UniProtKB - Q96M98 (PACRG_HUMAN)
Parkin coregulated gene protein
PACRG
Functioni
Miscellaneous
GO - Molecular functioni
- actin binding Source: ParkinsonsUK-UCL
- alpha-tubulin binding Source: ParkinsonsUK-UCL
- beta-tubulin binding Source: ParkinsonsUK-UCL
- chaperone binding Source: ParkinsonsUK-UCL
- G protein-coupled receptor binding Source: ParkinsonsUK-UCL
- heat shock protein binding Source: ParkinsonsUK-UCL
- Hsp70 protein binding Source: ParkinsonsUK-UCL
- Hsp90 protein binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- cellular response to unfolded protein Source: ParkinsonsUK-UCL
- negative regulation of cell death Source: ParkinsonsUK-UCL
- spermatid development Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q96M98 |
Names & Taxonomyi
Protein namesi | Recommended name: Parkin coregulated gene proteinAlternative name(s): Molecular chaperone/chaperonin-binding protein PARK2 coregulated gene protein |
Gene namesi | Name:PACRG Synonyms:GLUP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112530.11 |
HGNCi | HGNC:19152, PACRG |
MIMi | 608427, gene |
neXtProti | NX_Q96M98 |
Subcellular locationi
Cytosol
- cytosol Source: ParkinsonsUK-UCL
Nucleus
- nucleus Source: UniProtKB
Other locations
- cell body Source: Ensembl
- neuron projection Source: ParkinsonsUK-UCL
- sperm midpiece Source: Ensembl
- vesicle Source: ParkinsonsUK-UCL
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 135138 |
MIMi | 607572, phenotype |
OpenTargetsi | ENSG00000112530 |
PharmGKBi | PA134909011 |
Miscellaneous databases
Pharosi | Q96M98, Tbio |
Polymorphism and mutation databases
BioMutai | PACRG |
DMDMi | 77416872 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058169 | 1 – 296 | Parkin coregulated gene proteinAdd BLAST | 296 |
Proteomic databases
MassIVEi | Q96M98 |
PaxDbi | Q96M98 |
PeptideAtlasi | Q96M98 |
PRIDEi | Q96M98 |
ProteomicsDBi | 77323 [Q96M98-1] 77324 [Q96M98-2] |
PTM databases
iPTMneti | Q96M98 |
PhosphoSitePlusi | Q96M98 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000112530, Expressed in heart left ventricle and 151 other tissues |
ExpressionAtlasi | Q96M98, baseline and differential |
Genevisiblei | Q96M98, HS |
Organism-specific databases
HPAi | ENSG00000112530, Tissue enhanced (fallopian tube, pituitary gland, testis) |
Interactioni
Subunit structurei
Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components.
Interacts with STIP1, PRKN, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8.
Interacts with MEIG1 (By similarity).
By similarityBinary interactionsi
Isoform 2 [Q96M98-2]
With | #Exp. | IntAct |
---|---|---|
MEIG1 [Q5JSS6] | 5 | EBI-11945452,EBI-18583441 |
GO - Molecular functioni
- actin binding Source: ParkinsonsUK-UCL
- alpha-tubulin binding Source: ParkinsonsUK-UCL
- beta-tubulin binding Source: ParkinsonsUK-UCL
- chaperone binding Source: ParkinsonsUK-UCL
- G protein-coupled receptor binding Source: ParkinsonsUK-UCL
- heat shock protein binding Source: ParkinsonsUK-UCL
- Hsp70 protein binding Source: ParkinsonsUK-UCL
- Hsp90 protein binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 126421, 25 interactors |
IntActi | Q96M98, 4 interactors |
STRINGi | 9606.ENSP00000337946 |
Miscellaneous databases
RNActi | Q96M98, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96M98 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG3961, Eukaryota |
GeneTreei | ENSGT00940000157330 |
HOGENOMi | CLU_073223_1_0_1 |
InParanoidi | Q96M98 |
OMAi | INGPIHE |
OrthoDBi | 1095804at2759 |
PhylomeDBi | Q96M98 |
TreeFami | TF321123 |
Family and domain databases
InterProi | View protein in InterPro IPR019399, Parkin_co-regulated_protein |
PANTHERi | PTHR21207, PTHR21207, 1 hit |
Pfami | View protein in Pfam PF10274, ParcG, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVAEKETLSL NKCPDKMPKR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN
60 70 80 90 100
SVVRGPPAAG AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI
110 120 130 140 150
EKLDYHHYLP LFFDGLCEMT FPYEFFARQG IHDMLEHGGN KILPVLPQLI
160 170 180 190 200
IPIKNALNLR NRQVICVTLK VLQHLVVSAE MVGKALVPYY RQILPVLNIF
210 220 230 240 250
KNMNGSYSLP RLECSGAIMA RCNLDHLGSS DPPTSASQVA EIIVNSGDGI
260 270 280 290
DYSQQKRENI GDLIQETLEA FERYGGENAF INIKYVVPTY ESCLLN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YFE8 | H0YFE8_HUMAN | Parkin coregulated gene protein | PACRG | 127 | Annotation score: | ||
H0YFW3 | H0YFW3_HUMAN | Parkin coregulated gene protein | PACRG | 62 | Annotation score: | ||
H0YGE0 | H0YGE0_HUMAN | Parkin coregulated gene protein | PACRG | 125 | Annotation score: | ||
A0A087WT60 | A0A087WT60_HUMAN | Parkin coregulated gene protein | PACRG | 120 | Annotation score: | ||
