UniProtKB - Q96LL3 (FIMP_HUMAN)
Protein
Fertilization-influencing membrane protein
Gene
FIMP
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in sperm-oocyte fusion during fertilization.By similarity
GO - Biological processi
- fertilization Source: UniProtKB
- fusion of sperm to egg plasma membrane involved in single fertilization Source: UniProtKB
Keywordsi
Biological process | Fertilization |
Enzyme and pathway databases
PathwayCommonsi | Q96LL3 |
Names & Taxonomyi
Protein namesi | Recommended name: Fertilization-influencing membrane protein1 Publication |
Gene namesi | Name:FIMP1 Publication Synonyms:C16orf92Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167194.7 |
HGNCi | HGNC:26346, C16orf92 |
MIMi | 618911, gene |
neXtProti | NX_Q96LL3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 146378 |
PharmGKBi | PA164716866 |
Miscellaneous databases
Pharosi | Q96LL3, Tdark |
Polymorphism and mutation databases
BioMutai | C16orf92 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000321511 | 1 – 132 | Fertilization-influencing membrane proteinAdd BLAST | 132 |
Proteomic databases
PaxDbi | Q96LL3 |
PeptideAtlasi | Q96LL3 |
PRIDEi | Q96LL3 |
ProteomicsDBi | 77220 [Q96LL3-1] 77221 [Q96LL3-2] |
PTM databases
iPTMneti | Q96LL3 |
PhosphoSitePlusi | Q96LL3 |
Expressioni
Tissue specificityi
Testis-specific.1 Publication
Gene expression databases
Bgeei | ENSG00000167194, Expressed in left testis and 105 other tissues |
ExpressionAtlasi | Q96LL3, baseline and differential |
Genevisiblei | Q96LL3, HS |
Organism-specific databases
HPAi | ENSG00000167194, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ96LL3
Protein-protein interaction databases
BioGRIDi | 126982, 17 interactors |
IntActi | Q96LL3, 10 interactors |
STRINGi | 9606.ENSP00000300575 |
Miscellaneous databases
RNActi | Q96LL3, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RVJG, Eukaryota |
GeneTreei | ENSGT00390000002780 |
HOGENOMi | CLU_163070_0_0_1 |
InParanoidi | Q96LL3 |
OMAi | NSEFFHH |
OrthoDBi | 1443078at2759 |
PhylomeDBi | Q96LL3 |
TreeFami | TF338342 |
Family and domain databases
InterProi | View protein in InterPro IPR038813, C16orf92 |
PANTHERi | PTHR38648, PTHR38648, 1 hit |
Pfami | View protein in Pfam PF17672, DUF5589, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96LL3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAGVGVAGC TRGHRNWVPS QLPPREIKAG VSLAVVTEFA WVLAPRPKRA
60 70 80 90 100
TASALGTESP RFLDRPDFFD YPDSDQARLL AVAQFIGEKP IVFINSGSSP
110 120 130
GLFHHILVGL LVVAFFFLLF QFCTHINFQK GA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BMV0 | H3BMV0_HUMAN | Chromosome 16 open reading frame 92 | C16orf92 | 114 | Annotation score: | ||
H3BVC3 | H3BVC3_HUMAN | Chromosome 16 open reading frame 92 | C16orf92 | 49 | Annotation score: | ||
H3BSP6 | H3BSP6_HUMAN | Chromosome 16 open reading frame 92 | C16orf92 | 39 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031783 | 1 – 43 | MGAGV…FAWVL → MRLWPWVLVWVWLAALGAIE T in isoform 2. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK058133 mRNA Translation: BAB71678.1 CH471238 Genomic DNA Translation: EAW79941.1 BC101433 mRNA Translation: AAI01434.1 BC101434 mRNA Translation: AAI01435.1 BC101435 mRNA Translation: AAI01436.1 BC101436 mRNA Translation: AAI01437.1 BC127955 mRNA Translation: AAI27956.1 |
CCDSi | CCDS42146.1 [Q96LL3-1] |
RefSeqi | NP_001103129.1, NM_001109659.1 [Q96LL3-2] NP_001103130.1, NM_001109660.1 [Q96LL3-1] |
Genome annotation databases
Ensembli | ENST00000300575; ENSP00000300575; ENSG00000167194 [Q96LL3-1] |
GeneIDi | 146378 |
KEGGi | hsa:146378 |
UCSCi | uc002dvs.2, human [Q96LL3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK058133 mRNA Translation: BAB71678.1 CH471238 Genomic DNA Translation: EAW79941.1 BC101433 mRNA Translation: AAI01434.1 BC101434 mRNA Translation: AAI01435.1 BC101435 mRNA Translation: AAI01436.1 BC101436 mRNA Translation: AAI01437.1 BC127955 mRNA Translation: AAI27956.1 |
CCDSi | CCDS42146.1 [Q96LL3-1] |
RefSeqi | NP_001103129.1, NM_001109659.1 [Q96LL3-2] NP_001103130.1, NM_001109660.1 [Q96LL3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126982, 17 interactors |
IntActi | Q96LL3, 10 interactors |
STRINGi | 9606.ENSP00000300575 |
PTM databases
iPTMneti | Q96LL3 |
PhosphoSitePlusi | Q96LL3 |
Polymorphism and mutation databases
BioMutai | C16orf92 |
Proteomic databases
PaxDbi | Q96LL3 |
PeptideAtlasi | Q96LL3 |
PRIDEi | Q96LL3 |
ProteomicsDBi | 77220 [Q96LL3-1] 77221 [Q96LL3-2] |
Genome annotation databases
Ensembli | ENST00000300575; ENSP00000300575; ENSG00000167194 [Q96LL3-1] |
GeneIDi | 146378 |
KEGGi | hsa:146378 |
UCSCi | uc002dvs.2, human [Q96LL3-1] |
Organism-specific databases
CTDi | 146378 |
DisGeNETi | 146378 |
EuPathDBi | HostDB:ENSG00000167194.7 |
GeneCardsi | C16orf92 |
HGNCi | HGNC:26346, C16orf92 |
HPAi | ENSG00000167194, Tissue enriched (testis) |
MIMi | 618911, gene |
neXtProti | NX_Q96LL3 |
PharmGKBi | PA164716866 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RVJG, Eukaryota |
GeneTreei | ENSGT00390000002780 |
HOGENOMi | CLU_163070_0_0_1 |
InParanoidi | Q96LL3 |
OMAi | NSEFFHH |
OrthoDBi | 1443078at2759 |
PhylomeDBi | Q96LL3 |
TreeFami | TF338342 |
Enzyme and pathway databases
PathwayCommonsi | Q96LL3 |
Miscellaneous databases
BioGRID-ORCSi | 146378, 12 hits in 841 CRISPR screens |
GenomeRNAii | 146378 |
Pharosi | Q96LL3, Tdark |
PROi | PR:Q96LL3 |
RNActi | Q96LL3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167194, Expressed in left testis and 105 other tissues |
ExpressionAtlasi | Q96LL3, baseline and differential |
Genevisiblei | Q96LL3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038813, C16orf92 |
PANTHERi | PTHR38648, PTHR38648, 1 hit |
Pfami | View protein in Pfam PF17672, DUF5589, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIMP_HUMAN | |
Accessioni | Q96LL3Primary (citable) accession number: Q96LL3 Secondary accession number(s): Q494R8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM