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UniProtKB - Q96LW2 (KS6R_HUMAN)
Protein
Ribosomal protein S6 kinase-related protein
Gene
RSKR
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 136 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 229 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 113 – 121 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
GO - Biological processi
- protein phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96LW2 |
SignaLinki | Q96LW2 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein S6 kinase-related proteinCurated (EC:2.7.11.1PROSITE-ProRule annotation)Alternative name(s): Sugen kinase 494 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26314, RSKR |
neXtProti | NX_Q96LW2 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000167524 ENSG00000258472 |
Miscellaneous databases
Pharosi | Q96LW2, Tdark |
Genetic variation databases
BioMutai | ENSG00000167524 SGK494 |
DMDMi | 74724242 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250646 | 1 – 410 | Ribosomal protein S6 kinase-related proteinAdd BLAST | 410 |
Proteomic databases
jPOSTi | Q96LW2 |
MassIVEi | Q96LW2 |
PaxDbi | Q96LW2 |
PRIDEi | Q96LW2 |
PTM databases
iPTMneti | Q96LW2 |
PhosphoSitePlusi | Q96LW2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167524, Expressed in right hemisphere of cerebellum and 197 other tissues |
Interactioni
Binary interactionsi
Q96LW2
Protein-protein interaction databases
IntActi | Q96LW2, 7 interactors |
STRINGi | 9606.ENSP00000301037 |
Miscellaneous databases
RNActi | Q96LW2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 107 – 274 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 168 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0605, Eukaryota KOG0694, Eukaryota |
GeneTreei | ENSGT00400000022377 ENSGT00940000160082 |
InParanoidi | Q96LW2 |
OrthoDBi | 694650at2759 |
PhylomeDBi | Q96LW2 |
Family and domain databases
CDDi | cd05123, STKc_AGC, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR045270, STKc_AGC |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96LW2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS
60 70 80 90 100
DLEELWELRG HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP
110 120 130 140 150
IRGQQQLKIL GLVAKGSFGT VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR
160 170 180 190 200
QCKEEVSIQR QINHPFVHSL GDSWQGKRHL FIMCSYCSTD LYSLWSAVGC
210 220 230 240 250
FPEASIRLFA AELVLVLCYL HDLGIMHRDV KVENILLDER GHLKLTDFGL
260 270 280 290 300
SRHVPQGAQA YTICGTLQYM APEVLSGGPY NHAADWWSLG VLLFSLATGK
310 320 330 340 350
FPVAAERDHV AMLASVTHSD SEIPASLNQG LSLLLHELLC QNPLHRLRYL
360 370 380 390 400
HHFQVHPFFR GVAFDPELLQ KQPVNFVTET QATQPSSAET MPFDDFDCDL
410
ESFLLYPIPA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PPC7 | E9PPC7_HUMAN | Ribosomal protein S6 kinase-related... | RSKR | 186 | Annotation score: | ||
J3KTE0 | J3KTE0_HUMAN | Ribosomal protein S6 kinase-related... | RSKR | 173 | Annotation score: | ||
A0A5H1ZRP1 | A0A5H1ZRP1_HUMAN | Ribosomal protein S6 kinase-related... | RSKR | 410 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020678 | 160 – 171 | RQINH…VHSLG → VISMTWASCIEM in isoform 2. 2 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_020679 | 172 – 410 | Missing in isoform 2. 2 PublicationsAdd BLAST | 239 | |
Alternative sequenceiVSP_059421 | 271 – 274 | APEV → GERG in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_059422 | 275 – 410 | Missing in isoform 3. 1 PublicationAdd BLAST | 136 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057735 mRNA Translation: BAB71555.1 AK294189 mRNA Translation: BAG57505.1 AC005726 Genomic DNA No translation available. BC045622 mRNA Translation: AAH45622.1 |
Genome annotation databases
Ensembli | ENST00000584196.1; ENSP00000464466.1; ENSG00000167524.16 [Q96LW2-2] |
UCSCi | uc010crq.4, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057735 mRNA Translation: BAB71555.1 AK294189 mRNA Translation: BAG57505.1 AC005726 Genomic DNA No translation available. BC045622 mRNA Translation: AAH45622.1 |
3D structure databases
AlphaFoldDBi | Q96LW2 |
SMRi | Q96LW2 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q96LW2, 7 interactors |
STRINGi | 9606.ENSP00000301037 |
PTM databases
iPTMneti | Q96LW2 |
PhosphoSitePlusi | Q96LW2 |
Genetic variation databases
BioMutai | ENSG00000167524 SGK494 |
DMDMi | 74724242 |
Proteomic databases
jPOSTi | Q96LW2 |
MassIVEi | Q96LW2 |
PaxDbi | Q96LW2 |
PRIDEi | Q96LW2 |
Genome annotation databases
Ensembli | ENST00000584196.1; ENSP00000464466.1; ENSG00000167524.16 [Q96LW2-2] |
UCSCi | uc010crq.4, human |
Organism-specific databases
GeneCardsi | RSKR |
HGNCi | HGNC:26314, RSKR |
neXtProti | NX_Q96LW2 |
OpenTargetsi | ENSG00000167524 ENSG00000258472 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0605, Eukaryota KOG0694, Eukaryota |
GeneTreei | ENSGT00400000022377 ENSGT00940000160082 |
InParanoidi | Q96LW2 |
OrthoDBi | 694650at2759 |
PhylomeDBi | Q96LW2 |
Enzyme and pathway databases
PathwayCommonsi | Q96LW2 |
SignaLinki | Q96LW2 |
Miscellaneous databases
BioGRID-ORCSi | 124923, 9 hits in 231 CRISPR screens |
GenomeRNAii | 124923 |
Pharosi | Q96LW2, Tdark |
PROi | PR:Q96LW2 |
RNActi | Q96LW2, protein |
Gene expression databases
Bgeei | ENSG00000167524, Expressed in right hemisphere of cerebellum and 197 other tissues |
Family and domain databases
CDDi | cd05123, STKc_AGC, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR045270, STKc_AGC |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KS6R_HUMAN | |
Accessioni | Q96LW2Primary (citable) accession number: Q96LW2 Secondary accession number(s): B4DFP4, L7N484, Q49A48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | March 28, 2018 | |
Last modified: | May 25, 2022 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families