UniProtKB - Q96LW7 (CAR19_HUMAN)

BLAST

>sp|Q96LW7|CAR19_HUMAN Caspase recruitment domain-containing protein 19 OS=Homo sapiens OX=9606 GN=CARD19 PE=1 SV=1
MTDQTYCDRLVQDTPFLTGHGRLSEQQVDRIILQLNRYYPQILTNKEAEKFRNPKASLRV
RLCDLLSHLQRSGERDCQEFYRALYIHAQPLHSRLPSRHALRKFHITNHACLVLARGGHP
SLPLMAWMSSMTTQVCCSPGLASPLASAPPQRPPSGPEGRVWQAQAVQMLVSVSHFLPLP
PSLSHGSFHTAWGILYVHSCPSFSNLIPRGSLHVCVDSNLVPTAAWRS

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History
Entry version 141 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Caspase recruitment domain-containing protein 19

Gene

CARD19

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.1 Publication

GO - Molecular functionⁱ

CARD domain binding
Source: UniProtKB
Non-traceable author statementⁱ
- 15637807

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Non-traceable author statementⁱ
- 15637807

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Caspase recruitment domain-containing protein 19 Alternative name(s): Bcl10-interacting CARD protein Short name: BinCARD
Gene namesⁱ	Name:CARD19 Synonyms:C9orf89
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165233.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28148 CARD19
MIMⁱ	617726 gene
neXtProtⁱ	NX_Q96LW7

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	17	L → A: Abolishes the NF-kappa-B inhibitory activity. 1 Publication		1
Mutagenesisⁱ	65	L → A: Abolishes the NF-kappa-B inhibitory activity. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000165233
PharmGKBⁱ	PA134909664

Polymorphism and mutation databases

BioMutaⁱ	C9orf89
DMDMⁱ	71658794

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064927	1 – 228	Caspase recruitment domain-containing protein 19Add BLAST		228

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	7 ↔ 77	Redox-active1 Publication
Isoform 2 (identifier: Q96LW7-2)
Modified residueⁱ	113	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	Q96LW7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96LW7
PeptideAtlas More...PeptideAtlasⁱ	Q96LW7
PRIDEⁱ	Q96LW7
ProteomicsDBⁱ	77259 77260 [Q96LW7-2]

PTM databases

iPTMnetⁱ	Q96LW7
PhosphoSitePlusⁱ	Q96LW7

Expressionⁱ

Tissue specificityⁱ

Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000165233 Expressed in 193 organ(s), highest expression level in blood
CleanExⁱ	HS_C9orf89
ExpressionAtlasⁱ	Q96LW7 baseline and differential
Genevisibleⁱ	Q96LW7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010921 HPA010990 HPA038297

HPAⁱ

HPA010921
HPA010990
HPA038297

Interactionⁱ

Subunit structureⁱ

Associates with BCL10 by CARD-CARD interaction (PubMed:15637807).1 Publication

GO - Molecular functionⁱ

CARD domain binding
Source: UniProtKB
Non-traceable author statementⁱ
- 15637807

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123997, 11 interactors
IntActⁱ	Q96LW7, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q96LW7

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 17	Combined sources	12
Helixⁱ	25 – 36	Combined sources	12
Beta strandⁱ	37 – 40	Combined sources	4
Helixⁱ	45 – 51	Combined sources	7
Helixⁱ	58 – 72	Combined sources	15
Helixⁱ	74 – 87	Combined sources	14
Helixⁱ	89 – 94	Combined sources	6
Helixⁱ	96 – 98	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96LW7
SMRⁱ	Q96LW7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 99	CARDAdd BLAST		92

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016408
InParanoidⁱ	Q96LW7
OMAⁱ	YCCPPDP
PhylomeDBⁱ	Q96LW7
TreeFamⁱ	TF335747

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q96LW7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDQTYCDRL VQDTPFLTGH GRLSEQQVDR IILQLNRYYP QILTNKEAEK 
        60         70         80         90        100
FRNPKASLRV RLCDLLSHLQ RSGERDCQEF YRALYIHAQP LHSRLPSRHA 
       110        120        130        140        150
LRKFHITNHA CLVLARGGHP SLPLMAWMSS MTTQVCCSPG LASPLASAPP 
       160        170        180        190        200
QRPPSGPEGR VWQAQAVQML VSVSHFLPLP PSLSHGSFHT AWGILYVHSC 
       210        220 
PSFSNLIPRG SLHVCVDSNL VPTAAWRS

Length:228

Mass (Da):25,589

Last modified:December 1, 2001 - v1

Checksum:ⁱ7A58F5AB69882CF8

Isoform 2 (identifier: Q96LW7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
102-228: RKFHITNHAC...NLVPTAAWRS → QNSDCTELDS...AFLADDLGGL

« Hide

        10         20         30         40         50
MTDQTYCDRL VQDTPFLTGH GRLSEQQVDR IILQLNRYYP QILTNKEAEK 
        60         70         80         90        100
FRNPKASLRV RLCDLLSHLQ RSGERDCQEF YRALYIHAQP LHSRLPSRHA 
       110        120        130        140        150
LQNSDCTELD SGSQSGELSN RGPMSFLAGL GLAVGLALLL YCYPPDPKGL 
       160        170        180 
PGTRRVLGFS PVIIDRHVSR YLLAFLADDL GGL

