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Protein

Uncharacterized serine/threonine-protein kinase SgK494

Gene

SGK494

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136ATPPROSITE-ProRule annotation1
Active sitei229Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi113 – 121ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96LW2

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized serine/threonine-protein kinase SgK494 (EC:2.7.11.1)
Alternative name(s):
Sugen kinase 494
Gene namesi
Name:SGK494
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000167524.14
neXtProtiNX_Q96LW2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000258472

Polymorphism and mutation databases

DMDMi74724242

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002506461 – 410Uncharacterized serine/threonine-protein kinase SgK494Add BLAST410

Proteomic databases

PaxDbiQ96LW2
PeptideAtlasiQ96LW2
PRIDEiQ96LW2
ProteomicsDBi77256
77257 [Q96LW2-2]

PTM databases

iPTMnetiQ96LW2
PhosphoSitePlusiQ96LW2

Expressioni

Gene expression databases

BgeeiENSG00000167524 Expressed in 182 organ(s), highest expression level in right hemisphere of cerebellum

Organism-specific databases

HPAiHPA046590

Interactioni

Protein-protein interaction databases

IntActiQ96LW2, 6 interactors
STRINGi9606.ENSP00000301037

Structurei

3D structure databases

ProteinModelPortaliQ96LW2
SMRiQ96LW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 274Protein kinasePROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0694 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00400000022377
HOGENOMiHOG000154304
HOVERGENiHBG093948
InParanoidiQ96LW2
OrthoDBiEOG091G076X
PhylomeDBiQ96LW2

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96LW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS
60 70 80 90 100
DLEELWELRG HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP
110 120 130 140 150
IRGQQQLKIL GLVAKGSFGT VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR
160 170 180 190 200
QCKEEVSIQR QINHPFVHSL GDSWQGKRHL FIMCSYCSTD LYSLWSAVGC
210 220 230 240 250
FPEASIRLFA AELVLVLCYL HDLGIMHRDV KVENILLDER GHLKLTDFGL
260 270 280 290 300
SRHVPQGAQA YTICGTLQYM APEVLSGGPY NHAADWWSLG VLLFSLATGK
310 320 330 340 350
FPVAAERDHV AMLASVTHSD SEIPASLNQG LSLLLHELLC QNPLHRLRYL
360 370 380 390 400
HHFQVHPFFR GVAFDPELLQ KQPVNFVTET QATQPSSAET MPFDDFDCDL
410
ESFLLYPIPA
Length:410
Mass (Da):46,191
Last modified:March 28, 2018 - v2
Checksum:iF9147BCCEA5638A8
GO
Isoform 2 (identifier: Q96LW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-171: RQINHPFVHSLG → VISMTWASCIEM
     172-410: Missing.

Show »
Length:171
Mass (Da):19,316
Checksum:i8D125411B846D917
GO
Isoform 3 (identifier: Q96LW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-274: APEV → GERG
     275-410: Missing.

Note: May be due to an intron retention.
Show »
Length:274
Mass (Da):31,012
Checksum:i07873AD72B263670
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020678160 – 171RQINH…VHSLG → VISMTWASCIEM in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_020679172 – 410Missing in isoform 2. 2 PublicationsAdd BLAST239
Alternative sequenceiVSP_059421271 – 274APEV → GERG in isoform 3. 1 Publication4
Alternative sequenceiVSP_059422275 – 410Missing in isoform 3. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057735 mRNA Translation: BAB71555.1
AK294189 mRNA Translation: BAG57505.1
AC005726 Genomic DNA No translation available.
BC045622 mRNA Translation: AAH45622.1
UniGeneiHs.729077

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057735 mRNA Translation: BAB71555.1
AK294189 mRNA Translation: BAG57505.1
AC005726 Genomic DNA No translation available.
BC045622 mRNA Translation: AAH45622.1
UniGeneiHs.729077

3D structure databases

ProteinModelPortaliQ96LW2
SMRiQ96LW2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96LW2, 6 interactors
STRINGi9606.ENSP00000301037

PTM databases

iPTMnetiQ96LW2
PhosphoSitePlusiQ96LW2

Polymorphism and mutation databases

DMDMi74724242

Proteomic databases

PaxDbiQ96LW2
PeptideAtlasiQ96LW2
PRIDEiQ96LW2
ProteomicsDBi77256
77257 [Q96LW2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

EuPathDBiHostDB:ENSG00000167524.14
GeneCardsiSGK494
HPAiHPA046590
neXtProtiNX_Q96LW2
OpenTargetsiENSG00000258472

Phylogenomic databases

eggNOGiKOG0694 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00400000022377
HOGENOMiHOG000154304
HOVERGENiHBG093948
InParanoidiQ96LW2
OrthoDBiEOG091G076X
PhylomeDBiQ96LW2

Enzyme and pathway databases

SignaLinkiQ96LW2

Miscellaneous databases

ChiTaRSiSGK494 human
GenomeRNAii124923
PROiPR:Q96LW2

Gene expression databases

BgeeiENSG00000167524 Expressed in 182 organ(s), highest expression level in right hemisphere of cerebellum

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSG494_HUMAN
AccessioniPrimary (citable) accession number: Q96LW2
Secondary accession number(s): B4DFP4, L7N484, Q49A48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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