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Protein

Parkin coregulated gene protein

Gene

PACRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.1 Publication

Miscellaneous

Linked to PRKN in a head-to-head arrangement on opposite DNA strands and share a common 5'-flanking promoter region.

GO - Molecular functioni

GO - Biological processi

  • cellular response to unfolded protein Source: ParkinsonsUK-UCL
  • negative regulation of cell death Source: ParkinsonsUK-UCL
  • spermatid development Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Parkin coregulated gene protein
Alternative name(s):
Molecular chaperone/chaperonin-binding protein
PARK2 coregulated gene protein
Gene namesi
Name:PACRG
Synonyms:GLUP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112530.11
HGNCiHGNC:19152 PACRG
MIMi608427 gene
neXtProtiNX_Q96M98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi135138
MIMi607572 phenotype
OpenTargetsiENSG00000112530
PharmGKBiPA134909011

Polymorphism and mutation databases

BioMutaiPACRG
DMDMi77416872

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581691 – 296Parkin coregulated gene proteinAdd BLAST296

Proteomic databases

PaxDbiQ96M98
PeptideAtlasiQ96M98
PRIDEiQ96M98
ProteomicsDBi77323
77324 [Q96M98-2]

PTM databases

iPTMnetiQ96M98
PhosphoSitePlusiQ96M98

Expressioni

Tissue specificityi

Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.1 Publication

Gene expression databases

BgeeiENSG00000112530 Expressed in 134 organ(s), highest expression level in heart left ventricle
CleanExiHS_PACRG
ExpressionAtlasiQ96M98 baseline and differential
GenevisibleiQ96M98 HS

Organism-specific databases

HPAiHPA066293

Interactioni

Subunit structurei

Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PRKN, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8. Interacts with MEIG1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MEIG1Q5JSS64EBI-11945452,EBI-18583441

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126421, 22 interactors
IntActiQ96M98, 2 interactors
STRINGi9606.ENSP00000337946

Structurei

3D structure databases

ProteinModelPortaliQ96M98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3961 Eukaryota
ENOG410XSXW LUCA
GeneTreeiENSGT00530000063549
HOGENOMiHOG000230829
HOVERGENiHBG053487
InParanoidiQ96M98
OMAiINGPIHE
OrthoDBiEOG091G0HH5
PhylomeDBiQ96M98
TreeFamiTF321123

Family and domain databases

InterProiView protein in InterPro
IPR019399 Parkin_co-regulated_protein
PANTHERiPTHR21207 PTHR21207, 1 hit
PfamiView protein in Pfam
PF10274 ParcG, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96M98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAEKETLSL NKCPDKMPKR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN
60 70 80 90 100
SVVRGPPAAG AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI
110 120 130 140 150
EKLDYHHYLP LFFDGLCEMT FPYEFFARQG IHDMLEHGGN KILPVLPQLI
160 170 180 190 200
IPIKNALNLR NRQVICVTLK VLQHLVVSAE MVGKALVPYY RQILPVLNIF
210 220 230 240 250
KNMNGSYSLP RLECSGAIMA RCNLDHLGSS DPPTSASQVA EIIVNSGDGI
260 270 280 290
DYSQQKRENI GDLIQETLEA FERYGGENAF INIKYVVPTY ESCLLN
Note: No experimental confirmation available.
Length:296
Mass (Da):33,342
Last modified:October 11, 2005 - v2
Checksum:i4A415741D430C7FB
GO
Isoform 2 (identifier: Q96M98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-243: Missing.

Note: May be due to exon skipping.
Show »
Length:257
Mass (Da):29,312
Checksum:i76E319E0C76A98D0
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YFE8H0YFE8_HUMAN
Parkin coregulated gene protein
PACRG
127Annotation score:
H0YFW3H0YFW3_HUMAN
Parkin coregulated gene protein
PACRG
62Annotation score:
H0YGE0H0YGE0_HUMAN
Parkin coregulated gene protein
PACRG
125Annotation score:
A0A087WXG4A0A087WXG4_HUMAN
Parkin coregulated gene protein
PACRG
92Annotation score:
A0A087WT60A0A087WT60_HUMAN
Parkin coregulated gene protein
PACRG
120Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93K → R in BAB71410 (PubMed:14702039).Curated1
Sequence conflicti185A → T in AAH30642 (PubMed:15489334).Curated1

Polymorphismi

Involved in susceptibility to leprosy (LPRS2) [MIMi:607572]. LPRS2 is associated with polymorphisms in the 5'-regulatory region shared by the PRKN gene.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010033205 – 243Missing in isoform 2. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546872 mRNA Translation: AAN37911.1
AK057286 mRNA Translation: BAB71410.1
AL031121 Genomic DNA No translation available.
AL137182 Genomic DNA No translation available.
AL354942 Genomic DNA No translation available.
AP001576 Genomic DNA No translation available.
AL078585 Genomic DNA No translation available.
AL590286 Genomic DNA No translation available.
AL603788 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47565.1
CH471051 Genomic DNA Translation: EAW47566.1
BC030642 mRNA Translation: AAH30642.1
BC044227 mRNA Translation: AAH44227.1
BK001670 mRNA Translation: DAA02134.1
CCDSiCCDS43524.1 [Q96M98-2]
CCDS5284.1 [Q96M98-1]
RefSeqiNP_001073847.1, NM_001080378.1 [Q96M98-2]
NP_001073848.1, NM_001080379.1 [Q96M98-2]
NP_689623.2, NM_152410.2 [Q96M98-1]
UniGeneiHs.25791
Hs.653916

Genome annotation databases

EnsembliENST00000337019; ENSP00000337946; ENSG00000112530 [Q96M98-1]
ENST00000366888; ENSP00000355854; ENSG00000112530 [Q96M98-2]
ENST00000366889; ENSP00000355855; ENSG00000112530 [Q96M98-2]
GeneIDi135138
KEGGihsa:135138
UCSCiuc003qua.4 human [Q96M98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546872 mRNA Translation: AAN37911.1
AK057286 mRNA Translation: BAB71410.1
AL031121 Genomic DNA No translation available.
AL137182 Genomic DNA No translation available.
AL354942 Genomic DNA No translation available.
AP001576 Genomic DNA No translation available.
AL078585 Genomic DNA No translation available.
AL590286 Genomic DNA No translation available.
AL603788 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47565.1
CH471051 Genomic DNA Translation: EAW47566.1
BC030642 mRNA Translation: AAH30642.1
BC044227 mRNA Translation: AAH44227.1
BK001670 mRNA Translation: DAA02134.1
CCDSiCCDS43524.1 [Q96M98-2]
CCDS5284.1 [Q96M98-1]
RefSeqiNP_001073847.1, NM_001080378.1 [Q96M98-2]
NP_001073848.1, NM_001080379.1 [Q96M98-2]
NP_689623.2, NM_152410.2 [Q96M98-1]
UniGeneiHs.25791
Hs.653916

3D structure databases

ProteinModelPortaliQ96M98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126421, 22 interactors
IntActiQ96M98, 2 interactors
STRINGi9606.ENSP00000337946

PTM databases

iPTMnetiQ96M98
PhosphoSitePlusiQ96M98

Polymorphism and mutation databases

BioMutaiPACRG
DMDMi77416872

Proteomic databases

PaxDbiQ96M98
PeptideAtlasiQ96M98
PRIDEiQ96M98
ProteomicsDBi77323
77324 [Q96M98-2]

Protocols and materials databases

DNASUi135138
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337019; ENSP00000337946; ENSG00000112530 [Q96M98-1]
ENST00000366888; ENSP00000355854; ENSG00000112530 [Q96M98-2]
ENST00000366889; ENSP00000355855; ENSG00000112530 [Q96M98-2]
GeneIDi135138
KEGGihsa:135138
UCSCiuc003qua.4 human [Q96M98-1]

Organism-specific databases

CTDi135138
DisGeNETi135138
EuPathDBiHostDB:ENSG00000112530.11
GeneCardsiPACRG
HGNCiHGNC:19152 PACRG
HPAiHPA066293
MIMi607572 phenotype
608427 gene
neXtProtiNX_Q96M98
OpenTargetsiENSG00000112530
PharmGKBiPA134909011
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3961 Eukaryota
ENOG410XSXW LUCA
GeneTreeiENSGT00530000063549
HOGENOMiHOG000230829
HOVERGENiHBG053487
InParanoidiQ96M98
OMAiINGPIHE
OrthoDBiEOG091G0HH5
PhylomeDBiQ96M98
TreeFamiTF321123

Miscellaneous databases

ChiTaRSiPACRG human
GeneWikiiPACRG
GenomeRNAii135138
PROiPR:Q96M98
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112530 Expressed in 134 organ(s), highest expression level in heart left ventricle
CleanExiHS_PACRG
ExpressionAtlasiQ96M98 baseline and differential
GenevisibleiQ96M98 HS

Family and domain databases

InterProiView protein in InterPro
IPR019399 Parkin_co-regulated_protein
PANTHERiPTHR21207 PTHR21207, 1 hit
PfamiView protein in Pfam
PF10274 ParcG, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPACRG_HUMAN
AccessioniPrimary (citable) accession number: Q96M98
Secondary accession number(s): E1P5B5
, Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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