H4 - Histamine receptor H4 - Homo sapiens (Human)

Functionⁱ

GO - Molecular functionⁱ

histamine receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inflammatory response Source: InterPro
positive regulation of cytosolic calcium ion concentration Source: InterPro
regulation of MAPK cascade Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptorUniRule annotation, Receptor, Transducer

Molecular function

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Histamine receptor H4Imported
Gene namesⁱ	Name:H4Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	20 – 41	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	53 – 73	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	88 – 108	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	129 – 152	HelicalSequence analysisAdd BLAST	24
Transmembraneⁱ	172 – 194	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	305 – 330	HelicalSequence analysisAdd BLAST	26
Transmembraneⁱ	342 – 361	HelicalSequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	Q96LD9

PRIDEⁱ

Q96LD9

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96LD9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	32 – 358	G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST		327

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOVERGENⁱ	HBG102132

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008102 Histamine_H4_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01726 HISTAMINEH4R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96LD9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADTNSTINL SLSTRVTLAF FMSLVAFAIM LGNALVILAF VVDKNLRHRS 
        60         70         80         90        100
SYFFLNLAIS DFFVGVISIP LYIPHTLFEW DFGKEICVFW LTTDYLLCTA 
       110        120        130        140        150
SVYNIVLISY DRYLSVSNAV SYRTQHTGVL KIVTLMVAVW VLAFLVNGPM 
       160        170        180        190        200
ILVSESWKDE GSECEPGFFS EWYILAITSF LEFVIPVILV AYFNMNIYWS 
       210        220        230        240        250
LWKRDHLSRC QSHPGLTAVS SNICGHSFRG RLSSRRSLSA STEVPASFHS 
       260        270        280        290        300
ERQRRKSSLM FSSRTKMNSN TIASKMGSFS QSDSVALHQR EHVELLRARR 
       310        320        330        340        350
LAKSLAILLG VFAVCWAPYS LFTIVLSFYS SATGPKSVWY RIAFWLQWFN 
       360        370        380        390
SFVNPLLYPL CHKRFQKAFL KIFCIKKQPL PSQHSRSVSS

Length:390

Mass (Da):44,470

Last modified:December 1, 2001 - v1

Checksum:ⁱCC82B5D30D216C66

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY008280 mRNA Translation: AAL09297.1
UniGeneⁱ	Hs.287388

Protein	Similar proteins		Species	Score	Length	Source
Q96LD9	Histamine H4 receptor		HUMAN		390	UniRef90_Q9H3N8
HRH4 isoform 1		PANTR		390
Histamine H4 receptor		MACFA		390
HRH4 isoform 1		PONAB		390
Histamine H4 receptor		MACMU		390
+23

Protein	Similar proteins		Species	Score	Length	Source
Q96LD9	Histamine H4 receptor		HUMAN		390	UniRef50_Q9H3N8
Histamine H4 receptor		MACFA		390
Histamine receptor H4		PANPA		390
HRH4 isoform 1		PANTR		390
HRH4 isoform 1		PONAB		390
+52

Entry informationⁱ

Entry nameⁱ	Q96LD9_HUMAN
Accessionⁱ	Q96LD9Primary (citable) accession number: Q96LD9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 1, 2001
	Last sequence update:	December 1, 2001
	Last modified:	May 23, 2018
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q96LD9 (Q96LD9_HUMAN)

Your basket is currently empty. ⁱ

Histamine receptor H4

H4

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Other locations

Topology

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Entry informationⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96LD9 (Q96LD9_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Histamine receptor H4

H4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Entry informationⁱ