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Protein

Spermatogenesis-associated protein 32

Gene

SPATA32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 32
Alternative name(s):
Testis-expressed protein 34
Gene namesi
Name:SPATA32
Synonyms:C17orf46, TEX34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000184361.12
HGNCiHGNC:26349 SPATA32
neXtProtiNX_Q96LK8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184361
PharmGKBiPA142672229

Polymorphism and mutation databases

BioMutaiSPATA32
DMDMi296439385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829061 – 384Spermatogenesis-associated protein 32Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96LK8
PeptideAtlasiQ96LK8
PRIDEiQ96LK8
ProteomicsDBi77218

PTM databases

iPTMnetiQ96LK8
PhosphoSitePlusiQ96LK8

Expressioni

Tissue specificityi

Detected in testis, and on the acrosomal cap of spermatids.

Gene expression databases

BgeeiENSG00000184361 Expressed in 115 organ(s), highest expression level in caecum
CleanExiHS_C17orf46
ExpressionAtlasiQ96LK8 baseline and differential
GenevisibleiQ96LK8 HS

Organism-specific databases

HPAiHPA024549

Interactioni

Subunit structurei

Interacts with syntaxin-1 and ACTB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ96LK8, 2 interactors
STRINGi9606.ENSP00000331532

Structurei

3D structure databases

ProteinModelPortaliQ96LK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410JBQ4 Eukaryota
ENOG41119M8 LUCA
GeneTreeiENSGT00390000006879
HOGENOMiHOG000140856
HOVERGENiHBG060335
InParanoidiQ96LK8
OMAiTSKHLFW
OrthoDBiEOG091G0NZF
PhylomeDBiQ96LK8
TreeFamiTF338309

Family and domain databases

InterProiView protein in InterPro
IPR029297 SPATA32
PANTHERiPTHR37338 PTHR37338, 1 hit
PfamiView protein in Pfam
PF15310 VAD1-2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q96LK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVTGAHGFP CCGKGSVEVA EMRDDLSQHQ IQEEQELEAD MLEQKPQLQV
60 70 80 90 100
DLDLDPDPDP DPELEIGQVP ALLESELYPA LKLEAELDTE ANSNEESDFE
110 120 130 140 150
EPMQLVCKIE SVHSNMGLPT PQTFRPWSLN SNCRSFTEEN HVSACHHSIS
160 170 180 190 200
AQTSKHLFWA NKLIQASEHS LQRAINMQLN NGSAGQPIRS PLREAIPTNA
210 220 230 240 250
LCSEEQLQIP DAHSAPPTTS SQAPSPLLSS DLPPPIDLTE LITFASSLAM
260 270 280 290 300
ASSSRMDLPS LEHMMKAPPQ EALEPSTEPL LTTVEEREPE NHAETLPEKP
310 320 330 340 350
REARAPLKSW SQEDKNFAQS YFDFSKPGIK RATIKGQIQL LQPPATSPLL
360 370 380
QGSKEDSVPP GKEKENPLLV KIHFKLSAPT IPEK
Length:384
Mass (Da):42,325
Last modified:May 18, 2010 - v3
Checksum:i129700AB96ABFFD0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQM9K7EQM9_HUMAN
Spermatogenesis-associated protein ...
SPATA32
37Annotation score:
K7EPE1K7EPE1_HUMAN
Spermatogenesis-associated protein ...
SPATA32
40Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112V → A in BAB71683 (PubMed:14702039).Curated1
Sequence conflicti198 – 199TN → SK in AAP97314 (Ref. 2) Curated2
Sequence conflicti218 – 219TT → SK in AAP97314 (Ref. 2) Curated2
Sequence conflicti223A → E in AAP97314 (Ref. 2) Curated1
Sequence conflicti234P → A in AAP97314 (Ref. 2) Curated1
Sequence conflicti237D → E in AAP97314 (Ref. 2) Curated1
Sequence conflicti243T → H in AAP97314 (Ref. 2) Curated1
Sequence conflicti251A → D in AAP97314 (Ref. 2) Curated1
Sequence conflicti343P → S in BAB71683 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060279142V → M2 PublicationsCorresponds to variant dbSNP:rs11651968Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058143 mRNA Translation: BAB71683.1
AF433663 mRNA Translation: AAP97314.1
AC008105 Genomic DNA No translation available.
BC028124 mRNA Translation: AAH28124.1
CCDSiCCDS32669.1
RefSeqiNP_689556.2, NM_152343.2
UniGeneiHs.412719

Genome annotation databases

EnsembliENST00000331780; ENSP00000331532; ENSG00000184361
GeneIDi124783
KEGGihsa:124783
UCSCiuc002iis.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPT32_HUMAN
AccessioniPrimary (citable) accession number: Q96LK8
Secondary accession number(s): Q7Z4U1, Q8N6V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 86 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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