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Entry version 145 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Leucine-rich repeat and guanylate kinase domain-containing protein

Gene

LRGUK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi421 – 428ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96M69

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat and guanylate kinase domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRGUK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000155530.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21964, LRGUK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616478, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96M69

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
136332

Open Targets

More...
OpenTargetsi
ENSG00000155530

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394330

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96M69, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRGUK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732316

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003264081 – 825Leucine-rich repeat and guanylate kinase domain-containing proteinAdd BLAST825

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96M69

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96M69

PeptideAtlas

More...
PeptideAtlasi
Q96M69

PRoteomics IDEntifications database

More...
PRIDEi
Q96M69

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77304

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96M69

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96M69

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155530, Expressed in testis and 106 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96M69, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96M69, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000155530, Tissue enhanced (brain, pituitary gland, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via guanylate kinase-like domain) with RIMBP3 (via coiled-coil region).

Interacts (via guanylate kinase-like domain) with HOOK2.

Interacts (via LRRCT domain) with KLC3.

Interacts with HOOK1 and HOOK3.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126458, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96M69

Protein interaction database and analysis system

More...
IntActi
Q96M69, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000285928

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96M69, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96M69

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati129 – 149LRR 1Add BLAST21
Repeati150 – 171LRR 2Add BLAST22
Repeati172 – 193LRR 3Add BLAST22
Repeati194 – 215LRR 4Add BLAST22
Repeati216 – 237LRR 5Add BLAST22
Repeati238 – 259LRR 6Add BLAST22
Repeati260 – 280LRR 7Add BLAST21
Repeati281 – 302LRR 8Add BLAST22
Repeati303 – 324LRR 9Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini337 – 375LRRCTAdd BLAST39
Domaini414 – 597Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST184

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0531, Eukaryota
KOG0707, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157992

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019293_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96M69

Identification of Orthologs from Complete Genome Data

More...
OMAi
VNKYNPP

Database of Orthologous Groups

More...
OrthoDBi
156510at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96M69

TreeFam database of animal gene trees

More...
TreeFami
TF329158

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625, Guanylate_kin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072, GuKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51450, LRR, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96M69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSERALLR TRAASLLRGL GRSRTGARSL QFRAEKERQP CWSFPMGQKT
60 70 80 90 100
KGSSNIASSY LLQQLMHRYQ ELDSDGDEDQ GEGEAGSEES SESEMLNLEE
110 120 130 140 150
EFDGVLREEA VAKALHHLGR SGSGTEQVYL NLTLSGCNLI DVSILCGYVH
160 170 180 190 200
LQKLDLSANK IEDLSCVSCM PYLLELNASQ NNLTTFFNFK PPKNLKKADF
210 220 230 240 250
SHNQISEICD LSAYHALTKL ILDGNEIEEI SGLEMCNNLI HLSLANNKIT
260 270 280 290 300
TINGLNKLPI KILCLSNNQI EMITGLEDLK ALQNLDLSHN QISSLQGLEN
310 320 330 340 350
HDLLEVINLE DNKIAELREI EYIKNLPILR VLNLLENPIQ EKSEYWFFVI
360 370 380 390 400
FMLLRLTELD QKKIKVEEKV SAVNKYDPPP EVVAAQDHLT HVVNSVMQPQ
410 420 430 440 450
RIFDSTLPSL DAPYPMLILA GPEACGKREL AHRLCRQFST YFRYGACHTT
460 470 480 490 500
RPPYFGEGDR VDYHFISQDV FDEMVNMGKF ILTFSYGNHK YGLNRDTVEG
510 520 530 540 550
IARDGLASCI HMEIEGVRSL KYSYFEPRYI LVVPMNKEKY EGYLRRKGLF
560 570 580 590 600
SRAEIEFAVS RVDLYIKINQ NFPGYFDEVI NADDLDVAYQ KLSQLIREYL
610 620 630 640 650
GLTEEPAKSL ATTADVKTSH LKPEAHPTKY ISSNMGDFLH STDRNYLIKF
660 670 680 690 700
WAKLSAKKTP AERDSIHRQH EAARQALMGR IRPDHTLLFQ RGPVPAPLTS
710 720 730 740 750
GLHYYTTLEE LWKSFDLCED YFKPPFGPYP EKSGKDSLVS MKCSLFRFCP
760 770 780 790 800
WSKELPFQPP EGSISSHLGS GASDSETEET RKALPIQSFS HEKESHQHRQ
810 820
HSVPVISRPG SNVKPTLPPI PQGRR
Length:825
Mass (Da):93,618
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A66F149DFE15E2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YEJ5A0A2R8YEJ5_HUMAN
Leucine-rich repeat and guanylate k...
LRGUK
1,130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti606P → L in AAI04900 (PubMed:15489334).Curated1
Sequence conflicti606P → L in AAI04898 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_040063302D → Y. Corresponds to variant dbSNP:rs17167553Ensembl.1
Natural variantiVAR_040064661A → V. Corresponds to variant dbSNP:rs35149449Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057348 mRNA Translation: BAB71441.1
CH236950 Genomic DNA Translation: EAL24072.1
CH471070 Genomic DNA Translation: EAW83807.1
BC104897 mRNA Translation: AAI04898.1
BC104899 mRNA Translation: AAI04900.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5830.1

