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Protein

Apolipoprotein L domain-containing protein 1

Gene

APOLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.1 Publication

GO - Molecular functioni

  • lipid binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L domain-containing protein 1
Alternative name(s):
Vascular early response gene protein
Gene namesi
Name:APOLD1
Synonyms:VERGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000178878.12
HGNCiHGNC:25268 APOLD1
MIMi612456 gene
neXtProtiNX_Q96LR9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 105HelicalSequence analysisAdd BLAST23
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81575
OpenTargetsiENSG00000178878
PharmGKBiPA143485306

Polymorphism and mutation databases

BioMutaiAPOLD1
DMDMi110832749

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472751 – 279Apolipoprotein L domain-containing protein 1Add BLAST279

Proteomic databases

PaxDbiQ96LR9
PRIDEiQ96LR9
ProteomicsDBi77241
77242 [Q96LR9-2]

Expressioni

Tissue specificityi

Expressed in neonatal dermal microvascular endothelial cells.1 Publication

Inductioni

In neonatal dermal microvascular endothelial cells, by hypoxia.1 Publication

Gene expression databases

BgeeiENSG00000178878 Expressed in 219 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ96LR9 baseline and differential
GenevisibleiQ96LR9 HS

Organism-specific databases

HPAiHPA052462
HPA058882

Interactioni

Protein-protein interaction databases

BioGridi123535, 5 interactors
STRINGi9606.ENSP00000324277

Structurei

3D structure databases

ProteinModelPortaliQ96LR9
SMRiQ96LR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili226 – 253Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 82Arg-richAdd BLAST80

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWGQ Eukaryota
ENOG410YM8A LUCA
GeneTreeiENSGT00710000106780
HOGENOMiHOG000092978
HOVERGENiHBG079426
InParanoidiQ96LR9
OMAiMALYNSV
OrthoDBiEOG091G0L8F
PhylomeDBiQ96LR9
TreeFamiTF334681

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96LR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRAPCHRLR ARGTRKARAG AWRGCTFPCL GKGMERPAAR EPHGPDALRR
60 70 80 90 100
FQGLLLDRRG RLHGQVLRLR EVARRLERLR RRSLVANVAG SSLSATGALA
110 120 130 140 150
AIVGLSLSPV TLGTSLLVSA VGLGVATAGG AVTITSDLSL IFCNSRELRR
160 170 180 190 200
VQEIAATCQD QMREILSCLE FFCRWQGCGD RQLLQCGRNA SIALYNSVYF
210 220 230 240 250
IVFFGSRGFL IPRRAEGDTK VSQAVLKAKI QKLAESLESC TGALDELSEQ
260 270
LESRVQLCTK SSRGHDLKIS ADQRAGLFF
Note: No experimental confirmation available.
Length:279
Mass (Da):30,546
Last modified:July 25, 2006 - v2
Checksum:iE2CDA210C1FD80C3
GO
Isoform 2 (identifier: Q96LR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-32: Missing.

Show »
Length:248
Mass (Da):27,063
Checksum:i291DE656CDC04338
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX34F5GX34_HUMAN
Apolipoprotein L domain-containing ...
APOLD1
40Annotation score:

Sequence cautioni

The sequence AAH42478 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64G → R in CAB66717 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0199602 – 32Missing in isoform 2. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136783 mRNA Translation: CAB66717.1
AK057867 mRNA Translation: BAB71601.1
BC042478 mRNA Translation: AAH42478.1 Different initiation.
CCDSiCCDS44833.1 [Q96LR9-1]
CCDS8654.1 [Q96LR9-2]
RefSeqiNP_001123887.1, NM_001130415.1 [Q96LR9-1]
NP_110444.3, NM_030817.2 [Q96LR9-2]
UniGeneiHs.23388
Hs.719938

Genome annotation databases

EnsembliENST00000326765; ENSP00000324277; ENSG00000178878 [Q96LR9-1]
ENST00000356591; ENSP00000348998; ENSG00000178878 [Q96LR9-2]
GeneIDi81575
KEGGihsa:81575
UCSCiuc001rau.5 human [Q96LR9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136783 mRNA Translation: CAB66717.1
AK057867 mRNA Translation: BAB71601.1
BC042478 mRNA Translation: AAH42478.1 Different initiation.
CCDSiCCDS44833.1 [Q96LR9-1]
CCDS8654.1 [Q96LR9-2]
RefSeqiNP_001123887.1, NM_001130415.1 [Q96LR9-1]
NP_110444.3, NM_030817.2 [Q96LR9-2]
UniGeneiHs.23388
Hs.719938

3D structure databases

ProteinModelPortaliQ96LR9
SMRiQ96LR9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123535, 5 interactors
STRINGi9606.ENSP00000324277

Polymorphism and mutation databases

BioMutaiAPOLD1
DMDMi110832749

Proteomic databases

PaxDbiQ96LR9
PRIDEiQ96LR9
ProteomicsDBi77241
77242 [Q96LR9-2]

Protocols and materials databases

DNASUi81575
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326765; ENSP00000324277; ENSG00000178878 [Q96LR9-1]
ENST00000356591; ENSP00000348998; ENSG00000178878 [Q96LR9-2]
GeneIDi81575
KEGGihsa:81575
UCSCiuc001rau.5 human [Q96LR9-1]

Organism-specific databases

CTDi81575
DisGeNETi81575
EuPathDBiHostDB:ENSG00000178878.12
GeneCardsiAPOLD1
HGNCiHGNC:25268 APOLD1
HPAiHPA052462
HPA058882
MIMi612456 gene
neXtProtiNX_Q96LR9
OpenTargetsiENSG00000178878
PharmGKBiPA143485306
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWGQ Eukaryota
ENOG410YM8A LUCA
GeneTreeiENSGT00710000106780
HOGENOMiHOG000092978
HOVERGENiHBG079426
InParanoidiQ96LR9
OMAiMALYNSV
OrthoDBiEOG091G0L8F
PhylomeDBiQ96LR9
TreeFamiTF334681

Miscellaneous databases

ChiTaRSiAPOLD1 human
GeneWikiiAPOLD1_(gene)
GenomeRNAii81575
PROiPR:Q96LR9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178878 Expressed in 219 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ96LR9 baseline and differential
GenevisibleiQ96LR9 HS

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPLD1_HUMAN
AccessioniPrimary (citable) accession number: Q96LR9
Secondary accession number(s): Q8IVR2, Q9H0I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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