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Protein

Adenosine deaminase domain-containing protein 1

Gene

ADAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase domain-containing protein 1
Alternative name(s):
Testis nuclear RNA-binding protein
Gene namesi
Name:ADAD1
Synonyms:TENR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164113.10
HGNCiHGNC:30713 ADAD1
MIMi614130 gene
neXtProtiNX_Q96M93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi132612
OpenTargetsiENSG00000164113
PharmGKBiPA162375590

Polymorphism and mutation databases

BioMutaiADAD1
DMDMi74732329

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095201 – 576Adenosine deaminase domain-containing protein 1Add BLAST576

Proteomic databases

PaxDbiQ96M93
PeptideAtlasiQ96M93
PRIDEiQ96M93
ProteomicsDBi77315
77316 [Q96M93-2]
77317 [Q96M93-3]

PTM databases

iPTMnetiQ96M93
PhosphoSitePlusiQ96M93

Expressioni

Gene expression databases

BgeeiENSG00000164113 Expressed in 43 organ(s), highest expression level in testis
CleanExiHS_ADAD1
ExpressionAtlasiQ96M93 baseline and differential
GenevisibleiQ96M93 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296513

Structurei

3D structure databases

ProteinModelPortaliQ96M93
SMRiQ96M93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 164DRBMPROSITE-ProRule annotationAdd BLAST69
Domaini249 – 574A to I editasePROSITE-ProRule annotationAdd BLAST326

Sequence similaritiesi

Belongs to the ADAD family.Curated

Phylogenomic databases

eggNOGiKOG2777 Eukaryota
ENOG410XT0Z LUCA
GeneTreeiENSGT00550000074412
HOGENOMiHOG000033798
HOVERGENiHBG058021
InParanoidiQ96M93
OMAiWIVKSPC
OrthoDBiEOG091G04IU
PhylomeDBiQ96M93
TreeFamiTF315806

Family and domain databases

CDDicd00048 DSRM, 1 hit
InterProiView protein in InterPro
IPR002466 A_deamin
IPR014720 dsRBD_dom
PfamiView protein in Pfam
PF02137 A_deamin, 1 hit
PF00035 dsrm, 1 hit
SMARTiView protein in SMART
SM00552 ADEAMc, 1 hit
SM00358 DSRM, 1 hit
PROSITEiView protein in PROSITE
PS50141 A_DEAMIN_EDITASE, 1 hit
PS50137 DS_RBD, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q96M93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASNNHWFQS SQVPSFAQML KKNLPVQPAT KTITTPTGWS SESYGLSKMA
60 70 80 90 100
SKVTQVTGNF PEPLLSKNLS SISNPVLPPK KIPKEFIMKY KRGEINPVSA
110 120 130 140 150
LHQFAQMQRV QLDLKETVTT GNVMGPYFAF CAVVDGIQYK TGLGQNKKES
160 170 180 190 200
RSNAAKLALD ELLQLDEPEP RILETSGPPP FPAEPVVLSE LAYVSKVHYE
210 220 230 240 250
GRHIQYAKIS QIVKERFNQL ISNRSEYLKY SSSLAAFIIE RAGQHEVVAI
260 270 280 290 300
GTGEYNYSQD IKPDGRVLHD THAVVTARRS LLRYFYRQLL LFYSKNPAMM
310 320 330 340 350
EKSIFCTEPT SNLLTLKQNI NICLYMNQLP KGSAQIKSQL RLNPHSISAF
360 370 380 390 400
EANEELCLHV AVEGKIYLTV YCPKDGVNRI SSMSSSDKLT RWEVLGVQGA
410 420 430 440 450
LLSHFIQPVY ISSILIGDGN CSDTRGLEIA IKQRVDDALT SKLPMFYLVN
460 470 480 490 500
RPHISLVPSA YPLQMNLEYK FLSLNWAQGD VSLEIVDGLS GKITESSPFK
510 520 530 540 550
SGMSMASRLC KAAMLSRFNL LAKEAKKELL EAGTYHAAKC MSASYQEAKC
560 570
KLKSYLQQHG YGSWIVKSPC IEQFNM
Length:576
Mass (Da):64,411
Last modified:December 1, 2001 - v1
Checksum:i379A6849ABDEEFAB
GO
Isoform 2 (identifier: Q96M93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-293: Missing.

Show »
Length:565
Mass (Da):62,847
Checksum:iCFF0F974AE08AFD8
GO
Isoform 3 (identifier: Q96M93-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MASNNHWFQSSQVPSFAQM → M

