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Entry version 136 (26 Feb 2020)
Sequence version 2 (13 Jul 2010)
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Protein

Dynein heavy chain domain-containing protein 1

Gene

DNHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain domain-containing protein 1
Alternative name(s):
Dynein heavy chain domain 1-like protein
Protein CCDC35
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNHD1
Synonyms:C11orf47, CCDC35, DHCD1, DNHD1L
ORF Names:UNQ5781/PRO12970
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26532 DNHD1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617277 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96M86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
144132

Open Targets

More...
OpenTargetsi
ENSG00000179532

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671968

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96M86 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
DNHD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300669633

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119851 – 4753Dynein heavy chain domain-containing protein 1Add BLAST4753

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96M86

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96M86

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96M86

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96M86

PeptideAtlas

More...
PeptideAtlasi
Q96M86

PRoteomics IDEntifications database

More...
PRIDEi
Q96M86

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77309 [Q96M86-3]
77310 [Q96M86-4]
77311 [Q96M86-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96M86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96M86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179532 Expressed in right testis and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96M86 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96M86 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039698
HPA040267
HPA057639

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126834, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q96M86, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254579

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96M86 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili826 – 858Sequence analysisAdd BLAST33
Coiled coili936 – 991Sequence analysisAdd BLAST56
Coiled coili3125 – 3227Sequence analysisAdd BLAST103
Coiled coili3590 – 3651Sequence analysisAdd BLAST62
Coiled coili4431 – 4460Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi886 – 896Poly-ProAdd BLAST11
Compositional biasi2695 – 2732Glu-richAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
ENOG410XZRW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155523

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96M86

Identification of Orthologs from Complete Genome Data

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OMAi
HEAQRTF

Database of Orthologous Groups

More...
OrthoDBi
6155at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96M86

