic databases
EPDi | Q96ME1 |
jPOSTi | Q96ME1 |
MassIVEi | Q96ME1 |
MaxQBi | Q96ME1 |
PaxDbi | Q96ME1 |
PeptideAtlasi | Q96ME1 |
PRIDEi | Q96ME1 |
ProteomicsDBi | 77339 [Q96ME1-1] 77340 [Q96ME1-2] 77341 [Q96ME1-3] 77342 [Q96ME1-4] |
Protocols and materials databases
Antibodypediai | 24615, 91 antibodies |
Genome annotation databases
Ensembli | ENST00000382368; ENSP00000371805; ENSG00000155034 [Q96ME1-4] ENST00000415009; ENSP00000415064; ENSG00000155034 [Q96ME1-2] ENST00000453700; ENSP00000444797; ENSG00000155034 [Q96ME1-3] |
UCSCi | uc003son.5, human [Q96ME1-1] |
Organism-specific databases
GeneCardsi | FBXL18 |
HGNCi | HGNC:21874, FBXL18 |
HPAi | ENSG00000155034, Low tissue specificity |
MIMi | 609084, gene |
neXtProti | NX_Q96ME1 |
OpenTargetsi | ENSG00000155034 |
PharmGKBi | PA134949446 |
VEuPathDBi | HostDB:ENSG00000155034.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVW9, Eukaryota |
GeneTreei | ENSGT00390000015109 |
HOGENOMi | CLU_758549_0_0_1 |
InParanoidi | Q96ME1 |
OMAi | PNPAHWP |
PhylomeDBi | Q96ME1 |
TreeFami | TF331865 |
Enzyme and pathway databases
PathwayCommonsi | Q96ME1 |
Reactomei | R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
ChiTaRSi | FBXL18, human |
Pharosi | Q96ME1, Tdark |
PROi | PR:Q96ME1 |
RNActi | Q96ME1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155034, Expressed in subthalamic nucleus and 181 other tissues |
ExpressionAtlasi | Q96ME1, baseline and differential |
Genevisiblei | Q96ME1, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 3 hits |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF00646, F-box, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FXL18_HUMAN | |
Accessioni | Q96ME1Primary (citable) accession number: Q96ME1 Secondary accession number(s): Q9BR90, Q9BTC7, Q9HAK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM