UniProtKB - Q96LW7 (CAR19_HUMAN)
Protein
Caspase recruitment domain-containing protein 19
Gene
CARD19
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.1 Publication
GO - Molecular functioni
- CARD domain binding Source: UniProtKB
GO - Biological processi
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q96LW7 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase recruitment domain-containing protein 19Alternative name(s): Bcl10-interacting CARD protein Short name: BinCARD |
Gene namesi | Name:CARD19 Synonyms:C9orf89 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165233.17 |
HGNCi | HGNC:28148, CARD19 |
MIMi | 617726, gene |
neXtProti | NX_Q96LW7 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Coexpression with BCL10 induced translocation from nucleus to cytosol.
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication
Mitochondrion
- Mitochondrion membrane 1 Publication; Single-pass membrane protein 1 Publication
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: HPA
Nucleus
- nucleus Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, Mitochondrion, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 17 | L → A: Abolishes the NF-kappa-B inhibitory activity. 1 Publication | 1 | |
Mutagenesisi | 65 | L → A: Abolishes the NF-kappa-B inhibitory activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 84270 |
OpenTargetsi | ENSG00000165233 |
PharmGKBi | PA134909664 |
Miscellaneous databases
Pharosi | Q96LW7, Tdark |
Polymorphism and mutation databases
BioMutai | CARD19 |
DMDMi | 71658794 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064927 | 1 – 228 | Caspase recruitment domain-containing protein 19Add BLAST | 228 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Disulfide bondi | 7 ↔ 77 | Redox-active1 Publication | |||
Isoform 2 (identifier: Q96LW7-2) | |||||
Modified residuei | 113 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
jPOSTi | Q96LW7 |
MassIVEi | Q96LW7 |
MaxQBi | Q96LW7 |
PeptideAtlasi | Q96LW7 |
PRIDEi | Q96LW7 |
ProteomicsDBi | 77259 [Q96LW7-1] 77260 [Q96LW7-2] |
PTM databases
iPTMneti | Q96LW7 |
PhosphoSitePlusi | Q96LW7 |
Expressioni
Tissue specificityi
Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.1 Publication
Gene expression databases
Bgeei | ENSG00000165233, Expressed in blood and 206 other tissues |
ExpressionAtlasi | Q96LW7, baseline and differential |
Genevisiblei | Q96LW7, HS |
Organism-specific databases
HPAi | ENSG00000165233, Low tissue specificity |
Interactioni
Subunit structurei
Associates with BCL10 by CARD-CARD interaction (PubMed:15637807).
1 PublicationGO - Molecular functioni
- CARD domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 123997, 14 interactors |
IntActi | Q96LW7, 8 interactors |
MINTi | Q96LW7 |
Miscellaneous databases
RNActi | Q96LW7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96LW7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 99 | CARDAdd BLAST | 92 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00390000016408 |
HOGENOMi | CLU_103797_0_0_1 |
InParanoidi | Q96LW7 |
OMAi | TLQNSDC |
PhylomeDBi | Q96LW7 |
TreeFami | TF335747 |
Family and domain databases
CDDi | cd13785, CARD_BinCARD_like, 1 hit |
InterProi | View protein in InterPro IPR043574, CARD19 IPR042146, CARD_BinCARD |
PANTHERi | PTHR34765, PTHR34765, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96LW7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTDQTYCDRL VQDTPFLTGH GRLSEQQVDR IILQLNRYYP QILTNKEAEK
60 70 80 90 100
FRNPKASLRV RLCDLLSHLQ RSGERDCQEF YRALYIHAQP LHSRLPSRHA
110 120 130 140 150
LRKFHITNHA CLVLARGGHP SLPLMAWMSS MTTQVCCSPG LASPLASAPP
160 170 180 190 200
QRPPSGPEGR VWQAQAVQML VSVSHFLPLP PSLSHGSFHT AWGILYVHSC
210 220
PSFSNLIPRG SLHVCVDSNL VPTAAWRS
Isoform 2 (identifier: Q96LW7-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
102-228: RKFHITNHAC...NLVPTAAWRS → QNSDCTELDS...AFLADDLGGL
Note: Appears to be the dominant isoform in peripheral blood cell fractions. Contains a transmembrane helix.Curated
Show »Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014723 | 102 – 228 | RKFHI…AAWRS → QNSDCTELDSGSQSGELSNR GPMSFLAGLGLAVGLALLLY CYPPDPKGLPGTRRVLGFSP VIIDRHVSRYLLAFLADDLG GL in isoform 2. 1 PublicationAdd BLAST | 127 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057716 mRNA Translation: BAB71550.1 AL451065 Genomic DNA No translation available. BC004500 mRNA Translation: AAH04500.1 BC038856 mRNA Translation: AAH38856.1 |
CCDSi | CCDS6702.2 [Q96LW7-2] |
RefSeqi | NP_115686.3, NM_032310.4 [Q96LW7-2] |
Genome annotation databases
Ensembli | ENST00000375464; ENSP00000364613; ENSG00000165233 [Q96LW7-2] ENST00000466409; ENSP00000437237; ENSG00000165233 [Q96LW7-1] |
GeneIDi | 84270 |
KEGGi | hsa:84270 |
UCSCi | uc004atd.4, human [Q96LW7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057716 mRNA Translation: BAB71550.1 AL451065 Genomic DNA No translation available. BC004500 mRNA Translation: AAH04500.1 BC038856 mRNA Translation: AAH38856.1 |
CCDSi | CCDS6702.2 [Q96LW7-2] |
RefSeqi | NP_115686.3, NM_032310.4 [Q96LW7-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4DWN | X-ray | 1.58 | A/B | 3-99 | [»] | |
4FH0 | X-ray | 1.40 | A/B | 3-101 | [»] | |
SMRi | Q96LW7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123997, 14 interactors |
IntActi | Q96LW7, 8 interactors |
MINTi | Q96LW7 |
PTM databases
iPTMneti | Q96LW7 |
PhosphoSitePlusi | Q96LW7 |
Polymorphism and mutation databases
BioMutai | CARD19 |
DMDMi | 71658794 |
Proteomic databases
jPOSTi | Q96LW7 |
MassIVEi | Q96LW7 |
MaxQBi | Q96LW7 |
PeptideAtlasi | Q96LW7 |
PRIDEi | Q96LW7 |
ProteomicsDBi | 77259 [Q96LW7-1] 77260 [Q96LW7-2] |
Protocols and materials databases
Antibodypediai | 28349, 127 antibodies |
DNASUi | 84270 |
Genome annotation databases
Ensembli | ENST00000375464; ENSP00000364613; ENSG00000165233 [Q96LW7-2] ENST00000466409; ENSP00000437237; ENSG00000165233 [Q96LW7-1] |
GeneIDi | 84270 |
KEGGi | hsa:84270 |
UCSCi | uc004atd.4, human [Q96LW7-1] |
Organism-specific databases
CTDi | 84270 |
DisGeNETi | 84270 |
EuPathDBi | HostDB:ENSG00000165233.17 |
GeneCardsi | CARD19 |
HGNCi | HGNC:28148, CARD19 |
HPAi | ENSG00000165233, Low tissue specificity |
MIMi | 617726, gene |
neXtProti | NX_Q96LW7 |
OpenTargetsi | ENSG00000165233 |
PharmGKBi | PA134909664 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000016408 |
HOGENOMi | CLU_103797_0_0_1 |
InParanoidi | Q96LW7 |
OMAi | TLQNSDC |
PhylomeDBi | Q96LW7 |
TreeFami | TF335747 |
Enzyme and pathway databases
PathwayCommonsi | Q96LW7 |
Miscellaneous databases
BioGRID-ORCSi | 84270, 3 hits in 843 CRISPR screens |
ChiTaRSi | CARD19, human |
GenomeRNAii | 84270 |
Pharosi | Q96LW7, Tdark |
PROi | PR:Q96LW7 |
RNActi | Q96LW7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165233, Expressed in blood and 206 other tissues |
ExpressionAtlasi | Q96LW7, baseline and differential |
Genevisiblei | Q96LW7, HS |
Family and domain databases
CDDi | cd13785, CARD_BinCARD_like, 1 hit |
InterProi | View protein in InterPro IPR043574, CARD19 IPR042146, CARD_BinCARD |
PANTHERi | PTHR34765, PTHR34765, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAR19_HUMAN | |
Accessioni | Q96LW7Primary (citable) accession number: Q96LW7 Secondary accession number(s): Q5BJH8, Q9BSY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 2, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references