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UniProtKB - Q96ME1 (FXL18_HUMAN)

Entry version 152 (17 Jun 2020)
Sequence version 2 (15 Mar 2005)
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Protein

F-box/LRR-repeat protein 18

Gene

FBXL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box/LRR-repeat protein 18
Alternative name(s):
F-box and leucine-rich repeat protein 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXL18
Synonyms:FBL18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000155034.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:21874 FBXL18

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609084 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96ME1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000155034

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134949446

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96ME1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FBXL18

Domain mapping of disease mutations (DMDM)

More...DMDMi		61213731

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198671 – 805F-box/LRR-repeat protein 18Add BLAST805

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96ME1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96ME1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96ME1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96ME1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96ME1

PeptideAtlas

More...PeptideAtlasi		Q96ME1

PRoteomics IDEntifications database

More...PRIDEi		Q96ME1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77339 [Q96ME1-1]
77340 [Q96ME1-2]
77341 [Q96ME1-3]
77342 [Q96ME1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96ME1

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q96ME1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96ME1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155034 Expressed in subthalamic nucleus and 159 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96ME1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96ME1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155034 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with SKP1 and CUL1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123080, 46 interactors

Protein interaction database and analysis system

More...IntActi		Q96ME1, 16 interactors

Molecular INTeraction database

More...MINTi		Q96ME1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000371805

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96ME1 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 72F-boxPROSITE-ProRule annotationAdd BLAST48
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati77 – 103LRR 1Add BLAST27
Repeati104 – 128LRR 2Add BLAST25
Repeati129 – 153LRR 3Add BLAST25
Repeati177 – 201LRR 4Add BLAST25
Repeati324 – 352LRR 5Add BLAST29
Repeati367 – 392LRR 6Add BLAST26
Repeati393 – 422LRR 7Add BLAST30
Repeati468 – 492LRR 8Add BLAST25
Repeati516 – 540LRR 9Add BLAST25
Repeati542 – 567LRR 10Add BLAST26
Repeati572 – 597LRR 11Add BLAST26
Repeati599 – 623LRR 12Add BLAST25

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IEMD Eukaryota
ENOG410ZR0R LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015109

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_758549_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96ME1

Identification of Orthologs from Complete Genome Data

More...OMAi		PNPAHWP

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96ME1

TreeFam database of animal gene trees

More...TreeFami		TF331865

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00646 F-box, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50181 FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96ME1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL 
        60         70         80         90        100
NVRRTCRKLA ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS 
       110        120        130        140        150
MAGCYWLPGS TVEHVARCRS LVKVNLSGCH LTSLRLSKML SALQHLRSLA 
       160        170        180        190        200
IDVSPGFDAS QLSSECKATL SRVRELKQTL FTPSYGVVPC CTSLEKLLLY 
       210        220        230        240        250
FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG YINQEVVRLY 
       260        270        280        290        300
LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS 
       310        320        330        340        350
WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL 
       360        370        380        390        400
SGCVHCLSPD SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG 
       410        420        430        440        450
LGRHLCQLLA RLRHLRSLSL PVCSVADSAP RADRAPAQPA MHAVPRGFGK 
       460        470        480        490        500
KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK NLPFLEHLEL IGSNFSSAMP 
       510        520        530        540        550
RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ LPSVLTGSGL 
       560        570        580        590        600
VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF 
       610        620        630        640        650
SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT 
       660        670        680        690        700
GESLATCKSL QQSLLRRWGE VTGRRPQLFT ELREEPSART SRATGRRQPC 
       710        720        730        740        750
LPDSGVVCCP CGRPLAVSGI ILVGVSPSLV VKTTCVYRVL FKNLDYASIF 
       760        770        780        790        800
FLVCLFETES HSVVQAGVQW RDLSSLQPLL SGLQPQPPEQ LENELEIGFS 

YCFVI
Length:805
Mass (Da):88,341
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i823FDC403787809C
GO
Isoform 2 (identifier: Q96ME1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-668: RW → SR
     669-805: Missing.

Show »
Length:668
Mass (Da):73,159
Checksum:iD3D385AFB3D1E6E5
GO
Isoform 3 (identifier: Q96ME1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-365: RK → CR
     366-805: Missing.

Show »
Length:365
Mass (Da):40,223
Checksum:iC5D7F25C9AFE44F4
GO
Isoform 4 (identifier: Q96ME1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-718: RWGEVTGRRP...CPCGRPLAVS → SFQAERPALN...VAEEPPNLWW
     719-805: Missing.

Show »
Length:718
Mass (Da):78,919
Checksum:iA4BB27A1195DE07B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96D16Q96D16_HUMAN
F-box/LRR-repeat protein 18
FBXL18
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6I6H0Y6I6_HUMAN
F-box/LRR-repeat protein 18
FBXL18
685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13838 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti555L → P in BAB13838 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055800552N → K. Corresponds to variant dbSNP:rs33941092Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013009364 – 365RK → CR in isoform 3. 1 Publication2
Alternative sequenceiVSP_013010366 – 805Missing in isoform 3. 1 PublicationAdd BLAST440
Alternative sequenceiVSP_013011667 – 718RWGEV…PLAVS → SFQAERPALNVVIFPLLHEG LTDVIRDVPLVHLDEITLFK SRVAEEPPNLWW in isoform 4. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_013012667 – 668RW → SR in isoform 2. 1 Publication2
Alternative sequenceiVSP_013013669 – 805Missing in isoform 2. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_013014719 – 805Missing in isoform 4. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK021529 mRNA Translation: BAB13838.1 Different initiation.
AK057042 mRNA Translation: BAB71354.1
BC004228 mRNA Translation: AAH04228.1
BC006426 mRNA Translation: AAH06426.2
BC024256 mRNA Translation: AAH24256.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43546.1 [Q96ME1-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000382368; ENSP00000371805; ENSG00000155034 [Q96ME1-4]
ENST00000415009; ENSP00000415064; ENSG00000155034 [Q96ME1-2]
ENST00000453700; ENSP00000444797; ENSG00000155034 [Q96ME1-3]

UCSC genome browser

More...UCSCi		uc003son.5 human [Q96ME1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021529 mRNA Translation: BAB13838.1 Different initiation.
AK057042 mRNA Translation: BAB71354.1
BC004228 mRNA Translation: AAH04228.1
BC006426 mRNA Translation: AAH06426.2
BC024256 mRNA Translation: AAH24256.1
CCDSiCCDS43546.1 [Q96ME1-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123080, 46 interactors
IntActiQ96ME1, 16 interactors
MINTiQ96ME1
STRINGi9606.ENSP00000371805

PTM databases

iPTMnetiQ96ME1
MetOSiteiQ96ME1
PhosphoSitePlusiQ96ME1

Polymorphism and mutation databases

BioMutaiFBXL18
DMDMi61213731

Proteomic databases

EPDiQ96ME1
jPOSTiQ96ME1
MassIVEiQ96ME1
MaxQBiQ96ME1
PaxDbiQ96ME1
PeptideAtlasiQ96ME1
PRIDEiQ96ME1
ProteomicsDBi77339 [Q96ME1-1]
77340 [Q96ME1-2]
77341 [Q96ME1-3]
77342 [Q96ME1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24615 89 antibodies

Genome annotation databases

EnsembliENST00000382368; ENSP00000371805; ENSG00000155034 [Q96ME1-4]
ENST00000415009; ENSP00000415064; ENSG00000155034 [Q96ME1-2]
ENST00000453700; ENSP00000444797; ENSG00000155034 [Q96ME1-3]
UCSCiuc003son.5 human [Q96ME1-1]

Organism-specific databases

EuPathDBiHostDB:ENSG00000155034.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		FBXL18
HGNCiHGNC:21874 FBXL18
HPAiENSG00000155034 Low tissue specificity
MIMi609084 gene
neXtProtiNX_Q96ME1
OpenTargetsiENSG00000155034
PharmGKBiPA134949446

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IEMD Eukaryota
ENOG410ZR0R LUCA
GeneTreeiENSGT00390000015109
HOGENOMiCLU_758549_0_0_1
InParanoidiQ96ME1
OMAiPNPAHWP
PhylomeDBiQ96ME1
TreeFamiTF331865

Enzyme and pathway databases

ReactomeiR-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FBXL18 human
PharosiQ96ME1 Tdark

Protein Ontology

More...PROi		PR:Q96ME1
RNActiQ96ME1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155034 Expressed in subthalamic nucleus and 159 other tissues
ExpressionAtlasiQ96ME1 baseline and differential
GenevisibleiQ96ME1 HS

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00646 F-box, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFXL18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96ME1
Secondary accession number(s): Q9BR90, Q9BTC7, Q9HAK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 17, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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