TreeFam database of animal gene trees

More...
TreeFami
TF337443

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035699 AAA_6
IPR026983 DHC_fam
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676 PTHR10676, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96M86-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPEERRVGL SSDETSSDSL KSWHSICVLD SKEQPLACQQ KQRQFVKPVT
60 70 80 90 100
ESEQPTVLEL LLAELRTLFS AVLQDSSPAA WRYLHAVLGL LPPYRELLVG
110 120 130 140 150
HLDLLPFLEQ LYCWAPWVQT HLHLDLLGAI VQAFPPDSSL LDSASHADCC
160 170 180 190 200
PQKRRLHHRP PCPACPFVQA QWSRQQVKEE LATWLRPLTL PELQRCLGIV
210 220 230 240 250
GAQVALEEAV WLDGLSLLPL ALAADIPVRY ESSDTDNAEV EPVGRKETRS
260 270 280 290 300
QLDYEVPREK AFQKSSTGFS PETSFLDSQV MTALKMERYL KKIHFLYLNV
310 320 330 340 350
APSRYFRPYS LMVVPPDKVN PEHYIFSPFG ILHVHPVEGS ETMTLGTWHH
360 370 380 390 400
HCVLWQQLQF IPFFKYCLLR KSFTCWKKNV RLQGLHRLQK FLENHLLLAV
410 420 430 440 450
PHFGAGLLHI SRLLQELHSV SWLPQELDRC YELLDLQTAL AEEKHKALRL
460 470 480 490 500
LHRCLNLCTS ILRLVHEDTY HMQQCLQERV QNCDRIRTGQ GSIYLQRVQH
510 520 530 540 550
KQLEQKLKQA EAWWLQLGKF ARLVDYMICQ SLISVLEEQI TSFVANILQA
560 570 580 590 600
PRQKPFLSSQ LVFDDHGQLS HVPCVENMIQ TLTGGLQSVK TSALQVVQSA
610 620 630 640 650
DLKTSSDSLY SEEEDEEEDS KDEFLMPKFQ GQPSDAVSIF CGPNVGLVWP
660 670 680 690 700
WKSHPIAGIL EVRGCRLRGQ YFPHNYKQLE EDLDNNPKIQ QALNIQQVLL
710 720 730 740 750
EGVLCKVQEF CREHHWITGI YEFLQSWGPQ KLEDMRGGPI KNYVTLVSRL
760 770 780 790 800
NVWQARVSSM PIELLTKGGL LLLSCHDVQA EMESKLNSIR KDILAHVQNE
810 820 830 840 850
CWNLSQQLMT ELTDFMHIFR TINSDIHAIA QCTQKLNEAN EQYVELEERM
860 870 880 890 900
EYVRALHELI RNHFSLFSAE NEALDISVRR QFGESPIPPC PPPPQPHLLH
910 920 930 940 950
CPLLAPQLLD MWEAFQFEKS QASEFLLSKR HAIMPKLQQL MAAALAELEG
960 970 980 990 1000
LLAKALSGPF MDPTQDQRST EHQLVSLERQ FQNTVSDLSE LHHAYAIFTE
1010 1020 1030 1040 1050
DETPVPLPIC GTRPIVQQQR IWHLYRVISE NISEWKCMAF AKFSPAMAQE
1060 1070 1080 1090 1100
KTEGWLTEAA RMSTTLELHS PVLQHCMRIL GEFRSYLPLL TKLGSLHPQS
1110 1120 1130 1140 1150
LNCQCLLRAL GLGSLQTIEL LTLGQLLTYP LLEFADRINQ VWQNENERIH
1160 1170 1180 1190 1200
AQETIRRLQR YWEARQLRLL NFILHVPYEP PASERSKRQV LRSPQWEVVD
1210 1220 1230 1240 1250
KDSGTFILSD YSNLQDSIQE SLQVLSKILA IEKSGDLNKI ALEWVAIMHG
1260 1270 1280 1290 1300
LGALLEVWLT FQQKWIFLNK VLHEMKIQFP NADLNSRFKV MDDQYRTLMR
1310 1320 1330 1340 1350
ISVADPMVLS LVVPSAERSP YFQGQQLQQL LQAGSVELEG IIMSLESVLY
1360 1370 1380 1390 1400
GVCAHFPRLF FLSDSELVAL LAARLESCEA QLWVRRCFPH VHAVSFRSCP
1410 1420 1430 1440 1450
TGEKNTDDWE SSPNTQTQVE ALAVLGAGGE EVKLQGPLPL HPDLPKWLAS
1460 1470 1480 1490 1500
LEKCLRLALV HMLQGCVAAR LARGPSLGEA LKQLPKQNKL YLQLYVQHWI
