ZNF354B

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	214 – 236	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	242 – 264	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	270 – 292	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 320	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	354 – 376	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	382 – 404	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	410 – 432	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	438 – 460	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	466 – 488	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	494 – 516	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	522 – 544	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	550 – 572	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	578 – 600	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 354B
Gene namesⁱ	Name:ZNF354B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000178338.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17197 ZNF354B
neXtProtⁱ	NX_Q96LW1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000178338
PharmGKBⁱ	PA38210

Polymorphism and mutation databases

BioMutaⁱ	ZNF354B
DMDMⁱ	74762673

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280406	1 – 612	Zinc finger protein 354BAdd BLAST		612

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	150	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	175	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q96LW1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96LW1
PaxDbⁱ	Q96LW1
PeptideAtlas More...PeptideAtlasⁱ	Q96LW1
PRIDEⁱ	Q96LW1
ProteomicsDBⁱ	77255

PTM databases

iPTMnetⁱ	Q96LW1
PhosphoSitePlusⁱ	Q96LW1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000178338 Expressed in 143 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_ZNF354B
ExpressionAtlasⁱ	Q96LW1 baseline and differential
Genevisibleⁱ	Q96LW1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029056

HPAⁱ

HPA029056

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	125594, 1 interactor
IntActⁱ	Q96LW1, 2 interactors
STRINGⁱ	9606.ENSP00000327143

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96LW1
SMRⁱ	Q96LW1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 85	KRABPROSITE-ProRule annotationAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	214 – 236	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	242 – 264	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	270 – 292	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 320	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	354 – 376	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	382 – 404	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	410 – 432	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	438 – 460	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	466 – 488	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	494 – 516	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	522 – 544	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	550 – 572	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	578 – 600	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150883
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q96LW1
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	KQQDKNE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q96LW1
TreeFamⁱ	TF341817

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 12 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 9 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q96LW1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAGQREARP QVSLTFEDVA VLFTWDEWRK LAPSQRNLYR DVMLENYRNL 
        60         70         80         90        100
VSLGLSFTKP KVISLLQQGE DPWEVEKDSS GVSSLGCKST PKMTKSTQTQ 
       110        120        130        140        150
DSFQEQIRKR LKRDEPWNFI SERSCIYEEK LKKQQDKNEN LQIISVAHTK 
       160        170        180        190        200
ILTVDRSHKN VEFGQNFYLK SVFIKQQRFA KEKTPSKCEI QRNSFKQNSN 
       210        220        230        240        250
LLNQSKIKTA EKRYKCSTCE KAFIHNSSLR KHQKNHTGEK LFKCKECLKA 
       260        270        280        290        300
FSQSSALIQH QRTHTGEKPY ICKECGKAFS HSASLCKHLR THTVEKCYRC 
       310        320        330        340        350
KECGKSFSRR SGLFIHQKIH AQENPHKYNP GRKASSYSTS LSGSQKIHLR 
       360        370        380        390        400
KKSYLCNECG NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH 
       410        420        430        440        450
ERIHTGEKPY RCNECGKGFT SISRLNRHRI IHTGEKLYNC NECGKALSSH 
       460        470        480        490        500
STLIIHERIH TGEKPCKCKV CGKAFRQSSA LIQHQRMHTG ERPYKCNECD 
       510        520        530        540        550
KTFRCNSSLS NHQRIHTGEK PYRCLECGMS FGQSAALIQH QRIHTGEKPF 
       560        570        580        590        600
KCNTCGKTFR QSSSLIAHQR IHTGEKPYEC NACGKLFSQR SSLTNHYKIH 
       610 
IEEDSLKADL HV

Length:612

Mass (Da):70,529

Last modified:December 1, 2001 - v1

Checksum:ⁱD1E94FD6B22305B0

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E5RH89	E5RH89_HUMAN		Zinc finger protein 354B Zinc finger protein 354B	ZNF354B	134	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057737 mRNA Translation: BAB71556.1 AK289667 mRNA Translation: BAF82356.1 BC104777 mRNA Translation: AAI04778.1 BC112111 mRNA Translation: AAI12112.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4439.1
NCBI Reference Sequences More...RefSeqⁱ	NP_478137.1, NM_058230.2
UniGeneⁱ	Hs.724051

Genome annotation databases

Ensemblⁱ	ENST00000322434; ENSP00000327143; ENSG00000178338
GeneIDⁱ	117608
KEGGⁱ	hsa:117608
UCSC genome browser More...UCSCⁱ	uc003mjl.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96LW1	Zinc finger protein 354B		HUMAN		676	UniRef100_Q96LW1
Zinc finger protein 354B (Fragment)		HUMAN		134

Protein	Similar proteins		Species	Score	Length	Source
Q96LW1	Zinc finger protein 354B		HUMAN		676	UniRef90_Q96LW1
Zinc finger protein 354B		PANTR		676
Uncharacterized protein		PANPA		676
Uncharacterized protein		NOMLE		676
Zinc finger protein 354B		GORGO		676
+53

Protein	Similar proteins		Species	Score	Length	Source
Q96LW1	Zinc finger protein 354A		HUMAN		605	UniRef50_O60765
zinc finger protein 354A		URSMA		718
zinc finger protein 354A isoform X1		NEOSC		647
zinc finger protein 354A		LEPWE		643
Uncharacterized protein		BOVIN		606
+246

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057737 mRNA Translation: BAB71556.1 AK289667 mRNA Translation: BAF82356.1 BC104777 mRNA Translation: AAI04778.1 BC112111 mRNA Translation: AAI12112.1
CCDSⁱ	CCDS4439.1
RefSeqⁱ	NP_478137.1, NM_058230.2
UniGeneⁱ	Hs.724051

3D structure databases

ProteinModelPortalⁱ	Q96LW1
SMRⁱ	Q96LW1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125594, 1 interactor
IntActⁱ	Q96LW1, 2 interactors
STRINGⁱ	9606.ENSP00000327143

PTM databases

iPTMnetⁱ	Q96LW1
PhosphoSitePlusⁱ	Q96LW1

Polymorphism and mutation databases

BioMutaⁱ	ZNF354B
DMDMⁱ	74762673

Proteomic databases

EPDⁱ	Q96LW1
MaxQBⁱ	Q96LW1
PaxDbⁱ	Q96LW1
PeptideAtlasⁱ	Q96LW1
PRIDEⁱ	Q96LW1
ProteomicsDBⁱ	77255

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	117608
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000322434; ENSP00000327143; ENSG00000178338
GeneIDⁱ	117608
KEGGⁱ	hsa:117608
UCSCⁱ	uc003mjl.4 human

Organism-specific databases

CTDⁱ	117608
EuPathDBⁱ	HostDB:ENSG00000178338.10
GeneCardsⁱ	ZNF354B
HGNCⁱ	HGNC:17197 ZNF354B
HPAⁱ	HPA029056
neXtProtⁱ	NX_Q96LW1
OpenTargetsⁱ	ENSG00000178338
PharmGKBⁱ	PA38210
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150883
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q96LW1
KOⁱ	K09228
OMAⁱ	KQQDKNE
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q96LW1
TreeFamⁱ	TF341817

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	ZNF354B human
GenomeRNAiⁱ	117608
Protein Ontology More...PROⁱ	PR:Q96LW1

Gene expression databases

Bgeeⁱ	ENSG00000178338 Expressed in 143 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_ZNF354B
ExpressionAtlasⁱ	Q96LW1 baseline and differential
Genevisibleⁱ	Q96LW1 HS

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 12 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 9 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Z354B_HUMAN
Accessionⁱ	Q96LW1Primary (citable) accession number: Q96LW1 Secondary accession number(s): A8K0V2, Q5U5Z4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96LW1 (Z354B_HUMAN)

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Zinc finger protein 354B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