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Protein

Coiled-coil domain-containing protein 138

Gene

CCDC138

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 138
Gene namesi
Name:CCDC138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163006.11
HGNCiHGNC:26531 CCDC138
neXtProtiNX_Q96M89

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163006
PharmGKBiPA162381439

Polymorphism and mutation databases

BioMutaiCCDC138
DMDMi74732327

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884541 – 665Coiled-coil domain-containing protein 138Add BLAST665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphothreonineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96M89
MaxQBiQ96M89
PaxDbiQ96M89
PeptideAtlasiQ96M89
PRIDEiQ96M89
ProteomicsDBi77312
77313 [Q96M89-2]

PTM databases

GlyConnecti1123
iPTMnetiQ96M89
PhosphoSitePlusiQ96M89

Expressioni

Gene expression databases

BgeeiENSG00000163006 Expressed in 124 organ(s), highest expression level in sperm
CleanExiHS_CCDC138
ExpressionAtlasiQ96M89 baseline and differential
GenevisibleiQ96M89 HS

Organism-specific databases

HPAiHPA049899
HPA054223

Interactioni

Protein-protein interaction databases

BioGridi127905, 46 interactors
IntActiQ96M89, 46 interactors
STRINGi9606.ENSP00000295124

Structurei

3D structure databases

ProteinModelPortaliQ96M89
SMRiQ96M89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili198 – 323Sequence analysisAdd BLAST126

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHCE Eukaryota
ENOG410XNYA LUCA
GeneTreeiENSGT00390000000217
HOGENOMiHOG000111388
HOVERGENiHBG054024
InParanoidiQ96M89
OMAiHQKLQCE
OrthoDBiEOG091G044I
PhylomeDBiQ96M89
TreeFamiTF329029

Family and domain databases

InterProiView protein in InterPro
IPR038798 CCDC138
PANTHERiPTHR34523 PTHR34523, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96M89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRVVKPPG QDLVVESLKS RYGLGGSCPD EYDFSNFYQS KYKRRTLTSP
60 70 80 90 100
GDLDIYSGDK VGSSLKYSDE SKHCRTPLGS LFKHVNVNCL DDELDSFHDL
110 120 130 140 150
KKQETEEELI ENDYRVSTSK ITKQSFKEIE KVALPTNTTS SRPRTECCSD
160 170 180 190 200
AGDSPLKPVS CPKSKASDKR SLLPHQISQI YDELFQIHLK LQCETAAQQK
210 220 230 240 250
FAEELQKRER FLLEREQLLF RHENALSKIK GVEEEVLTRF QIIKEQHDAE
260 270 280 290 300
VEHLTEVLKE KNKETKRLRS SFDALKELND TLKKQLNEAS EENRKIDIQA
310 320 330 340 350
KRVQARLDNL QRKYEFMTIQ RLKGSSHAVH EMKSLKQEKA PVSKTYKVPL
360 370 380 390 400
NGQVYELLTV FMDWISDHHL SKVKHEESGM DGKKPQLKFA SQRNDIQEKC
410 420 430 440 450
VKLLPLMTEQ LQWMPFVNIK LHEPFVKFIY WSLRQLDAGA QHSTMTSTLR
460 470 480 490 500
RLGEDIFKGV VTKGIQDNSP QHSVENKPKT AAFFKSSNLP LRFLSTLIVL
510 520 530 540 550
KTVTQADYLA QAFDSLCLDL KTEEGKTLFL EYQAVPVILS HLRISSKGLL
560 570 580 590 600
SNVIDSLLQM TVESKSLQPF LEACSNSLFF RTCSVLLRAP KLDLQILEKL
610 620 630 640 650
SIILQKLSKI KSNKKLFELF TIHLMLQEIQ RTTNPEHAFL CINLNSTLFN
660
LGLTKCNSLV SSASP
Length:665
Mass (Da):76,219
Last modified:December 1, 2001 - v1
Checksum:i0723A65295914E82
GO
Isoform 2 (identifier: Q96M89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     565-577: KSLQPFLEACSNS → RVIRSSLNFLRFI
     578-665: Missing.

