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Protein

Coiled-coil domain-containing protein 74B

Gene

CCDC74B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 74B
Gene namesi
Name:CCDC74B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000152076.18
HGNCiHGNC:25267 CCDC74B
neXtProtiNX_Q96LY2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152076
PharmGKBiPA143485426

Polymorphism and mutation databases

BioMutaiCCDC74B
DMDMi74732259

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743751 – 380Coiled-coil domain-containing protein 74BAdd BLAST380

Proteomic databases

PaxDbiQ96LY2
PeptideAtlasiQ96LY2
PRIDEiQ96LY2
ProteomicsDBi77267
77268 [Q96LY2-2]

PTM databases

iPTMnetiQ96LY2
PhosphoSitePlusiQ96LY2

Expressioni

Gene expression databases

BgeeiENSG00000152076 Expressed in 89 organ(s), highest expression level in right uterine tube
CleanExiHS_CCDC74B
ExpressionAtlasiQ96LY2 baseline and differential
GenevisibleiQ96LY2 HS

Organism-specific databases

HPAiHPA060727

Interactioni

Protein-protein interaction databases

BioGridi124829, 25 interactors
IntActiQ96LY2, 4 interactors
MINTiQ96LY2
STRINGi9606.ENSP00000308873

Structurei

3D structure databases

ProteinModelPortaliQ96LY2
SMRiQ96LY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 93Sequence analysisAdd BLAST47

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J255 Eukaryota
ENOG4112DFU LUCA
GeneTreeiENSGT00390000007249
HOGENOMiHOG000111398
HOVERGENiHBG081034
InParanoidiQ96LY2
OMAiSKTDRTH
OrthoDBiEOG091G0GX9
PhylomeDBiQ96LY2
TreeFamiTF329669

Family and domain databases

InterProiView protein in InterPro
IPR033226 CCDC74
IPR029422 CCDC74_C
IPR039496 CCDC92/74_CC_dom
PANTHERiPTHR14882:SF5 PTHR14882:SF5, 1 hit
PfamiView protein in Pfam
PF14917 CCDC74_C, 1 hit
PF14916 CCDC92, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96LY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGAGVAAGT RPPSSPTPGS RRRRQRPSVG VQSLRPQSPQ LRQSDPQKRN
60 70 80 90 100
LDLEKSLQFL QQQHSEMLAK LHEEIEHLKR ENKDLRYKLI MNQTSQKKDG
110 120 130 140 150
PSGNHLSRAS APLGARWVCI NGVWVEPGGP SPARLKEGSS RTHRPGGKHG
160 170 180 190 200
RLAGGSADTV RSPADSLSTS SFQSVKSISN SGKARPQPGS FNKQDSKADV
210 220 230 240 250
PQKADLEEEP LLHNSKLDKV PGVQGQARKE KAEASNAGAA CMGNSQHQGR
260 270 280 290 300
QMGAAAHPPM ILPLPLRKPT TLRQCEVLIR ELWNTNLLQT QELQHLKSLL
310 320 330 340 350
EGSQRPQAVP EEASFPRDQE ATHFPKVSTK SLSKKCLLLS PPVAERAILP
360 370 380
ALKQTPKNNF AERQKRLQAM QKRRLHRSVL
Length:380
Mass (Da):41,826
Last modified:December 1, 2001 - v1
Checksum:i2B18E643CEB9E242
GO
Isoform 2 (identifier: Q96LY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-165: Missing.

