UniProtKB - Q96LJ7 (DHRS1_HUMAN)
Protein
Dehydrogenase/reductase SDR family member 1
Gene
DHRS1
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 151 | SubstrateBy similarity | 1 | |
Active sitei | 163 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- oxidoreductase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Enzyme and pathway databases
PathwayCommonsi | Q96LJ7 |
Names & Taxonomyi
Protein namesi | Recommended name: Dehydrogenase/reductase SDR family member 1 (EC:1.1.-.-)Alternative name(s): Short chain dehydrogenase/reductase family 19C member 1 |
Gene namesi | Name:DHRS1 Synonyms:SDR19C1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16445, DHRS1 |
MIMi | 610410, gene |
neXtProti | NX_Q96LJ7 |
VEuPathDBi | HostDB:ENSG00000157379.13 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 115817 |
OpenTargetsi | ENSG00000157379 |
PharmGKBi | PA134914102 |
Miscellaneous databases
Pharosi | Q96LJ7, Tdark |
Genetic variation databases
BioMutai | DHRS1 |
DMDMi | 37999854 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000054640 | 2 – 313 | Dehydrogenase/reductase SDR family member 1Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 21 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Acetylation, MethylationProteomic databases
EPDi | Q96LJ7 |
jPOSTi | Q96LJ7 |
MassIVEi | Q96LJ7 |
MaxQBi | Q96LJ7 |
PaxDbi | Q96LJ7 |
PeptideAtlasi | Q96LJ7 |
PRIDEi | Q96LJ7 |
ProteomicsDBi | 77214 |
PTM databases
iPTMneti | Q96LJ7 |
PhosphoSitePlusi | Q96LJ7 |
SwissPalmi | Q96LJ7 |
Expressioni
Tissue specificityi
Detected in heart and liver, and at low levels in skeletal muscle, kidney and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000157379, Expressed in esophagus squamous epithelium and 236 other tissues |
ExpressionAtlasi | Q96LJ7, baseline and differential |
Genevisiblei | Q96LJ7, HS |
Organism-specific databases
HPAi | ENSG00000157379, Tissue enhanced (liver) |
Interactioni
Binary interactionsi
Hide detailsQ96LJ7
Protein-protein interaction databases
BioGRIDi | 125457, 38 interactors |
IntActi | Q96LJ7, 29 interactors |
MINTi | Q96LJ7 |
STRINGi | 9606.ENSP00000288111 |
Miscellaneous databases
RNActi | Q96LJ7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96LJ7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96LJ7 |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | KOG0725, Eukaryota |
GeneTreei | ENSGT00940000157797 |
HOGENOMi | CLU_010194_14_1_1 |
InParanoidi | Q96LJ7 |
OMAi | PADVTGY |
OrthoDBi | 1513822at2759 |
PhylomeDBi | Q96LJ7 |
TreeFami | TF314146 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH |
SUPFAMi | SSF51735, SSF51735, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96LJ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPMNGQVC VVTGASRGIG RGIALQLCKA GATVYITGRH LDTLRVVAQE
60 70 80 90 100
AQSLGGQCVP VVCDSSQESE VRSLFEQVDR EQQGRLDVLV NNAYAGVQTI
110 120 130 140 150
LNTRNKAFWE TPASMWDDIN NVGLRGHYFC SVYGARLMVP AGQGLIVVIS
160 170 180 190 200
SPGSLQYMFN VPYGVGKAAC DKLAADCAHE LRRHGVSCVS LWPGIVQTEL
210 220 230 240 250
LKEHMAKEEV LQDPVLKQFK SAFSSAETTE LSGKCVVALA TDPNILSLSG
260 270 280 290 300
KVLPSCDLAR RYGLRDVDGR PVQDYLSLSS VLSHVSGLGW LASYLPSFLR
310
VPKWIIALYT SKF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YNC2 | H0YNC2_HUMAN | Dehydrogenase/reductase (SDR family... | DHRS1 hCG_40190 | 147 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | V → A in AAH15943 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 162 | P → L in AAH14057 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 303 | K → R in CAD38773 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052318 | 241 | T → I. Corresponds to variant dbSNP:rs10134537Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF418205 mRNA Translation: AAN32660.1 BX247980 mRNA Translation: CAD62314.1 AK058159 mRNA Translation: BAB71694.1 AL833917 mRNA Translation: CAD38773.1 CH471078 Genomic DNA Translation: EAW66036.1 CH471078 Genomic DNA Translation: EAW66037.1 CH471078 Genomic DNA Translation: EAW66040.1 BC014057 mRNA Translation: AAH14057.1 BC015943 mRNA Translation: AAH15943.1 |
CCDSi | CCDS9623.1 |
RefSeqi | NP_001129522.1, NM_001136050.2 NP_612461.1, NM_138452.2 |
Genome annotation databases
Ensembli | ENST00000288111; ENSP00000288111; ENSG00000157379 ENST00000396813; ENSP00000380027; ENSG00000157379 ENST00000644514; ENSP00000496132; ENSG00000284868 ENST00000647514; ENSP00000493735; ENSG00000284868 |
GeneIDi | 115817 |
KEGGi | hsa:115817 |
UCSCi | uc001woj.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF418205 mRNA Translation: AAN32660.1 BX247980 mRNA Translation: CAD62314.1 AK058159 mRNA Translation: BAB71694.1 AL833917 mRNA Translation: CAD38773.1 CH471078 Genomic DNA Translation: EAW66036.1 CH471078 Genomic DNA Translation: EAW66037.1 CH471078 Genomic DNA Translation: EAW66040.1 BC014057 mRNA Translation: AAH14057.1 BC015943 mRNA Translation: AAH15943.1 |
CCDSi | CCDS9623.1 |
RefSeqi | NP_001129522.1, NM_001136050.2 NP_612461.1, NM_138452.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QQ5 | X-ray | 1.80 | A | 3-262 | [»] | |
SMRi | Q96LJ7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125457, 38 interactors |
IntActi | Q96LJ7, 29 interactors |
MINTi | Q96LJ7 |
STRINGi | 9606.ENSP00000288111 |
PTM databases
iPTMneti | Q96LJ7 |
PhosphoSitePlusi | Q96LJ7 |
SwissPalmi | Q96LJ7 |
Genetic variation databases
BioMutai | DHRS1 |
DMDMi | 37999854 |
Proteomic databases
EPDi | Q96LJ7 |
jPOSTi | Q96LJ7 |
MassIVEi | Q96LJ7 |
MaxQBi | Q96LJ7 |
PaxDbi | Q96LJ7 |
PeptideAtlasi | Q96LJ7 |
PRIDEi | Q96LJ7 |
ProteomicsDBi | 77214 |
Protocols and materials databases
Antibodypediai | 23, 146 antibodies |
DNASUi | 115817 |
Genome annotation databases
Ensembli | ENST00000288111; ENSP00000288111; ENSG00000157379 ENST00000396813; ENSP00000380027; ENSG00000157379 ENST00000644514; ENSP00000496132; ENSG00000284868 ENST00000647514; ENSP00000493735; ENSG00000284868 |
GeneIDi | 115817 |
KEGGi | hsa:115817 |
UCSCi | uc001woj.3, human |
Organism-specific databases
CTDi | 115817 |
DisGeNETi | 115817 |
GeneCardsi | DHRS1 |
HGNCi | HGNC:16445, DHRS1 |
HPAi | ENSG00000157379, Tissue enhanced (liver) |
MIMi | 610410, gene |
neXtProti | NX_Q96LJ7 |
OpenTargetsi | ENSG00000157379 |
PharmGKBi | PA134914102 |
VEuPathDBi | HostDB:ENSG00000157379.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0725, Eukaryota |
GeneTreei | ENSGT00940000157797 |
HOGENOMi | CLU_010194_14_1_1 |
InParanoidi | Q96LJ7 |
OMAi | PADVTGY |
OrthoDBi | 1513822at2759 |
PhylomeDBi | Q96LJ7 |
TreeFami | TF314146 |
Enzyme and pathway databases
PathwayCommonsi | Q96LJ7 |
Miscellaneous databases
BioGRID-ORCSi | 115817, 1 hit in 875 CRISPR screens |
ChiTaRSi | DHRS1, human |
EvolutionaryTracei | Q96LJ7 |
GeneWikii | DHRS1 |
GenomeRNAii | 115817 |
Pharosi | Q96LJ7, Tdark |
PROi | PR:Q96LJ7 |
RNActi | Q96LJ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157379, Expressed in esophagus squamous epithelium and 236 other tissues |
ExpressionAtlasi | Q96LJ7, baseline and differential |
Genevisiblei | Q96LJ7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH |
SUPFAMi | SSF51735, SSF51735, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DHRS1_HUMAN | |
Accessioni | Q96LJ7Primary (citable) accession number: Q96LJ7 Secondary accession number(s): D3DS71 Q96CQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families