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Protein

Mas-related G-protein coupled receptor member X3

Gene

MRGPRX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X3
Alternative name(s):
Sensory neuron-specific G-protein coupled receptor 1/2
Gene namesi
Name:MRGPRX3
Synonyms:MRGX3, SNSR1, SNSR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000179826.6
HGNCiHGNC:17980 MRGPRX3
MIMi607229 gene
neXtProtiNX_Q96LB0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 96ExtracellularSequence analysisAdd BLAST15
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 140CytoplasmicSequence analysisAdd BLAST23
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 177ExtracellularSequence analysisAdd BLAST16
Transmembranei178 – 198Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini199 – 213CytoplasmicSequence analysisAdd BLAST15
Transmembranei214 – 234Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini235 – 254ExtracellularSequence analysisAdd BLAST20
Transmembranei255 – 275Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini276 – 322CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi117195
OpenTargetsiENSG00000179826
PharmGKBiPA142671336

Polymorphism and mutation databases

BioMutaiMRGPRX3
DMDMi311033400

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697821 – 322Mas-related G-protein coupled receptor member X3Add BLAST322

Proteomic databases

PaxDbiQ96LB0
PRIDEiQ96LB0
ProteomicsDBi77184

Expressioni

Tissue specificityi

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.1 Publication

Gene expression databases

BgeeiENSG00000179826
CleanExiHS_MRGPRX3
ExpressionAtlasiQ96LB0 baseline and differential
GenevisibleiQ96LB0 HS

Interactioni

Protein-protein interaction databases

IntActiQ96LB0, 1 interactor
STRINGi9606.ENSP00000379571

Structurei

3D structure databases

ProteinModelPortaliQ96LB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM Eukaryota
ENOG4111AUB LUCA
GeneTreeiENSGT00550000074531
HOGENOMiHOG000015412
HOVERGENiHBG003592
InParanoidiQ96LB0
KOiK08396
OMAiRIHLDWK
OrthoDBiEOG091G0CSX
PhylomeDBiQ96LB0
TreeFamiTF336336

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR026234 MRGPCRFAMILY
PANTHERiPTHR11334 PTHR11334, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR02108 MRGPCRFAMILY
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96LB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTIPVLGT ELTPINGREE TPCYKQTLSF TGLTCIVSLV ALTGNAVVLW
60 70 80 90 100
LLGCRMRRNA VSIYILNLVA ADFLFLSGHI ICSPLRLINI RHPISKILSP
110 120 130 140 150
VMTFPYFIGL SMLSAISTER CLSILWPIWY HCRRPRYLSS VMCVLLWALS
160 170 180 190 200
LLRSILEWMF CDFLFSGANS VWCETSDFIT IAWLVFLCVV LCGSSLVLLV
210 220 230 240 250
RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGIQWALFS RIHLDWKVLF
260 270 280 290 300
CHVHLVSIFL SALNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDTPE
310 320
VDEGGGWLPQ ETLELSGSRL EQ
Length:322
Mass (Da):36,483
Last modified:November 2, 2010 - v2
Checksum:iCBDF55AF4C1EEB7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → P in AAL86878 (PubMed:11850634).Curated1
Sequence conflicti3S → P in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti5I → V in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti91R → S in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti114S → N in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti149L → P in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti172W → R in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti188C → R in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti275V → M in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti281R → L in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti285 – 286QN → KT in AAL86879 (PubMed:11850634).Curated2
Sequence conflicti294A → D in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti306G → W in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti307W → Q in AAH67292 (Ref. 5) Curated1
Sequence conflicti319R → K in AAL86878 (PubMed:11850634).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02550782C → R1 PublicationCorresponds to variant dbSNP:rs12291017Ensembl.1
Natural variantiVAR_019434169N → D5 PublicationsCorresponds to variant dbSNP:rs4274188Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042215 Genomic DNA Translation: AAK91806.1
AF474987 Genomic DNA Translation: AAL86878.2
AF474988 Genomic DNA Translation: AAL86879.2
EU432126 mRNA Translation: ABY87925.1
AC090099 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68417.1
BC067292 mRNA Translation: AAH67292.1
CCDSiCCDS7830.1
RefSeqiNP_473372.3, NM_054031.3
XP_011518184.1, XM_011519882.2
UniGeneiHs.380177

Genome annotation databases

EnsembliENST00000396275; ENSP00000379571; ENSG00000179826
ENST00000621697; ENSP00000481943; ENSG00000179826
GeneIDi117195
KEGGihsa:117195
UCSCiuc001mnu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMRGX3_HUMAN
AccessioniPrimary (citable) accession number: Q96LB0
Secondary accession number(s): B0M0L1, Q8TDE0, Q8TDE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 2, 2010
Last modified: July 18, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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