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Entry version 188 (02 Jun 2021)
Sequence version 3 (28 Nov 2006)
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Protein

Sialic acid-binding Ig-like lectin 10

Gene

SIGLEC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity).

The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025).

Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity).

In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity).

In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598).

Plays a role in the control of autoimmunity (By similarity).

During initiation of adaptive immune responses by CD8-alpha+ dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).

By similarity1 Publication2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei119Sialic acidBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • phosphatase binding Source: UniProtKB
  • SH2 domain binding Source: UniProtKB
  • sialic acid binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Cell adhesion, Immunity, Innate immunity
LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96LC7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96LC7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 10
Short name:
Siglec-10
Alternative name(s):
Siglec-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIGLEC10
Synonyms:SLG2
ORF Names:UNQ477/PRO940
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15620, SIGLEC10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606091, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96LC7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000142512.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 550ExtracellularSequence analysisAdd BLAST534
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 697CytoplasmicSequence analysisAdd BLAST126

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi119R → A: Disrupts interaction with CD24. 1 Publication1
Mutagenesisi667Y → F: Abolishes binding to PTPN6. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
89790

Open Targets

More...
OpenTargetsi
ENSG00000142512

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38004

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96LC7, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4303061

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIGLEC10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001495017 – 697Sialic acid-binding Ig-like lectin 10Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 173PROSITE-ProRule annotation
Disulfide bondi41 ↔ 101PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 215PROSITE-ProRule annotation
Disulfide bondi276 ↔ 323PROSITE-ProRule annotation
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi380 ↔ 425PROSITE-ProRule annotation
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi504N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei667Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Tyr-667 is involved in binding to PTPN6.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96LC7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96LC7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96LC7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96LC7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96LC7

PeptideAtlas

More...
PeptideAtlasi
Q96LC7

PRoteomics IDEntifications database

More...
PRIDEi
Q96LC7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
10427
10785
30242
77195 [Q96LC7-1]
77196 [Q96LC7-2]
77197 [Q96LC7-3]
77198 [Q96LC7-4]
77199 [Q96LC7-5]
77200 [Q96LC7-6]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q96LC7, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96LC7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96LC7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142512, Expressed in blood and 164 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96LC7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96LC7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000142512, Group enriched (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPN6/SHP-1 upon phosphorylation (PubMed:12163025).

Interacts with NCF1 (By similarity).

Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response.

Interacts with HMGB1; the interaction is dependent on CD24 (PubMed:19264983).

Interacts with DDX58, CBL and PTPN11 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124602, 10 interactors

Protein interaction database and analysis system

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IntActi
Q96LC7, 11 interactors

Molecular INTeraction database

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MINTi
Q96LC7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345243

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96LC7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 121Ig-like V-typeAdd BLAST104
Domaini146 – 231Ig-like C2-type 1Add BLAST86
Domaini251 – 339Ig-like C2-type 2Add BLAST89
Domaini344 – 441Ig-like C2-type 3Add BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni606 – 697DisorderedSequence analysisAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi595 – 600ITIM motif 16
Motifi665 – 670ITIM motif 26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi633 – 666Polar residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S41V, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT01030000234562

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024444_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96LC7

Identification of Orthologs from Complete Genome Data

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OMAi
RYNFMND

Database of Orthologous Groups

More...
OrthoDBi
1124645at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96LC7

TreeFam database of animal gene trees

More...
TreeFami
TF332441

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895, Ig_2, 1 hit
PF07686, V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96LC7-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPLLLSSL LGGSQAMDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW
60 70 80 90 100
TGSTPAYGYW FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN
110 120 130 140 150
CSLVIRDAQM QDESQYFFRV ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI
160 170 180 190 200
PETLEPGQPV TVICVFNWAF EECPPPSFSW TGAALSSQGT KPTTSHFSVL
210 220 230 240 250
SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD LVISISRDNT
260 270 280 290 300
PALEPQPQGN VPYLEAQKGQ FLRLLCAADS QPPATLSWVL QNRVLSSSHP
310 320 330 340 350
WGPRPLGLEL PGVKAGDSGR YTCRAENRLG SQQRALDLSV QYPPENLRVM
360 370 380 390 400
VSQANRTVLE NLGNGTSLPV LEGQSLCLVC VTHSSPPARL SWTQRGQVLS
410 420 430 440 450
PSQPSDPGVL ELPRVQVEHE GEFTCHARHP LGSQHVSLSL SVHYSPKLLG
460 470 480 490 500
PSCSWEAEGL HCSCSSQASP APSLRWWLGE ELLEGNSSQD SFEVTPSSAG
510 520 530 540 550
PWANSSLSLH GGLSSGLRLR CEAWNVHGAQ SGSILQLPDK KGLISTAFSN
560 570 580 590 600
GAFLGIGITA LLFLCLALII MKILPKRRTQ TETPRPRFSR HSTILDYINV
610 620 630 640 650
VPTAGPLAQK RNQKATPNSP RTPLPPGAPS PESKKNQKKQ YQLPSFPEPK
660 670 680 690
SSTQAPESQE SQEELHYATL NFPGVRPRPE ARMPKGTQAD YAEVKFQ
Length:697
Mass (Da):76,592
Last modified:November 28, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1B787F34CF7201A
GO
Isoform 2 (identifier: Q96LC7-2) [UniParc]FASTAAdd to basket
Also known as: Short, Sv1

The sequence of this isoform differs from the canonical sequence as follows:
     445-539: Missing.

Show »
Length:602
Mass (Da):66,618
Checksum:i217A05584B94C5AA
GO
Isoform 3 (identifier: Q96LC7-3) [UniParc]FASTAAdd to basket
Also known as: Sv3

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.

Show »
Length:639
Mass (Da):70,313
Checksum:iCDD93752BDACDD45
GO
Isoform 4 (identifier: Q96LC7-4) [UniParc]FASTAAdd to basket
Also known as: Sv4

The sequence of this isoform differs from the canonical sequence as follows:
     125-214: Missing.

Show »
Length:607
Mass (Da):66,493
Checksum:i225AD8FB560EC751
GO
Isoform 5 (identifier: Q96LC7-5) [UniParc]FASTAAdd to basket
Also known as: Sv2

The sequence of this isoform differs from the canonical sequence as follows:
     140-185: TALTQKPDVY...PSFSWTGAAL → TGMRWGGNPC...NLPPRSLSQP
     186-697: Missing.

Show »
Length:185
Mass (Da):20,612
Checksum:i353945F95129A5C9
GO
Isoform 6 (identifier: Q96LC7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.
     445-539: Missing.

Show »
Length:544
Mass (Da):60,339
Checksum:iB56274BD619B164C
GO
Isoform 7 (identifier: Q96LC7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-188: Missing.
     445-539: Missing.

Show »
Length:554
Mass (Da):61,383
Checksum:iAAB64A61743F4535
GO
Isoform 8 (identifier: Q96LC7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.
     252-252: A → D
     253-342: Missing.
     445-539: Missing.

Show »
Length:454
Mass (Da):50,517
Checksum:i8E27B12146B5DC30
GO
Isoform 9 (identifier: Q96LC7-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-228: Missing.
     445-539: Missing.

Show »
Length:519
Mass (Da):57,486
Checksum:i95F307C2BDDCF32D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PL79E9PL79_HUMAN
Sialic acid-binding Ig-like lectin ...
SIGLEC10
512Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKV9E9PKV9_HUMAN
Sialic acid-binding Ig-like lectin ...
SIGLEC10
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJA1E9PJA1_HUMAN
Sialic acid-binding Ig-like lectin ...
SIGLEC10
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28S → P in AAK51124 (PubMed:12163025).Curated1
Sequence conflicti127R → T in AAQ88703 (PubMed:12975309).Curated1
Sequence conflicti134G → R in AAK51124 (PubMed:12163025).Curated1
Sequence conflicti268K → R in AK303514 (PubMed:14702039).Curated1
Sequence conflicti344P → S in AAK92542 (PubMed:11358961).Curated1
Sequence conflicti440L → P in AAK51124 (PubMed:12163025).Curated1
Sequence conflicti564L → P in AK303514 (PubMed:14702039).Curated1
Sequence conflicti587R → K in AAK92542 (PubMed:11358961).Curated1
Sequence conflicti624L → P in AAQ88703 (PubMed:12975309).Curated1
Sequence conflicti625P → S in AAK92542 (PubMed:11358961).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019955226A → V5 PublicationsCorresponds to variant dbSNP:rs9304711Ensembl.1
Natural variantiVAR_019956520R → S. Corresponds to variant dbSNP:rs1833785Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002561125 – 214Missing in isoform 4. CuratedAdd BLAST90
Alternative sequenceiVSP_002562140 – 185TALTQ…TGAAL → TGMRWGGNPCLSHWGGTLGT AYGLSREGSQGPLQHKNLPP RSLSQP in isoform 5. CuratedAdd BLAST46
Alternative sequenceiVSP_002564141 – 198Missing in isoform 3, isoform 6 and isoform 8. 3 PublicationsAdd BLAST58
Alternative sequenceiVSP_045365141 – 188Missing in isoform 7. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_045888146 – 228Missing in isoform 9. CuratedAdd BLAST83
Alternative sequenceiVSP_002563186 – 697Missing in isoform 5. CuratedAdd BLAST512
Alternative sequenceiVSP_045853252A → D in isoform 8. Curated1
Alternative sequenceiVSP_045854253 – 342Missing in isoform 8. CuratedAdd BLAST90
Alternative sequenceiVSP_002565445 – 539Missing in isoform 2, isoform 6, isoform 7, isoform 8 and isoform 9. 3 PublicationsAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY029277 Genomic DNA Translation: AAK40255.1
AY029277 Genomic DNA Translation: AAK40256.1
AF310233 mRNA Translation: AAK55139.1
AF311905 mRNA Translation: AAK92542.1
AY032685 mRNA Translation: AAK51124.1
AY358337 mRNA Translation: AAQ88703.1
AK289900 mRNA Translation: BAF82589.1
AK290542 mRNA Translation: BAF83231.1
AK303514 mRNA No translation available.
AC008750 Genomic DNA No translation available.
BC009955 mRNA Translation: AAH09955.2
BC101725 mRNA Translation: AAI01726.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12832.1 [Q96LC7-1]
CCDS54301.1 [Q96LC7-8]
CCDS54302.1 [Q96LC7-6]
CCDS54303.1 [Q96LC7-3]
CCDS54304.1 [Q96LC7-7]
CCDS54305.1 [Q96LC7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001164627.1, NM_001171156.1 [Q96LC7-3]
NP_001164628.1, NM_001171157.1 [Q96LC7-2]
NP_001164629.1, NM_001171158.1 [Q96LC7-7]
NP_001164630.1, NM_001171159.1 [Q96LC7-6]
NP_001164632.1, NM_001171161.1 [Q96LC7-8]
NP_001309034.1, NM_001322105.1
NP_149121.2, NM_033130.4 [Q96LC7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339313; ENSP00000345243; ENSG00000142512 [Q96LC7-1]
ENST00000353836; ENSP00000342389; ENSG00000142512 [Q96LC7-2]
ENST00000436984; ENSP00000414324; ENSG00000142512 [Q96LC7-7]
ENST00000439889; ENSP00000389132; ENSG00000142512 [Q96LC7-3]
ENST00000441969; ENSP00000408387; ENSG00000142512 [Q96LC7-6]
ENST00000442846; ENSP00000395475; ENSG00000142512 [Q96LC7-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89790

UCSC genome browser

More...
UCSCi
uc002pwo.4, human [Q96LC7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-10 [5 Fc Domains]

Functional Glycomics Gateway - Glycan Binding

Siglec-10 long

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029277 Genomic DNA Translation: AAK40255.1
AY029277 Genomic DNA Translation: AAK40256.1
AF310233 mRNA Translation: AAK55139.1
AF311905 mRNA Translation: AAK92542.1
AY032685 mRNA Translation: AAK51124.1
AY358337 mRNA Translation: AAQ88703.1
AK289900 mRNA Translation: BAF82589.1
AK290542 mRNA Translation: BAF83231.1
AK303514 mRNA No translation available.
AC008750 Genomic DNA No translation available.
BC009955 mRNA Translation: AAH09955.2
BC101725 mRNA Translation: AAI01726.1
CCDSiCCDS12832.1 [Q96LC7-1]
CCDS54301.1 [Q96LC7-8]
CCDS54302.1 [Q96LC7-6]
CCDS54303.1 [Q96LC7-3]
CCDS54304.1 [Q96LC7-7]
CCDS54305.1 [Q96LC7-2]
RefSeqiNP_001164627.1, NM_001171156.1 [Q96LC7-3]
NP_001164628.1, NM_001171157.1 [Q96LC7-2]
NP_001164629.1, NM_001171158.1 [Q96LC7-7]
NP_001164630.1, NM_001171159.1 [Q96LC7-6]
NP_001164632.1, NM_001171161.1 [Q96LC7-8]
NP_001309034.1, NM_001322105.1
NP_149121.2, NM_033130.4 [Q96LC7-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124602, 10 interactors
IntActiQ96LC7, 11 interactors
MINTiQ96LC7
STRINGi9606.ENSP00000345243

Chemistry databases

ChEMBLiCHEMBL4303061

PTM databases

GlyGeniQ96LC7, 6 sites
iPTMnetiQ96LC7
PhosphoSitePlusiQ96LC7

Genetic variation databases

BioMutaiSIGLEC10
DMDMi118572721

Proteomic databases

EPDiQ96LC7
jPOSTiQ96LC7
MassIVEiQ96LC7
MaxQBiQ96LC7
PaxDbiQ96LC7
PeptideAtlasiQ96LC7
PRIDEiQ96LC7
ProteomicsDBi10427
10785
30242
77195 [Q96LC7-1]
77196 [Q96LC7-2]
77197 [Q96LC7-3]
77198 [Q96LC7-4]
77199 [Q96LC7-5]
77200 [Q96LC7-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19024, 311 antibodies

The DNASU plasmid repository

More...
DNASUi
89790

Genome annotation databases

EnsembliENST00000339313; ENSP00000345243; ENSG00000142512 [Q96LC7-1]
ENST00000353836; ENSP00000342389; ENSG00000142512 [Q96LC7-2]
ENST00000436984; ENSP00000414324; ENSG00000142512 [Q96LC7-7]
ENST00000439889; ENSP00000389132; ENSG00000142512 [Q96LC7-3]
ENST00000441969; ENSP00000408387; ENSG00000142512 [Q96LC7-6]
ENST00000442846; ENSP00000395475; ENSG00000142512 [Q96LC7-8]
GeneIDi89790
KEGGihsa:89790
UCSCiuc002pwo.4, human [Q96LC7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89790
DisGeNETi89790

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SIGLEC10
HGNCiHGNC:15620, SIGLEC10
HPAiENSG00000142512, Group enriched (blood, lymphoid tissue)
MIMi606091, gene
neXtProtiNX_Q96LC7
OpenTargetsiENSG00000142512
PharmGKBiPA38004
VEuPathDBiHostDB:ENSG00000142512.14

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S41V, Eukaryota
GeneTreeiENSGT01030000234562
HOGENOMiCLU_024444_5_1_1
InParanoidiQ96LC7
OMAiRYNFMND
OrthoDBi1124645at2759
PhylomeDBiQ96LC7
TreeFamiTF332441

Enzyme and pathway databases

PathwayCommonsiQ96LC7
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGNORiQ96LC7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89790, 5 hits in 984 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SIGLEC10, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SIGLEC10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89790
PharosiQ96LC7, Tbio

Protein Ontology

More...
PROi
PR:Q96LC7
RNActiQ96LC7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142512, Expressed in blood and 164 other tissues
ExpressionAtlasiQ96LC7, baseline and differential
GenevisibleiQ96LC7, HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
PfamiView protein in Pfam
PF13895, Ig_2, 1 hit
PF07686, V-set, 1 hit
SMARTiView protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 2 hits
SUPFAMiSSF48726, SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS00290, IG_MHC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIG10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LC7
Secondary accession number(s): A8K1I5
, A8K3C7, C9JJ33, C9JM10, F8W917, Q3MIR5, Q6UXI8, Q96G54, Q96LC8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 28, 2006
Last modified: June 2, 2021
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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