UniProtKB - Q96LB1 (MRGX2_HUMAN)
Protein
Mas-related G-protein coupled receptor member X2
Gene
MRGPRX2
Organism
Homo sapiens (Human)
Status
Functioni
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.By similarity1 Publication6 Publications
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB
- mast cell secretagogue receptor activity Source: UniProtKB
- neuropeptide binding Source: UniProtKB
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- mast cell activation Source: UniProtKB
- mast cell degranulation Source: UniProtKB
- positive regulation of cytokinesis Source: UniProtKB
- sensory perception of pain Source: UniProtKB
- sleep Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q96LB1 |
SIGNORi | Q96LB1 |
Names & Taxonomyi
Protein namesi | Recommended name: Mas-related G-protein coupled receptor member X2 |
Gene namesi | Name:MRGPRX2 Synonyms:MRGX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17983, MRGPRX2 |
MIMi | 607228, gene |
neXtProti | NX_Q96LB1 |
VEuPathDBi | HostDB:ENSG00000183695.2 |
Subcellular locationi
Plasma membrane
- Cell membrane ; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 34 – 54 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 63 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 64 – 84 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 96 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 97 – 117 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 144 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 145 – 165 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 166 – 184 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 185 – 205 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 228 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 229 – 249 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 250 – 264 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 265 – 285 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 286 – 330 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 117194 |
OpenTargetsi | ENSG00000183695 |
PharmGKBi | PA142671335 |
Miscellaneous databases
Pharosi | Q96LB1, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5849 |
GuidetoPHARMACOLOGYi | 157 |
Genetic variation databases
BioMutai | MRGPRX2 |
DMDMi | 50401127 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069775 | 1 – 330 | Mas-related G-protein coupled receptor member X2Add BLAST | 330 |
Proteomic databases
PaxDbi | Q96LB1 |
PeptideAtlasi | Q96LB1 |
PRIDEi | Q96LB1 |
ProteomicsDBi | 77185 |
Expressioni
Tissue specificityi
Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007).2 Publications
Gene expression databases
Bgeei | ENSG00000183695, Expressed in lower esophagus and 33 other tissues |
Genevisiblei | Q96LB1, HS |
Organism-specific databases
HPAi | ENSG00000183695, Tissue enhanced (smooth) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000333800 |
Chemistry databases
BindingDBi | Q96LB1 |
Miscellaneous databases
RNActi | Q96LB1, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RTWA, Eukaryota |
GeneTreei | ENSGT01010000222446 |
HOGENOMi | CLU_009579_4_1_1 |
InParanoidi | Q96LB1 |
OMAi | NMSAIIC |
OrthoDBi | 1123658at2759 |
PhylomeDBi | Q96LB1 |
TreeFami | TF336336 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026234, MRGPCRFAMILY IPR027338, MRGPCRX1/MRGPCRX2 |
PANTHERi | PTHR11334, PTHR11334, 1 hit PTHR11334:SF22, PTHR11334:SF22, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96LB1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPTTPAWGT ESTTVNGNDQ ALLLLCGKET LIPVFLILFI ALVGLVGNGF
