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Protein

UPF0739 protein C1orf74

Gene

C1orf74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0739 protein C1orf74
Gene namesi
Name:C1orf74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162757.4
HGNCiHGNC:26319 C1orf74
neXtProtiNX_Q96LT6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162757
PharmGKBiPA142672523

Polymorphism and mutation databases

BioMutaiC1orf74

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710921 – 269UPF0739 protein C1orf74Add BLAST269

Proteomic databases

EPDiQ96LT6
PaxDbiQ96LT6
PeptideAtlasiQ96LT6
PRIDEiQ96LT6
ProteomicsDBi77247

Expressioni

Gene expression databases

BgeeiENSG00000162757
CleanExiHS_C1orf74
ExpressionAtlasiQ96LT6 baseline and differential
GenevisibleiQ96LT6 HS

Organism-specific databases

HPAiHPA028496

Interactioni

Protein-protein interaction databases

BioGridi127141, 6 interactors
IntActiQ96LT6, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96LT6
SMRiQ96LT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0739 family.Curated

Phylogenomic databases

eggNOGiENOG410IVPG Eukaryota
ENOG4112A34 LUCA
GeneTreeiENSGT00390000002240
HOGENOMiHOG000111227
HOVERGENiHBG080000
InParanoidiQ96LT6
OMAiHILEIGE
OrthoDBiEOG091G0N3X
PhylomeDBiQ96LT6
TreeFamiTF328609

Family and domain databases

InterProiView protein in InterPro
IPR027850 DUF4504
PANTHERiPTHR31366 PTHR31366, 1 hit
PfamiView protein in Pfam
PF14953 DUF4504, 1 hit

Sequencei

Sequence statusi: Complete.

Q96LT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLDLMSSP SPQLLVAAAQ QTLGMGKRRS PPQAICLHLA GEVLAVARGL
60 70 80 90 100
KPAVLYDCNC AGASELQSYL EELKGLGFLT FGLHILEIGE NSLIVSPEHV
110 120 130 140 150
CQHLEQVLLG TIAFVDVSSC QRHPSVCSLD QLQDLKALVA EIITHLQGLQ
160 170 180 190 200
RDLSLAVSYS RLHSSDWNLC TVFGILLGYP VPYTFHLNQG DDNCLALTPL
210 220 230 240 250
RVFTARISWL LGQPPILLYS FSVPESLFPG LRDILNTWEK DLRTRFRTQN
260
DFADLSISSE IVTLPAVAL
Length:269
Mass (Da):29,561
Last modified:December 1, 2001 - v1
Checksum:i12E2D58AA1E2F617
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050701146L → F. Corresponds to variant dbSNP:rs7550857Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057807 mRNA Translation: BAB71584.1
AL022398 Genomic DNA No translation available.
BC039719 mRNA Translation: AAH39719.1
CCDSiCCDS1491.1
RefSeqiNP_689698.1, NM_152485.3
UniGeneiHs.497642
Hs.634602

Genome annotation databases

EnsembliENST00000294811; ENSP00000294811; ENSG00000162757
GeneIDi148304
KEGGihsa:148304
UCSCiuc001hhp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCA074_HUMAN
AccessioniPrimary (citable) accession number: Q96LT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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