1510 1520 1530 1540 1550
DLVQAFPWQC VLVAEEVVWR AEMEEALLEW GTLAMVSMHM RKLEVLVNFM
1560 1570 1580 1590 1600
RAQRASQGGQ SLPSVRQTSL LSALLVMAVT HRDIAQLLEQ HQVSDLTDFH
1610 1620 1630 1640 1650
WVRQLKYHLG SPHIIPKSPL QSLKTIASSE PSLSPAACWI DVLGRSFLYN
1660 1670 1680 1690 1700
YEYLGPRLGP LPSLLPERPA LVLLLALEEV ACGTVLGPNG VGKRAIVNSL
1710 1720 1730 1740 1750
AQALGRQLVM LPCSPQIEAQ CLSNYLNGAL QGGAWLLLEK VHQLPPGLLS
1760 1770 1780 1790 1800
ALGQRLGELH HLYAPLYQEA SRNTSTIDPT QPQLLGSSFF EKHHVSVRLG
1810 1820 1830 1840 1850
YGCLLVLRAL SSAVPANLHL LLRPVALALP DLRQVAELTL LGAGMRDAFQ
1860 1870 1880 1890 1900
MATRLSKFFS LERELVSGPL PCRLPLLKQI LEDTIRTLNV TKEEPKCQKP
1910 1920 1930 1940 1950
RSLAAIEEAA LLRSPLFSIL NGLHLHNLRG LLCALFPSAS QVLAEPMTYK
1960 1970 1980 1990 2000
LMKPLVVEEL QQVGLDPSPD ILGSLEQLSQ ALSRASGILL LGPAGSGKTT
2010 2020 2030 2040 2050
CWHSLFKIQN RLAAMEDTST QGCQPVEITH LYPSGLSPQE FLGWLEGSCW
2060 2070 2080 2090 2100
HHGIFPKVLR AAGQCNNMGQ KRQTEESIGI QHWIICDGAS NGAWLDSITC
2110 2120 2130 2140 2150
LLSELPQLSL PSGQQIARPP GTFLLMEVAD TTGISPTVVG CCALVWCGGE
2160 2170 2180 2190 2200
QTWQCILSAL MASLPYEYRL QHRTVAELNH MAEVLVPATL RFLTCQGVSS
2210 2220 2230 2240 2250
LLQVHGQQAV CAGVAEVTSM ARILHSLLDL HLRLKEEKAP GPEDLSYSDP
2260 2270 2280 2290 2300
VAQSFRSSKS SFLNRSQVDS DDVPDKCREH LLAVSSFLFA LIWGFGAHLP
2310 2320 2330 2340 2350
SRFWPIFDTF IRDSISRLSN YPEPPPSALV FDLHVSPEDG TLVPFTGQYL
2360 2370 2380 2390 2400
SSHIKGTLGT FHPSIQTERL LYVVDLLLSG GQPVLLAGEA ATGKSAFVEV
2410 2420 2430 2440 2450
LVEPHHPYIY SPIHPAFSSS HLRLLLSRGI QGQTQASPQP GHHQDSKPSL
2460 2470 2480 2490 2500
LFLLEDLHLA TSDPEKSCQP VLETLRQAMD GTVYAHSTLE LQTLQPTVNF
2510 2520 2530 2540 2550
LATVTVPGYC ERPLCPRLFR LFTVLALESM TQATLLERHV PIIQAWLERF
2560 2570 2580 2590 2600
PSVERERALA RGLVRASVEA WEAVCNCFMP SPLHPHYHFS LHSVSHLLSS
2610 2620 2630 2640 2650
LQLLPNRTGS RGFVDYPNHQ EHLRRVSGLR GTCLTVMMAT RNVVRLWLHE
2660 2670 2680 2690 2700
AQRTFCDRLD SPRERSYCAK LLLVVAQSVF CCGPGPQHLG KDHQESEEEE
2710 2720 2730 2740 2750
EEERVPEVES EGELAQWEDF SNSNSETEEE EEPYGLQVAR VSNSRDPSLT
2760 2770 2780 2790 2800
PSIGPVSRGM KESISHKIRQ EKGTRASNYR LQVRRSFKTW WQKKPQMDLI
2810 2820 2830 2840 2850
SPLLLPVLLL HPQEKPSDLV FSQELILGPN SETPNLYLER QWEKLEEQLA
2860 2870 2880 2890 2900
TSAAQLKLSP HLARCHSMAQ HVARLVRVLA RPRQHGLLLS GALGTGRHTA
2910 2920 2930 2940 2950
ITLASSICQA HFFHLPSGSE EAILQCLRDA SWHAGMLSQP VALLVPSGVD
2960 2970 2980 2990 3000
LTTLHRLLAL ATSGSFPGQY TEADLDRIGE HLPRENLGVK QNIKKEMVLQ
3010 3020 3030 3040 3050
RFHQQVCSHL HLFFLIGDKQ AHKQLPSTLF LRLLQLATAS IDRYEPWDQA
3060 3070 3080 3090 3100
ALAKVAQHHL EGAQSVPLDD GSWKYPDLQA SIPSVAKAMA LIHLSATHYH
3110 3120 3130 3140 3150
