UniProtKB - Q96LZ3 (CANB2_HUMAN)
Calcineurin subunit B type 2
PPP3R2
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 31 – 42 | 1By similarityAdd BLAST | 12 | |
Calcium bindingi | 63 – 74 | 2By similarityAdd BLAST | 12 | |
Calcium bindingi | 100 – 111 | 3By similarityAdd BLAST | 12 | |
Calcium bindingi | 141 – 152 | 4By similarityAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent protein serine/threonine phosphatase regulator activity Source: InterPro
- calcium ion binding Source: InterPro
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.3.16, 2681 |
PathwayCommonsi | Q96LZ3 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcineurin subunit B type 2Alternative name(s): Calcineurin B-like protein Short name: CBLP Calcineurin BII Short name: CNBII PPP3R1-like Protein phosphatase 2B regulatory subunit 2 Protein phosphatase 3 regulatory subunit B beta isoform |
Gene namesi | Name:PPP3R2 Synonyms:CBLP, PPP3RL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9318, PPP3R2 |
MIMi | 613821, gene |
neXtProti | NX_Q96LZ3 |
VEuPathDBi | HostDB:ENSG00000188386.5 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5535 |
OpenTargetsi | ENSG00000188386 |
PharmGKBi | PA33682 |
Miscellaneous databases
Pharosi | Q96LZ3, Tbio |
Chemistry databases
DrugBanki | DB00091, Cyclosporine DB11693, Voclosporin |
Genetic variation databases
BioMutai | PPP3R2 |
DMDMi | 52000731 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000073499 | 2 – 170 | Calcineurin subunit B type 2Add BLAST | 169 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, MyristateProteomic databases
EPDi | Q96LZ3 |
jPOSTi | Q96LZ3 |
MassIVEi | Q96LZ3 |
MaxQBi | Q96LZ3 |
PaxDbi | Q96LZ3 |
PeptideAtlasi | Q96LZ3 |
PRIDEi | Q96LZ3 |
ProteomicsDBi | 77271 |
PTM databases
CarbonylDBi | Q96LZ3 |
iPTMneti | Q96LZ3 |
PhosphoSitePlusi | Q96LZ3 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000188386, Expressed in testis and 18 other tissues |
ExpressionAtlasi | Q96LZ3, baseline and differential |
Genevisiblei | Q96LZ3, HS |
Organism-specific databases
HPAi | ENSG00000188386, Tissue enriched (testis) |
Interactioni
Subunit structurei
Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca2+-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 118 | Interaction with PxVP motif in substrates of the catalytic subunitBy similarity | 1 | |
Sitei | 122 | Interaction with PxVP motif in substrates of the catalytic subunitBy similarity | 1 |
Binary interactionsi
Q96LZ3
With | #Exp. | IntAct |
---|---|---|
TFCP2 [Q12800] | 3 | EBI-3906025,EBI-717422 |
Protein-protein interaction databases
BioGRIDi | 111527, 27 interactors |
ComplexPortali | CPX-1002, Calcineurin-Calmodulin complex, beta-R2 variant CPX-1048, Calcineurin-Calmodulin complex, alpha-R2 variant CPX-1050, Calcineurin-Calmodulin complex, gamma-R2 variant CPX-1114, Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant CPX-1116, Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant CPX-1118, Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant |
IntActi | Q96LZ3, 14 interactors |
MINTi | Q96LZ3 |
STRINGi | 9606.ENSP00000363939 |
Miscellaneous databases
RNActi | Q96LZ3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 51 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 50 – 85 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 87 – 122 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 128 – 163 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 131 – 136 | Calcineurin A bindingBy similarity | 6 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0034, Eukaryota |
GeneTreei | ENSGT00940000165130 |
HOGENOMi | CLU_061288_10_1_1 |
InParanoidi | Q96LZ3 |
OrthoDBi | 1271942at2759 |
PhylomeDBi | Q96LZ3 |
TreeFami | TF105558 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR015757, Calcineur_B IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR45942, PTHR45942, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGNEASYPAE MCSHFDNDEI KRLGRRFKKL DLDKSGSLSV EEFMSLPELR
60 70 80 90 100
HNPLVRRVID VFDTDGDGEV DFKEFILGTS QFSVKGDEEQ KLRFAFSIYD
110 120 130 140 150
MDKDGYISNG ELFQVLKMMV GNNLTDWQLQ QLVDKTIIIL DKDGDGKISF
160 170
EEFSAVVRDL EIHKKLVLIV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GUC7 | A0A1B0GUC7_HUMAN | Calcineurin subunit B type 2 | PPP3R2 | 70 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | D → N in AAL40395 (Ref. 3) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145026 mRNA Translation: AAP97278.1 AF400667 mRNA Translation: AAP57772.1 Different initiation. AF085237 mRNA Translation: AAL40395.1 AK057524 mRNA Translation: BAB71521.1 Different initiation. AL591377 Genomic DNA No translation available. CH471105 Genomic DNA Translation: EAW58961.1 Different initiation. BC030595 mRNA Translation: AAH30595.1 Different initiation. BC066299 mRNA Translation: AAH66299.1 Different initiation. |
CCDSi | CCDS6759.1 |
RefSeqi | NP_671709.1, NM_147180.3 |
Genome annotation databases
Ensembli | ENST00000374806; ENSP00000363939; ENSG00000188386 |
GeneIDi | 5535 |
KEGGi | hsa:5535 |
UCSCi | uc004bbr.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145026 mRNA Translation: AAP97278.1 AF400667 mRNA Translation: AAP57772.1 Different initiation. AF085237 mRNA Translation: AAL40395.1 AK057524 mRNA Translation: BAB71521.1 Different initiation. AL591377 Genomic DNA No translation available. CH471105 Genomic DNA Translation: EAW58961.1 Different initiation. BC030595 mRNA Translation: AAH30595.1 Different initiation. BC066299 mRNA Translation: AAH66299.1 Different initiation. |
CCDSi | CCDS6759.1 |
RefSeqi | NP_671709.1, NM_147180.3 |
3D structure databases
SMRi | Q96LZ3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111527, 27 interactors |
ComplexPortali | CPX-1002, Calcineurin-Calmodulin complex, beta-R2 variant CPX-1048, Calcineurin-Calmodulin complex, alpha-R2 variant CPX-1050, Calcineurin-Calmodulin complex, gamma-R2 variant CPX-1114, Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant CPX-1116, Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant CPX-1118, Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant |
IntActi | Q96LZ3, 14 interactors |
MINTi | Q96LZ3 |
STRINGi | 9606.ENSP00000363939 |
Chemistry databases
DrugBanki | DB00091, Cyclosporine DB11693, Voclosporin |
PTM databases
CarbonylDBi | Q96LZ3 |
iPTMneti | Q96LZ3 |
PhosphoSitePlusi | Q96LZ3 |
Genetic variation databases
BioMutai | PPP3R2 |
DMDMi | 52000731 |
Proteomic databases
EPDi | Q96LZ3 |
jPOSTi | Q96LZ3 |
MassIVEi | Q96LZ3 |
MaxQBi | Q96LZ3 |
PaxDbi | Q96LZ3 |
PeptideAtlasi | Q96LZ3 |
PRIDEi | Q96LZ3 |
ProteomicsDBi | 77271 |
Protocols and materials databases
Antibodypediai | 29196, 195 antibodies |
DNASUi | 5535 |
Genome annotation databases
Ensembli | ENST00000374806; ENSP00000363939; ENSG00000188386 |
GeneIDi | 5535 |
KEGGi | hsa:5535 |
UCSCi | uc004bbr.3, human |
Organism-specific databases
CTDi | 5535 |
DisGeNETi | 5535 |
GeneCardsi | PPP3R2 |
HGNCi | HGNC:9318, PPP3R2 |
HPAi | ENSG00000188386, Tissue enriched (testis) |
MIMi | 613821, gene |
neXtProti | NX_Q96LZ3 |
OpenTargetsi | ENSG00000188386 |
PharmGKBi | PA33682 |
VEuPathDBi | HostDB:ENSG00000188386.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0034, Eukaryota |
GeneTreei | ENSGT00940000165130 |
HOGENOMi | CLU_061288_10_1_1 |
InParanoidi | Q96LZ3 |
OrthoDBi | 1271942at2759 |
PhylomeDBi | Q96LZ3 |
TreeFami | TF105558 |
Enzyme and pathway databases
BRENDAi | 3.1.3.16, 2681 |
PathwayCommonsi | Q96LZ3 |
Miscellaneous databases
BioGRID-ORCSi | 5535, 5 hits in 984 CRISPR screens |
GeneWikii | PPP3R2 |
GenomeRNAii | 5535 |
Pharosi | Q96LZ3, Tbio |
PROi | PR:Q96LZ3 |
RNActi | Q96LZ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188386, Expressed in testis and 18 other tissues |
ExpressionAtlasi | Q96LZ3, baseline and differential |
Genevisiblei | Q96LZ3, HS |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR015757, Calcineur_B IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR45942, PTHR45942, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CANB2_HUMAN | |
Accessioni | Q96LZ3Primary (citable) accession number: Q96LZ3 Secondary accession number(s): Q5VTR4, Q7Z4V8, Q8WYJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families