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Protein

Calcineurin subunit B type 2

Gene

PPP3R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.By similarity

Miscellaneous

This protein has four functional calcium-binding sites.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi31 – 421By similarityAdd BLAST12
Calcium bindingi63 – 742By similarityAdd BLAST12
Calcium bindingi100 – 1113By similarityAdd BLAST12
Calcium bindingi141 – 1524By similarityAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.16 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Calcineurin B-like protein
Short name:
CBLP
Calcineurin BII
Short name:
CNBII
PPP3R1-like
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene namesi
Name:PPP3R2
Synonyms:CBLP, PPP3RL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000188386.5
HGNCiHGNC:9318 PPP3R2
MIMi613821 gene
neXtProtiNX_Q96LZ3

Pathology & Biotechi

Organism-specific databases

DisGeNETi5535
PharmGKBiPA33682

Chemistry databases

DrugBankiDB00091 Cyclosporine
DB04906 ISA247

Polymorphism and mutation databases

BioMutaiPPP3R2
DMDMi52000731

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000734992 – 170Calcineurin subunit B type 2Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ96LZ3
MaxQBiQ96LZ3
PaxDbiQ96LZ3
PeptideAtlasiQ96LZ3
PRIDEiQ96LZ3
ProteomicsDBi77271

PTM databases

CarbonylDBiQ96LZ3
iPTMnetiQ96LZ3
PhosphoSitePlusiQ96LZ3

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiENSG00000188386 Expressed in 14 organ(s), highest expression level in testis
CleanExiHS_PPP3R2
ExpressionAtlasiQ96LZ3 baseline and differential
GenevisibleiQ96LZ3 HS

Organism-specific databases

HPAiHPA047157

Interactioni

Subunit structurei

Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca2+-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei118Interaction with PxVP motif in substrates of the catalytic subunitBy similarity1
Sitei122Interaction with PxVP motif in substrates of the catalytic subunitBy similarity1

Binary interactionsi

WithEntry#Exp.IntActNotes
TFCP2Q128003EBI-3906025,EBI-717422

Protein-protein interaction databases

BioGridi111527, 12 interactors
ComplexPortaliCPX-1002 Calcineurin-Calmodulin complex, beta-R2 variant
CPX-1048 Calcineurin-Calmodulin complex, alpha-R2 variant
CPX-1050 Calcineurin-Calmodulin complex, gamma-R2 variant
CPX-1114 Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant
CPX-1116 Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant
CPX-1118 Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant
IntActiQ96LZ3, 14 interactors
MINTiQ96LZ3
STRINGi9606.ENSP00000363939

Structurei

3D structure databases

ProteinModelPortaliQ96LZ3
SMRiQ96LZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 51EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini87 – 122EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 163EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 136Calcineurin A bindingBy similarity6

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
HOGENOMiHOG000233019
HOVERGENiHBG105307
InParanoidiQ96LZ3
KOiK06268
OrthoDBiEOG091G0R0W
PhylomeDBiQ96LZ3
TreeFamiTF105558

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96LZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNEASYPAE MCSHFDNDEI KRLGRRFKKL DLDKSGSLSV EEFMSLPELR
60 70 80 90 100
HNPLVRRVID VFDTDGDGEV DFKEFILGTS QFSVKGDEEQ KLRFAFSIYD
110 120 130 140 150
MDKDGYISNG ELFQVLKMMV GNNLTDWQLQ QLVDKTIIIL DKDGDGKISF
160 170
EEFSAVVRDL EIHKKLVLIV
Length:170
Mass (Da):19,533
Last modified:January 23, 2007 - v3
Checksum:i322F9CA4123BA2C3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUC7A0A1B0GUC7_HUMAN
Calcineurin subunit B type 2
PPP3R2
70Annotation score:

Sequence cautioni

The sequence AAH30595 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH66299 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP57772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB71521 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW58961 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16D → N in AAL40395 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145026 mRNA Translation: AAP97278.1
AF400667 mRNA Translation: AAP57772.1 Different initiation.
AF085237 mRNA Translation: AAL40395.1
AK057524 mRNA Translation: BAB71521.1 Different initiation.
AL591377 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58961.1 Different initiation.
BC030595 mRNA Translation: AAH30595.1 Different initiation.
BC066299 mRNA Translation: AAH66299.1 Different initiation.
RefSeqiNP_671709.1, NM_147180.3
UniGeneiHs.151167

Genome annotation databases

EnsembliENST00000374806; ENSP00000363939; ENSG00000188386
GeneIDi5535
KEGGihsa:5535
UCSCiuc004bbr.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145026 mRNA Translation: AAP97278.1
AF400667 mRNA Translation: AAP57772.1 Different initiation.
AF085237 mRNA Translation: AAL40395.1
AK057524 mRNA Translation: BAB71521.1 Different initiation.
AL591377 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58961.1 Different initiation.
BC030595 mRNA Translation: AAH30595.1 Different initiation.
BC066299 mRNA Translation: AAH66299.1 Different initiation.
RefSeqiNP_671709.1, NM_147180.3
UniGeneiHs.151167

3D structure databases

ProteinModelPortaliQ96LZ3
SMRiQ96LZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111527, 12 interactors
ComplexPortaliCPX-1002 Calcineurin-Calmodulin complex, beta-R2 variant
CPX-1048 Calcineurin-Calmodulin complex, alpha-R2 variant
CPX-1050 Calcineurin-Calmodulin complex, gamma-R2 variant
CPX-1114 Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant
CPX-1116 Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant
CPX-1118 Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant
IntActiQ96LZ3, 14 interactors
MINTiQ96LZ3
STRINGi9606.ENSP00000363939

Chemistry databases

DrugBankiDB00091 Cyclosporine
DB04906 ISA247

PTM databases

CarbonylDBiQ96LZ3
iPTMnetiQ96LZ3
PhosphoSitePlusiQ96LZ3

Polymorphism and mutation databases

BioMutaiPPP3R2
DMDMi52000731

Proteomic databases

EPDiQ96LZ3
MaxQBiQ96LZ3
PaxDbiQ96LZ3
PeptideAtlasiQ96LZ3
PRIDEiQ96LZ3
ProteomicsDBi77271

Protocols and materials databases

DNASUi5535
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374806; ENSP00000363939; ENSG00000188386
GeneIDi5535
KEGGihsa:5535
UCSCiuc004bbr.3 human

Organism-specific databases

CTDi5535
DisGeNETi5535
EuPathDBiHostDB:ENSG00000188386.5
GeneCardsiPPP3R2
HGNCiHGNC:9318 PPP3R2
HPAiHPA047157
MIMi613821 gene
neXtProtiNX_Q96LZ3
PharmGKBiPA33682
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
HOGENOMiHOG000233019
HOVERGENiHBG105307
InParanoidiQ96LZ3
KOiK06268
OrthoDBiEOG091G0R0W
PhylomeDBiQ96LZ3
TreeFamiTF105558

Enzyme and pathway databases

BRENDAi3.1.3.16 2681

Miscellaneous databases

GeneWikiiPPP3R2
GenomeRNAii5535
PROiPR:Q96LZ3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188386 Expressed in 14 organ(s), highest expression level in testis
CleanExiHS_PPP3R2
ExpressionAtlasiQ96LZ3 baseline and differential
GenevisibleiQ96LZ3 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCANB2_HUMAN
AccessioniPrimary (citable) accession number: Q96LZ3
Secondary accession number(s): Q5VTR4, Q7Z4V8, Q8WYJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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