Show »
Length:558
Mass (Da):62,363
Checksum:iABCF6E031C9300AF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAT9C9JAT9_HUMAN
Adenosine deaminase domain-containi...
ADAD1
241Annotation score:
C9JGM6C9JGM6_HUMAN
Adenosine deaminase domain-containi...
ADAD1
156Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198H → Y in BAC04125 (PubMed:14702039).Curated1
Sequence conflicti407Q → R in BAC04125 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0292251 – 19MASNN…SFAQM → M in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_029226283 – 293Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057303 mRNA Translation: BAB71416.1
AK093297 mRNA Translation: BAC04125.1
AC022489 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05228.1
CH471056 Genomic DNA Translation: EAX05229.1
CH471056 Genomic DNA Translation: EAX05234.1
CH471056 Genomic DNA Translation: EAX05230.1
CH471056 Genomic DNA Translation: EAX05231.1
CH471056 Genomic DNA Translation: EAX05232.1
BC040229 mRNA Translation: AAH40229.1
CCDSiCCDS34058.1 [Q96M93-1]
CCDS54800.1 [Q96M93-2]
CCDS54801.1 [Q96M93-3]
RefSeqiNP_001152757.1, NM_001159285.1 [Q96M93-2]
NP_001152767.1, NM_001159295.1 [Q96M93-3]
NP_640336.1, NM_139243.3 [Q96M93-1]
XP_005262798.1, XM_005262741.2 [Q96M93-1]
XP_005262800.1, XM_005262743.2 [Q96M93-1]
XP_005262801.1, XM_005262744.2 [Q96M93-2]
XP_011529905.1, XM_011531603.1 [Q96M93-1]
UniGeneiHs.518957

Genome annotation databases

EnsembliENST00000296513; ENSP00000296513; ENSG00000164113 [Q96M93-1]
ENST00000388724; ENSP00000373376; ENSG00000164113 [Q96M93-2]
ENST00000388725; ENSP00000373377; ENSG00000164113 [Q96M93-3]
GeneIDi132612
KEGGihsa:132612
UCSCiuc003ieo.4 human [Q96M93-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057303 mRNA Translation: BAB71416.1
AK093297 mRNA Translation: BAC04125.1
AC022489 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05228.1
CH471056 Genomic DNA Translation: EAX05229.1
CH471056 Genomic DNA Translation: EAX05234.1
CH471056 Genomic DNA Translation: EAX05230.1
CH471056 Genomic DNA Translation: EAX05231.1
CH471056 Genomic DNA Translation: EAX05232.1
BC040229 mRNA Translation: AAH40229.1
CCDSiCCDS34058.1 [Q96M93-1]
CCDS54800.1 [Q96M93-2]
CCDS54801.1 [Q96M93-3]
RefSeqiNP_001152757.1, NM_001159285.1 [Q96M93-2]
NP_001152767.1, NM_001159295.1 [Q96M93-3]
NP_640336.1, NM_139243.3 [Q96M93-1]
XP_005262798.1, XM_005262741.2 [Q96M93-1]
XP_005262800.1, XM_005262743.2 [Q96M93-1]
XP_005262801.1, XM_005262744.2 [Q96M93-2]
XP_011529905.1, XM_011531603.1 [Q96M93-1]
UniGeneiHs.518957

3D structure databases

ProteinModelPortaliQ96M93
SMRiQ96M93
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296513

PTM databases

iPTMnetiQ96M93
PhosphoSitePlusiQ96M93

Polymorphism and mutation databases

BioMutaiADAD1
DMDMi74732329

Proteomic databases

PaxDbiQ96M93
PeptideAtlasiQ96M93
PRIDEiQ96M93
ProteomicsDBi77315
77316 [Q96M93-2]
77317 [Q96M93-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296513; ENSP00000296513; ENSG00000164113 [Q96M93-1]
ENST00000388724; ENSP00000373376; ENSG00000164113 [Q96M93-2]
ENST00000388725; ENSP00000373377; ENSG00000164113 [Q96M93-3]
GeneIDi132612
KEGGihsa:132612
UCSCiuc003ieo.4 human [Q96M93-1]

Organism-specific databases

CTDi132612
DisGeNETi132612
EuPathDBiHostDB:ENSG00000164113.10
GeneCardsiADAD1
HGNCiHGNC:30713 ADAD1
MIMi614130 gene
neXtProtiNX_Q96M93
OpenTargetsiENSG00000164113
PharmGKBiPA162375590
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2777 Eukaryota
ENOG410XT0Z LUCA
GeneTreeiENSGT00550000074412
HOGENOMiHOG000033798
HOVERGENiHBG058021
InParanoidiQ96M93
OMAiWIVKSPC
OrthoDBiEOG091G04IU
PhylomeDBiQ96M93
TreeFamiTF315806

Miscellaneous databases

GenomeRNAii132612
PROiPR:Q96M93
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164113 Expressed in 43 organ(s), highest expression level in testis
CleanExiHS_ADAD1
ExpressionAtlasiQ96M93 baseline and differential
GenevisibleiQ96M93 HS

Family and domain databases

CDDicd00048 DSRM, 1 hit
InterProiView protein in InterPro
IPR002466 A_deamin
IPR014720 dsRBD_dom
PfamiView protein in Pfam
PF02137 A_deamin, 1 hit
PF00035 dsrm, 1 hit
SMARTiView protein in SMART
SM00552 ADEAMc, 1 hit
SM00358 DSRM, 1 hit
PROSITEiView protein in PROSITE
PS50141 A_DEAMIN_EDITASE, 1 hit
PS50137 DS_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADAD1_HUMAN
AccessioniPrimary (citable) accession number: Q96M93
Secondary accession number(s): A6NKN4
, B7WPB0, D3DNX2, Q8IWG6, Q8NA06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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