60 70 80 90 100
VLWLLGFRMR RNAFSVYVLS LAGADFLFLC FQIINCLVYL SNFFCSISIN
110 120 130 140 150
FPSFFTTVMT CAYLAGLSML STVSTERCLS VLWPIWYRCR RPRHLSAVVC
160 170 180 190 200
VLLWALSLLL SILEGKFCGF LFSDGDSGWC QTFDFITAAW LIFLFMVLCG
210 220 230 240 250
SSLALLVRIL CGSRGLPLTR LYLTILLTVL VFLLCGLPFG IQWFLILWIW
260 270 280 290 300
KDSDVLFCHI HPVSVVLSSL NSSANPIIYF FVGSFRKQWR LQQPILKLAL
310 320 330
QRALQDIAEV DHSEGCFRQG TPEMSRSSLV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024739 | 16 | N → H1 PublicationCorresponds to variant dbSNP:rs11024970Ensembl. | 1 | |
Natural variantiVAR_049418 | 43 | V → I. Corresponds to variant dbSNP:rs11823569Ensembl. | 1 | |
Natural variantiVAR_019433 | 62 | N → S2 PublicationsCorresponds to variant dbSNP:rs10833049Ensembl. | 1 | |
Natural variantiVAR_024740 | 78 | F → L1 PublicationCorresponds to variant dbSNP:rs79763999Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY042214 Genomic DNA Translation: AAK91805.1 HG426071 Genomic DNA Translation: CDG86189.1 AY651130 Genomic DNA Translation: AAW70043.1 AY651131 Genomic DNA Translation: AAW70044.1 AY651132 Genomic DNA Translation: AAW70045.1 AY651133 Genomic DNA Translation: AAW70046.1 AY651134 Genomic DNA Translation: AAW70047.1 AY651135 Genomic DNA Translation: AAW70048.1 AY651136 Genomic DNA Translation: AAW70049.1 AY651137 Genomic DNA Translation: AAW70050.1 AY651138 Genomic DNA Translation: AAW70051.1 AY651139 Genomic DNA Translation: AAW70052.1 AY651140 Genomic DNA Translation: AAW70053.1 AY651141 Genomic DNA Translation: AAW70054.1 AY651142 Genomic DNA Translation: AAW70055.1 AY651143 Genomic DNA Translation: AAW70056.1 AY651144 Genomic DNA Translation: AAW70057.1 AY651145 Genomic DNA Translation: AAW70058.1 AY651146 Genomic DNA Translation: AAW70059.1 AY651147 Genomic DNA Translation: AAW70060.1 AY651148 Genomic DNA Translation: AAW70061.1 AY651149 Genomic DNA Translation: AAW70062.1 AY651150 Genomic DNA Translation: AAW70063.1 AY651151 Genomic DNA Translation: AAW70064.1 AY651152 Genomic DNA Translation: AAW70065.1 AY651153 Genomic DNA Translation: AAW70066.1 AY651154 Genomic DNA Translation: AAW70067.1 AY651155 Genomic DNA Translation: AAW70068.1 AY651156 Genomic DNA Translation: AAW70069.1 AY651157 Genomic DNA Translation: AAW70070.1 AY651158 Genomic DNA Translation: AAW70071.1 AY651159 Genomic DNA Translation: AAW70072.1 AY651160 Genomic DNA Translation: AAW70073.1 AY651161 Genomic DNA Translation: AAW70074.1 AY845175 Genomic DNA Translation: AAW70082.1 AY845176 Genomic DNA Translation: AAW70083.1 EU883579 Genomic DNA Translation: ACG60653.1 AB083626 Genomic DNA Translation: BAB89339.1 AB065811 Genomic DNA Translation: BAC06030.1 CH471064 Genomic DNA Translation: EAW68359.1 BC063450 mRNA Translation: AAH63450.1 |
CCDSi | CCDS7847.1 |
RefSeqi | NP_001290544.1, NM_001303615.1 NP_473371.1, NM_054030.3 |
Genome annotation databases
Ensembli | ENST00000329773; ENSP00000333800; ENSG00000183695 |
GeneIDi | 117194 |
KEGGi | hsa:117194 |
