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Protein

Uncharacterized protein C12orf42

Gene

C12orf42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf42
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000179088.14
HGNCiHGNC:24729 C12orf42
neXtProtiNX_Q96LP6

Pathology & Biotechi

Organism-specific databases

DisGeNETi374470
OpenTargetsiENSG00000179088
PharmGKBiPA143485372

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742741 – 360Uncharacterized protein C12orf42Add BLAST360

Proteomic databases

PaxDbiQ96LP6
PeptideAtlasiQ96LP6
PRIDEiQ96LP6
ProteomicsDBi77232
77233 [Q96LP6-2]
77234 [Q96LP6-3]

PTM databases

iPTMnetiQ96LP6
PhosphoSitePlusiQ96LP6

Expressioni

Gene expression databases

BgeeiENSG00000179088 Expressed in 74 organ(s), highest expression level in testis
CleanExiHS_C12orf42
ExpressionAtlasiQ96LP6 baseline and differential
GenevisibleiQ96LP6 HS

Structurei

3D structure databases

ProteinModelPortaliQ96LP6
SMRiQ96LP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J392 Eukaryota
ENOG4111C2M LUCA
GeneTreeiENSGT00390000015477
HOGENOMiHOG000169664
HOVERGENiHBG081237
InParanoidiQ96LP6
OMAiQYIVPRS
OrthoDBiEOG091G0FXU
PhylomeDBiQ96LP6
TreeFamiTF338230

Family and domain databases

InterProiView protein in InterPro
IPR029288 DUF4607
PANTHERiPTHR40708 PTHR40708, 1 hit
PfamiView protein in Pfam
PF15380 DUF4607, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96LP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTVICMKQR EEEFLLTIRP FANRMQKSPC YIPIVSSATL WDRSTPSAKH
60 70 80 90 100
IPCYERTSVP CSRFINHMKN FSESPKFRSL HFLNFPVFPE RTQNSMACKR
110 120 130 140 150
LLHTCQYIVP RCSVSTVSFD EESYEEFRSS PAPSSETDEA PLIFTARGET
160 170 180 190 200
EERARGAPKQ AWNSSFLEQL VKKPNWAHSV NPVHLEAQGI HISRHTRPKG
210 220 230 240 250
QPLSSPKKNS GSAARPSTAI GLCRRSQTPG ALQSTGPSNT ELEPEERMAV
260 270 280 290 300
PAGAQAHPDD IQSRLLGASG NPVGKGAVAM APEMLPKHPH TPRDRRPQAD
310 320 330 340 350
TSLHGNLAGA PLPLLAGAST HFPSKRLIKV CSSAPPRPTR RFHTVCSQAL
360
SRPVVNAHLH
Length:360
Mass (Da):39,738
Last modified:May 18, 2010 - v2
Checksum:i1935263A48633526
GO
Isoform 2 (identifier: Q96LP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Note: No experimental confirmation available.
Show »
Length:265
Mass (Da):28,584
Checksum:iD5B354AAD1F5D448
GO
Isoform 3 (identifier: Q96LP6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-107: VFPERTQNSMACKRLLHTCQY → GSHHGQATQKLQGAMVLHLEE
     108-360: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:107
Mass (Da):12,366
Checksum:i544BEC0EA49969F5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VV63F8VV63_HUMAN
Uncharacterized protein C12orf42
C12orf42
293Annotation score:
F8W1Y6F8W1Y6_HUMAN
Uncharacterized protein C12orf42
C12orf42
207Annotation score:
F8VX61F8VX61_HUMAN
Uncharacterized protein C12orf42
C12orf42
90Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38A → D in BC039352 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03022911E → D2 PublicationsCorresponds to variant dbSNP:rs10778257Ensembl.1
Natural variantiVAR_030230182P → R. Corresponds to variant dbSNP:rs7484376Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226911 – 95Missing in isoform 2. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_02269287 – 107VFPER…HTCQY → GSHHGQATQKLQGAMVLHLE E in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_022693108 – 360Missing in isoform 3. 1 PublicationAdd BLAST253

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058052 mRNA Translation: BAB71641.1
AC084364 Genomic DNA No translation available.
AC090000 Genomic DNA No translation available.
AC126176 Genomic DNA No translation available.
BC039352 mRNA No translation available.
BC044617 mRNA Translation: AAH44617.1
BC117392 mRNA Translation: AAI17393.1
BC117394 mRNA Translation: AAI17395.1
CCDSiCCDS44963.1 [Q96LP6-1]
RefSeqiNP_001092806.1, NM_001099336.2 [Q96LP6-1]
NP_001265348.1, NM_001278419.1 [Q96LP6-2]
NP_001265349.1, NM_001278420.1 [Q96LP6-2]
NP_940923.2, NM_198521.3 [Q96LP6-1]
XP_011536594.1, XM_011538292.2 [Q96LP6-1]
XP_011536595.1, XM_011538293.2 [Q96LP6-1]
XP_016874765.1, XM_017019276.1 [Q96LP6-1]
UniGeneiHs.534649

Genome annotation databases

EnsembliENST00000378113; ENSP00000367353; ENSG00000179088 [Q96LP6-1]
ENST00000547347; ENSP00000446908; ENSG00000179088 [Q96LP6-3]
ENST00000548883; ENSP00000447908; ENSG00000179088 [Q96LP6-1]
GeneIDi374470
KEGGihsa:374470
UCSCiuc001tjt.4 human [Q96LP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058052 mRNA Translation: BAB71641.1
AC084364 Genomic DNA No translation available.
AC090000 Genomic DNA No translation available.
AC126176 Genomic DNA No translation available.
BC039352 mRNA No translation available.
BC044617 mRNA Translation: AAH44617.1
BC117392 mRNA Translation: AAI17393.1
BC117394 mRNA Translation: AAI17395.1
CCDSiCCDS44963.1 [Q96LP6-1]
RefSeqiNP_001092806.1, NM_001099336.2 [Q96LP6-1]
NP_001265348.1, NM_001278419.1 [Q96LP6-2]
NP_001265349.1, NM_001278420.1 [Q96LP6-2]
NP_940923.2, NM_198521.3 [Q96LP6-1]
XP_011536594.1, XM_011538292.2 [Q96LP6-1]
XP_011536595.1, XM_011538293.2 [Q96LP6-1]
XP_016874765.1, XM_017019276.1 [Q96LP6-1]
UniGeneiHs.534649

3D structure databases

ProteinModelPortaliQ96LP6
SMRiQ96LP6
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ96LP6
PhosphoSitePlusiQ96LP6

Proteomic databases

PaxDbiQ96LP6
PeptideAtlasiQ96LP6
PRIDEiQ96LP6
ProteomicsDBi77232
77233 [Q96LP6-2]
77234 [Q96LP6-3]

Protocols and materials databases

DNASUi374470
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378113; ENSP00000367353; ENSG00000179088 [Q96LP6-1]
ENST00000547347; ENSP00000446908; ENSG00000179088 [Q96LP6-3]
ENST00000548883; ENSP00000447908; ENSG00000179088 [Q96LP6-1]
GeneIDi374470
KEGGihsa:374470
UCSCiuc001tjt.4 human [Q96LP6-1]

Organism-specific databases

CTDi374470
DisGeNETi374470
EuPathDBiHostDB:ENSG00000179088.14
GeneCardsiC12orf42
HGNCiHGNC:24729 C12orf42
neXtProtiNX_Q96LP6
OpenTargetsiENSG00000179088
PharmGKBiPA143485372
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J392 Eukaryota
ENOG4111C2M LUCA
GeneTreeiENSGT00390000015477
HOGENOMiHOG000169664
HOVERGENiHBG081237
InParanoidiQ96LP6
OMAiQYIVPRS
OrthoDBiEOG091G0FXU
PhylomeDBiQ96LP6
TreeFamiTF338230

Miscellaneous databases

ChiTaRSiC12orf42 human
GenomeRNAii374470
PROiPR:Q96LP6

Gene expression databases

BgeeiENSG00000179088 Expressed in 74 organ(s), highest expression level in testis
CleanExiHS_C12orf42
ExpressionAtlasiQ96LP6 baseline and differential
GenevisibleiQ96LP6 HS

Family and domain databases

InterProiView protein in InterPro
IPR029288 DUF4607
PANTHERiPTHR40708 PTHR40708, 1 hit
PfamiView protein in Pfam
PF15380 DUF4607, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCL042_HUMAN
AccessioniPrimary (citable) accession number: Q96LP6
Secondary accession number(s): Q49A64, Q4G0S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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