Show »
Length:314
Mass (Da):35,149
Checksum:i678CF7C383515741
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZB0B8ZZB0_HUMAN
Coiled-coil domain-containing prote...
CCDC74B
204Annotation score:
E9PG54E9PG54_HUMAN
Coiled-coil domain-containing prote...
CCDC74B
225Annotation score:
C9JC78C9JC78_HUMAN
Coiled-coil domain-containing prote...
CCDC74B
159Annotation score:
F8WCQ0F8WCQ0_HUMAN
Coiled-coil domain-containing prote...
CCDC74B
93Annotation score:
F8WB40F8WB40_HUMAN
Coiled-coil domain-containing prote...
CCDC74B
115Annotation score:
E7ESC5E7ESC5_HUMAN
Coiled-coil domain-containing prote...
CCDC74B
274Annotation score:
H7C1C8H7C1C8_HUMAN
Coiled-coil domain-containing prote...
CCDC74B
205Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030269169T → M. Corresponds to variant dbSNP:rs184349150Ensembl.1
Natural variantiVAR_030270346R → H. Corresponds to variant dbSNP:rs3177472Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022730100 – 165Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057609 mRNA Translation: BAB71533.1
BC067771 mRNA Translation: AAH67771.1
CCDSiCCDS2155.1 [Q96LY2-1]
CCDS58726.1 [Q96LY2-2]
RefSeqiNP_001245236.1, NM_001258307.1 [Q96LY2-2]
NP_997193.1, NM_207310.2 [Q96LY2-1]
UniGeneiHs.29383

Genome annotation databases

EnsembliENST00000310463; ENSP00000308873; ENSG00000152076 [Q96LY2-1]
ENST00000409943; ENSP00000386294; ENSG00000152076 [Q96LY2-2]
GeneIDi91409
KEGGihsa:91409
UCSCiuc002tqm.3 human [Q96LY2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057609 mRNA Translation: BAB71533.1
BC067771 mRNA Translation: AAH67771.1
CCDSiCCDS2155.1 [Q96LY2-1]
CCDS58726.1 [Q96LY2-2]
RefSeqiNP_001245236.1, NM_001258307.1 [Q96LY2-2]
NP_997193.1, NM_207310.2 [Q96LY2-1]
UniGeneiHs.29383

3D structure databases

ProteinModelPortaliQ96LY2
SMRiQ96LY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124829, 25 interactors
IntActiQ96LY2, 4 interactors
MINTiQ96LY2
STRINGi9606.ENSP00000308873

PTM databases

iPTMnetiQ96LY2
PhosphoSitePlusiQ96LY2

Polymorphism and mutation databases

BioMutaiCCDC74B
DMDMi74732259

Proteomic databases

PaxDbiQ96LY2
PeptideAtlasiQ96LY2
PRIDEiQ96LY2
ProteomicsDBi77267
77268 [Q96LY2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310463; ENSP00000308873; ENSG00000152076 [Q96LY2-1]
ENST00000409943; ENSP00000386294; ENSG00000152076 [Q96LY2-2]
GeneIDi91409
KEGGihsa:91409
UCSCiuc002tqm.3 human [Q96LY2-1]

Organism-specific databases

CTDi91409
EuPathDBiHostDB:ENSG00000152076.18
GeneCardsiCCDC74B
HGNCiHGNC:25267 CCDC74B
HPAiHPA060727
neXtProtiNX_Q96LY2
OpenTargetsiENSG00000152076
PharmGKBiPA143485426
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J255 Eukaryota
ENOG4112DFU LUCA
GeneTreeiENSGT00390000007249
HOGENOMiHOG000111398
HOVERGENiHBG081034
InParanoidiQ96LY2
OMAiSKTDRTH
OrthoDBiEOG091G0GX9
PhylomeDBiQ96LY2
TreeFamiTF329669

Miscellaneous databases

GenomeRNAii91409
PROiPR:Q96LY2

Gene expression databases

BgeeiENSG00000152076 Expressed in 89 organ(s), highest expression level in right uterine tube
CleanExiHS_CCDC74B
ExpressionAtlasiQ96LY2 baseline and differential
GenevisibleiQ96LY2 HS

Family and domain databases

InterProiView protein in InterPro
IPR033226 CCDC74
IPR029422 CCDC74_C
IPR039496 CCDC92/74_CC_dom
PANTHERiPTHR14882:SF5 PTHR14882:SF5, 1 hit
PfamiView protein in Pfam
PF14917 CCDC74_C, 1 hit
PF14916 CCDC92, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC74B_HUMAN
AccessioniPrimary (citable) accession number: Q96LY2
Secondary accession number(s): Q6NW18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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