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Protein

Adenylate kinase 8

Gene

AK8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.1 µM for AMP1 Publication
  2. KM=630 µM for dAMP1 Publication
  3. KM=1.4 µM for CMP1 Publication
  1. Vmax=2400 pmol/min/µg enzyme with AMP as substrate1 Publication
  2. Vmax=1360 pmol/min/µg enzyme with dAMP as substrate1 Publication
  3. Vmax=190 pmol/min/µg enzyme with CMP as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei147AMP 1By similarity1
Binding sitei203AMP 1By similarity1
Binding sitei361AMP 2By similarity1
Binding sitei392ATP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi67 – 72ATP 1By similarity6
Nucleotide bindingi140 – 143AMP 1By similarity4
Nucleotide bindingi278 – 283ATP 2By similarity6
Nucleotide bindingi325 – 327AMP 2By similarity3
Nucleotide bindingi354 – 357AMP 2By similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-499943 Interconversion of nucleotide di- and triphosphates

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylate kinase 8 (EC:2.7.4.31 Publication, EC:2.7.4.62 Publications)
Short name:
AK 8
Alternative name(s):
ATP-AMP transphosphorylase 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AK8
Synonyms:C9orf98
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165695.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26526 AK8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615365 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MA6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
158067

Open Targets

More...
OpenTargetsi
ENSG00000165695

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134971772

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01717 Bis(Adenosine)-5'-Pentaphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AK8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752032

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002793831 – 479Adenylate kinase 8Add BLAST479

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96MA6

PeptideAtlas

More...
PeptideAtlasi
Q96MA6

PRoteomics IDEntifications database

More...
PRIDEi
Q96MA6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77326
77327 [Q96MA6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165695 Expressed in 123 organ(s), highest expression level in nasal cavity epithelium

CleanEx database of gene expression profiles

More...
CleanExi
HS_C9orf98

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96MA6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021443
HPA021445
HPA023894

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127645, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q96MA6, 15 interactors

Molecular INTeraction database

More...
MINTi
Q96MA6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298545

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96MA6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96MA6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 258Adenylate kinase 11 PublicationAdd BLAST201
Regioni87 – 113NMPbind 1By similarityAdd BLAST27
Regioni177 – 206LID 1By similarityAdd BLAST30
Regioni269 – 471Adenylate kinase 21 PublicationAdd BLAST203
Regioni298 – 327NMPbind 2By similarityAdd BLAST30
Regioni391 – 424LID 2By similarityAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylate kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3078 Eukaryota
COG0563 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161613

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080569

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96MA6

KEGG Orthology (KO)

More...
KOi
K00939

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQYGEAN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06BH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96MA6

TreeFam database of animal gene trees

More...
TreeFami
TF328560

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01428 ADK, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00235 Adenylate_kinase_Adk, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000850 Adenylat/UMP-CMP_kin
IPR036193 ADK_active_lid_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR23359 PTHR23359, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00094 ADENYLTKNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF57774 SSF57774, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96MA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDATIAPHRI PPEMPQYGEE NHIFELMQNM LEQLLIHQPE DPIPFMIQHL
60 70 80 90 100
HRDNDNVPRI VILGPPASGK TTIAMWLCKH LNSSLLTLEN LILNEFSYTA
110 120 130 140 150
TEARRLYLQR KTVPSALLVQ LIQERLAEED CIKQGWILDG IPETREQALR
160 170 180 190 200
IQTLGITPRH VIVLSAPDTV LIERNLGKRI DPQTGEIYHT TFDWPPESEI
210 220 230 240 250
QNRLMVPEDI SELETAQKLL EYHRNIVRVI PSYPKILKVI SADQPCVDVF
260 270 280 290 300
YQALTYVQSN HRTNAPFTPR VLLLGPVGSG KSLQAALLAQ KYRLVNVCCG
310 320 330 340 350
QLLKEAVADR TTFGELIQPF FEKEMAVPDS LLMKVLSQRL DQQDCIQKGW
360 370 380 390 400
VLHGVPRDLD QAHLLNRLGY NPNRVFFLNV PFDSIMERLT LRRIDPVTGE
410 420 430 440 450
RYHLMYKPPP TMEIQARLLQ NPKDAEEQVK LKMDLFYRNS ADLEQLYGSA
460 470
ITLNGDQDPY TVFEYIESGI INPLPKKIP
Length:479
Mass (Da):54,926
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E4EABA3F429B731
GO
Isoform 2 (identifier: Q96MA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):31,455
Checksum:iB90C76CF137D6C34
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0308735I → T. Corresponds to variant dbSNP:rs2231400Ensembl.1
Natural variantiVAR_030874130D → G. Corresponds to variant dbSNP:rs17407084Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0234191 – 204Missing in isoform 2. 1 PublicationAdd BLAST204

