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UniProtKB - Q96LB1 (MRGX2_HUMAN)

Entry version 147 (10 Feb 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Mas-related G-protein coupled receptor member X2

Gene

MRGPRX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.By similarity1 Publication6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96LB1

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96LB1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRGPRX2
Synonyms:MRGX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17983, MRGPRX2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607228, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96LB1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183695.2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 63CytoplasmicSequence analysis9
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 96ExtracellularSequence analysisAdd BLAST12
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 144CytoplasmicSequence analysisAdd BLAST27
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 184ExtracellularSequence analysisAdd BLAST19
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 228CytoplasmicSequence analysisAdd BLAST23
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 264ExtracellularSequence analysisAdd BLAST15
Transmembranei265 – 285Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini286 – 330CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		117194

Open Targets

More...OpenTargetsi		ENSG00000183695

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671335

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96LB1, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5849

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		157

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MRGPRX2

Domain mapping of disease mutations (DMDM)

More...DMDMi		50401127

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000697751 – 330Mas-related G-protein coupled receptor member X2Add BLAST330

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96LB1

PeptideAtlas

More...PeptideAtlasi		Q96LB1

PRoteomics IDEntifications database

More...PRIDEi		Q96LB1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77185

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183695, Expressed in lower esophagus and 33 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96LB1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183695, Tissue enhanced (smooth)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333800

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q96LB1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96LB1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RTWA, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222446

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96LB1

Identification of Orthologs from Complete Genome Data

More...OMAi		NMSAIIC

Database of Orthologous Groups

More...OrthoDBi		1123658at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96LB1

TreeFam database of animal gene trees

More...TreeFami		TF336336

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR026234, MRGPCRFAMILY
IPR027338, MRGPCRX1/MRGPCRX2

The PANTHER Classification System

More...PANTHERi		PTHR11334, PTHR11334, 1 hit
PTHR11334:SF22, PTHR11334:SF22, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR02108, MRGPCRFAMILY

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96LB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPTTPAWGT ESTTVNGNDQ ALLLLCGKET LIPVFLILFI ALVGLVGNGF 
        60         70         80         90        100
VLWLLGFRMR RNAFSVYVLS LAGADFLFLC FQIINCLVYL SNFFCSISIN 
       110        120        130        140        150
FPSFFTTVMT CAYLAGLSML STVSTERCLS VLWPIWYRCR RPRHLSAVVC 
       160        170        180        190        200
VLLWALSLLL SILEGKFCGF LFSDGDSGWC QTFDFITAAW LIFLFMVLCG 
       210        220        230        240        250
SSLALLVRIL CGSRGLPLTR LYLTILLTVL VFLLCGLPFG IQWFLILWIW 
       260        270        280        290        300
KDSDVLFCHI HPVSVVLSSL NSSANPIIYF FVGSFRKQWR LQQPILKLAL 
       310        320        330
QRALQDIAEV DHSEGCFRQG TPEMSRSSLV
Length:330
Mass (Da):37,099
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B328FD78B1DF6BE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02473916N → H1 PublicationCorresponds to variant dbSNP:rs11024970Ensembl.1
Natural variantiVAR_04941843V → I. Corresponds to variant dbSNP:rs11823569Ensembl.1
Natural variantiVAR_01943362N → S2 PublicationsCorresponds to variant dbSNP:rs10833049Ensembl.1
Natural variantiVAR_02474078F → L1 PublicationCorresponds to variant dbSNP:rs79763999Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY042214 Genomic DNA Translation: AAK91805.1
HG426071 Genomic DNA Translation: CDG86189.1
AY651130 Genomic DNA Translation: AAW70043.1
AY651131 Genomic DNA Translation: AAW70044.1
AY651132 Genomic DNA Translation: AAW70045.1
AY651133 Genomic DNA Translation: AAW70046.1
AY651134 Genomic DNA Translation: AAW70047.1
AY651135 Genomic DNA Translation: AAW70048.1
AY651136 Genomic DNA Translation: AAW70049.1
AY651137 Genomic DNA Translation: AAW70050.1
AY651138 Genomic DNA Translation: AAW70051.1
AY651139 Genomic DNA Translation: AAW70052.1
AY651140 Genomic DNA Translation: AAW70053.1
AY651141 Genomic DNA Translation: AAW70054.1
AY651142 Genomic DNA Translation: AAW70055.1
AY651143 Genomic DNA Translation: AAW70056.1
AY651144 Genomic DNA Translation: AAW70057.1
AY651145 Genomic DNA Translation: AAW70058.1
AY651146 Genomic DNA Translation: AAW70059.1
AY651147 Genomic DNA Translation: AAW70060.1
AY651148 Genomic DNA Translation: AAW70061.1
AY651149 Genomic DNA Translation: AAW70062.1
AY651150 Genomic DNA Translation: AAW70063.1
AY651151 Genomic DNA Translation: AAW70064.1
AY651152 Genomic DNA Translation: AAW70065.1
AY651153 Genomic DNA Translation: AAW70066.1
AY651154 Genomic DNA Translation: AAW70067.1
AY651155 Genomic DNA Translation: AAW70068.1
AY651156 Genomic DNA Translation: AAW70069.1
AY651157 Genomic DNA Translation: AAW70070.1
AY651158 Genomic DNA Translation: AAW70071.1
AY651159 Genomic DNA Translation: AAW70072.1
AY651160 Genomic DNA Translation: AAW70073.1
AY651161 Genomic DNA Translation: AAW70074.1
AY845175 Genomic DNA Translation: AAW70082.1
AY845176 Genomic DNA Translation: AAW70083.1
EU883579 Genomic DNA Translation: ACG60653.1
AB083626 Genomic DNA Translation: BAB89339.1
AB065811 Genomic DNA Translation: BAC06030.1
CH471064 Genomic DNA Translation: EAW68359.1
BC063450 mRNA Translation: AAH63450.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7847.1

