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UniProtKB - Q96LW1 (Z354B_HUMAN)

Entry version 159 (23 Feb 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Zinc finger protein 354B

Gene

ZNF354B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96LW1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96LW1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 354B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF354B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17197, ZNF354B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96LW1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000178338

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000178338

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38210

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96LW1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF354B

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762673

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804061 – 612Zinc finger protein 354BAdd BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96LW1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96LW1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96LW1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96LW1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96LW1

PeptideAtlas

More...PeptideAtlasi		Q96LW1

PRoteomics IDEntifications database

More...PRIDEi		Q96LW1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77255

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96LW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96LW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000178338, Expressed in placenta and 162 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96LW1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96LW1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000178338, Group enriched (brain, choroid plexus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125594, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q96LW1, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000327143

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96LW1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96LW1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 102DisorderedSequence analysisAdd BLAST27
Regioni320 – 340DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi82 – 102Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162570

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96LW1

Identification of Orthologs from Complete Genome Data

More...OMAi		SVTHTKI

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96LW1

TreeFam database of animal gene trees

More...TreeFami		TF341817

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96LW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGQREARP QVSLTFEDVA VLFTWDEWRK LAPSQRNLYR DVMLENYRNL 
        60         70         80         90        100
VSLGLSFTKP KVISLLQQGE DPWEVEKDSS GVSSLGCKST PKMTKSTQTQ 
       110        120        130        140        150
DSFQEQIRKR LKRDEPWNFI SERSCIYEEK LKKQQDKNEN LQIISVAHTK 
       160        170        180        190        200
ILTVDRSHKN VEFGQNFYLK SVFIKQQRFA KEKTPSKCEI QRNSFKQNSN 
       210        220        230        240        250
LLNQSKIKTA EKRYKCSTCE KAFIHNSSLR KHQKNHTGEK LFKCKECLKA 
       260        270        280        290        300
FSQSSALIQH QRTHTGEKPY ICKECGKAFS HSASLCKHLR THTVEKCYRC 
       310        320        330        340        350
KECGKSFSRR SGLFIHQKIH AQENPHKYNP GRKASSYSTS LSGSQKIHLR 
       360        370        380        390        400
KKSYLCNECG NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH 
       410        420        430        440        450
ERIHTGEKPY RCNECGKGFT SISRLNRHRI IHTGEKLYNC NECGKALSSH 
       460        470        480        490        500
STLIIHERIH TGEKPCKCKV CGKAFRQSSA LIQHQRMHTG ERPYKCNECD 
       510        520        530        540        550
KTFRCNSSLS NHQRIHTGEK PYRCLECGMS FGQSAALIQH QRIHTGEKPF 
       560        570        580        590        600
KCNTCGKTFR QSSSLIAHQR IHTGEKPYEC NACGKLFSQR SSLTNHYKIH 
       610 
IEEDSLKADL HV
Length:612
Mass (Da):70,529
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1E94FD6B22305B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RH89E5RH89_HUMAN
Zinc finger protein 354B
ZNF354B
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK057737 mRNA Translation: BAB71556.1
AK289667 mRNA Translation: BAF82356.1
BC104777 mRNA Translation: AAI04778.1
BC112111 mRNA Translation: AAI12112.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4439.1

NCBI Reference Sequences

More...RefSeqi		NP_478137.1, NM_058230.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000322434; ENSP00000327143; ENSG00000178338

Database of genes from NCBI RefSeq genomes

More...GeneIDi		117608

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:117608

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000322434.8; ENSP00000327143.3; NM_058230.3; NP_478137.1

UCSC genome browser

More...UCSCi		uc003mjl.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057737 mRNA Translation: BAB71556.1
AK289667 mRNA Translation: BAF82356.1
BC104777 mRNA Translation: AAI04778.1
BC112111 mRNA Translation: AAI12112.1
CCDSiCCDS4439.1
RefSeqiNP_478137.1, NM_058230.2

3D structure databases

SMRiQ96LW1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125594, 3 interactors
IntActiQ96LW1, 2 interactors
STRINGi9606.ENSP00000327143

PTM databases

iPTMnetiQ96LW1
PhosphoSitePlusiQ96LW1

Genetic variation databases

BioMutaiZNF354B
DMDMi74762673

Proteomic databases

EPDiQ96LW1
jPOSTiQ96LW1
MassIVEiQ96LW1
MaxQBiQ96LW1
PaxDbiQ96LW1
PeptideAtlasiQ96LW1
PRIDEiQ96LW1
ProteomicsDBi77255

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29455, 16 antibodies from 9 providers

The DNASU plasmid repository

More...DNASUi		117608

Genome annotation databases

EnsembliENST00000322434; ENSP00000327143; ENSG00000178338
GeneIDi117608
KEGGihsa:117608
MANE-SelectiENST00000322434.8; ENSP00000327143.3; NM_058230.3; NP_478137.1
UCSCiuc003mjl.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		117608

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF354B
HGNCiHGNC:17197, ZNF354B
HPAiENSG00000178338, Group enriched (brain, choroid plexus)
neXtProtiNX_Q96LW1
OpenTargetsiENSG00000178338
PharmGKBiPA38210
VEuPathDBiHostDB:ENSG00000178338

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162570
HOGENOMiCLU_002678_44_5_1
InParanoidiQ96LW1
OMAiSVTHTKI
OrthoDBi1318335at2759
PhylomeDBiQ96LW1
TreeFamiTF341817

Enzyme and pathway databases

PathwayCommonsiQ96LW1
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiQ96LW1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		117608, 4 hits in 1033 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF354B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		117608
PharosiQ96LW1, Tdark

Protein Ontology

More...PROi		PR:Q96LW1
RNActiQ96LW1, protein

Gene expression databases

BgeeiENSG00000178338, Expressed in placenta and 162 other tissues
ExpressionAtlasiQ96LW1, baseline and differential
GenevisibleiQ96LW1, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ354B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LW1
Secondary accession number(s): A8K0V2, Q5U5Z4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: February 23, 2022
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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