Note: Appears to be the dominant isoform in peripheral blood cell fractions. Contains a transmembrane helix.Combined sources

Show »

Length:183

Mass (Da):20,626

Checksum:ⁱ9F0FB9192B11D0EF

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_014723	102 – 228	RKFHI…AAWRS → QNSDCTELDSGSQSGELSNR GPMSFLAGLGLAVGLALLLY CYPPDPKGLPGTRRVLGFSP VIIDRHVSRYLLAFLADDLG GL in isoform 2. 1 PublicationAdd BLAST		127

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057716 mRNA Translation: BAB71550.1 AL451065 Genomic DNA No translation available. BC004500 mRNA Translation: AAH04500.1 BC038856 mRNA Translation: AAH38856.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6702.2 [Q96LW7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_115686.3, NM_032310.4 [Q96LW7-2]
UniGeneⁱ	Hs.434213

Genome annotation databases

Ensemblⁱ	ENST00000375464; ENSP00000364613; ENSG00000165233 [Q96LW7-2] ENST00000466409; ENSP00000437237; ENSG00000165233 [Q96LW7-1]
GeneIDⁱ	84270
KEGGⁱ	hsa:84270
UCSC genome browser More...UCSCⁱ	uc004atd.4 human [Q96LW7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96LW7	CARD19 isoform 2		PONAB		258	UniRef50_Q96LW7
UPI000DC19273		THEGE		222
UPI00053306C0		RHIRO		225
UPI0008130C90		MANJA		182
UPI0004BE135E		EQUPR		214
+6
Q96LW7-2	Chromosome 9 open reading frame 89, isoform CRA_b		HUMAN		183	UniRef50_A0A024R248
Uncharacterized protein		PANPA		183
Caspase recruitment domain family member 19		GORGO		183
Uncharacterized protein		PAPAN		183
Uncharacterized protein		CERAT		183
+81

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057716 mRNA Translation: BAB71550.1 AL451065 Genomic DNA No translation available. BC004500 mRNA Translation: AAH04500.1 BC038856 mRNA Translation: AAH38856.1
CCDSⁱ	CCDS6702.2 [Q96LW7-2]
RefSeqⁱ	NP_115686.3, NM_032310.4 [Q96LW7-2]
UniGeneⁱ	Hs.434213

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4DWN	X-ray	1.58	A/B	3-99	[»]
	4FH0	X-ray	1.40	A/B	3-101	[»]
ProteinModelPortalⁱ	Q96LW7
SMRⁱ	Q96LW7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123997, 11 interactors
IntActⁱ	Q96LW7, 1 interactor
MINTⁱ	Q96LW7

PTM databases

iPTMnetⁱ	Q96LW7
PhosphoSitePlusⁱ	Q96LW7

Polymorphism and mutation databases

BioMutaⁱ	C9orf89
DMDMⁱ	71658794

Proteomic databases

EPDⁱ	Q96LW7
MaxQBⁱ	Q96LW7
PeptideAtlasⁱ	Q96LW7
PRIDEⁱ	Q96LW7
ProteomicsDBⁱ	77259 77260 [Q96LW7-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84270
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375464; ENSP00000364613; ENSG00000165233 [Q96LW7-2] ENST00000466409; ENSP00000437237; ENSG00000165233 [Q96LW7-1]
GeneIDⁱ	84270
KEGGⁱ	hsa:84270
UCSCⁱ	uc004atd.4 human [Q96LW7-1]

Organism-specific databases

CTDⁱ	84270
EuPathDBⁱ	HostDB:ENSG00000165233.17
GeneCardsⁱ	CARD19
HGNCⁱ	HGNC:28148 CARD19
HPAⁱ	HPA010921 HPA010990 HPA038297
MIMⁱ	617726 gene
neXtProtⁱ	NX_Q96LW7
OpenTargetsⁱ	ENSG00000165233
PharmGKBⁱ	PA134909664
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000016408
InParanoidⁱ	Q96LW7
OMAⁱ	YCCPPDP
PhylomeDBⁱ	Q96LW7
TreeFamⁱ	TF335747

Miscellaneous databases

ChiTaRSⁱ	CARD19 human
GenomeRNAiⁱ	84270
Protein Ontology More...PROⁱ	PR:Q96LW7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165233 Expressed in 193 organ(s), highest expression level in blood
CleanExⁱ	HS_C9orf89
ExpressionAtlasⁱ	Q96LW7 baseline and differential
Genevisibleⁱ	Q96LW7 HS

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	CAR19_HUMAN
Accessionⁱ	Q96LW7Primary (citable) accession number: Q96LW7 Secondary accession number(s): Q5BJH8, Q9BSY2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 2, 2005
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96LW7 (CAR19_HUMAN)

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Caspase recruitment domain-containing protein 19

CARD19

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endoplasmic reticulum

Mitochondrion

Cytosol

Endoplasmic reticulum

Mitochondrion

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