A0A087WXG4 | A0A087WXG4_HUMAN | Parkin coregulated gene protein | PACRG | 92 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | K → R in BAB71410 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 185 | A → T in AAH30642 (PubMed:15489334).Curated | 1 |
Polymorphismi
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010033 | 205 – 243 | Missing in isoform 2. 2 PublicationsAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF546872 mRNA Translation: AAN37911.1 AK057286 mRNA Translation: BAB71410.1 AL031121 Genomic DNA No translation available. AL137182 Genomic DNA No translation available. AL354942 Genomic DNA No translation available. AP001576 Genomic DNA No translation available. AL078585 Genomic DNA No translation available. AL590286 Genomic DNA No translation available. AL603788 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47565.1 CH471051 Genomic DNA Translation: EAW47566.1 BC030642 mRNA Translation: AAH30642.1 BC044227 mRNA Translation: AAH44227.1 BK001670 mRNA Translation: DAA02134.1 |
CCDSi | CCDS43524.1 [Q96M98-2] CCDS5284.1 [Q96M98-1] |
RefSeqi | NP_001073847.1, NM_001080378.1 [Q96M98-2] NP_001073848.1, NM_001080379.1 [Q96M98-2] NP_689623.2, NM_152410.2 [Q96M98-1] |
Genome annotation databases
Ensembli | ENST00000337019; ENSP00000337946; ENSG00000112530 [Q96M98-1] ENST00000366888; ENSP00000355854; ENSG00000112530 [Q96M98-2] ENST00000366889; ENSP00000355855; ENSG00000112530 [Q96M98-2] |
GeneIDi | 135138 |
KEGGi | hsa:135138 |
UCSCi | uc003qua.4, human [Q96M98-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF546872 mRNA Translation: AAN37911.1 AK057286 mRNA Translation: BAB71410.1 AL031121 Genomic DNA No translation available. AL137182 Genomic DNA No translation available. AL354942 Genomic DNA No translation available. AP001576 Genomic DNA No translation available. AL078585 Genomic DNA No translation available. AL590286 Genomic DNA No translation available. AL603788 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47565.1 CH471051 Genomic DNA Translation: EAW47566.1 BC030642 mRNA Translation: AAH30642.1 BC044227 mRNA Translation: AAH44227.1 BK001670 mRNA Translation: DAA02134.1 |
CCDSi | CCDS43524.1 [Q96M98-2] CCDS5284.1 [Q96M98-1] |
RefSeqi | NP_001073847.1, NM_001080378.1 [Q96M98-2] NP_001073848.1, NM_001080379.1 [Q96M98-2] NP_689623.2, NM_152410.2 [Q96M98-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6NDU | X-ray | 2.10 | A | 70-296 | [»] | |
6NEP | X-ray | 2.10 | A | 70-296 | [»] | |
6UCC | X-ray | 2.60 | A | 1-296 | [»] | |
SMRi | Q96M98 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126421, 25 interactors |
IntActi | Q96M98, 4 interactors |
STRINGi | 9606.ENSP00000337946 |
PTM databases
iPTMneti | Q96M98 |
PhosphoSitePlusi | Q96M98 |
Polymorphism and mutation databases
BioMutai | PACRG |
DMDMi | 77416872 |
Proteomic databases
MassIVEi | Q96M98 |
PaxDbi | Q96M98 |
PeptideAtlasi | Q96M98 |
PRIDEi | Q96M98 |
ProteomicsDBi | 77323 [Q96M98-1] 77324 [Q96M98-2] |
Protocols and materials databases
Antibodypediai | 20047, 152 antibodies |
DNASUi | 135138 |
Genome annotation databases
Ensembli | ENST00000337019; ENSP00000337946; ENSG00000112530 [Q96M98-1] ENST00000366888; ENSP00000355854; ENSG00000112530 [Q96M98-2] ENST00000366889; ENSP00000355855; ENSG00000112530 [Q96M98-2] |
GeneIDi | 135138 |
KEGGi | hsa:135138 |
UCSCi | uc003qua.4, human [Q96M98-1] |
Organism-specific databases
CTDi | 135138 |
DisGeNETi | 135138 |
EuPathDBi | HostDB:ENSG00000112530.11 |
GeneCardsi | PACRG |
HGNCi | HGNC:19152, PACRG |
HPAi | ENSG00000112530, Tissue enhanced (fallopian tube, pituitary gland, testis) |
MIMi | 607572, phenotype 608427, gene |
neXtProti | NX_Q96M98 |
OpenTargetsi | ENSG00000112530 |
PharmGKBi | PA134909011 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3961, Eukaryota |
GeneTreei | ENSGT00940000157330 |
HOGENOMi | CLU_073223_1_0_1 |
InParanoidi | Q96M98 |
OMAi | INGPIHE |
OrthoDBi | 1095804at2759 |
PhylomeDBi | Q96M98 |
TreeFami | TF321123 |
Enzyme and pathway databases
PathwayCommonsi | Q96M98 |
Miscellaneous databases
BioGRID-ORCSi | 135138, 3 hits in 842 CRISPR screens |
ChiTaRSi | PACRG, human |
GeneWikii | PACRG |
GenomeRNAii | 135138 |
Pharosi | Q96M98, Tbio |
PROi | PR:Q96M98 |
RNActi | Q96M98, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112530, Expressed in heart left ventricle and 151 other tissues |
ExpressionAtlasi | Q96M98, baseline and differential |
Genevisiblei | Q96M98, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019399, Parkin_co-regulated_protein |
PANTHERi | PTHR21207, PTHR21207, 1 hit |
Pfami | View protein in Pfam PF10274, ParcG, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PACRG_HUMAN | |
Accessioni | Q96M98Primary (citable) accession number: Q96M98 Secondary accession number(s): E1P5B5 Q9H1V9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references