SGK494

Functionⁱ

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	136	ATPPROSITE-ProRule annotation		1
Active siteⁱ	229	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	113 – 121	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q96LW2

SignaLinkⁱ

Q96LW2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Uncharacterized serine/threonine-protein kinase SgK494 (EC:2.7.11.1) Alternative name(s): Sugen kinase 494
Gene namesⁱ	Name:SGK494
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167524.14
neXtProtⁱ	NX_Q96LW2

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000258472

OpenTargetsⁱ

ENSG00000258472

Polymorphism and mutation databases

DMDMⁱ	74724242

DMDMⁱ

74724242

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000250646	1 – 410	Uncharacterized serine/threonine-protein kinase SgK494Add BLAST		410

Proteomic databases

PaxDbⁱ	Q96LW2
PeptideAtlas More...PeptideAtlasⁱ	Q96LW2
PRIDEⁱ	Q96LW2
ProteomicsDBⁱ	77256 77257 [Q96LW2-2]

PTM databases

iPTMnetⁱ	Q96LW2
PhosphoSitePlusⁱ	Q96LW2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167524

Bgeeⁱ

ENSG00000167524

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046590

HPAⁱ

HPA046590

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q96LW2, 7 interactors
STRINGⁱ	9606.ENSP00000301037

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96LW2
SMRⁱ	Q96LW2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	107 – 274	Protein kinasePROSITE-ProRule annotationAdd BLAST		168

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0694 Eukaryota ENOG410XNPH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00400000022377
HOGENOMⁱ	HOG000154304
HOVERGENⁱ	HBG093948
InParanoidⁱ	Q96LW2
OMAⁱ	HLFIMCS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G076X
PhylomeDBⁱ	Q96LW2

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q96LW2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS 
        60         70         80         90        100
DLEELWELRG HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP 
       110        120        130        140        150
IRGQQQLKIL GLVAKGSFGT VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR 
       160        170        180        190        200
QCKEEVSIQR QINHPFVHSL GDSWQGKRHL FIMCSYCSTD LYSLWSAVGC 
       210        220        230        240        250
FPEASIRLFA AELVLVLCYL HDLGIMHRDV KVENILLDER GHLKLTDFGL 
       260        270        280        290        300
SRHVPQGAQA YTICGTLQYM APEVLSGGPY NHAADWWSLG VLLFSLATGK 
       310        320        330        340        350
FPVAAERDHV AMLASVTHSD SEIPASLNQG LSLLLHELLC QNPLHRLRYL 
       360        370        380        390        400
HHFQVHPFFR GVAFDPELLQ KQPVNFVTET QATQPSSAET MPFDDFDCDL 
       410
ESFLLYPIPA

Length:410

Mass (Da):46,191

Last modified:March 28, 2018 - v2

Checksum:ⁱF9147BCCEA5638A8

GO

Isoform 2 (identifier: Q96LW2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
160-171: RQINHPFVHSLG → VISMTWASCIEM
172-410: Missing.

« Hide

        10         20         30         40         50
MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS 
        60         70         80         90        100
DLEELWELRG HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP 
       110        120        130        140        150
IRGQQQLKIL GLVAKGSFGT VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR 
       160        170 
QCKEEVSIQV ISMTWASCIE M

Show »

Length:171

Mass (Da):19,316

Checksum:ⁱ8D125411B846D917

GO

Isoform 3 (identifier: Q96LW2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
271-274: APEV → GERG
275-410: Missing.

« Hide

        10         20         30         40         50
MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS 
        60         70         80         90        100
DLEELWELRG HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP 
       110        120        130        140        150
IRGQQQLKIL GLVAKGSFGT VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR 
       160        170        180        190        200
QCKEEVSIQR QINHPFVHSL GDSWQGKRHL FIMCSYCSTD LYSLWSAVGC 
       210        220        230        240        250
FPEASIRLFA AELVLVLCYL HDLGIMHRDV KVENILLDER GHLKLTDFGL 
       260        270 
SRHVPQGAQA YTICGTLQYM GERG

Note: May be due to an intron retention.

