UniProtKB - Q96LC9 (BMF_HUMAN)
Protein
Bcl-2-modifying factor
Gene
BMF
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in apoptosis. Isoform 1 seems to be the main initiator.
GO - Biological processi
- anoikis Source: MGI
- cellular response to UV Source: CAFA
- negative regulation of autophagy Source: CAFA
- positive regulation of apoptotic process Source: BHF-UCL
- positive regulation of intrinsic apoptotic signaling pathway Source: Reactome
- positive regulation of protein-containing complex assembly Source: BHF-UCL
- positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
- protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q96LC9 |
Reactomei | R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-139910, Activation of BMF and translocation to mitochondria |
SIGNORi | Q96LC9 |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-modifying factor |
Gene namesi | Name:BMF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104081.13 |
HGNCi | HGNC:24132, BMF |
MIMi | 606266, gene |
neXtProti | NX_Q96LC9 |
Subcellular locationi
Cytoskeleton
- myosin complex Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial outer membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- acrosomal vesicle Source: Ensembl
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 90427 |
OpenTargetsi | ENSG00000104081 |
PharmGKBi | PA134893658 |
Miscellaneous databases
Pharosi | Q96LC9, Tbio |
Polymorphism and mutation databases
BioMutai | BMF |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143111 | 1 – 184 | Bcl-2-modifying factorAdd BLAST | 184 |
Proteomic databases
MassIVEi | Q96LC9 |
PaxDbi | Q96LC9 |
PeptideAtlasi | Q96LC9 |
PRIDEi | Q96LC9 |
ProteomicsDBi | 77201 [Q96LC9-1] 77202 [Q96LC9-2] 77203 [Q96LC9-3] |
PTM databases
iPTMneti | Q96LC9 |
PhosphoSitePlusi | Q96LC9 |
Expressioni
Tissue specificityi
Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells.1 Publication
Gene expression databases
Bgeei | ENSG00000104081, Expressed in monocyte and 153 other tissues |
ExpressionAtlasi | Q96LC9, baseline and differential |
Genevisiblei | Q96LC9, HS |
Organism-specific databases
HPAi | ENSG00000104081, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w.
Interacts with the myosin V actin motor complex through its binding to DLC2 (By similarity).
By similarityBinary interactionsi
Hide detailsQ96LC9
Protein-protein interaction databases
BioGRIDi | 124716, 27 interactors |
IntActi | Q96LC9, 20 interactors |
STRINGi | 9606.ENSP00000346697 |
Miscellaneous databases
RNActi | Q96LC9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 75 | Interaction with DLC2By similarity | 9 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 133 – 147 | BH3Add BLAST | 15 |
Sequence similaritiesi
Belongs to the Bcl-2 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S0P3, Eukaryota |
GeneTreei | ENSGT00390000017896 |
HOGENOMi | CLU_090680_0_0_1 |
InParanoidi | Q96LC9 |
OMAi | TFREIKC |
OrthoDBi | 1454053at2759 |
PhylomeDBi | Q96LC9 |
TreeFami | TF336039 |
Family and domain databases
InterProi | View protein in InterPro IPR028192, BMF |
PANTHERi | PTHR32014, PTHR32014, 1 hit |
Pfami | View protein in Pfam PF15185, BMF, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96LC9-1) [UniParc]FASTAAdd to basket
Also known as: BMF-I
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPSQCVEEL EDDVFQPEDG EPVTQPGSLL SADLFAQSLL DCPLSRLQLF
60 70 80 90 100
PLTHCCGPGL RPTSQEDKAT QTLSPASPSQ GVMLPCGVTE EPQRLFYGNA
110 120 130 140 150
GYRLPLPASF PAVLPIGEQP PEGQWQHQAE VQIARKLQCI ADQFHRLHVQ
160 170 180
QHQQNQNRVW WQILLFLHNL ALNGEENRNG AGPR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YNT3 | H0YNT3_HUMAN | Bcl-2-modifying factor | BMF | 61 | Annotation score: | ||
H0YK50 | H0YK50_HUMAN | Bcl-2-modifying factor | BMF | 13 | Annotation score: |
Sequence cautioni
The sequence AAH60783 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15762 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | R → Q in AAH69328 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 80 | Q → P in AAH69505 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012293 | 98 – 129 | GNAGY…WQHQA → APAEPKSCVVADPPLPAQPC FEWRREQERGRP in isoform 3. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_012294 | 130 – 184 | Missing in isoform 3. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_012292 | 131 – 151 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY029254 mRNA Translation: AAK38748.1 AY222040 mRNA Translation: AAP22965.1 AY222041 mRNA Translation: AAP22966.1 AK024472 mRNA Translation: BAB15762.1 Different initiation. BC060783 mRNA Translation: AAH60783.1 Different initiation. BC069328 mRNA Translation: AAH69328.1 BC069505 mRNA Translation: AAH69505.1 BC070043 mRNA Translation: AAH70043.2 BC104983 mRNA Translation: AAI04984.1 BC104985 mRNA Translation: AAI04986.1 |
CCDSi | CCDS10052.1 [Q96LC9-1] CCDS32196.1 [Q96LC9-3] CCDS45223.1 [Q96LC9-2] |
RefSeqi | NP_001003940.1, NM_001003940.1 [Q96LC9-1] NP_001003942.1, NM_001003942.1 [Q96LC9-2] NP_001003943.1, NM_001003943.2 [Q96LC9-3] NP_277038.1, NM_033503.3 [Q96LC9-1] |
Genome annotation databases
Ensembli | ENST00000354670; ENSP00000346697; ENSG00000104081 [Q96LC9-1] ENST00000397573; ENSP00000380703; ENSG00000104081 [Q96LC9-1] ENST00000431415; ENSP00000396511; ENSG00000104081 [Q96LC9-2] ENST00000558774; ENSP00000453913; ENSG00000104081 [Q96LC9-3] ENST00000559701; ENSP00000453919; ENSG00000104081 [Q96LC9-3] ENST00000561282; ENSP00000453522; ENSG00000104081 [Q96LC9-1] ENST00000561360; ENSP00000453892; ENSG00000104081 [Q96LC9-1] |
GeneIDi | 90427 |
KEGGi | hsa:90427 |
UCSCi | uc001zkt.6, human [Q96LC9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY029254 mRNA Translation: AAK38748.1 AY222040 mRNA Translation: AAP22965.1 AY222041 mRNA Translation: AAP22966.1 AK024472 mRNA Translation: BAB15762.1 Different initiation. BC060783 mRNA Translation: AAH60783.1 Different initiation. BC069328 mRNA Translation: AAH69328.1 BC069505 mRNA Translation: AAH69505.1 BC070043 mRNA Translation: AAH70043.2 BC104983 mRNA Translation: AAI04984.1 BC104985 mRNA Translation: AAI04986.1 |
CCDSi | CCDS10052.1 [Q96LC9-1] CCDS32196.1 [Q96LC9-3] CCDS45223.1 [Q96LC9-2] |
RefSeqi | NP_001003940.1, NM_001003940.1 [Q96LC9-1] NP_001003942.1, NM_001003942.1 [Q96LC9-2] NP_001003943.1, NM_001003943.2 [Q96LC9-3] NP_277038.1, NM_033503.3 [Q96LC9-1] |
3D structure databases
SMRi | Q96LC9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124716, 27 interactors |
IntActi | Q96LC9, 20 interactors |
STRINGi | 9606.ENSP00000346697 |
PTM databases
iPTMneti | Q96LC9 |
PhosphoSitePlusi | Q96LC9 |
Polymorphism and mutation databases
BioMutai | BMF |
Proteomic databases
MassIVEi | Q96LC9 |
PaxDbi | Q96LC9 |
PeptideAtlasi | Q96LC9 |
PRIDEi | Q96LC9 |
ProteomicsDBi | 77201 [Q96LC9-1] 77202 [Q96LC9-2] 77203 [Q96LC9-3] |
Protocols and materials databases
Antibodypediai | 1506, 444 antibodies |
DNASUi | 90427 |
Genome annotation databases
Organism-specific databases
CTDi | 90427 |
DisGeNETi | 90427 |
EuPathDBi | HostDB:ENSG00000104081.13 |
GeneCardsi | BMF |
HGNCi | HGNC:24132, BMF |
HPAi | ENSG00000104081, Tissue enhanced (lymphoid) |
MIMi | 606266, gene |
neXtProti | NX_Q96LC9 |
OpenTargetsi | ENSG00000104081 |
PharmGKBi | PA134893658 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0P3, Eukaryota |
GeneTreei | ENSGT00390000017896 |
HOGENOMi | CLU_090680_0_0_1 |
InParanoidi | Q96LC9 |
OMAi | TFREIKC |
OrthoDBi | 1454053at2759 |
PhylomeDBi | Q96LC9 |
TreeFami | TF336039 |
Enzyme and pathway databases
PathwayCommonsi | Q96LC9 |
Reactomei | R-HSA-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-139910, Activation of BMF and translocation to mitochondria |
SIGNORi | Q96LC9 |
Miscellaneous databases
BioGRID-ORCSi | 90427, 23 hits in 845 CRISPR screens |
GeneWikii | BMF_(gene) |
GenomeRNAii | 90427 |
Pharosi | Q96LC9, Tbio |
PROi | PR:Q96LC9 |
RNActi | Q96LC9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104081, Expressed in monocyte and 153 other tissues |
ExpressionAtlasi | Q96LC9, baseline and differential |
Genevisiblei | Q96LC9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028192, BMF |
PANTHERi | PTHR32014, PTHR32014, 1 hit |
Pfami | View protein in Pfam PF15185, BMF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMF_HUMAN | |
Accessioni | Q96LC9Primary (citable) accession number: Q96LC9 Secondary accession number(s): Q2M396 Q9H7K7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM