PGLYRP3

Functionⁱ

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	231	Murein	1
Binding siteⁱ	235	Murein	1
Binding siteⁱ	242	Murein	1

GO - Molecular functionⁱ

N-acetylmuramoyl-L-alanine amidase activity Source: InterPro
peptidoglycan binding
Source: UniProtKB
Inferred from direct assayⁱ
peptidoglycan receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11461926
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 16354652
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 16354652
antimicrobial humoral response Source: Reactome
defense response to Gram-positive bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 16354652
- 11461926
detection of bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 11461926
growth of symbiont in host Source: Ensembl
innate immune response
Source: UniProtKB
Non-traceable author statementⁱ
- 11461926
killing of cells of other organism
Source: UniProtKB
Inferred from direct assayⁱ
- 16354652
negative regulation of interferon-gamma production Source: Ensembl
negative regulation of natural killer cell differentiation involved in immune response Source: Ensembl
peptidoglycan catabolic process Source: InterPro
positive regulation of cytolysis in other organism
Source: UniProtKB
Inferred from direct assayⁱ
- 16354652

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antibiotic, Antimicrobial
Biological process	Immunity, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803157 Antimicrobial peptides

Reactomeⁱ

R-HSA-6803157 Antimicrobial peptides

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptidoglycan recognition protein 3 Alternative name(s): Peptidoglycan recognition protein I-alpha Short name: PGLYRPIalpha Short name: PGRP-I-alpha Peptidoglycan recognition protein intermediate alpha
Gene namesⁱ	Name:PGLYRP3 Synonyms:PGRPIA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159527.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30014 PGLYRP3
MIMⁱ	608197 gene
neXtProtⁱ	NX_Q96LB9

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	114771
Open Targets More...OpenTargetsⁱ	ENSG00000159527
PharmGKBⁱ	PA134861692

Polymorphism and mutation databases

BioMutaⁱ	PGLYRP3
DMDMⁱ	38604974

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000023923	18 – 341	Peptidoglycan recognition protein 3Add BLAST		324

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	113	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	178 ↔ 300
Disulfide bondⁱ	194 ↔ 238
Disulfide bondⁱ	214 ↔ 220

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q96LB9
PaxDbⁱ	Q96LB9
PRIDEⁱ	Q96LB9
ProteomicsDBⁱ	77194

PTM databases

iPTMnetⁱ	Q96LB9
PhosphoSitePlusⁱ	Q96LB9

Expressionⁱ

Tissue specificityⁱ

Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.2 Publications

Inductionⁱ

Up-regulated by exposure to Gram-positive and Gram-negative bacteria.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000159527
CleanExⁱ	HS_PGLYRP3
Genevisibleⁱ	Q96LB9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030369

HPAⁱ

HPA030369

Interactionⁱ

Subunit structureⁱ

Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked.4 Publications

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 16354652

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	125341, 2 interactors
IntActⁱ	Q96LB9, 5 interactors
STRINGⁱ	9606.ENSP00000290722

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	184 – 187	Combined sources	4
Beta strandⁱ	199 – 208	Combined sources	10
Helixⁱ	217 – 233	Combined sources	17
Beta strandⁱ	243 – 246	Combined sources	4
Beta strandⁱ	252 – 256	Combined sources	5
Beta strandⁱ	258 – 260	Combined sources	3
Beta strandⁱ	263 – 265	Combined sources	3
Turnⁱ	269 – 271	Combined sources	3
Beta strandⁱ	272 – 279	Combined sources	8
Beta strandⁱ	282 – 284	Combined sources	3
Helixⁱ	288 – 303	Combined sources	16
Beta strandⁱ	306 – 315	Combined sources	10
Helixⁱ	316 – 318	Combined sources	3
Beta strandⁱ	320 – 322	Combined sources	3
Helixⁱ	328 – 333	Combined sources	6
Turnⁱ	337 – 340	Combined sources	4

