LURAP1

Functionⁱ

Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).By similarity1 Publication

GO - Biological processⁱ

actomyosin structure organization Source: Ensembl
cell migration Source: Ensembl
positive regulation of cytokine production
Source: UniProtKB
Inferred from direct assayⁱ
- 21048106
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 21048106

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine rich adaptor protein 1 Alternative name(s): Leucine repeat adapter protein 35A
Gene namesⁱ	Name:LURAP1 Synonyms:C1orf190, LRAP35A, LRP35A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171357.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32327 LURAP1
MIMⁱ	616129 gene
neXtProtⁱ	NX_Q96LR2

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	541468
Open Targets More...OpenTargetsⁱ	ENSG00000171357
PharmGKBⁱ	PA142672401

Polymorphism and mutation databases

BioMutaⁱ	LURAP1
DMDMⁱ	74752014

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000271078	1 – 239	Leucine rich adaptor protein 1Add BLAST		239

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	118	PhosphoserineBy similarity	1
Modified residueⁱ	126	PhosphoserineBy similarity	1
Modified residueⁱ	129	PhosphoserineBy similarity	1
Modified residueⁱ	213	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96LR2
PaxDbⁱ	Q96LR2
PeptideAtlas More...PeptideAtlasⁱ	Q96LR2
PRIDEⁱ	Q96LR2
ProteomicsDBⁱ	77237

PTM databases

iPTMnetⁱ	Q96LR2
PhosphoSitePlusⁱ	Q96LR2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171357 Expressed in 116 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_C1orf190
Genevisibleⁱ	Q96LR2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030060 HPA030061

HPAⁱ

HPA030060
HPA030061

Interactionⁱ

Subunit structureⁱ

Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation. Interacts with CDC42BPA and CDC42BPB.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AMOT	Q4VCS5-2	3	EBI-741355,EBI-3891843
CSNK1D	P48730	4	EBI-741355,EBI-751621
HAUS1	Q96CS2	3	EBI-741355,EBI-2514791
HGS	O14964	3	EBI-741355,EBI-740220
PRPF31	Q8WWY3	6	EBI-741355,EBI-1567797
TPM3	P06753	3	EBI-741355,EBI-355607
TXLNB	Q8N3L3	5	EBI-741355,EBI-6116822
ZNF417	Q8TAU3	3	EBI-741355,EBI-740727

Protein-protein interaction databases

BioGridⁱ	139071, 18 interactors
IntActⁱ	Q96LR2, 23 interactors
STRINGⁱ	9606.ENSP00000361048

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96LR2
SMRⁱ	Q96LR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	55 – 83	LRR 1Add BLAST		29
Repeatⁱ	93 – 114	LRR 2Add BLAST		22

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IJRV Eukaryota ENOG4111FFM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063790
HOGENOMⁱ	HOG000231120
HOVERGENⁱ	HBG099631
InParanoidⁱ	Q96LR2
OMAⁱ	PEMDWAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OGC
PhylomeDBⁱ	Q96LR2
TreeFamⁱ	TF332089

Family and domain databases

InterProⁱ	View protein in InterPro IPR039499 LURA1/LRA25 IPR037443 LURAP1
PANTHERⁱ	PTHR33767 PTHR33767, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14854 LURAP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96LR2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGTVESQTP DLRDVEGKVG RKTPEGLLRG LRGECELGTS GALLLPGASS 
        60         70         80         90        100
TGHDLGDKIM ALKMELAYLR AIDVKILQQL VTLNEGIEAV RWLLEERGTL 
       110        120        130        140        150
TSHCSSLTSS QYSLTGGSPG RSRRGSWDSL PDTSTTDRLD SVSIGSFLDT 
       160        170        180        190        200
VAPSELDEQG PPGAPRSEMD WAKVIAGGER ARTEVDVAAT RLGSLRAVWK 
       210        220        230 
PPGERLQGGP PESPEDESAK LGFEAHWFWE QCQDDVTFL

Length:239

Mass (Da):25,806

Last modified:December 1, 2001 - v1

Checksum:ⁱE6D06F384B5448C1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057892 mRNA Translation: BAB71608.1 AL672043 Genomic DNA No translation available. BC034422 mRNA Translation: AAH34422.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30703.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001013633.1, NM_001013615.2
UniGeneⁱ	Hs.568642

Genome annotation databases

Ensemblⁱ	ENST00000371980; ENSP00000361048; ENSG00000171357
GeneIDⁱ	541468
KEGGⁱ	hsa:541468
UCSC genome browser More...UCSCⁱ	uc010oma.3 human

Protein	Similar proteins		Species	Score	Length	Source
Q96LR2	Leucine rich adaptor protein 1		MACMU		239	UniRef90_Q96LR2
Uncharacterized protein		MACFA		239
Uncharacterized protein		MACNE		239
Leucine rich adaptor protein 1		CALJA		239
Chromosome 1 open reading frame 190		PANTR		239
+20

Protein	Similar proteins		Species	Score	Length	Source
Q96LR2	NF-kappa-B activator C1orf190		MACMU		239	UniRef50_Q96LR2
Uncharacterized protein		PAPAN		239
Uncharacterized protein		MANLE		239
leucine rich adaptor protein 1		TARSY		239
Leucine rich adaptor protein 1		CALJA		239
+45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057892 mRNA Translation: BAB71608.1 AL672043 Genomic DNA No translation available. BC034422 mRNA Translation: AAH34422.1
CCDSⁱ	CCDS30703.1
RefSeqⁱ	NP_001013633.1, NM_001013615.2
UniGeneⁱ	Hs.568642

3D structure databases

ProteinModelPortalⁱ	Q96LR2
SMRⁱ	Q96LR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	139071, 18 interactors
IntActⁱ	Q96LR2, 23 interactors
STRINGⁱ	9606.ENSP00000361048

PTM databases

iPTMnetⁱ	Q96LR2
PhosphoSitePlusⁱ	Q96LR2

Polymorphism and mutation databases

BioMutaⁱ	LURAP1
DMDMⁱ	74752014

Proteomic databases

EPDⁱ	Q96LR2
PaxDbⁱ	Q96LR2
PeptideAtlasⁱ	Q96LR2
PRIDEⁱ	Q96LR2
ProteomicsDBⁱ	77237

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	541468
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371980; ENSP00000361048; ENSG00000171357
GeneIDⁱ	541468
KEGGⁱ	hsa:541468
UCSCⁱ	uc010oma.3 human

Organism-specific databases

CTDⁱ	541468
DisGeNETⁱ	541468
EuPathDBⁱ	HostDB:ENSG00000171357.5
GeneCardsⁱ	LURAP1
H-InvDBⁱ	HIX0000545
HGNCⁱ	HGNC:32327 LURAP1
HPAⁱ	HPA030060 HPA030061
MIMⁱ	616129 gene
neXtProtⁱ	NX_Q96LR2
OpenTargetsⁱ	ENSG00000171357
PharmGKBⁱ	PA142672401
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJRV Eukaryota ENOG4111FFM LUCA
GeneTreeⁱ	ENSGT00530000063790
HOGENOMⁱ	HOG000231120
HOVERGENⁱ	HBG099631
InParanoidⁱ	Q96LR2
OMAⁱ	PEMDWAK
OrthoDBⁱ	EOG091G0OGC
PhylomeDBⁱ	Q96LR2
TreeFamⁱ	TF332089

Miscellaneous databases

GenomeRNAiⁱ	541468
Protein Ontology More...PROⁱ	PR:Q96LR2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171357 Expressed in 116 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_C1orf190
Genevisibleⁱ	Q96LR2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039499 LURA1/LRA25 IPR037443 LURAP1
PANTHERⁱ	PTHR33767 PTHR33767, 1 hit
Pfamⁱ	View protein in Pfam PF14854 LURAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LURA1_HUMAN
Accessionⁱ	Q96LR2Primary (citable) accession number: Q96LR2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96LR2 (LURA1_HUMAN)

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Leucine rich adaptor protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