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Protein

Zeta-sarcoglycan

Gene

SGCZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity).By similarity

GO - Biological processi

  • heart contraction Source: GO_Central
  • membrane organization Source: BHF-UCL
  • muscle cell cellular homeostasis Source: BHF-UCL
  • muscle cell development Source: BHF-UCL

Names & Taxonomyi

Protein namesi
Recommended name:
Zeta-sarcoglycan
Short name:
Zeta-SG
Alternative name(s):
ZSG1
Gene namesi
Name:SGCZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000185053.12
HGNCiHGNC:14075 SGCZ
MIMi608113 gene
neXtProtiNX_Q96LD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 299ExtracellularSequence analysisAdd BLAST241

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi137868
OpenTargetsiENSG00000185053
PharmGKBiPA38378

Polymorphism and mutation databases

BioMutaiSGCZ
DMDMi41018110

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001752511 – 299Zeta-sarcoglycanAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi273 ↔ 289Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96LD1
PeptideAtlasiQ96LD1
PRIDEiQ96LD1
ProteomicsDBi77204
77205 [Q96LD1-2]

PTM databases

iPTMnetiQ96LD1
PhosphoSitePlusiQ96LD1

Expressioni

Gene expression databases

BgeeiENSG00000185053 Expressed in 37 organ(s), highest expression level in corpus callosum
CleanExiHS_SGCZ
ExpressionAtlasiQ96LD1 baseline and differential
GenevisibleiQ96LD1 HS

Organism-specific databases

HPAiHPA017585

Interactioni

Protein-protein interaction databases

BioGridi126488, 13 interactors
STRINGi9606.ENSP00000371512

Structurei

3D structure databases

SMRiQ96LD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi252 – 263Poly-SerAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3950 Eukaryota
ENOG4111GCH LUCA
GeneTreeiENSGT00390000017950
HOGENOMiHOG000007853
HOVERGENiHBG008669
InParanoidiQ96LD1
OMAiYILAAQP
OrthoDBiEOG091G11VY
PhylomeDBiQ96LD1
TreeFamiTF313538

Family and domain databases

InterProiView protein in InterPro
IPR006875 Sarcoglycan
IPR039972 Sarcoglycan_gamma/delta/zeta
IPR027662 Sgcz
PANTHERiPTHR12939 PTHR12939, 1 hit
PTHR12939:SF5 PTHR12939:SF5, 1 hit
PfamiView protein in Pfam
PF04790 Sarcoglycan_1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96LD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTREQYILAT QQNNLPRTEN AQLYPVGIYG WRKRCLYFFV LLLLVTMIVN
60 70 80 90 100
LAMTIWILKV MNFTVDGMGN LRVTKKGIRL EGISEFLLPL YVKEIHSRKD
110 120 130 140 150
SPLVLQSDRN VTVNARNHMG QLTGQLTIGA DAVEAQCKRF EVRASEDGRV
160 170 180 190 200
LFSADEDEIT IGAEKLKVTG TEGAVFGHSV ETPHIRAEPS QDLRLESPTR
210 220 230 240 250
SLIMEAPRGV QVSAAAGDFK ATCRKELHLQ STEGEIFLNA ETIKLGNLPT
260 270 280 290
GSFSSSSPSS SSSRQTVYEL CVCPNGKLYL SPAGVGSTCQ SSSNICLWS
Length:299
Mass (Da):32,949
Last modified:December 1, 2001 - v1
Checksum:iBB2C14302AD477C0
GO
Isoform 2 (identifier: Q96LD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDRSTNLDIEELKM

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):34,494
Checksum:i4EFE83C1D7B4E8F1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q08AT0Q08AT0_HUMAN
SGCZ protein
SGCZ
265Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0374101M → MDRSTNLDIEELKM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028700 mRNA Translation: AAK21962.1
AY502063 mRNA Translation: AAR89453.1
BC069459 mRNA Translation: AAH69459.1
CCDSiCCDS5992.2 [Q96LD1-2]
RefSeqiNP_001309808.1, NM_001322879.1
NP_001309809.1, NM_001322880.1
NP_001309810.1, NM_001322881.1
NP_631906.2, NM_139167.3 [Q96LD1-2]
UniGeneiHs.545526
Hs.676196

Genome annotation databases

EnsembliENST00000382080; ENSP00000371512; ENSG00000185053 [Q96LD1-2]
GeneIDi137868
KEGGihsa:137868
UCSCiuc003wwq.4 human [Q96LD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028700 mRNA Translation: AAK21962.1
AY502063 mRNA Translation: AAR89453.1
BC069459 mRNA Translation: AAH69459.1
CCDSiCCDS5992.2 [Q96LD1-2]
RefSeqiNP_001309808.1, NM_001322879.1
NP_001309809.1, NM_001322880.1
NP_001309810.1, NM_001322881.1
NP_631906.2, NM_139167.3 [Q96LD1-2]
UniGeneiHs.545526
Hs.676196

3D structure databases

SMRiQ96LD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126488, 13 interactors
STRINGi9606.ENSP00000371512

PTM databases

iPTMnetiQ96LD1
PhosphoSitePlusiQ96LD1

Polymorphism and mutation databases

BioMutaiSGCZ
DMDMi41018110

Proteomic databases

PaxDbiQ96LD1
PeptideAtlasiQ96LD1
PRIDEiQ96LD1
ProteomicsDBi77204
77205 [Q96LD1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382080; ENSP00000371512; ENSG00000185053 [Q96LD1-2]
GeneIDi137868
KEGGihsa:137868
UCSCiuc003wwq.4 human [Q96LD1-1]

Organism-specific databases

CTDi137868
DisGeNETi137868
EuPathDBiHostDB:ENSG00000185053.12
GeneCardsiSGCZ
HGNCiHGNC:14075 SGCZ
HPAiHPA017585
MIMi608113 gene
neXtProtiNX_Q96LD1
OpenTargetsiENSG00000185053
PharmGKBiPA38378
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3950 Eukaryota
ENOG4111GCH LUCA
GeneTreeiENSGT00390000017950
HOGENOMiHOG000007853
HOVERGENiHBG008669
InParanoidiQ96LD1
OMAiYILAAQP
OrthoDBiEOG091G11VY
PhylomeDBiQ96LD1
TreeFamiTF313538

Miscellaneous databases

ChiTaRSiSGCZ human
GeneWikiiSGCZ
GenomeRNAii137868
PROiPR:Q96LD1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185053 Expressed in 37 organ(s), highest expression level in corpus callosum
CleanExiHS_SGCZ
ExpressionAtlasiQ96LD1 baseline and differential
GenevisibleiQ96LD1 HS

Family and domain databases

InterProiView protein in InterPro
IPR006875 Sarcoglycan
IPR039972 Sarcoglycan_gamma/delta/zeta
IPR027662 Sgcz
PANTHERiPTHR12939 PTHR12939, 1 hit
PTHR12939:SF5 PTHR12939:SF5, 1 hit
PfamiView protein in Pfam
PF04790 Sarcoglycan_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGCZ_HUMAN
AccessioniPrimary (citable) accession number: Q96LD1
Secondary accession number(s): Q6REU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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