UniProtKB - Q96M27 (PRRC1_HUMAN)
Protein
Protein PRRC1
Gene
PRRC1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein kinase A regulatory subunit binding Source: GO_Central
GO - Biological processi
- activation of protein kinase A activity Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96M27 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein PRRC1Alternative name(s): Proline-rich and coiled-coil-containing protein 1 |
Gene namesi | Name:PRRC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28164, PRRC1 |
neXtProti | NX_Q96M27 |
VEuPathDBi | HostDB:ENSG00000164244.20 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus 1 Publication
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Golgi apparatusPathology & Biotechi
Organism-specific databases
DisGeNETi | 133619 |
OpenTargetsi | ENSG00000164244 |
PharmGKBi | PA162400175 |
Miscellaneous databases
Pharosi | Q96M27, Tdark |
Genetic variation databases
BioMutai | PRRC1 |
DMDMi | 74732288 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307338 | 1 – 445 | Protein PRRC1Add BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 209 | PhosphoserineCombined sources | 1 | |
Modified residuei | 408 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96M27 |
jPOSTi | Q96M27 |
MassIVEi | Q96M27 |
MaxQBi | Q96M27 |
PaxDbi | Q96M27 |
PeptideAtlasi | Q96M27 |
PRIDEi | Q96M27 |
ProteomicsDBi | 77284 [Q96M27-1] 77285 [Q96M27-2] 77286 [Q96M27-3] 77287 [Q96M27-4] 77288 [Q96M27-5] |
PTM databases
GlyGeni | Q96M27, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q96M27 |
MetOSitei | Q96M27 |
PhosphoSitePlusi | Q96M27 |
Expressioni
Tissue specificityi
Isoform 4 is specifically expressed in liver. Ubiquitously expressed with higher expression in kidney, liver and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000164244, Expressed in tibia and 233 other tissues |
Genevisiblei | Q96M27, HS |
Organism-specific databases
HPAi | ENSG00000164244, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96M27
With | #Exp. | IntAct |
---|---|---|
HTT [P42858] | 7 | EBI-2560879,EBI-466029 |
PIN1 [Q13526] | 3 | EBI-2560879,EBI-714158 |
SEC23B [Q15437] | 3 | EBI-2560879,EBI-742673 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein kinase A regulatory subunit binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 126367, 36 interactors |
IntActi | Q96M27, 15 interactors |
STRINGi | 9606.ENSP00000421965 |
Miscellaneous databases
RNActi | Q96M27, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 129 | Pro-richAdd BLAST | 119 |
Sequence similaritiesi
Belongs to the PRRC1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QUZV, Eukaryota |
GeneTreei | ENSGT00390000003837 |
HOGENOMi | CLU_041959_0_0_1 |
InParanoidi | Q96M27 |
OMAi | KAIAGMY |
OrthoDBi | 930508at2759 |
PhylomeDBi | Q96M27 |
TreeFami | TF343676 |
Family and domain databases
Gene3Di | 3.90.950.10, 1 hit |
InterProi | View protein in InterPro IPR029001, ITPase-like_fam IPR026533, NTPase/PRRC1 IPR026534, PRRC1 |
PANTHERi | PTHR23276, PTHR23276, 1 hit |
Pfami | View protein in Pfam PF01931, NTPase_I-T, 1 hit |
SUPFAMi | SSF52972, SSF52972, 1 hit |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96M27-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMEESGIETT PPGTPPPNPA GLAATAMSST PVPLAATSSF SSPNVSSMES
60 70 80 90 100
FPPLAYSTPQ PPLPPVRPSA PLPFVPPPAV PSVPPLVTSM PPPVSPSTAA
110 120 130 140 150
AFGNPPVSHF PPSTSAPNTL LPAPPSGPPI SGFSVGSTYD ITRGHAGRAP
160 170 180 190 200
QTPLMPSFSA PSGTGLLPTP ITQQASLTSL AQGTGTTSAI TFPEEQEDPR
210 220 230 240 250
ITRGQDEASA GGIWGFIKGV AGNPMVKSVL DKTKHSVESM ITTLDPGMAP
260 270 280 290 300
YIKSGGELDI VVTSNKEVKV AAVRDAFQEV FGLAVVVGEA GQSNIAPQPV
310 320 330 340 350
GYAAGLKGAQ ERIDSLRRTG VIHEKQTAVS VENFIAELLP DKWFDIGCLV
360 370 380 390 400
VEDPVHGIHL ETFTQATPVP LEFVQQAQSL TPQDYNLRWS GLLVTVGEVL
410 420 430 440
EKSLLNVSRT DWHMAFTGMS RRQMIYSAAR AIAGMYKQRL PPRTV
Sequence cautioni
The sequence AAH17066 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03467 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | A → T in CAH10384 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 338 | L → S in CAH10384 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028720 | 311 | E → A in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_028721 | 312 – 445 | Missing in isoform 4. 1 PublicationAdd BLAST | 134 | |
Alternative sequenceiVSP_028722 | 377 | A → VGFLLCFFIMLQRNLHYCFQ NKNLFGFFVRNMFLILFQSF FF in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_028723 | 378 – 445 | Missing in isoform 5. 1 PublicationAdd BLAST | 68 | |