3D structure databases

ProteinModelPortalⁱ	Q96LB9
SMRⁱ	Q96LB9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q96LB9

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	264 – 269	Interaction with murein		6

Sequence similaritiesⁱ

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IYTD Eukaryota ENOG4111PQD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016833
HOGENOMⁱ	HOG000267017
HOVERGENⁱ	HBG053579
InParanoidⁱ	Q96LB9
KEGG Orthology (KO) More...KOⁱ	K01446
OMAⁱ	QSFHMDT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O6Z
PhylomeDBⁱ	Q96LB9
TreeFamⁱ	TF323898

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06583 PGRP, 2 hits
Gene3Dⁱ	3.40.80.10, 2 hits
InterProⁱ	View protein in InterPro IPR036505 Amidase/PGRP_sf IPR002502 Amidase_domain IPR015510 PGRP IPR006619 PGRP_domain_met/bac
PANTHERⁱ	PTHR11022 PTHR11022, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01510 Amidase_2, 2 hits
SMARTⁱ	View protein in SMART SM00644 Ami_2, 2 hits SM00701 PGRP, 2 hits
SUPFAMⁱ	SSF55846 SSF55846, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q96LB9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGTLPWLLAF FILGLQAWDT PTIVSRKEWG ARPLACRALL TLPVAYIITD 
        60         70         80         90        100
QLPGMQCQQQ SVCSQMLRGL QSHSVYTIGW CDVAYNFLVG DDGRVYEGVG 
       110        120        130        140        150
WNIQGLHTQG YNNISLGIAF FGNKIGSSPS PAALSAAEGL ISYAIQKGHL 
       160        170        180        190        200
SPRYIQPLLL KEETCLDPQH PVMPRKVCPN IIKRSAWEAR ETHCPKMNLP 
       210        220        230        240        250
AKYVIIIHTA GTSCTVSTDC QTVVRNIQSF HMDTRNFCDI GYHFLVGQDG 
       260        270        280        290        300
GVYEGVGWHI QGSHTYGFND IALGIAFIGY FVEKPPNAAA LEAAQDLIQC 
       310        320        330        340 
AVVEGYLTPN YLLMGHSDVV NILSPGQALY NIISTWPHFK H

Length:341

Mass (Da):37,611

Last modified:December 1, 2001 - v1

Checksum:ⁱ8ADD5AA97B632076

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061515	35	A → T. Corresponds to variant dbSNP:rs55991125Ensembl.		1
Natural variantⁱVAR_024561	126	G → S1 PublicationCorresponds to variant dbSNP:rs843971Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY035376 mRNA Translation: AAK72484.1 AL591704 Genomic DNA No translation available. AL161636 Genomic DNA No translation available. BC069741 mRNA Translation: AAH69741.1 BC069798 mRNA Translation: AAH69798.1 BC069801 mRNA Translation: AAH69801.1 BC128114 mRNA Translation: AAI28115.1 BC128115 mRNA Translation: AAI28116.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1035.1
NCBI Reference Sequences More...RefSeqⁱ	NP_443123.1, NM_052891.2 XP_011507421.1, XM_011509119.1
UniGeneⁱ	Hs.348266

Genome annotation databases

Ensemblⁱ	ENST00000290722; ENSP00000290722; ENSG00000159527
GeneIDⁱ	114771
KEGGⁱ	hsa:114771
UCSC genome browser More...UCSCⁱ	uc001fbn.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q96LB9	UPI0005CFFD4B		HUMAN		377
Uncharacterized protein		MACMU		341
Peptidoglycan recognition protein 3		MACFA		341
Peptidoglycan recognition protein 4		RHIRO		341
UPI000C2A5383		Ugandan red Colobus		341
+14

Protein	Similar proteins		Species	Score	Length
Q96LB9	UPI0005CFFD4B		HUMAN		377
Peptidoglycan recognition protein 3		CERAT		341
Peptidoglycan recognition protein 3		RHIBE		341
UPI000C2A5383		Ugandan red Colobus		341
Peptidoglycan recognition protein 3		PAPAN		341
+112

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY035376 mRNA Translation: AAK72484.1 AL591704 Genomic DNA No translation available. AL161636 Genomic DNA No translation available. BC069741 mRNA Translation: AAH69741.1 BC069798 mRNA Translation: AAH69798.1 BC069801 mRNA Translation: AAH69801.1 BC128114 mRNA Translation: AAI28115.1 BC128115 mRNA Translation: AAI28116.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1035.1
NCBI Reference Sequences More...RefSeqⁱ	NP_443123.1, NM_052891.2 XP_011507421.1, XM_011509119.1
UniGeneⁱ	Hs.348266

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1SK3	X-ray	2.80	A	177-341	[»]
	1SK4	X-ray	1.65	A	179-341	[»]
	1TWQ	X-ray	2.30	A	177-341	[»]
	2APH	X-ray	2.10	A/B	177-341	[»]
ProteinModelPortalⁱ	Q96LB9
SMRⁱ	Q96LB9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125341, 2 interactors
IntActⁱ	Q96LB9, 5 interactors
STRINGⁱ	9606.ENSP00000290722

PTM databases

iPTMnetⁱ	Q96LB9
PhosphoSitePlusⁱ	Q96LB9

Polymorphism and mutation databases

BioMutaⁱ	PGLYRP3
DMDMⁱ	38604974

Proteomic databases

EPDⁱ	Q96LB9
PaxDbⁱ	Q96LB9
PRIDEⁱ	Q96LB9
ProteomicsDBⁱ	77194

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	114771
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000290722; ENSP00000290722; ENSG00000159527
GeneIDⁱ	114771
KEGGⁱ	hsa:114771
UCSC genome browser More...UCSCⁱ	uc001fbn.1 human

Organism-specific databases

CTDⁱ	114771
DisGeNET More...DisGeNETⁱ	114771
EuPathDBⁱ	HostDB:ENSG00000159527.3
GeneCardsⁱ	PGLYRP3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30014 PGLYRP3
Human Protein Atlas More...HPAⁱ	HPA030369
MIMⁱ	608197 gene
neXtProtⁱ	NX_Q96LB9
Open Targets More...OpenTargetsⁱ	ENSG00000159527
PharmGKBⁱ	PA134861692
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IYTD Eukaryota ENOG4111PQD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016833
HOGENOMⁱ	HOG000267017
HOVERGENⁱ	HBG053579
InParanoidⁱ	Q96LB9
KEGG Orthology (KO) More...KOⁱ	K01446
OMAⁱ	QSFHMDT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O6Z
PhylomeDBⁱ	Q96LB9
TreeFamⁱ	TF323898

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803157 Antimicrobial peptides

Reactomeⁱ

R-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

EvolutionaryTraceⁱ	Q96LB9
GenomeRNAiⁱ	114771
Protein Ontology More...PROⁱ	PR:Q96LB9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159527
CleanExⁱ	HS_PGLYRP3
Genevisibleⁱ	Q96LB9 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06583 PGRP, 2 hits
Gene3Dⁱ	3.40.80.10, 2 hits
InterProⁱ	View protein in InterPro IPR036505 Amidase/PGRP_sf IPR002502 Amidase_domain IPR015510 PGRP IPR006619 PGRP_domain_met/bac
PANTHERⁱ	PTHR11022 PTHR11022, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01510 Amidase_2, 2 hits
SMARTⁱ	View protein in SMART SM00644 Ami_2, 2 hits SM00701 PGRP, 2 hits
SUPFAMⁱ	SSF55846 SSF55846, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PGRP3_HUMAN
Accessionⁱ	Q96LB9Primary (citable) accession number: Q96LB9 Secondary accession number(s): A1A4U8, Q5SY65
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
	Last sequence update:	December 1, 2001
	Last modified:	July 18, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniRef

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UniProtKB - Q96LB9 (PGRP3_HUMAN)

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Peptidoglycan recognition protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