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Protein

Intraflagellar transport protein 74 homolog

Gene

IFT74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-tubulin binding Source: UniProtKB
  • chromatin binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5620924 Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intraflagellar transport protein 74 homolog
Alternative name(s):
Capillary morphogenesis gene 1 protein
Short name:
CMG-1
Coiled-coil domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFT74
Synonyms:CCDC2, CMG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000096872.15

Human Gene Nomenclature Database

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HGNCi
HGNC:21424 IFT74

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608040 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96LB3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Bardet-Biedl syndrome 20 (BBS20)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Bardet-Biedl syndrome, a syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.
See also OMIM:617119

Keywords - Diseasei

Bardet-Biedl syndrome, Ciliopathy, Obesity

Organism-specific databases

DisGeNET

More...
DisGeNETi
80173

MalaCards human disease database

More...
MalaCardsi
IFT74
MIMi617119 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000096872

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134976961

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFT74

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50400610

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000841691 – 600Intraflagellar transport protein 74 homologAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51Omega-N-methylarginineCombined sources1
Modified residuei73PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96LB3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96LB3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96LB3

PeptideAtlas

More...
PeptideAtlasi
Q96LB3

PRoteomics IDEntifications database

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PRIDEi
Q96LB3

ProteomicsDB human proteome resource

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ProteomicsDBi
77187
77188 [Q96LB3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96LB3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96LB3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000096872 Expressed in 211 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

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CleanExi
HS_IFT74

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96LB3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96LB3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020247
HPA026684

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:23990561). Interacts with IFT81; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium (PubMed:15955805, PubMed:23990561). Interacts (via basic region) with beta-tubulin (via acidic region); interaction is direct (PubMed:23990561). Interacts with ARL13B and IFT88 (PubMed:24339792). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (PubMed:28428259, PubMed:28625565).5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123156, 58 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96LB3

Protein interaction database and analysis system

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IntActi
Q96LB3, 35 interactors

Molecular INTeraction database

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MINTi
Q96LB3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000369402

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96LB3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96LB3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 90Basic regionAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili98 – 482Sequence analysisAdd BLAST385

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFT74 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFCX Eukaryota
ENOG410XWAZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007109

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000031494

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050820

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96LB3

KEGG Orthology (KO)

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KOi
K19679

Identification of Orthologs from Complete Genome Data

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OMAi
QESDYRP

Database of Orthologous Groups

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OrthoDBi
EOG091G05UB

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96LB3

TreeFam database of animal gene trees

More...
TreeFami
TF318352

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029602 IFT74

The PANTHER Classification System

More...
PANTHERi
PTHR31432 PTHR31432, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96LB3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASNHKSSAA RPVSRGGVGL TGRPPSGIRP LSGNIRVATA MPPGTARPGS
60 70 80 90 100
RGCPIGTGGV LSSQIKVAHR PVTQQGLTGM KTGTKGPQRQ ILDKSYYLGL
110 120 130 140 150
LRSKISELTT EVNKLQKGIE MYNQENSVYL SYEKRAETLA VEIKELQGQL
160 170 180 190 200
ADYNMLVDKL NTNTEMEEVM NDYNMLKAQN DRETQSLDVI FTERQAKEKQ
210 220 230 240 250
IRSVEEEIEQ EKQATDDIIK NMSFENQVKY LEMKTTNEKL LQELDTLQQQ
260 270 280 290 300
LDSQNMKKES LEAEIAHSQV KQEAVLLHEK LYELESHRDQ MIAEDKSIGS
310 320 330 340 350
PMEEREKLLK QIKDDNQEIA SMERQLTDTK EKINQFIEEI RQLDMDLEEH
360 370 380 390 400
QGEMNQKYKE LKKREEHMDT FIETFEETKN QELKRKAQIE ANIVALLEHC
410 420 430 440 450
SRNINRIEQI SSITNQELKM MQDDLNFKST EVQKSQSTAQ NLTSDIQRLQ
460 470 480 490 500
LDLQKMELLE SKMTEEQHSL KSKIKQMTTD LEIYNDLPAL KSSGEEKIKK
510 520 530 540 550
LHQERMILST HRNAFKKIME KQNIEYEALK TQLQENETHS QLTNLERKWQ
560 570 580 590 600
HLEQNNFAMK EFIATKSQES DYQPIKKNVT KQIAEYNKTI VDALHSTSGN
Length:600
Mass (Da):69,239
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01366A697500D52D
GO
Isoform 2 (identifier: Q96LB3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-600: GEMNQKYKEL...VDALHSTSGN → DPTNYGWKILEKNTGSFKKQV

Show »
Length:372
Mass (Da):42,332
Checksum:i339DC80C2F9E9ED7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RH29E5RH29_HUMAN
Intraflagellar transport protein 74...
IFT74
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIF0E5RIF0_HUMAN
Intraflagellar transport protein 74...
IFT74
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGX6E5RGX6_HUMAN
Intraflagellar transport protein 74...
IFT74
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJK3E5RJK3_HUMAN
Intraflagellar transport protein 74...
IFT74
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14650 differs from that shown. Reason: Erroneous termination at position 159. Translated as Lys.Curated
The sequence BAB15423 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti172D → G in BAB14650 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05106255I → M. Corresponds to variant dbSNP:rs10812505Ensembl.1
Natural variantiVAR_06166785K → R. Corresponds to variant dbSNP:rs11555693Ensembl.1
Natural variantiVAR_051063110T → A. Corresponds to variant dbSNP:rs12004404Ensembl.1
Natural variantiVAR_051064224F → L1 PublicationCorresponds to variant dbSNP:rs17694549Ensembl.1
Natural variantiVAR_051065355N → T. Corresponds to variant dbSNP:rs34628525Ensembl.1
Natural variantiVAR_076977579V → M1 PublicationCorresponds to variant dbSNP:rs138591335Ensembl.1
Natural variantiVAR_051066597T → I1 PublicationCorresponds to variant dbSNP:rs3429Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041328352 – 600GEMNQ…STSGN → DPTNYGWKILEKNTGSFKKQ V in isoform 2. 2 PublicationsAdd BLAST249

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY040325 mRNA Translation: AAK77221.1
AK023707 mRNA Translation: BAB14650.1 Sequence problems.
AK026274 mRNA Translation: BAB15423.1 Different initiation.
AL355432 Genomic DNA No translation available.
AL356133 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58573.1
BC107742 mRNA Translation: AAI07743.1
BX436367 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS43793.1 [Q96LB3-1]
CCDS47955.1 [Q96LB3-2]

NCBI Reference Sequences

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RefSeqi
NP_001092692.1, NM_001099222.1 [Q96LB3-1]
NP_001092693.1, NM_001099223.1 [Q96LB3-1]
NP_001092694.1, NM_001099224.1 [Q96LB3-2]
NP_079379.2, NM_025103.2 [Q96LB3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.145402

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380062; ENSP00000369402; ENSG00000096872 [Q96LB3-1]
ENST00000429045; ENSP00000393907; ENSG00000096872 [Q96LB3-2]
ENST00000433700; ENSP00000389224; ENSG00000096872 [Q96LB3-1]
ENST00000443698; ENSP00000404122; ENSG00000096872 [Q96LB3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80173

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80173

UCSC genome browser

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UCSCi
uc003zqf.5 human [Q96LB3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040325 mRNA Translation: AAK77221.1
AK023707 mRNA Translation: BAB14650.1 Sequence problems.
AK026274 mRNA Translation: BAB15423.1 Different initiation.
AL355432 Genomic DNA No translation available.
AL356133 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58573.1
BC107742 mRNA Translation: AAI07743.1
BX436367 mRNA No translation available.
CCDSiCCDS43793.1 [Q96LB3-1]
CCDS47955.1 [Q96LB3-2]
RefSeqiNP_001092692.1, NM_001099222.1 [Q96LB3-1]
NP_001092693.1, NM_001099223.1 [Q96LB3-1]
NP_001092694.1, NM_001099224.1 [Q96LB3-2]
NP_079379.2, NM_025103.2 [Q96LB3-1]
UniGeneiHs.145402

3D structure databases

ProteinModelPortaliQ96LB3
SMRiQ96LB3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123156, 58 interactors
CORUMiQ96LB3
IntActiQ96LB3, 35 interactors
MINTiQ96LB3
STRINGi9606.ENSP00000369402

PTM databases

iPTMnetiQ96LB3
PhosphoSitePlusiQ96LB3

Polymorphism and mutation databases

BioMutaiIFT74
DMDMi50400610

Proteomic databases

EPDiQ96LB3
MaxQBiQ96LB3
PaxDbiQ96LB3
PeptideAtlasiQ96LB3
PRIDEiQ96LB3
ProteomicsDBi77187
77188 [Q96LB3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380062; ENSP00000369402; ENSG00000096872 [Q96LB3-1]
ENST00000429045; ENSP00000393907; ENSG00000096872 [Q96LB3-2]
ENST00000433700; ENSP00000389224; ENSG00000096872 [Q96LB3-1]
ENST00000443698; ENSP00000404122; ENSG00000096872 [Q96LB3-1]
GeneIDi80173
KEGGihsa:80173
UCSCiuc003zqf.5 human [Q96LB3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80173
DisGeNETi80173
EuPathDBiHostDB:ENSG00000096872.15

GeneCards: human genes, protein and diseases

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GeneCardsi
IFT74
HGNCiHGNC:21424 IFT74
HPAiHPA020247
HPA026684
MalaCardsiIFT74
MIMi608040 gene
617119 phenotype
neXtProtiNX_Q96LB3
OpenTargetsiENSG00000096872
PharmGKBiPA134976961

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFCX Eukaryota
ENOG410XWAZ LUCA
GeneTreeiENSGT00390000007109
HOGENOMiHOG000031494
HOVERGENiHBG050820
InParanoidiQ96LB3
KOiK19679
OMAiQESDYRP
OrthoDBiEOG091G05UB
PhylomeDBiQ96LB3
TreeFamiTF318352

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IFT74 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IFT74

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80173

Protein Ontology

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PROi
PR:Q96LB3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000096872 Expressed in 211 organ(s), highest expression level in testis
CleanExiHS_IFT74
ExpressionAtlasiQ96LB3 baseline and differential
GenevisibleiQ96LB3 HS

Family and domain databases

InterProiView protein in InterPro
IPR029602 IFT74
PANTHERiPTHR31432 PTHR31432, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFT74_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LB3
Secondary accession number(s): Q3B789
, Q5VY34, Q6PGQ8, Q9H643, Q9H8G7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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