EHLCPALPLV TPKTFLDFLD TFLMLQQQTI LKIKNKAQRV QNALENLRML
3160 3170 3180 3190 3200
IKEHGTHANL IFDLEQQLKD SGKSLSMFQQ QLEQSKLLYK QQLEECRHQE
3210 3220 3230 3240 3250
NLIENLARQR DALQAQREAF LEQMSKAFLE PLSQLQVADF EEIRSYRAPP
3260 3270 3280 3290 3300
ESVVRVTDAM CDLFHHETGW ASAKQLLCTE DFYQELVFFP KEKITDSELI
3310 3320 3330 3340 3350
KLHLILKAPG MDDAALRAVS RPAASLAAWL WAVLHYGLAH CRGLPTDLLL
3360 3370 3380 3390 3400
QQVEATLTRE QARLGYYQFQ AQETLEHNLA LAKMVEDAQA SHNCVAKTLS
3410 3420 3430 3440 3450
QAQCGQYHKW PMKAALLTPM RAWTTQLQKL KGRCMTVFGD TLLCSAAIIY
3460 3470 3480 3490 3500
LGPFPPLRRQ ELLDEWLALC RGFQEALGPD DVAQALKRKQ KSVSIPPKNP
3510 3520 3530 3540 3550
LLATHSPFSI LSLLSSESEQ YQWDGNLKPQ AKSAHLAGLL LRSPTHYSSC
3560 3570 3580 3590 3600
RWPLLLDPSN EALIWLDPLP LEENRSFAPA LTEGRGKGLM RNQKRESKTD
3610 3620 3630 3640 3650
MKEEDDESEE SNEAEDQTKE QKAEERKNEQ EKEQEENEEK EEEKTESQGS
3660 3670 3680 3690 3700
KPAYETQLPS LPYLSVLSGA DPELGSQLQE AAACGLPVLL TNVELGLGCE
3710 3720 3730 3740 3750
ELQWLLQREQ LSPPQVQPGF CLYLSTTLSL CAMEKVLGCE LLKGLNVLDL
3760 3770 3780 3790 3800
GLNMEILEEQ MLHEILCREY PELETRWQDL KIRALDTCKA VEAAEERLLT
3810 3820 3830 3840 3850
MLLFQNPKRQ KPAKFLRNIV RAQGKLCQLR AHCEELEGQK LQEMVLWAPY
3860 3870 3880 3890 3900
RPVVWHGMAM VKALSQLQNL LPLFCMSPEN WLAVTKQALD SMKPREINHG
3910 3920 3930 3940 3950
EDLASHLLQL RAHLTRQLLG STVTALGLTQ VPLVGALGAL ALLQATGKAS
3960 3970 3980 3990 4000
ELERLALWPG LAASPSTVHS KPVSDVARPA WLGPKAWHEC EMLELLPPFV
4010 4020 4030 4040 4050
GLCASLAGHS SAWQAYLSLS STVLGPAPGP GPEPLSLLQK LILWRVLRPE
4060 4070 4080 4090 4100
CLAGALADFT TSLLGRPLDE NTYAPTMPFK HSQATQPMLI LLPPPGHPSA
4110 4120 4130 4140 4150
TLHPLTVIQK LAAKYQQGQK QLQVIALGSE AWDPVSVVVS TLSQAMYEGH
4160 4170 4180 4190 4200
WLVLDNCHLM PHWPKELLQL LLELLGRAKV VADLESEQLL DQPESRNVST
4210 4220 4230 4240 4250
VHRDFRLWLI VPAESSASLP AVLTQHSMPV FWNQSLELGH VLIDSVELAQ
4260 4270 4280 4290 4300
QVLYMQPPTQ ALPLLLLHGL LLHRQLYGTR LQAHRGRWSQ VTLTQVLQTQ
4310 4320 4330 4340 4350
DQLWASLSNP RAAMQELAAS VFYGGPLGDT EDREALISLT QACLSPSSGS
4360 4370 4380 4390 4400
WVQPHTPQSL LATLMPLPEL RELDAMAECK AQMHLLPSPP EPRLCGLSEG
4410 4420 4430 4440 4450
PQAWLLRRQS RALLSALQRS SPVWVPESRR GAQLAERRLR QRLVQVNRRL
4460 4470 4480 4490 4500
ESLQDLLTHV IRQDESDAPW SVLGPNARRP LEGVLETEAL ELSQLVGTLQ
4510 4520 4530 4540 4550
RDLDCLLQQL KGAPPCPSRR CAAVAHALWT GRLPLPWRPH APAGPQPPWH
4560 4570 4580 4590 4600
WLRQLSRRGQ LLVRYLGVGA DASSDVPERV FHLSAFRHPR RLLLALRGEA
4610 4620 4630 4640 4650
ALDQNVPSSN FPGSRGSVSS QLQYKRLEMN SNPLHFRVEN GPNPTVPERG
4660 4670 4680 4690 4700
LLLIGLQVLH AEWDPIAGAL QDSPSSQPSP LPPVSISTQA PGTSDLPAPA
4710 4720 4730 4740 4750
DLTVYSCPVY MGGPLGTAKL QSRNIVMHLP LPTKLTPNTC VQRRVHVCSP

PLS
Length:4,753
Mass (Da):533,644
Last modified:July 13, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADAB572B9861759B
GO
Isoform 2 (identifier: Q96M86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     597-597: V → F
     598-4753: Missing.

Show »
Length:597
Mass (Da):68,617
Checksum:i2DE1521BBDF5C31C
GO
Isoform 3 (identifier: Q96M86-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-311: Missing.
     597-597: V → F
     598-4753: Missing.

Show »
Length:286
Mass (Da):33,338
Checksum:iF69CEF2124C00C11
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM64E9PM64_HUMAN
Dynein heavy chain domain-containin...
DNHD1
360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRE5J3QRE5_HUMAN
Dynein heavy chain domain-containin...
DNHD1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTE2J3KTE2_HUMAN
Dynein heavy chain domain-containin...
DNHD1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJT4E9PJT4_HUMAN
Dynein heavy chain domain-containin...
DNHD1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ89130 differs from that shown. Reason: Frameshift.Curated
The sequence BAB85004 differs from that shown. Intron retention.Curated
The sequence CAB70845 differs from that shown. Intron retention.Curated
The sequence EAW68692 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1312V → P in BAB85004 (PubMed:12693554).Curated1
Sequence conflicti1909A → AALLH in BAB85004 (PubMed:12693554).Curated1
Sequence conflicti1909A → AALLH in CAB70845 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039308240V → E. Corresponds to variant dbSNP:rs2555158Ensembl.1
Natural variantiVAR_056829279Q → P. Corresponds to variant dbSNP:rs11605196Ensembl.1
Natural variantiVAR_039309317D → N. Corresponds to variant dbSNP:rs2555152Ensembl.1
Natural variantiVAR_056830403F → L. Corresponds to variant dbSNP:rs11040904Ensembl.1
Natural variantiVAR_039310418H → Y. Corresponds to variant dbSNP:rs4758423Ensembl.1
Natural variantiVAR_039311560Q → E. Corresponds to variant dbSNP:rs11603869Ensembl.1
Natural variantiVAR_0333531358R → C. Corresponds to variant dbSNP:rs12574381Ensembl.1
Natural variantiVAR_0333541896K → N. Corresponds to variant dbSNP:rs16915277Ensembl.1
Natural variantiVAR_0333552041F → L. Corresponds to variant dbSNP:rs11825154Ensembl.1
Natural variantiVAR_0373883830R → H. Corresponds to variant dbSNP:rs10769699Ensembl.1
Natural variantiVAR_0373894666I → T. Corresponds to variant dbSNP:rs11604362EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0406821 – 311Missing in isoform 3. 1 PublicationAdd BLAST311
Alternative sequenceiVSP_040683597V → F in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_040684598 – 4753Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST4156

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057314 mRNA Translation: BAB71423.1
AK093028 mRNA Translation: BAC04023.1
BC111765 mRNA Translation: AAI11766.1
BC117301 mRNA Translation: AAI17302.1
BC117303 mRNA Translation: AAI17304.1
AC009796 Genomic DNA No translation available.
AC084337 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68692.1 Sequence problems.
CH471064 Genomic DNA Translation: EAW68702.1
AK074178 mRNA Translation: BAB85004.1 Sequence problems.
AL137619 mRNA Translation: CAB70845.1 Sequence problems.
AY358770 mRNA Translation: AAQ89130.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44532.1 [Q96M86-3]
CCDS7767.1 [Q96M86-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46462

NCBI Reference Sequences

More...
RefSeqi
NP_653267.2, NM_144666.2 [Q96M86-3]
NP_775860.3, NM_173589.3 [Q96M86-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254579; ENSP00000254579; ENSG00000179532 [Q96M86-3]
ENST00000354685; ENSP00000346716; ENSG00000179532 [Q96M86-4]
ENST00000527990; ENSP00000436180; ENSG00000179532 [Q96M86-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
144132

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:144132

UCSC genome browser

More...
UCSCi
uc001mdp.4 human [Q96M86-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057314 mRNA Translation: BAB71423.1
AK093028 mRNA Translation: BAC04023.1
BC111765 mRNA Translation: AAI11766.1
BC117301 mRNA Translation: AAI17302.1
BC117303 mRNA Translation: AAI17304.1
AC009796 Genomic DNA No translation available.
AC084337 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68692.1 Sequence problems.
CH471064 Genomic DNA Translation: EAW68702.1
AK074178 mRNA Translation: BAB85004.1 Sequence problems.
AL137619 mRNA Translation: CAB70845.1 Sequence problems.
AY358770 mRNA Translation: AAQ89130.1 Frameshift.
CCDSiCCDS44532.1 [Q96M86-3]
CCDS7767.1 [Q96M86-4]
PIRiT46462
RefSeqiNP_653267.2, NM_144666.2 [Q96M86-3]
NP_775860.3, NM_173589.3 [Q96M86-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126834, 8 interactors
IntActiQ96M86, 4 interactors
STRINGi9606.ENSP00000254579

PTM databases

iPTMnetiQ96M86
PhosphoSitePlusiQ96M86

Polymorphism and mutation databases

BioMutaiDNHD1
DMDMi300669633

Proteomic databases

EPDiQ96M86
jPOSTiQ96M86
MassIVEiQ96M86
PaxDbiQ96M86
PeptideAtlasiQ96M86
PRIDEiQ96M86
ProteomicsDBi77309 [Q96M86-3]
77310 [Q96M86-4]
77311 [Q96M86-5]

Genome annotation databases

EnsembliENST00000254579; ENSP00000254579; ENSG00000179532 [Q96M86-3]
ENST00000354685; ENSP00000346716; ENSG00000179532 [Q96M86-4]
ENST00000527990; ENSP00000436180; ENSG00000179532 [Q96M86-3]
GeneIDi144132
KEGGihsa:144132
UCSCiuc001mdp.4 human [Q96M86-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
144132
DisGeNETi144132

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNHD1
HGNCiHGNC:26532 DNHD1
HPAiHPA039698
HPA040267
HPA057639
MIMi617277 gene
neXtProtiNX_Q96M86
OpenTargetsiENSG00000179532
PharmGKBiPA142671968

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
ENOG410XZRW LUCA
GeneTreeiENSGT00940000155523
HOGENOMiCLU_000038_0_3_1
InParanoidiQ96M86
OMAiHEAQRTF
OrthoDBi6155at2759
PhylomeDBiQ96M86
TreeFamiTF337443

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNHD1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
144132
PharosiQ96M86 Tdark

Protein Ontology

More...
PROi
PR:Q96M86
RNActiQ96M86 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179532 Expressed in right testis and 125 other tissues
ExpressionAtlasiQ96M86 baseline and differential
GenevisibleiQ96M86 HS

Family and domain databases

Gene3Di1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR035699 AAA_6
IPR026983 DHC_fam
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 2 hits
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNHD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96M86
Secondary accession number(s): Q2NKK8
, Q6UWI9, Q8NAA2, Q8TEE6, Q9NSZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 13, 2010
Last modified: February 26, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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