UniProtKB - Q96LD9 (Q96LD9_HUMAN)
Protein
Submitted name:
Histamine receptor H4
Gene
H4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- histamine receptor activity Source: InterPro
GO - Biological processi
- inflammatory response Source: InterPro
- positive regulation of cytosolic calcium ion concentration Source: InterPro
- regulation of MAPK cascade Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Histamine receptor H4Imported |
Gene namesi | Name:H4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- cell Source: GOC
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 41 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 152 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 172 – 194 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 305 – 330 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 342 – 361 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 358 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 327 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008102 Histamine_H4_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01726 HISTAMINEH4R |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96LD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADTNSTINL SLSTRVTLAF FMSLVAFAIM LGNALVILAF VVDKNLRHRS
60 70 80 90 100
SYFFLNLAIS DFFVGVISIP LYIPHTLFEW DFGKEICVFW LTTDYLLCTA
110 120 130 140 150
SVYNIVLISY DRYLSVSNAV SYRTQHTGVL KIVTLMVAVW VLAFLVNGPM
160 170 180 190 200
ILVSESWKDE GSECEPGFFS EWYILAITSF LEFVIPVILV AYFNMNIYWS
210 220 230 240 250
LWKRDHLSRC QSHPGLTAVS SNICGHSFRG RLSSRRSLSA STEVPASFHS
260 270 280 290 300
ERQRRKSSLM FSSRTKMNSN TIASKMGSFS QSDSVALHQR EHVELLRARR
310 320 330 340 350
LAKSLAILLG VFAVCWAPYS LFTIVLSFYS SATGPKSVWY RIAFWLQWFN
360 370 380 390
SFVNPLLYPL CHKRFQKAFL KIFCIKKQPL PSQHSRSVSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY008280 mRNA Translation: AAL09297.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY008280 mRNA Translation: AAL09297.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PeptideAtlasi | Q96LD9 |
PRIDEi | Q96LD9 |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008102 Histamine_H4_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01726 HISTAMINEH4R |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q96LD9_HUMAN | |
Accessioni | Q96LD9Primary (citable) accession number: Q96LD9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 8, 2019 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |