UniProtKB - Q96LR2 (LURA1_HUMAN)
Leucine rich adaptor protein 1
LURAP1
Functioni
Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106).
In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).
By similarity1 PublicationGO - Biological processi
- positive regulation of cytokine production Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q96LR2 |
SignaLinki | Q96LR2 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine rich adaptor protein 1Alternative name(s): Leucine repeat adapter protein 35A |
Gene namesi | Name:LURAP1 Synonyms:C1orf190, LRAP35A, LRP35A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32327, LURAP1 |
MIMi | 616129, gene |
neXtProti | NX_Q96LR2 |
VEuPathDBi | HostDB:ENSG00000171357 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 541468 |
OpenTargetsi | ENSG00000171357 |
PharmGKBi | PA142672401 |
Miscellaneous databases
Pharosi | Q96LR2, Tdark |
Genetic variation databases
BioMutai | LURAP1 |
DMDMi | 74752014 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271078 | 1 – 239 | Leucine rich adaptor protein 1Add BLAST | 239 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 118 | PhosphoserineBy similarity | 1 | |
Modified residuei | 126 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | PhosphoserineBy similarity | 1 | |
Modified residuei | 213 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96LR2 |
MassIVEi | Q96LR2 |
PaxDbi | Q96LR2 |
PeptideAtlasi | Q96LR2 |
PRIDEi | Q96LR2 |
ProteomicsDBi | 77237 |
PTM databases
iPTMneti | Q96LR2 |
PhosphoSitePlusi | Q96LR2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171357, Expressed in heart left ventricle and 134 other tissues |
Genevisiblei | Q96LR2, HS |
Organism-specific databases
HPAi | ENSG00000171357, Low tissue specificity |
Interactioni
Subunit structurei
Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation.
Interacts with CDC42BPA and CDC42BPB.
By similarityBinary interactionsi
Q96LR2
Protein-protein interaction databases
BioGRIDi | 139071, 131 interactors |
IntActi | Q96LR2, 32 interactors |
STRINGi | 9606.ENSP00000361048 |
Miscellaneous databases
RNActi | Q96LR2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 55 – 83 | LRR 1Add BLAST | 29 | |
Repeati | 93 – 114 | LRR 2Add BLAST | 22 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 107 – 139 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 200 – 219 | DisorderedSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502QQFH, Eukaryota |
GeneTreei | ENSGT00530000063790 |
HOGENOMi | CLU_066656_1_0_1 |
InParanoidi | Q96LR2 |
OMAi | MEGTAES |
OrthoDBi | 1385244at2759 |
PhylomeDBi | Q96LR2 |
TreeFami | TF332089 |
Family and domain databases
InterProi | View protein in InterPro IPR039499, LURA1/LRA25 IPR037443, LURAP1 |
PANTHERi | PTHR33767, PTHR33767, 1 hit |
Pfami | View protein in Pfam PF14854, LURAP, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MEGTVESQTP DLRDVEGKVG RKTPEGLLRG LRGECELGTS GALLLPGASS
60 70 80 90 100
TGHDLGDKIM ALKMELAYLR AIDVKILQQL VTLNEGIEAV RWLLEERGTL
110 120 130 140 150
TSHCSSLTSS QYSLTGGSPG RSRRGSWDSL PDTSTTDRLD SVSIGSFLDT
160 170 180 190 200
VAPSELDEQG PPGAPRSEMD WAKVIAGGER ARTEVDVAAT RLGSLRAVWK
210 220 230
PPGERLQGGP PESPEDESAK LGFEAHWFWE QCQDDVTFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057892 mRNA Translation: BAB71608.1 AL672043 Genomic DNA No translation available. BC034422 mRNA Translation: AAH34422.1 |
CCDSi | CCDS30703.1 |
RefSeqi | NP_001013633.1, NM_001013615.2 |
Genome annotation databases
Ensembli | ENST00000371980; ENSP00000361048; ENSG00000171357 |
GeneIDi | 541468 |
KEGGi | hsa:541468 |
MANE-Selecti | ENST00000371980.4; ENSP00000361048.3; NM_001013615.3; NP_001013633.1 |
UCSCi | uc010oma.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057892 mRNA Translation: BAB71608.1 AL672043 Genomic DNA No translation available. BC034422 mRNA Translation: AAH34422.1 |
CCDSi | CCDS30703.1 |
RefSeqi | NP_001013633.1, NM_001013615.2 |
3D structure databases
SMRi | Q96LR2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 139071, 131 interactors |
IntActi | Q96LR2, 32 interactors |
STRINGi | 9606.ENSP00000361048 |
PTM databases
iPTMneti | Q96LR2 |
PhosphoSitePlusi | Q96LR2 |
Genetic variation databases
BioMutai | LURAP1 |
DMDMi | 74752014 |
Proteomic databases
EPDi | Q96LR2 |
MassIVEi | Q96LR2 |
PaxDbi | Q96LR2 |
PeptideAtlasi | Q96LR2 |
PRIDEi | Q96LR2 |
ProteomicsDBi | 77237 |
Protocols and materials databases
Antibodypediai | 32773, 64 antibodies from 14 providers |
DNASUi | 541468 |
Genome annotation databases
Ensembli | ENST00000371980; ENSP00000361048; ENSG00000171357 |
GeneIDi | 541468 |
KEGGi | hsa:541468 |
MANE-Selecti | ENST00000371980.4; ENSP00000361048.3; NM_001013615.3; NP_001013633.1 |
UCSCi | uc010oma.3, human |
Organism-specific databases
CTDi | 541468 |
DisGeNETi | 541468 |
GeneCardsi | LURAP1 |
HGNCi | HGNC:32327, LURAP1 |
HPAi | ENSG00000171357, Low tissue specificity |
MIMi | 616129, gene |
neXtProti | NX_Q96LR2 |
OpenTargetsi | ENSG00000171357 |
PharmGKBi | PA142672401 |
VEuPathDBi | HostDB:ENSG00000171357 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQFH, Eukaryota |
GeneTreei | ENSGT00530000063790 |
HOGENOMi | CLU_066656_1_0_1 |
InParanoidi | Q96LR2 |
OMAi | MEGTAES |
OrthoDBi | 1385244at2759 |
PhylomeDBi | Q96LR2 |
TreeFami | TF332089 |
Enzyme and pathway databases
PathwayCommonsi | Q96LR2 |
SignaLinki | Q96LR2 |
Miscellaneous databases
BioGRID-ORCSi | 541468, 29 hits in 1032 CRISPR screens |
GenomeRNAii | 541468 |
Pharosi | Q96LR2, Tdark |
PROi | PR:Q96LR2 |
RNActi | Q96LR2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171357, Expressed in heart left ventricle and 134 other tissues |
Genevisiblei | Q96LR2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039499, LURA1/LRA25 IPR037443, LURAP1 |
PANTHERi | PTHR33767, PTHR33767, 1 hit |
Pfami | View protein in Pfam PF14854, LURAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LURA1_HUMAN | |
Accessioni | Q96LR2Primary (citable) accession number: Q96LR2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot