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Entry version 127 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Testis-expressed sequence 37 protein

Gene

TEX37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis-expressed sequence 37 protein
Alternative name(s):
Testis-specific conserved protein of 21 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEX37
Synonyms:C2orf51, TSC21
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000172073.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26341 TEX37

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96LM6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000172073

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379191

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96LM6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TEX37

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003049891 – 180Testis-expressed sequence 37 proteinAdd BLAST180

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96LM6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96LM6

PeptideAtlas

More...
PeptideAtlasi
Q96LM6

PRoteomics IDEntifications database

More...
PRIDEi
Q96LM6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77226

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96LM6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96LM6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific (PubMed:17091336, PubMed:26168773). Detected in the germ cell lineage at all stages (PubMed:26168773).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172073 Expressed in right testis and 23 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96LM6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96LM6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000172073 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q96LM6
With#Exp.IntAct
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-743976,EBI-12224467
ATXN1L [P0C7T5]3EBI-743976,EBI-8624731
BSCL2 [J3KQ12]3EBI-743976,EBI-11532900
CAMK2A [Q9UQM7]3EBI-743976,EBI-1383687
CTRC [Q99895]3EBI-743976,EBI-10295404
CYSRT1 [A8MQ03]3EBI-743976,EBI-3867333
DAZAP2 [Q15038]9EBI-743976,EBI-724310
FOXD2 [O60548]3EBI-743976,EBI-17282008
HOXC9 [P31274]3EBI-743976,EBI-1779423
KCTD9 [Q7L273]3EBI-743976,EBI-4397613
KLHDC7B [Q96G42]3EBI-743976,EBI-9478422
KPNA3 [O00505]3EBI-743976,EBI-358297
KRTAP12-2 [P59991]3EBI-743976,EBI-10176379
KRTAP12-4 [P60329]3EBI-743976,EBI-10176396
KRTAP13-2 [Q52LG2]3EBI-743976,EBI-11953846
KRTAP19-5 [Q3LI72]3EBI-743976,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-743976,EBI-10241353
KRTAP23-1 [A1A580]3EBI-743976,EBI-10171734
KRTAP26-1 [Q6PEX3]3EBI-743976,EBI-3957672
KRTAP3-1 [Q9BYR8]3EBI-743976,EBI-9996449
KRTAP6-2 [Q3LI66]4EBI-743976,EBI-11962084
OTX1 [P32242]3EBI-743976,EBI-740446
PITX2 - isoform PTX2C [Q99697-2]3EBI-743976,EBI-12138495
PRR30 [Q53SZ7]3EBI-743976,EBI-12360827
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-743976,EBI-12123390
RBFOX2 - isoform 10 [O43251-10]3EBI-743976,EBI-11963050
RBPMS [Q93062]4EBI-743976,EBI-740322
RBPMS - isoform C [Q93062-3]3EBI-743976,EBI-740343
RBPMS2 [Q6ZRY4]3EBI-743976,EBI-11987469
RNF44 [Q7L0R7]3EBI-743976,EBI-2845060
SOX14 [O95416]3EBI-743976,EBI-9087806
TFAP2D [Q7Z6R9]3EBI-743976,EBI-11952651
TFG [Q92734]3EBI-743976,EBI-357061
TLE5 - isoform 2 [Q08117-2]3EBI-743976,EBI-11741437
TLX3 [O43711]3EBI-743976,EBI-3939165
TRIP13 [Q15645]7EBI-743976,EBI-358993
UBAP2 [Q5T6F2]3EBI-743976,EBI-2514383
VAC14 [Q08AM6]3EBI-743976,EBI-2107455
VGLL3 - isoform 2 [A8MV65-2]3EBI-743976,EBI-11957216
WWOX - isoform 5 [Q9NZC7-5]3EBI-743976,EBI-12040603
ZBTB32 [A0A0C4DGF1]3EBI-743976,EBI-10188476
ZC3H10 [Q96K80]3EBI-743976,EBI-742550
Q96EJ43EBI-743976,EBI-750454

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128332, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q96LM6, 43 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307142