Show »
Length:577
Mass (Da):66,403
Checksum:i5B368F324F8FFEF7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C005H7C005_HUMAN
Coiled-coil domain-containing prote...
CCDC138
352Annotation score:
F8WF51F8WF51_HUMAN
Coiled-coil domain-containing prote...
CCDC138
45Annotation score:
H7BZ08H7BZ08_HUMAN
Coiled-coil domain-containing prote...
CCDC138
104Annotation score:
V9GZ19V9GZ19_HUMAN
Coiled-coil domain-containing prote...
CCDC138
39Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03242099D → Y. Corresponds to variant dbSNP:rs35794776Ensembl.1
Natural variantiVAR_032421115R → K. Corresponds to variant dbSNP:rs6740879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025683565 – 577KSLQP…ACSNS → RVIRSSLNFLRFI in isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_025684578 – 665Missing in isoform 2. 2 PublicationsAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057307 mRNA Translation: BAB71420.1
AK125199 mRNA Translation: BAC86081.1
AC010095 Genomic DNA Translation: AAY14985.1
AC073415 Genomic DNA Translation: AAX88855.1
BC015847 mRNA Translation: AAH15847.1 Different termination.
BC050579 mRNA Translation: AAH50579.1
CCDSiCCDS2080.1 [Q96M89-1]
CCDS77447.1 [Q96M89-2]
RefSeqiNP_001290034.1, NM_001303105.1 [Q96M89-2]
NP_659415.1, NM_144978.2 [Q96M89-1]
UniGeneiHs.362702
Hs.731709

Genome annotation databases

EnsembliENST00000295124; ENSP00000295124; ENSG00000163006 [Q96M89-1]
ENST00000412964; ENSP00000411800; ENSG00000163006 [Q96M89-2]
GeneIDi165055
KEGGihsa:165055
UCSCiuc002ten.2 human [Q96M89-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057307 mRNA Translation: BAB71420.1
AK125199 mRNA Translation: BAC86081.1
AC010095 Genomic DNA Translation: AAY14985.1
AC073415 Genomic DNA Translation: AAX88855.1
BC015847 mRNA Translation: AAH15847.1 Different termination.
BC050579 mRNA Translation: AAH50579.1
CCDSiCCDS2080.1 [Q96M89-1]
CCDS77447.1 [Q96M89-2]
RefSeqiNP_001290034.1, NM_001303105.1 [Q96M89-2]
NP_659415.1, NM_144978.2 [Q96M89-1]
UniGeneiHs.362702
Hs.731709

3D structure databases

ProteinModelPortaliQ96M89
SMRiQ96M89
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127905, 46 interactors
IntActiQ96M89, 46 interactors
STRINGi9606.ENSP00000295124

PTM databases

GlyConnecti1123
iPTMnetiQ96M89
PhosphoSitePlusiQ96M89

Polymorphism and mutation databases

BioMutaiCCDC138
DMDMi74732327

Proteomic databases

EPDiQ96M89
MaxQBiQ96M89
PaxDbiQ96M89
PeptideAtlasiQ96M89
PRIDEiQ96M89
ProteomicsDBi77312
77313 [Q96M89-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295124; ENSP00000295124; ENSG00000163006 [Q96M89-1]
ENST00000412964; ENSP00000411800; ENSG00000163006 [Q96M89-2]
GeneIDi165055
KEGGihsa:165055
UCSCiuc002ten.2 human [Q96M89-1]

Organism-specific databases

CTDi165055
EuPathDBiHostDB:ENSG00000163006.11
GeneCardsiCCDC138
H-InvDBiHIX0200282
HGNCiHGNC:26531 CCDC138
HPAiHPA049899
HPA054223
neXtProtiNX_Q96M89
OpenTargetsiENSG00000163006
PharmGKBiPA162381439
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHCE Eukaryota
ENOG410XNYA LUCA
GeneTreeiENSGT00390000000217
HOGENOMiHOG000111388
HOVERGENiHBG054024
InParanoidiQ96M89
OMAiHQKLQCE
OrthoDBiEOG091G044I
PhylomeDBiQ96M89
TreeFamiTF329029

Miscellaneous databases

ChiTaRSiCCDC138 human
GenomeRNAii165055
PROiPR:Q96M89

Gene expression databases

BgeeiENSG00000163006 Expressed in 124 organ(s), highest expression level in sperm
CleanExiHS_CCDC138
ExpressionAtlasiQ96M89 baseline and differential
GenevisibleiQ96M89 HS

Family and domain databases

InterProiView protein in InterPro
IPR038798 CCDC138
PANTHERiPTHR34523 PTHR34523, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC138_HUMAN
AccessioniPrimary (citable) accession number: Q96M89
Secondary accession number(s): Q05DF1
, Q4ZG07, Q53TE1, Q6ZUY5, Q86VL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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