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Entry version 117 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Protein phosphatase 1 regulatory subunit 36

Gene

PPP1R36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein phosphatase inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96LQ0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R36
Synonyms:C14orf50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20097, PPP1R36

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96LQ0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000165807.7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
145376

Open Targets

More...
OpenTargetsi
ENSG00000165807

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134955014

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96LQ0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R36

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898931 – 422Protein phosphatase 1 regulatory subunit 36Add BLAST422

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96LQ0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96LQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96LQ0

PeptideAtlas

More...
PeptideAtlasi
Q96LQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q96LQ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77235

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96LQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96LQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165807, Expressed in sperm and 167 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96LQ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96LQ0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165807, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPP1CA.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126908, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q96LQ0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298705

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96LQ0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RH2T, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012412

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_053706_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96LQ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRRKHED

Database of Orthologous Groups

More...
OrthoDBi
1188799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96LQ0

TreeFam database of animal gene trees

More...
TreeFami
TF329463

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026142, Pro_pase_1_reg_su_36

The PANTHER Classification System

More...
PANTHERi
PTHR21055, PTHR21055, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14895, PPPI_inhib, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96LQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYRVPEFYAR RKRLGGQTPY LMDQLGLRLG MWYWKDETRT LEFRRFAAED
60 70 80 90 100
SVQWLLKHHP HFTPAAEVKE KGKKGKAVHF AETDGPASDR LTDKRLAAKD
110 120 130 140 150
DKSAKAVEKR GQQGTITLDD VKFVTLLLLQ DTEMQRICSF TTFMRNKNLD
160 170 180 190 200
NFLMALLYYL SHYLEKNSLE KKPKSYMVGL VEKKEMELVL SELEAAQRYL
210 220 230 240 250
AQKYCILVLG LAVPDKHHMC CGKEKISDTQ KDWKFFESFY TFCTYVAWIV
260 270 280 290 300
FRRQHLTEIE EEVGRLFRTN MFNIPRRRRE DEESGGEKKR MTFVQFRRMM
310 320 330 340 350
AKRPAIKKAI NMRSPVMSTL LPSLREKAQN VFEKKYHQVD VRFPAEMQKH
360 370 380 390 400
VGTLDSVPMP VVGILGEPRC LFNPHTLHPL DPEENTKSFG RYPSLMENNN
410 420
MRIQDTLDLV MKTLSSHTSC PK
Length:422
Mass (Da):49,440
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82DF1D7AB2BC8C44
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5S6G3V5S6_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R36
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4N3G3V4N3_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R36
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLB5E9PLB5_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R36
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02299983T → I1 PublicationCorresponds to variant dbSNP:rs6573560Ensembl.1
Natural variantiVAR_061612267F → L. Corresponds to variant dbSNP:rs45482504Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK058044 mRNA Translation: BAB71637.1
BC068989 mRNA Translation: AAH68989.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9767.1

NCBI Reference Sequences

More...
RefSeqi
NP_758953.1, NM_172365.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298705; ENSP00000298705; ENSG00000165807

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
145376

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:145376

UCSC genome browser

More...
UCSCi
uc001xhl.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058044 mRNA Translation: BAB71637.1
BC068989 mRNA Translation: AAH68989.1
CCDSiCCDS9767.1
RefSeqiNP_758953.1, NM_172365.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126908, 3 interactors
IntActiQ96LQ0, 2 interactors
STRINGi9606.ENSP00000298705

PTM databases

iPTMnetiQ96LQ0
PhosphoSitePlusiQ96LQ0

Genetic variation databases

BioMutaiPPP1R36
DMDMi71153015

Proteomic databases

jPOSTiQ96LQ0
MassIVEiQ96LQ0
PaxDbiQ96LQ0
PeptideAtlasiQ96LQ0
PRIDEiQ96LQ0
ProteomicsDBi77235

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51345, 92 antibodies

The DNASU plasmid repository

More...
DNASUi
145376

Genome annotation databases

EnsembliENST00000298705; ENSP00000298705; ENSG00000165807
GeneIDi145376
KEGGihsa:145376
UCSCiuc001xhl.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
145376
DisGeNETi145376

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP1R36
HGNCiHGNC:20097, PPP1R36
HPAiENSG00000165807, Tissue enriched (testis)
neXtProtiNX_Q96LQ0
OpenTargetsiENSG00000165807
PharmGKBiPA134955014
VEuPathDBiHostDB:ENSG00000165807.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RH2T, Eukaryota
GeneTreeiENSGT00390000012412
HOGENOMiCLU_053706_0_0_1
InParanoidiQ96LQ0
OMAiPRRKHED
OrthoDBi1188799at2759
PhylomeDBiQ96LQ0
TreeFamiTF329463

Enzyme and pathway databases

PathwayCommonsiQ96LQ0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
145376, 6 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP1R36, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
145376
PharosiQ96LQ0, Tdark

Protein Ontology

More...
PROi
PR:Q96LQ0
RNActiQ96LQ0, protein

Gene expression databases

BgeeiENSG00000165807, Expressed in sperm and 167 other tissues
ExpressionAtlasiQ96LQ0, baseline and differential
GenevisibleiQ96LQ0, HS

Family and domain databases

InterProiView protein in InterPro
IPR026142, Pro_pase_1_reg_su_36
PANTHERiPTHR21055, PTHR21055, 1 hit
PfamiView protein in Pfam
PF14895, PPPI_inhib, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPR36_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LQ0
Secondary accession number(s): Q6NTH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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