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96LM6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J9TU Eukaryota
ENOG411193C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012177

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_132395_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96LM6

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSYMVDY

Database of Orthologous Groups

More...
OrthoDBi
1271554at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96LM6

TreeFam database of animal gene trees

More...
TreeFami
TF337872

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029361 TEX37

The PANTHER Classification System

More...
PANTHERi
PTHR36882 PTHR36882, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15217 TSC21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96LM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGVKYPGQD PVDLDIYQSS HMVDYQPYRK HKYSRVTPQE QAKLDAQLRD
60 70 80 90 100
KEFYRPIPNP NPKLTDGYPA FKRPHMTAKD LGLPGFFPSQ EHEATREDER
110 120 130 140 150
KFTSTCHFTY PASHDLHLAQ GDPNQVLQSA DFPCLVDPKH QPAAEMAKGY
160 170 180
LLLPGCPCLH CHIVKVPILN RWGPLMPFYQ
Length:180
Mass (Da):20,615
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB9BC8BFE2850E92
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03514224D → N. Corresponds to variant dbSNP:rs35750657Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK058098 mRNA Translation: BAB71663.1
AC104134 Genomic DNA Translation: AAY24330.1
CH471215 Genomic DNA Translation: EAW77070.1
BC029522 mRNA Translation: AAH29522.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2003.1

NCBI Reference Sequences

More...
RefSeqi
NP_689883.1, NM_152670.2
XP_005264245.3, XM_005264188.3
XP_011530993.1, XM_011532691.1
XP_011530994.1, XM_011532692.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303254; ENSP00000307142; ENSG00000172073

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
200523

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:200523

UCSC genome browser

More...
UCSCi
uc002stb.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058098 mRNA Translation: BAB71663.1
AC104134 Genomic DNA Translation: AAY24330.1
CH471215 Genomic DNA Translation: EAW77070.1
BC029522 mRNA Translation: AAH29522.1
CCDSiCCDS2003.1
RefSeqiNP_689883.1, NM_152670.2
XP_005264245.3, XM_005264188.3
XP_011530993.1, XM_011532691.1
XP_011530994.1, XM_011532692.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi128332, 10 interactors
IntActiQ96LM6, 43 interactors
STRINGi9606.ENSP00000307142

PTM databases

iPTMnetiQ96LM6
PhosphoSitePlusiQ96LM6

Polymorphism and mutation databases

BioMutaiTEX37

Proteomic databases

MassIVEiQ96LM6
PaxDbiQ96LM6
PeptideAtlasiQ96LM6
PRIDEiQ96LM6
ProteomicsDBi77226

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51969 76 antibodies

The DNASU plasmid repository

More...
DNASUi
200523

Genome annotation databases

EnsembliENST00000303254; ENSP00000307142; ENSG00000172073
GeneIDi200523
KEGGihsa:200523
UCSCiuc002stb.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
200523
EuPathDBiHostDB:ENSG00000172073.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TEX37
HGNCiHGNC:26341 TEX37
HPAiENSG00000172073 Tissue enriched (testis)
neXtProtiNX_Q96LM6
OpenTargetsiENSG00000172073
PharmGKBiPA162379191

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J9TU Eukaryota
ENOG411193C LUCA
GeneTreeiENSGT00390000012177
HOGENOMiCLU_132395_0_0_1
InParanoidiQ96LM6
OMAiSSYMVDY
OrthoDBi1271554at2759
PhylomeDBiQ96LM6
TreeFamiTF337872

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
200523 1 hit in 784 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TEX37 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
200523
PharosiQ96LM6 Tdark

Protein Ontology

More...
PROi
PR:Q96LM6
RNActiQ96LM6 protein

Gene expression databases

BgeeiENSG00000172073 Expressed in right testis and 23 other tissues
ExpressionAtlasiQ96LM6 baseline and differential
GenevisibleiQ96LM6 HS

Family and domain databases

InterProiView protein in InterPro
IPR029361 TEX37
PANTHERiPTHR36882 PTHR36882, 1 hit
PfamiView protein in Pfam
PF15217 TSC21, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEX37_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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