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Protein

Zinc finger and SCAN domain-containing protein 31

Gene

ZSCAN31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcription factor. May be involved in the development of multiple embryonic organs.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri239 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 31
Alternative name(s):
Zinc finger protein 323
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSCAN31
Synonyms:ZNF310P, ZNF323
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000235109.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14097 ZSCAN31

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610794 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96LW9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64288

Open Targets

More...
OpenTargetsi
ENSG00000235109

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37840

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZSCAN31

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23396994

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475321 – 406Zinc finger and SCAN domain-containing protein 31Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96LW9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96LW9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96LW9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96LW9

PeptideAtlas

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PeptideAtlasi
Q96LW9

PRoteomics IDEntifications database

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PRIDEi
Q96LW9

ProteomicsDB human proteome resource

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ProteomicsDBi
77261

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96LW9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96LW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the lung, liver, and kidney, while weakly expressed in intestine, brain, muscle, cholecyst, heart, and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000235109 Expressed in 188 organ(s), highest expression level in thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96LW9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96LW9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007124

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122130, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345339

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96LW9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96LW9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 121SCAN boxPROSITE-ProRule annotationAdd BLAST83

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000163314

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234619

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96LW9

KEGG Orthology (KO)

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KOi
K09230

Identification of Orthologs from Complete Genome Data

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OMAi
VEEDPIW

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96LW9

TreeFam database of animal gene trees

More...
TreeFami
TF338304

Family and domain databases

Conserved Domains Database

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CDDi
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

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Pfami
View protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96LW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTEEQYDL KIVKVEEDPI WDQETHLRGN NFSGQEASRQ LFRQFCYQET
60 70 80 90 100
PGPREALSRL RELCHQWLRP EIHTKEQILE LLVLEQFLTI LPEELQAWVR
110 120 130 140 150
EHHPESGEEA VAVVEDLEQE LSEPGNQAPD HEHGHSEVLL EDVEHLKVKQ
160 170 180 190 200
EPTDIQLQPM VTQLRYESFC LHQFQEQDGE SIPENQELAS KQEILKEMEH
210 220 230 240 250
LGDSKLQRDV SLDSKYRETC KRDSKAEKQQ AHSTGERRHR CNECGKSFTK
260 270 280 290 300
SSVLIEHQRI HTGEKPYECE ECGKAFSRRS SLNEHRRSHT GEKPYQCKEC
310 320 330 340 350
GKAFSASNGL TRHRRIHTGE KPYECKVCGK AFLLSSCLVQ HQRIHTGEKR
360 370 380 390 400
YQCRECGKAF IQNAGLFQHL RVHTGEKPYQ CSQCSKLFSK RTLLKKHQKI

HTGERP
Length:406
Mass (Da):47,293
Last modified:September 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6082E44F27101E8
GO
Isoform 2 (identifier: Q96LW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Show »
Length:247
Mass (Da):28,711
Checksum:i2E5E9499FBBE1D56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAI0C9JAI0_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYT1C9IYT1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPM5C9JPM5_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6S7C9J6S7_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIC2C9JIC2_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHB1C9JHB1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J423C9J423_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUE1C9JUE1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBH3C9JBH3_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JH14C9JH14_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN31
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58S → N in BAB71548 (PubMed:14702039).Curated1
Sequence conflicti173Q → R in BAB71548 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01998150T → S. Corresponds to variant dbSNP:rs853678Ensembl.1
Natural variantiVAR_052809128A → P. Corresponds to variant dbSNP:rs6922302Ensembl.1
Natural variantiVAR_024209205K → R. Corresponds to variant dbSNP:rs853684Ensembl.1
Natural variantiVAR_052810222R → Q. Corresponds to variant dbSNP:rs34223404Ensembl.1
Natural variantiVAR_059911365G → E. Corresponds to variant dbSNP:rs2394051Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0471051 – 159Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF513019 mRNA Translation: AAM47006.1
AK057702 mRNA Translation: BAB71548.1
AL021997 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03155.1
BC065241 mRNA Translation: AAH65241.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4649.1 [Q96LW9-1]
CCDS59001.1 [Q96LW9-2]

NCBI Reference Sequences

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RefSeqi
NP_001128687.1, NM_001135215.1 [Q96LW9-1]
NP_001128688.1, NM_001135216.1 [Q96LW9-1]
NP_001230170.1, NM_001243241.1 [Q96LW9-1]
NP_001230171.1, NM_001243242.1 [Q96LW9-2]
NP_001230172.1, NM_001243243.1 [Q96LW9-2]
NP_001230173.1, NM_001243244.1 [Q96LW9-2]
NP_112161.3, NM_030899.4 [Q96LW9-1]
NP_665916.1, NM_145909.2 [Q96LW9-1]
XP_005249352.1, XM_005249295.1 [Q96LW9-1]
XP_005249353.1, XM_005249296.4 [Q96LW9-1]
XP_011513109.1, XM_011514807.2 [Q96LW9-1]
XP_011513110.1, XM_011514808.2 [Q96LW9-1]
XP_011513111.1, XM_011514809.1 [Q96LW9-1]
XP_011513113.1, XM_011514811.2 [Q96LW9-1]
XP_011513114.1, XM_011514812.2 [Q96LW9-1]
XP_011513115.1, XM_011514813.2 [Q96LW9-1]
XP_016866685.1, XM_017011196.1 [Q96LW9-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.656413

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000344279; ENSP00000345339; ENSG00000235109 [Q96LW9-1]
ENST00000396838; ENSP00000380050; ENSG00000235109 [Q96LW9-1]
ENST00000414429; ENSP00000390076; ENSG00000235109 [Q96LW9-1]
ENST00000439158; ENSP00000413705; ENSG00000235109 [Q96LW9-1]
ENST00000446474; ENSP00000402937; ENSG00000235109 [Q96LW9-2]
ENST00000611469; ENSP00000480254; ENSG00000235109 [Q96LW9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64288

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64288

UCSC genome browser

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UCSCi
uc003nla.4 human [Q96LW9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513019 mRNA Translation: AAM47006.1
AK057702 mRNA Translation: BAB71548.1
AL021997 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03155.1
BC065241 mRNA Translation: AAH65241.1
CCDSiCCDS4649.1 [Q96LW9-1]
CCDS59001.1 [Q96LW9-2]
RefSeqiNP_001128687.1, NM_001135215.1 [Q96LW9-1]
NP_001128688.1, NM_001135216.1 [Q96LW9-1]
NP_001230170.1, NM_001243241.1 [Q96LW9-1]
NP_001230171.1, NM_001243242.1 [Q96LW9-2]
NP_001230172.1, NM_001243243.1 [Q96LW9-2]
NP_001230173.1, NM_001243244.1 [Q96LW9-2]
NP_112161.3, NM_030899.4 [Q96LW9-1]
NP_665916.1, NM_145909.2 [Q96LW9-1]
XP_005249352.1, XM_005249295.1 [Q96LW9-1]
XP_005249353.1, XM_005249296.4 [Q96LW9-1]
XP_011513109.1, XM_011514807.2 [Q96LW9-1]
XP_011513110.1, XM_011514808.2 [Q96LW9-1]
XP_011513111.1, XM_011514809.1 [Q96LW9-1]
XP_011513113.1, XM_011514811.2 [Q96LW9-1]
XP_011513114.1, XM_011514812.2 [Q96LW9-1]
XP_011513115.1, XM_011514813.2 [Q96LW9-1]
XP_016866685.1, XM_017011196.1 [Q96LW9-1]
UniGeneiHs.656413

3D structure databases

ProteinModelPortaliQ96LW9
SMRiQ96LW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122130, 15 interactors
STRINGi9606.ENSP00000345339

PTM databases

iPTMnetiQ96LW9
PhosphoSitePlusiQ96LW9

Polymorphism and mutation databases

BioMutaiZSCAN31
DMDMi23396994

Proteomic databases

EPDiQ96LW9
jPOSTiQ96LW9
MaxQBiQ96LW9
PaxDbiQ96LW9
PeptideAtlasiQ96LW9
PRIDEiQ96LW9
ProteomicsDBi77261

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
64288
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344279; ENSP00000345339; ENSG00000235109 [Q96LW9-1]
ENST00000396838; ENSP00000380050; ENSG00000235109 [Q96LW9-1]
ENST00000414429; ENSP00000390076; ENSG00000235109 [Q96LW9-1]
ENST00000439158; ENSP00000413705; ENSG00000235109 [Q96LW9-1]
ENST00000446474; ENSP00000402937; ENSG00000235109 [Q96LW9-2]
ENST00000611469; ENSP00000480254; ENSG00000235109 [Q96LW9-2]
GeneIDi64288
KEGGihsa:64288
UCSCiuc003nla.4 human [Q96LW9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64288
DisGeNETi64288
EuPathDBiHostDB:ENSG00000235109.7

GeneCards: human genes, protein and diseases

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GeneCardsi
ZSCAN31
HGNCiHGNC:14097 ZSCAN31
HPAiHPA007124
MIMi610794 gene
neXtProtiNX_Q96LW9
OpenTargetsiENSG00000235109
PharmGKBiPA37840

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163314
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ96LW9
KOiK09230
OMAiVEEDPIW
OrthoDBi1318335at2759
PhylomeDBiQ96LW9
TreeFamiTF338304

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZSCAN31 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64288

Protein Ontology

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PROi
PR:Q96LW9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000235109 Expressed in 188 organ(s), highest expression level in thyroid gland
ExpressionAtlasiQ96LW9 baseline and differential
GenevisibleiQ96LW9 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC31_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LW9
Secondary accession number(s): Q6P178, Q8WWS5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: January 16, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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