UCSCi | uc001mph.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY042214 Genomic DNA Translation: AAK91805.1 HG426071 Genomic DNA Translation: CDG86189.1 AY651130 Genomic DNA Translation: AAW70043.1 AY651131 Genomic DNA Translation: AAW70044.1 AY651132 Genomic DNA Translation: AAW70045.1 AY651133 Genomic DNA Translation: AAW70046.1 AY651134 Genomic DNA Translation: AAW70047.1 AY651135 Genomic DNA Translation: AAW70048.1 AY651136 Genomic DNA Translation: AAW70049.1 AY651137 Genomic DNA Translation: AAW70050.1 AY651138 Genomic DNA Translation: AAW70051.1 AY651139 Genomic DNA Translation: AAW70052.1 AY651140 Genomic DNA Translation: AAW70053.1 AY651141 Genomic DNA Translation: AAW70054.1 AY651142 Genomic DNA Translation: AAW70055.1 AY651143 Genomic DNA Translation: AAW70056.1 AY651144 Genomic DNA Translation: AAW70057.1 AY651145 Genomic DNA Translation: AAW70058.1 AY651146 Genomic DNA Translation: AAW70059.1 AY651147 Genomic DNA Translation: AAW70060.1 AY651148 Genomic DNA Translation: AAW70061.1 AY651149 Genomic DNA Translation: AAW70062.1 AY651150 Genomic DNA Translation: AAW70063.1 AY651151 Genomic DNA Translation: AAW70064.1 AY651152 Genomic DNA Translation: AAW70065.1 AY651153 Genomic DNA Translation: AAW70066.1 AY651154 Genomic DNA Translation: AAW70067.1 AY651155 Genomic DNA Translation: AAW70068.1 AY651156 Genomic DNA Translation: AAW70069.1 AY651157 Genomic DNA Translation: AAW70070.1 AY651158 Genomic DNA Translation: AAW70071.1 AY651159 Genomic DNA Translation: AAW70072.1 AY651160 Genomic DNA Translation: AAW70073.1 AY651161 Genomic DNA Translation: AAW70074.1 AY845175 Genomic DNA Translation: AAW70082.1 AY845176 Genomic DNA Translation: AAW70083.1 EU883579 Genomic DNA Translation: ACG60653.1 AB083626 Genomic DNA Translation: BAB89339.1 AB065811 Genomic DNA Translation: BAC06030.1 CH471064 Genomic DNA Translation: EAW68359.1 BC063450 mRNA Translation: AAH63450.1 |
CCDSi | CCDS7847.1 |
RefSeqi | NP_001290544.1, NM_001303615.1 NP_473371.1, NM_054030.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000333800 |
Chemistry databases
BindingDBi | Q96LB1 |
ChEMBLi | CHEMBL5849 |
GuidetoPHARMACOLOGYi | 157 |
Protein family/group databases
GPCRDBi | Search... |
Genetic variation databases
BioMutai | MRGPRX2 |
DMDMi | 50401127 |
Proteomic databases
PaxDbi | Q96LB1 |
PeptideAtlasi | Q96LB1 |
PRIDEi | Q96LB1 |
ProteomicsDBi | 77185 |
Protocols and materials databases
Antibodypediai | 12419, 272 antibodies |
DNASUi | 117194 |
Genome annotation databases
Ensembli | ENST00000329773; ENSP00000333800; ENSG00000183695 |
GeneIDi | 117194 |
KEGGi | hsa:117194 |
UCSCi | uc001mph.4, human |
Organism-specific databases
CTDi | 117194 |
DisGeNETi | 117194 |
GeneCardsi | MRGPRX2 |
HGNCi | HGNC:17983, MRGPRX2 |
HPAi | ENSG00000183695, Tissue enhanced (smooth) |
MIMi | 607228, gene |
neXtProti | NX_Q96LB1 |
OpenTargetsi | ENSG00000183695 |
PharmGKBi | PA142671335 |
VEuPathDBi | HostDB:ENSG00000183695.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RTWA, Eukaryota |
GeneTreei | ENSGT01010000222446 |
HOGENOMi | CLU_009579_4_1_1 |
InParanoidi | Q96LB1 |
OMAi | NMSAIIC |
OrthoDBi | 1123658at2759 |
PhylomeDBi | Q96LB1 |
TreeFami | TF336336 |
Enzyme and pathway databases
PathwayCommonsi | Q96LB1 |
SIGNORi | Q96LB1 |
Miscellaneous databases
BioGRID-ORCSi | 117194, 3 hits in 874 CRISPR screens |
GeneWikii | MRGPRX2 |
GenomeRNAii | 117194 |
Pharosi | Q96LB1, Tchem |
PROi | PR:Q96LB1 |
RNActi | Q96LB1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183695, Expressed in lower esophagus and 33 other tissues |
Genevisiblei | Q96LB1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026234, MRGPCRFAMILY IPR027338, MRGPCRX1/MRGPCRX2 |
PANTHERi | PTHR11334, PTHR11334, 1 hit PTHR11334:SF22, PTHR11334:SF22, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MRGX2_HUMAN | |
Accessioni | Q96LB1Primary (citable) accession number: Q96LB1 Secondary accession number(s): B5B0C7 W8W3L5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries