UniProtKB - Q96LB9 (PGRP3_HUMAN)
Protein
Peptidoglycan recognition protein 3
Gene
PGLYRP3
Organism
Homo sapiens (Human)
Status
Functioni
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 231 | Murein | 1 | |
Binding sitei | 235 | Murein | 1 | |
Binding sitei | 242 | Murein | 1 |
GO - Molecular functioni
- N-acetylmuramoyl-L-alanine amidase activity Source: InterPro
- peptidoglycan binding Source: UniProtKB
- peptidoglycan immune receptor activity Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- antimicrobial humoral response Source: Reactome
- defense response to Gram-positive bacterium Source: UniProtKB
- detection of bacterium Source: UniProtKB
- growth of symbiont in host Source: Ensembl
- innate immune response Source: UniProtKB
- killing of cells of other organism Source: UniProtKB
- negative regulation of interferon-gamma production Source: Ensembl
- negative regulation of natural killer cell differentiation involved in immune response Source: Ensembl
- peptidoglycan catabolic process Source: InterPro
Keywordsi
Molecular function | Antibiotic, Antimicrobial |
Biological process | Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q96LB9 |
Reactomei | R-HSA-6803157, Antimicrobial peptides |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidoglycan recognition protein 3Alternative name(s): Peptidoglycan recognition protein I-alpha Short name: PGLYRPIalpha Short name: PGRP-I-alpha Peptidoglycan recognition protein intermediate alpha |
Gene namesi | Name:PGLYRP3 Synonyms:PGRPIA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159527.3 |
HGNCi | HGNC:30014, PGLYRP3 |
MIMi | 608197, gene |
neXtProti | NX_Q96LB9 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: Reactome
Other locations
- membrane Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 114771 |
OpenTargetsi | ENSG00000159527 |
PharmGKBi | PA134861692 |
Miscellaneous databases
Pharosi | Q96LB9, Tbio |
Chemistry databases
DrugBanki | DB04736, 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE |
Polymorphism and mutation databases
BioMutai | PGLYRP3 |
DMDMi | 38604974 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000023923 | 18 – 341 | Peptidoglycan recognition protein 3Add BLAST | 324 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 113 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 178 ↔ 300 | |||
Disulfide bondi | 194 ↔ 238 | |||
Disulfide bondi | 214 ↔ 220 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q96LB9 |
PaxDbi | Q96LB9 |
PeptideAtlasi | Q96LB9 |
PRIDEi | Q96LB9 |
ProteomicsDBi | 77194 |
PTM databases
GlyGeni | Q96LB9, 1 site |
iPTMneti | Q96LB9 |
PhosphoSitePlusi | Q96LB9 |
Expressioni
Tissue specificityi
Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.2 Publications
Inductioni
Up-regulated by exposure to Gram-positive and Gram-negative bacteria.1 Publication
Gene expression databases
Bgeei | ENSG00000159527, Expressed in ectocervix and 44 other tissues |
Genevisiblei | Q96LB9, HS |
Organism-specific databases
HPAi | ENSG00000159527, Tissue enhanced (esophagus, skin, vagina) |
Interactioni
Subunit structurei
Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked.
4 PublicationsBinary interactionsi
Hide detailsQ96LB9
With | #Exp. | IntAct |
---|---|---|
CIDEB [Q9UHD4] | 3 | EBI-12339509,EBI-7062247 |
FAM209A [Q5JX71] | 3 | EBI-12339509,EBI-18304435 |
HSD17B14 [Q9BPX1] | 3 | EBI-12339509,EBI-742664 |
KRT34 [O76011] | 3 | EBI-12339509,EBI-1047093 |
GO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 125341, 6 interactors |
IntActi | Q96LB9, 6 interactors |
STRINGi | 9606.ENSP00000290722 |
Miscellaneous databases
RNActi | Q96LB9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96LB9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96LB9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 179 | N-acetylmuramoyl-L-alanine amidase 1Sequence analysisAdd BLAST | 103 | |
Domaini | 200 – 325 | N-acetylmuramoyl-L-alanine amidase 2Sequence analysisAdd BLAST | 126 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 264 – 269 | Interaction with murein | 6 |
Sequence similaritiesi
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502S2KY, Eukaryota |
GeneTreei | ENSGT00940000162657 |
HOGENOMi | CLU_037559_1_0_1 |
InParanoidi | Q96LB9 |
OMAi | WHIQGSH |
OrthoDBi | 1110472at2759 |
PhylomeDBi | Q96LB9 |
TreeFami | TF323898 |
Family and domain databases
CDDi | cd06583, PGRP, 2 hits |
Gene3Di | 3.40.80.10, 2 hits |
InterProi | View protein in InterPro IPR036505, Amidase/PGRP_sf IPR002502, Amidase_domain IPR015510, PGRP IPR006619, PGRP_domain_met/bac |
PANTHERi | PTHR11022, PTHR11022, 1 hit |
Pfami | View protein in Pfam PF01510, Amidase_2, 2 hits |
SMARTi | View protein in SMART SM00644, Ami_2, 2 hits SM00701, PGRP, 2 hits |
SUPFAMi | SSF55846, SSF55846, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q96LB9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTLPWLLAF FILGLQAWDT PTIVSRKEWG ARPLACRALL TLPVAYIITD
60 70 80 90 100
QLPGMQCQQQ SVCSQMLRGL QSHSVYTIGW CDVAYNFLVG DDGRVYEGVG
110 120 130 140 150
WNIQGLHTQG YNNISLGIAF FGNKIGSSPS PAALSAAEGL ISYAIQKGHL
160 170 180 190 200
SPRYIQPLLL KEETCLDPQH PVMPRKVCPN IIKRSAWEAR ETHCPKMNLP
210 220 230 240 250
AKYVIIIHTA GTSCTVSTDC QTVVRNIQSF HMDTRNFCDI GYHFLVGQDG
260 270 280 290 300
GVYEGVGWHI QGSHTYGFND IALGIAFIGY FVEKPPNAAA LEAAQDLIQC
310 320 330 340
AVVEGYLTPN YLLMGHSDVV NILSPGQALY NIISTWPHFK H
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061515 | 35 | A → T. Corresponds to variant dbSNP:rs55991125Ensembl. | 1 | |
Natural variantiVAR_024561 | 126 | G → S1 PublicationCorresponds to variant dbSNP:rs843971Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY035376 mRNA Translation: AAK72484.1 AL591704 Genomic DNA No translation available. AL161636 Genomic DNA No translation available. BC069741 mRNA Translation: AAH69741.1 BC069798 mRNA Translation: AAH69798.1 BC069801 mRNA Translation: AAH69801.1 BC128114 mRNA Translation: AAI28115.1 BC128115 mRNA Translation: AAI28116.1 |
CCDSi | CCDS1035.1 |
RefSeqi | NP_443123.1, NM_052891.2 XP_011507421.1, XM_011509119.1 |
Genome annotation databases
Ensembli | ENST00000290722; ENSP00000290722; ENSG00000159527 |
GeneIDi | 114771 |
KEGGi | hsa:114771 |
UCSCi | uc001fbn.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY035376 mRNA Translation: AAK72484.1 AL591704 Genomic DNA No translation available. AL161636 Genomic DNA No translation available. BC069741 mRNA Translation: AAH69741.1 BC069798 mRNA Translation: AAH69798.1 BC069801 mRNA Translation: AAH69801.1 BC128114 mRNA Translation: AAI28115.1 BC128115 mRNA Translation: AAI28116.1 |
CCDSi | CCDS1035.1 |
RefSeqi | NP_443123.1, NM_052891.2 XP_011507421.1, XM_011509119.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SK3 | X-ray | 2.80 | A | 177-341 | [»] | |
1SK4 | X-ray | 1.65 | A | 179-341 | [»] | |
1TWQ | X-ray | 2.30 | A | 177-341 | [»] | |
2APH | X-ray | 2.10 | A/B | 177-341 | [»] | |
SMRi | Q96LB9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125341, 6 interactors |
IntActi | Q96LB9, 6 interactors |
STRINGi | 9606.ENSP00000290722 |
Chemistry databases
DrugBanki | DB04736, 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE |
PTM databases
GlyGeni | Q96LB9, 1 site |
iPTMneti | Q96LB9 |
PhosphoSitePlusi | Q96LB9 |
Polymorphism and mutation databases
BioMutai | PGLYRP3 |
DMDMi | 38604974 |
Proteomic databases
MassIVEi | Q96LB9 |
PaxDbi | Q96LB9 |
PeptideAtlasi | Q96LB9 |
PRIDEi | Q96LB9 |
ProteomicsDBi | 77194 |
Protocols and materials databases
Antibodypediai | 34121, 63 antibodies |
DNASUi | 114771 |
Genome annotation databases
Ensembli | ENST00000290722; ENSP00000290722; ENSG00000159527 |
GeneIDi | 114771 |
KEGGi | hsa:114771 |
UCSCi | uc001fbn.1, human |
Organism-specific databases
CTDi | 114771 |
DisGeNETi | 114771 |
EuPathDBi | HostDB:ENSG00000159527.3 |
GeneCardsi | PGLYRP3 |
HGNCi | HGNC:30014, PGLYRP3 |
HPAi | ENSG00000159527, Tissue enhanced (esophagus, skin, vagina) |
MIMi | 608197, gene |
neXtProti | NX_Q96LB9 |
OpenTargetsi | ENSG00000159527 |
PharmGKBi | PA134861692 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2KY, Eukaryota |
GeneTreei | ENSGT00940000162657 |
HOGENOMi | CLU_037559_1_0_1 |
InParanoidi | Q96LB9 |
OMAi | WHIQGSH |
OrthoDBi | 1110472at2759 |
PhylomeDBi | Q96LB9 |
TreeFami | TF323898 |
Enzyme and pathway databases
PathwayCommonsi | Q96LB9 |
Reactomei | R-HSA-6803157, Antimicrobial peptides |
Miscellaneous databases
BioGRID-ORCSi | 114771, 3 hits in 851 CRISPR screens |
EvolutionaryTracei | Q96LB9 |
GenomeRNAii | 114771 |
Pharosi | Q96LB9, Tbio |
PROi | PR:Q96LB9 |
RNActi | Q96LB9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159527, Expressed in ectocervix and 44 other tissues |
Genevisiblei | Q96LB9, HS |
Family and domain databases
CDDi | cd06583, PGRP, 2 hits |
Gene3Di | 3.40.80.10, 2 hits |
InterProi | View protein in InterPro IPR036505, Amidase/PGRP_sf IPR002502, Amidase_domain IPR015510, PGRP IPR006619, PGRP_domain_met/bac |
PANTHERi | PTHR11022, PTHR11022, 1 hit |
Pfami | View protein in Pfam PF01510, Amidase_2, 2 hits |
SMARTi | View protein in SMART SM00644, Ami_2, 2 hits SM00701, PGRP, 2 hits |
SUPFAMi | SSF55846, SSF55846, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PGRP3_HUMAN | |
Accessioni | Q96LB9Primary (citable) accession number: Q96LB9 Secondary accession number(s): A1A4U8, Q5SY65 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations