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Protein

Mitochondrial inner membrane protease subunit 1

Gene

IMMP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40By similarity1
Active sitei83By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 1 (EC:3.4.21.-)
Alternative name(s):
IMP1-like protein
Gene namesi
Name:IMMP1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000148950.9
HGNCiHGNC:26317 IMMP1L
MIMi612323 gene
neXtProtiNX_Q96LU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi196294
OpenTargetsiENSG00000148950
PharmGKBiPA142671655

Polymorphism and mutation databases

BioMutaiIMMP1L
DMDMi74752020

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595731 – 166Mitochondrial inner membrane protease subunit 1Add BLAST166

Proteomic databases

EPDiQ96LU5
MaxQBiQ96LU5
PaxDbiQ96LU5
PeptideAtlasiQ96LU5
PRIDEiQ96LU5
ProteomicsDBi77251

PTM databases

iPTMnetiQ96LU5
PhosphoSitePlusiQ96LU5

Expressioni

Gene expression databases

BgeeiENSG00000148950 Expressed in 198 organ(s), highest expression level in kidney
CleanExiHS_IMMP1L
ExpressionAtlasiQ96LU5 baseline and differential
GenevisibleiQ96LU5 HS

Organism-specific databases

HPAiHPA058308

Interactioni

Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.By similarity

Protein-protein interaction databases

BioGridi128195, 4 interactors
STRINGi9606.ENSP00000278200

Structurei

3D structure databases

ProteinModelPortaliQ96LU5
SMRiQ96LU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family. IMP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0171 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00550000075025
HOGENOMiHOG000003673
HOVERGENiHBG080010
InParanoidiQ96LU5
KOiK09647
OMAiCKGPSME
OrthoDBiEOG091G0TXV
PhylomeDBiQ96LU5
TreeFamiTF315083

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR026730 Mitochondrial_IMP1
IPR000223 Pept_S26A_signal_pept_1
IPR015927 Peptidase_S24_S26A/B/C
PANTHERiPTHR12383:SF16 PTHR12383:SF16, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q96LU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRGVLGKTF RLVGYTIQYG CIAHCAFEYV GGVVMCSGPS MEPTIQNSDI
60 70 80 90 100
VFAENLSRHF YGIQRGDIVI AKSPSDPKSN ICKRVIGLEG DKILTTSPSD
110 120 130 140 150
FFKSHSYVPM GHVWLEGDNL QNSTDSRCYG PIPYGLIRGR IFFKIWPLSD
160
FGFLRASPNG HRFSDD
Length:166
Mass (Da):18,504
Last modified:December 1, 2001 - v1
Checksum:i53E4EB65757BA71A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIG6E9PIG6_HUMAN
Mitochondrial inner membrane protea...
IMMP1L
107Annotation score:
E9PNR7E9PNR7_HUMAN
Mitochondrial inner membrane protea...
IMMP1L
96Annotation score:
E9PR99E9PR99_HUMAN
Mitochondrial inner membrane protea...
IMMP1L
94Annotation score:
H0YD09H0YD09_HUMAN
Mitochondrial inner membrane protea...
IMMP1L
30Annotation score:
A0A0B4J221A0A0B4J221_HUMAN
Mitochondrial inner membrane protea...
IMMP1L
57Annotation score:

Sequence cautioni

The sequence CAC39221 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057788 mRNA Translation: BAB71573.1
AL133295 Genomic DNA Translation: CAC39221.1 Sequence problems.
CH471064 Genomic DNA Translation: EAW68239.1
CH471064 Genomic DNA Translation: EAW68240.1
BC023595 mRNA Translation: AAH23595.1
CCDSiCCDS7874.1
RefSeqiNP_001291203.1, NM_001304274.1
NP_659418.1, NM_144981.2
XP_005252869.1, XM_005252812.3
XP_011518244.1, XM_011519942.1
XP_011518245.1, XM_011519943.2
XP_011518246.1, XM_011519944.2
XP_011518247.1, XM_011519945.2
XP_011518248.1, XM_011519946.2
XP_011518249.1, XM_011519947.2
XP_016872794.1, XM_017017305.1
UniGeneiHs.502223

Genome annotation databases

EnsembliENST00000278200; ENSP00000278200; ENSG00000148950
ENST00000532287; ENSP00000435576; ENSG00000148950
GeneIDi196294
KEGGihsa:196294
UCSCiuc001msy.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057788 mRNA Translation: BAB71573.1
AL133295 Genomic DNA Translation: CAC39221.1 Sequence problems.
CH471064 Genomic DNA Translation: EAW68239.1
CH471064 Genomic DNA Translation: EAW68240.1
BC023595 mRNA Translation: AAH23595.1
CCDSiCCDS7874.1
RefSeqiNP_001291203.1, NM_001304274.1
NP_659418.1, NM_144981.2
XP_005252869.1, XM_005252812.3
XP_011518244.1, XM_011519942.1
XP_011518245.1, XM_011519943.2
XP_011518246.1, XM_011519944.2
XP_011518247.1, XM_011519945.2
XP_011518248.1, XM_011519946.2
XP_011518249.1, XM_011519947.2
XP_016872794.1, XM_017017305.1
UniGeneiHs.502223

3D structure databases

ProteinModelPortaliQ96LU5
SMRiQ96LU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128195, 4 interactors
STRINGi9606.ENSP00000278200

PTM databases

iPTMnetiQ96LU5
PhosphoSitePlusiQ96LU5

Polymorphism and mutation databases

BioMutaiIMMP1L
DMDMi74752020

Proteomic databases

EPDiQ96LU5
MaxQBiQ96LU5
PaxDbiQ96LU5
PeptideAtlasiQ96LU5
PRIDEiQ96LU5
ProteomicsDBi77251

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278200; ENSP00000278200; ENSG00000148950
ENST00000532287; ENSP00000435576; ENSG00000148950
GeneIDi196294
KEGGihsa:196294
UCSCiuc001msy.1 human

Organism-specific databases

CTDi196294
DisGeNETi196294
EuPathDBiHostDB:ENSG00000148950.9
GeneCardsiIMMP1L
HGNCiHGNC:26317 IMMP1L
HPAiHPA058308
MIMi612323 gene
neXtProtiNX_Q96LU5
OpenTargetsiENSG00000148950
PharmGKBiPA142671655
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0171 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00550000075025
HOGENOMiHOG000003673
HOVERGENiHBG080010
InParanoidiQ96LU5
KOiK09647
OMAiCKGPSME
OrthoDBiEOG091G0TXV
PhylomeDBiQ96LU5
TreeFamiTF315083

Miscellaneous databases

ChiTaRSiIMMP1L human
GenomeRNAii196294
PROiPR:Q96LU5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148950 Expressed in 198 organ(s), highest expression level in kidney
CleanExiHS_IMMP1L
ExpressionAtlasiQ96LU5 baseline and differential
GenevisibleiQ96LU5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR026730 Mitochondrial_IMP1
IPR000223 Pept_S26A_signal_pept_1
IPR015927 Peptidase_S24_S26A/B/C
PANTHERiPTHR12383:SF16 PTHR12383:SF16, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIMP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96LU5
Secondary accession number(s): D3DQZ7, Q96SH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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