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057266 mRNA Translation: BAB71402.1
AK093446 mRNA Translation: BAC04168.1
AK292186 mRNA Translation: BAF84875.1
AL160165 Genomic DNA No translation available.
AL445645 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88016.1
BC034776 mRNA Translation: AAH34776.1
BC050576 mRNA Translation: AAH50576.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6954.1 [Q96MA6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001304887.1, NM_001317958.1 [Q96MA6-2]
NP_001304888.1, NM_001317959.1
NP_689785.1, NM_152572.2 [Q96MA6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.421340

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298545; ENSP00000298545; ENSG00000165695 [Q96MA6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
158067

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:158067

UCSC genome browser

More...
UCSCi
uc004cbu.2 human [Q96MA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057266 mRNA Translation: BAB71402.1
AK093446 mRNA Translation: BAC04168.1
AK292186 mRNA Translation: BAF84875.1
AL160165 Genomic DNA No translation available.
AL445645 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88016.1
BC034776 mRNA Translation: AAH34776.1
BC050576 mRNA Translation: AAH50576.1
CCDSiCCDS6954.1 [Q96MA6-1]
RefSeqiNP_001304887.1, NM_001317958.1 [Q96MA6-2]
NP_001304888.1, NM_001317959.1
NP_689785.1, NM_152572.2 [Q96MA6-1]
UniGeneiHs.421340

3D structure databases

ProteinModelPortaliQ96MA6
SMRiQ96MA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127645, 11 interactors
IntActiQ96MA6, 15 interactors
MINTiQ96MA6
STRINGi9606.ENSP00000298545

Chemistry databases

DrugBankiDB01717 Bis(Adenosine)-5'-Pentaphosphate

PTM databases

iPTMnetiQ96MA6
PhosphoSitePlusiQ96MA6

Polymorphism and mutation databases

BioMutaiAK8
DMDMi74752032

Proteomic databases

PaxDbiQ96MA6
PeptideAtlasiQ96MA6
PRIDEiQ96MA6
ProteomicsDBi77326
77327 [Q96MA6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
158067
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298545; ENSP00000298545; ENSG00000165695 [Q96MA6-1]
GeneIDi158067
KEGGihsa:158067
UCSCiuc004cbu.2 human [Q96MA6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
158067
DisGeNETi158067
EuPathDBiHostDB:ENSG00000165695.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AK8

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008494
HGNCiHGNC:26526 AK8
HPAiHPA021443
HPA021445
HPA023894
MIMi615365 gene
neXtProtiNX_Q96MA6
OpenTargetsiENSG00000165695
PharmGKBiPA134971772

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3078 Eukaryota
COG0563 LUCA
GeneTreeiENSGT00940000161613
HOVERGENiHBG080569
InParanoidiQ96MA6
KOiK00939
OMAiPQYGEAN
OrthoDBiEOG091G06BH
PhylomeDBiQ96MA6
TreeFamiTF328560

Enzyme and pathway databases

ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AK8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
158067

Protein Ontology

More...
PROi
PR:Q96MA6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165695 Expressed in 123 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_C9orf98
GenevisibleiQ96MA6 HS

Family and domain databases

CDDicd01428 ADK, 2 hits
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
InterProiView protein in InterPro
IPR000850 Adenylat/UMP-CMP_kin
IPR036193 ADK_active_lid_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR23359 PTHR23359, 2 hits
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 2 hits
SSF57774 SSF57774, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAD8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MA6
Secondary accession number(s): A8K821, Q8N9W9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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