NCBI Reference Sequences

More...
RefSeqi
NP_653249.1, NM_144648.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000285928; ENSP00000285928; ENSG00000155530

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
136332

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:136332

UCSC genome browser

More...
UCSCi
uc003vrm.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057348 mRNA Translation: BAB71441.1
CH236950 Genomic DNA Translation: EAL24072.1
CH471070 Genomic DNA Translation: EAW83807.1
BC104897 mRNA Translation: AAI04898.1
BC104899 mRNA Translation: AAI04900.1
CCDSiCCDS5830.1
RefSeqiNP_653249.1, NM_144648.2

3D structure databases

SMRiQ96M69
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126458, 1 interactor
CORUMiQ96M69
IntActiQ96M69, 3 interactors
STRINGi9606.ENSP00000285928

PTM databases

iPTMnetiQ96M69
PhosphoSitePlusiQ96M69

Polymorphism and mutation databases

BioMutaiLRGUK
DMDMi74732316

Proteomic databases

MassIVEiQ96M69
PaxDbiQ96M69
PeptideAtlasiQ96M69
PRIDEiQ96M69
ProteomicsDBi77304

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18051, 64 antibodies

The DNASU plasmid repository

More...
DNASUi
136332

Genome annotation databases

EnsembliENST00000285928; ENSP00000285928; ENSG00000155530
GeneIDi136332
KEGGihsa:136332
UCSCiuc003vrm.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
136332
DisGeNETi136332
EuPathDBiHostDB:ENSG00000155530.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRGUK
HGNCiHGNC:21964, LRGUK
HPAiENSG00000155530, Tissue enhanced (brain, pituitary gland, testis)
MIMi616478, gene
neXtProtiNX_Q96M69
OpenTargetsiENSG00000155530
PharmGKBiPA162394330

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0531, Eukaryota
KOG0707, Eukaryota
GeneTreeiENSGT00940000157992
HOGENOMiCLU_019293_0_0_1
InParanoidiQ96M69
OMAiVNKYNPP
OrthoDBi156510at2759
PhylomeDBiQ96M69
TreeFamiTF329158

Enzyme and pathway databases

PathwayCommonsiQ96M69

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
136332, 5 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRGUK, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
136332
PharosiQ96M69, Tdark

Protein Ontology

More...
PROi
PR:Q96M69
RNActiQ96M69, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155530, Expressed in testis and 106 other tissues
ExpressionAtlasiQ96M69, baseline and differential
GenevisibleiQ96M69, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51450, LRR, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRGUK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96M69
Secondary accession number(s): Q2M3I1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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