Show »

Length:274

Mass (Da):31,012

Checksum:ⁱ07873AD72B263670

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_020678	160 – 171	RQINH…VHSLG → VISMTWASCIEM in isoform 2. 2 PublicationsAdd BLAST	12
Alternative sequenceⁱVSP_020679	172 – 410	Missing in isoform 2. 2 PublicationsAdd BLAST	239
Alternative sequenceⁱVSP_059421	271 – 274	APEV → GERG in isoform 3. 1 Publication	4
Alternative sequenceⁱVSP_059422	275 – 410	Missing in isoform 3. 1 PublicationAdd BLAST	136

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057735 mRNA Translation: BAB71555.1 AK294189 mRNA Translation: BAG57505.1 AC005726 Genomic DNA No translation available. BC045622 mRNA Translation: AAH45622.1
UniGeneⁱ	Hs.729077

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length
Q96LW2	UPI0004F002EC		PANPA		449
UPI0004F40374		PONAB		449
UPI0007DB9E24		PANTR		449
UPI0008F5053A		GORGO		449
UPI000C297728		Ugandan red Colobus		443
+46
Q96LW2-2	Uncharacterized serine/threonine-protein kinase SgK494 (Fragment)		HUMAN		186
Uncharacterized serine/threonine-protein kinase SgK494 (Fragment)		HUMAN		173
Q96LW2-3	Uncharacterized protein		HUMAN		289
Uncharacterized protein		PONAB		274
uncharacterized serine/threonine-protein kinase SgK494		TARSY		274
Uncharacterized protein		MACMU		266
Uncharacterized protein		MACFA		266

Protein	Similar proteins		Species	Score	Length
Q96LW2	UPI0008F5053A		GORGO		449
UPI0004F40374		PONAB		449
UPI0004F002EC		PANPA		449
UPI0007DB9E24		PANTR		449
UPI000C297728		Ugandan red Colobus		443
+142
Q96LW2-2	Uncharacterized serine/threonine-protein kinase SgK494 (Fragment)		HUMAN		186
Uncharacterized protein (Fragment)		NEOVI		149
Uncharacterized serine/threonine-protein kinase SgK494 (Fragment)		HUMAN		173
Q96LW2-3	Uncharacterized protein		HUMAN		289
Uncharacterized protein		PONAB		274
uncharacterized serine/threonine-protein kinase SgK494		TARSY		274
Uncharacterized protein		MACMU		266
Uncharacterized protein		MACFA		266
+20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057735 mRNA Translation: BAB71555.1 AK294189 mRNA Translation: BAG57505.1 AC005726 Genomic DNA No translation available. BC045622 mRNA Translation: AAH45622.1
UniGeneⁱ	Hs.729077

3D structure databases

ProteinModelPortalⁱ	Q96LW2
SMRⁱ	Q96LW2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q96LW2, 7 interactors
STRINGⁱ	9606.ENSP00000301037

PTM databases

iPTMnetⁱ	Q96LW2
PhosphoSitePlusⁱ	Q96LW2

Polymorphism and mutation databases

DMDMⁱ	74724242

DMDMⁱ

74724242

Proteomic databases

PaxDbⁱ	Q96LW2
PeptideAtlas More...PeptideAtlasⁱ	Q96LW2
PRIDEⁱ	Q96LW2
ProteomicsDBⁱ	77256 77257 [Q96LW2-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167524.14
GeneCardsⁱ	SGK494
Human Protein Atlas More...HPAⁱ	HPA046590
neXtProtⁱ	NX_Q96LW2
Open Targets More...OpenTargetsⁱ	ENSG00000258472

Phylogenomic databases

eggNOGⁱ	KOG0694 Eukaryota ENOG410XNPH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00400000022377
HOGENOMⁱ	HOG000154304
HOVERGENⁱ	HBG093948
InParanoidⁱ	Q96LW2
OMAⁱ	HLFIMCS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G076X
PhylomeDBⁱ	Q96LW2

Enzyme and pathway databases

SignaLinkⁱ	Q96LW2

SignaLinkⁱ

Q96LW2

Miscellaneous databases

ChiTaRSⁱ	SGK494 human
GenomeRNAiⁱ	124923
Protein Ontology More...PROⁱ	PR:Q96LW2

Gene expression databases

Bgeeⁱ	ENSG00000167524

Bgeeⁱ

ENSG00000167524

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SG494_HUMAN
Accessionⁱ	Q96LW2Primary (citable) accession number: Q96LW2 Secondary accession number(s): B4DFP4, L7N484, Q49A48
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	March 28, 2018
	Last modified:	July 18, 2018
	This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q96LW2 (SG494_HUMAN)

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Uncharacterized serine/threonine-protein kinase SgK494

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

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Enzyme and pathway databases

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