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Protein

Zinc finger and SCAN domain-containing protein 31

Gene

ZSCAN31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcription factor. May be involved in the development of multiple embryonic organs.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 31
Alternative name(s):
Zinc finger protein 323
Gene namesi
Name:ZSCAN31
Synonyms:ZNF310P, ZNF323
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000235109.7
HGNCiHGNC:14097 ZSCAN31
MIMi610794 gene
neXtProtiNX_Q96LW9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64288
OpenTargetsiENSG00000235109
PharmGKBiPA37840

Polymorphism and mutation databases

BioMutaiZSCAN31
DMDMi23396994

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475321 – 406Zinc finger and SCAN domain-containing protein 31Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96LW9
MaxQBiQ96LW9
PaxDbiQ96LW9
PeptideAtlasiQ96LW9
PRIDEiQ96LW9
ProteomicsDBi77261

PTM databases

iPTMnetiQ96LW9
PhosphoSitePlusiQ96LW9

Expressioni

Tissue specificityi

Expressed at high levels in the lung, liver, and kidney, while weakly expressed in intestine, brain, muscle, cholecyst, heart, and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000235109 Expressed in 188 organ(s), highest expression level in thyroid gland
ExpressionAtlasiQ96LW9 baseline and differential
GenevisibleiQ96LW9 HS

Organism-specific databases

HPAiHPA007124

Interactioni

Protein-protein interaction databases

BioGridi122130, 15 interactors
STRINGi9606.ENSP00000345339

Structurei

3D structure databases

ProteinModelPortaliQ96LW9
SMRiQ96LW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 121SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96LW9
KOiK09230
OMAiVEEDPIW
OrthoDBiEOG091G09O3
PhylomeDBiQ96LW9
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q96LW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTEEQYDL KIVKVEEDPI WDQETHLRGN NFSGQEASRQ LFRQFCYQET
60 70 80 90 100
PGPREALSRL RELCHQWLRP EIHTKEQILE LLVLEQFLTI LPEELQAWVR
110 120 130 140 150
EHHPESGEEA VAVVEDLEQE LSEPGNQAPD HEHGHSEVLL EDVEHLKVKQ
160 170 180 190 200
EPTDIQLQPM VTQLRYESFC LHQFQEQDGE SIPENQELAS KQEILKEMEH
210 220 230 240 250
LGDSKLQRDV SLDSKYRETC KRDSKAEKQQ AHSTGERRHR CNECGKSFTK
260 270 280 290 300
SSVLIEHQRI HTGEKPYECE ECGKAFSRRS SLNEHRRSHT GEKPYQCKEC
310 320 330 340 350
GKAFSASNGL TRHRRIHTGE KPYECKVCGK AFLLSSCLVQ HQRIHTGEKR
360 370 380 390 400
YQCRECGKAF IQNAGLFQHL RVHTGEKPYQ CSQCSKLFSK RTLLKKHQKI

HTGERP
Length:406
Mass (Da):47,293
Last modified:September 19, 2002 - v2
Checksum:iA6082E44F27101E8
GO
Isoform 2 (identifier: Q96LW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Show »
Length:247
Mass (Da):28,711
Checksum:i2E5E9499FBBE1D56
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAI0C9JAI0_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
103Annotation score:
C9JPM5C9JPM5_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
217Annotation score:
C9IYT1C9IYT1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
155Annotation score:
C9J6S7C9J6S7_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
106Annotation score:
C9JHB1C9JHB1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
78Annotation score:
C9JIC2C9JIC2_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
147Annotation score:
C9J423C9J423_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
205Annotation score:
C9JUE1C9JUE1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
104Annotation score:
C9JBH3C9JBH3_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
88Annotation score:
C9JH14C9JH14_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
24Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → N in BAB71548 (PubMed:14702039).Curated1
Sequence conflicti173Q → R in BAB71548 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01998150T → S. Corresponds to variant dbSNP:rs853678Ensembl.1
Natural variantiVAR_052809128A → P. Corresponds to variant dbSNP:rs6922302Ensembl.1
Natural variantiVAR_024209205K → R. Corresponds to variant dbSNP:rs853684Ensembl.1
Natural variantiVAR_052810222R → Q. Corresponds to variant dbSNP:rs34223404Ensembl.1
Natural variantiVAR_059911365G → E. Corresponds to variant dbSNP:rs2394051Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471051 – 159Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513019 mRNA Translation: AAM47006.1
AK057702 mRNA Translation: BAB71548.1
AL021997 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03155.1
BC065241 mRNA Translation: AAH65241.1
CCDSiCCDS4649.1 [Q96LW9-1]
CCDS59001.1 [Q96LW9-2]
RefSeqiNP_001128687.1, NM_001135215.1 [Q96LW9-1]
NP_001128688.1, NM_001135216.1 [Q96LW9-1]
NP_001230170.1, NM_001243241.1 [Q96LW9-1]
NP_001230171.1, NM_001243242.1 [Q96LW9-2]
NP_001230172.1, NM_001243243.1 [Q96LW9-2]
NP_001230173.1, NM_001243244.1 [Q96LW9-2]
NP_112161.3, NM_030899.4 [Q96LW9-1]
NP_665916.1, NM_145909.2 [Q96LW9-1]
XP_005249352.1, XM_005249295.1 [Q96LW9-1]
XP_005249353.1, XM_005249296.4 [Q96LW9-1]
XP_011513109.1, XM_011514807.2 [Q96LW9-1]
XP_011513110.1, XM_011514808.2 [Q96LW9-1]
XP_011513111.1, XM_011514809.1 [Q96LW9-1]
XP_011513113.1, XM_011514811.2 [Q96LW9-1]
XP_011513114.1, XM_011514812.2 [Q96LW9-1]
XP_011513115.1, XM_011514813.2 [Q96LW9-1]
XP_016866685.1, XM_017011196.1 [Q96LW9-1]
UniGeneiHs.656413

Genome annotation databases

EnsembliENST00000344279; ENSP00000345339; ENSG00000235109 [Q96LW9-1]
ENST00000396838; ENSP00000380050; ENSG00000235109 [Q96LW9-1]
ENST00000414429; ENSP00000390076; ENSG00000235109 [Q96LW9-1]
ENST00000439158; ENSP00000413705; ENSG00000235109 [Q96LW9-1]
ENST00000446474; ENSP00000402937; ENSG00000235109 [Q96LW9-2]
ENST00000611469; ENSP00000480254; ENSG00000235109 [Q96LW9-2]
GeneIDi64288
KEGGihsa:64288
UCSCiuc003nla.4 human [Q96LW9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513019 mRNA Translation: AAM47006.1
AK057702 mRNA Translation: BAB71548.1
AL021997 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03155.1
BC065241 mRNA Translation: AAH65241.1
CCDSiCCDS4649.1 [Q96LW9-1]
CCDS59001.1 [Q96LW9-2]
RefSeqiNP_001128687.1, NM_001135215.1 [Q96LW9-1]
NP_001128688.1, NM_001135216.1 [Q96LW9-1]
NP_001230170.1, NM_001243241.1 [Q96LW9-1]
NP_001230171.1, NM_001243242.1 [Q96LW9-2]
NP_001230172.1, NM_001243243.1 [Q96LW9-2]
NP_001230173.1, NM_001243244.1 [Q96LW9-2]
NP_112161.3, NM_030899.4 [Q96LW9-1]
NP_665916.1, NM_145909.2 [Q96LW9-1]
XP_005249352.1, XM_005249295.1 [Q96LW9-1]
XP_005249353.1, XM_005249296.4 [Q96LW9-1]
XP_011513109.1, XM_011514807.2 [Q96LW9-1]
XP_011513110.1, XM_011514808.2 [Q96LW9-1]
XP_011513111.1, XM_011514809.1 [Q96LW9-1]
XP_011513113.1, XM_011514811.2 [Q96LW9-1]
XP_011513114.1, XM_011514812.2 [Q96LW9-1]
XP_011513115.1, XM_011514813.2 [Q96LW9-1]
XP_016866685.1, XM_017011196.1 [Q96LW9-1]
UniGeneiHs.656413

3D structure databases

ProteinModelPortaliQ96LW9
SMRiQ96LW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122130, 15 interactors
STRINGi9606.ENSP00000345339

PTM databases

iPTMnetiQ96LW9
PhosphoSitePlusiQ96LW9

Polymorphism and mutation databases

BioMutaiZSCAN31
DMDMi23396994

Proteomic databases

EPDiQ96LW9
MaxQBiQ96LW9
PaxDbiQ96LW9
PeptideAtlasiQ96LW9
PRIDEiQ96LW9
ProteomicsDBi77261

Protocols and materials databases

DNASUi64288
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344279; ENSP00000345339; ENSG00000235109 [Q96LW9-1]
ENST00000396838; ENSP00000380050; ENSG00000235109 [Q96LW9-1]
ENST00000414429; ENSP00000390076; ENSG00000235109 [Q96LW9-1]
ENST00000439158; ENSP00000413705; ENSG00000235109 [Q96LW9-1]
ENST00000446474; ENSP00000402937; ENSG00000235109 [Q96LW9-2]
ENST00000611469; ENSP00000480254; ENSG00000235109 [Q96LW9-2]
GeneIDi64288
KEGGihsa:64288
UCSCiuc003nla.4 human [Q96LW9-1]

Organism-specific databases

CTDi64288
DisGeNETi64288
EuPathDBiHostDB:ENSG00000235109.7
GeneCardsiZSCAN31
HGNCiHGNC:14097 ZSCAN31
HPAiHPA007124
MIMi610794 gene
neXtProtiNX_Q96LW9
OpenTargetsiENSG00000235109
PharmGKBiPA37840
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96LW9
KOiK09230
OMAiVEEDPIW
OrthoDBiEOG091G09O3
PhylomeDBiQ96LW9
TreeFamiTF338304

Miscellaneous databases

ChiTaRSiZSCAN31 human
GenomeRNAii64288
PROiPR:Q96LW9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000235109 Expressed in 188 organ(s), highest expression level in thyroid gland
ExpressionAtlasiQ96LW9 baseline and differential
GenevisibleiQ96LW9 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZSC31_HUMAN
AccessioniPrimary (citable) accession number: Q96LW9
Secondary accession number(s): Q6P178, Q8WWS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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