Alternative sequenceiVSP_028724 | 433 – 445 | AGMYK…PPRTV → ENPQRAVAVHGLVEARNFPA PGDLVSLLLGTV in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_028725 | 434 – 445 | GMYKQ…PPRTV → DDYFPRIPKEQWQSMAWLKL EIFLPLVTW in isoform 3. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ427339 mRNA Translation: CAD22113.1 AJ441110 mRNA Translation: CAD29585.2 AJ496322 mRNA Translation: CAD42881.1 AJ515158 mRNA Translation: CAD56470.1 AJ515428 mRNA Translation: CAD56438.1 AJ515429 mRNA Translation: CAD56439.1 AK090486 mRNA Translation: BAC03467.1 Frameshift. AK057437 mRNA Translation: BAB71487.1 AL831963 mRNA Translation: CAD38605.1 AL832600 mRNA Translation: CAH10384.1 Different termination. CH471062 Genomic DNA Translation: EAW62402.1 CH471062 Genomic DNA Translation: EAW62405.1 BC017066 mRNA Translation: AAH17066.1 Different initiation. |
CCDSi | CCDS4143.1 [Q96M27-1] CCDS68943.1 [Q96M27-3] |
RefSeqi | NP_001273737.1, NM_001286808.1 [Q96M27-3] NP_570721.1, NM_130809.4 [Q96M27-1] XP_006714592.1, XM_006714529.3 [Q96M27-1] |
Genome annotation databases
Ensembli | ENST00000296666; ENSP00000296666; ENSG00000164244 [Q96M27-1] ENST00000442138; ENSP00000392873; ENSG00000164244 [Q96M27-5] ENST00000512635; ENSP00000421965; ENSG00000164244 [Q96M27-3] |
GeneIDi | 133619 |
KEGGi | hsa:133619 |
UCSCi | uc003kuj.6, human [Q96M27-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ427339 mRNA Translation: CAD22113.1 AJ441110 mRNA Translation: CAD29585.2 AJ496322 mRNA Translation: CAD42881.1 AJ515158 mRNA Translation: CAD56470.1 AJ515428 mRNA Translation: CAD56438.1 AJ515429 mRNA Translation: CAD56439.1 AK090486 mRNA Translation: BAC03467.1 Frameshift. AK057437 mRNA Translation: BAB71487.1 AL831963 mRNA Translation: CAD38605.1 AL832600 mRNA Translation: CAH10384.1 Different termination. CH471062 Genomic DNA Translation: EAW62402.1 CH471062 Genomic DNA Translation: EAW62405.1 BC017066 mRNA Translation: AAH17066.1 Different initiation. |
CCDSi | CCDS4143.1 [Q96M27-1] CCDS68943.1 [Q96M27-3] |
RefSeqi | NP_001273737.1, NM_001286808.1 [Q96M27-3] NP_570721.1, NM_130809.4 [Q96M27-1] XP_006714592.1, XM_006714529.3 [Q96M27-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126367, 36 interactors |
IntActi | Q96M27, 15 interactors |
STRINGi | 9606.ENSP00000421965 |
PTM databases
GlyGeni | Q96M27, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q96M27 |
MetOSitei | Q96M27 |
PhosphoSitePlusi | Q96M27 |
Genetic variation databases
BioMutai | PRRC1 |
DMDMi | 74732288 |
Proteomic databases
EPDi | Q96M27 |
jPOSTi | Q96M27 |
MassIVEi | Q96M27 |
MaxQBi | Q96M27 |
PaxDbi | Q96M27 |
PeptideAtlasi | Q96M27 |
PRIDEi | Q96M27 |
ProteomicsDBi | 77284 [Q96M27-1] 77285 [Q96M27-2] 77286 [Q96M27-3] 77287 [Q96M27-4] 77288 [Q96M27-5] |
Protocols and materials databases
Antibodypediai | 45054, 60 antibodies |
DNASUi | 133619 |
Genome annotation databases
Ensembli | ENST00000296666; ENSP00000296666; ENSG00000164244 [Q96M27-1] ENST00000442138; ENSP00000392873; ENSG00000164244 [Q96M27-5] ENST00000512635; ENSP00000421965; ENSG00000164244 [Q96M27-3] |
GeneIDi | 133619 |
KEGGi | hsa:133619 |
UCSCi | uc003kuj.6, human [Q96M27-1] |
Organism-specific databases
CTDi | 133619 |
DisGeNETi | 133619 |
GeneCardsi | PRRC1 |
HGNCi | HGNC:28164, PRRC1 |
HPAi | ENSG00000164244, Low tissue specificity |
neXtProti | NX_Q96M27 |
OpenTargetsi | ENSG00000164244 |
PharmGKBi | PA162400175 |
VEuPathDBi | HostDB:ENSG00000164244.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUZV, Eukaryota |
GeneTreei | ENSGT00390000003837 |
HOGENOMi | CLU_041959_0_0_1 |
InParanoidi | Q96M27 |
OMAi | KAIAGMY |
OrthoDBi | 930508at2759 |
PhylomeDBi | Q96M27 |
TreeFami | TF343676 |
Enzyme and pathway databases
PathwayCommonsi | Q96M27 |
Miscellaneous databases
BioGRID-ORCSi | 133619, 16 hits in 995 CRISPR screens |
ChiTaRSi | PRRC1, human |
GenomeRNAii | 133619 |
Pharosi | Q96M27, Tdark |
PROi | PR:Q96M27 |
RNActi | Q96M27, protein |
Gene expression databases
Bgeei | ENSG00000164244, Expressed in tibia and 233 other tissues |
Genevisiblei | Q96M27, HS |
Family and domain databases
Gene3Di | 3.90.950.10, 1 hit |
InterProi | View protein in InterPro IPR029001, ITPase-like_fam IPR026533, NTPase/PRRC1 IPR026534, PRRC1 |
PANTHERi | PTHR23276, PTHR23276, 1 hit |
Pfami | View protein in Pfam PF01931, NTPase_I-T, 1 hit |
SUPFAMi | SSF52972, SSF52972, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRRC1_HUMAN | |
Accessioni | Q96M27Primary (citable) accession number: Q96M27 Secondary accession number(s): Q69YM8 Q96AJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families