NCBI Reference Sequences

More...RefSeqi		NP_001290544.1, NM_001303615.1
NP_473371.1, NM_054030.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329773; ENSP00000333800; ENSG00000183695

Database of genes from NCBI RefSeq genomes

More...GeneIDi		117194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:117194

UCSC genome browser

More...UCSCi		uc001mph.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042214 Genomic DNA Translation: AAK91805.1
HG426071 Genomic DNA Translation: CDG86189.1
AY651130 Genomic DNA Translation: AAW70043.1
AY651131 Genomic DNA Translation: AAW70044.1
AY651132 Genomic DNA Translation: AAW70045.1
AY651133 Genomic DNA Translation: AAW70046.1
AY651134 Genomic DNA Translation: AAW70047.1
AY651135 Genomic DNA Translation: AAW70048.1
AY651136 Genomic DNA Translation: AAW70049.1
AY651137 Genomic DNA Translation: AAW70050.1
AY651138 Genomic DNA Translation: AAW70051.1
AY651139 Genomic DNA Translation: AAW70052.1
AY651140 Genomic DNA Translation: AAW70053.1
AY651141 Genomic DNA Translation: AAW70054.1
AY651142 Genomic DNA Translation: AAW70055.1
AY651143 Genomic DNA Translation: AAW70056.1
AY651144 Genomic DNA Translation: AAW70057.1
AY651145 Genomic DNA Translation: AAW70058.1
AY651146 Genomic DNA Translation: AAW70059.1
AY651147 Genomic DNA Translation: AAW70060.1
AY651148 Genomic DNA Translation: AAW70061.1
AY651149 Genomic DNA Translation: AAW70062.1
AY651150 Genomic DNA Translation: AAW70063.1
AY651151 Genomic DNA Translation: AAW70064.1
AY651152 Genomic DNA Translation: AAW70065.1
AY651153 Genomic DNA Translation: AAW70066.1
AY651154 Genomic DNA Translation: AAW70067.1
AY651155 Genomic DNA Translation: AAW70068.1
AY651156 Genomic DNA Translation: AAW70069.1
AY651157 Genomic DNA Translation: AAW70070.1
AY651158 Genomic DNA Translation: AAW70071.1
AY651159 Genomic DNA Translation: AAW70072.1
AY651160 Genomic DNA Translation: AAW70073.1
AY651161 Genomic DNA Translation: AAW70074.1
AY845175 Genomic DNA Translation: AAW70082.1
AY845176 Genomic DNA Translation: AAW70083.1
EU883579 Genomic DNA Translation: ACG60653.1
AB083626 Genomic DNA Translation: BAB89339.1
AB065811 Genomic DNA Translation: BAC06030.1
CH471064 Genomic DNA Translation: EAW68359.1
BC063450 mRNA Translation: AAH63450.1
CCDSiCCDS7847.1
RefSeqiNP_001290544.1, NM_001303615.1
NP_473371.1, NM_054030.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000333800

Chemistry databases

BindingDBiQ96LB1
ChEMBLiCHEMBL5849
GuidetoPHARMACOLOGYi157

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

Genetic variation databases

BioMutaiMRGPRX2
DMDMi50401127

Proteomic databases

PaxDbiQ96LB1
PeptideAtlasiQ96LB1
PRIDEiQ96LB1
ProteomicsDBi77185

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12419, 272 antibodies

The DNASU plasmid repository

More...DNASUi		117194

Genome annotation databases

EnsembliENST00000329773; ENSP00000333800; ENSG00000183695
GeneIDi117194
KEGGihsa:117194
UCSCiuc001mph.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		117194
DisGeNETi117194

GeneCards: human genes, protein and diseases

More...GeneCardsi		MRGPRX2
HGNCiHGNC:17983, MRGPRX2
HPAiENSG00000183695, Tissue enhanced (smooth)
MIMi607228, gene
neXtProtiNX_Q96LB1
OpenTargetsiENSG00000183695
PharmGKBiPA142671335
VEuPathDBiHostDB:ENSG00000183695.2

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RTWA, Eukaryota
GeneTreeiENSGT01010000222446
HOGENOMiCLU_009579_4_1_1
InParanoidiQ96LB1
OMAiNMSAIIC
OrthoDBi1123658at2759
PhylomeDBiQ96LB1
TreeFamiTF336336

Enzyme and pathway databases

PathwayCommonsiQ96LB1
SIGNORiQ96LB1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		117194, 3 hits in 874 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MRGPRX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		117194
PharosiQ96LB1, Tchem

Protein Ontology

More...PROi		PR:Q96LB1
RNActiQ96LB1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183695, Expressed in lower esophagus and 33 other tissues
GenevisibleiQ96LB1, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR026234, MRGPCRFAMILY
IPR027338, MRGPCRX1/MRGPCRX2
PANTHERiPTHR11334, PTHR11334, 1 hit
PTHR11334:SF22, PTHR11334:SF22, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR02108, MRGPCRFAMILY
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRGX2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LB1
Secondary accession number(s): B5B0C7
, Q4QXW4, Q4QXW7, Q4QXX0, Q4QXX2, Q4QXX3, Q4QXX4, Q4QXX6, Q4QXX7, W8W3L5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: February 10, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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