UniProtKB - Q96LA9 (MRGX4_HUMAN)
Protein
Mas-related G-protein coupled receptor member X4
Gene
MRGPRX4
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q96LA9 |
Names & Taxonomyi
Protein namesi | Recommended name: Mas-related G-protein coupled receptor member X4Alternative name(s): Sensory neuron-specific G-protein coupled receptor 5/6 |
Gene namesi | Name:MRGPRX4 Synonyms:MRGX4, SNSR5, SNSR6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000179817.4 |
HGNCi | HGNC:17617, MRGPRX4 |
MIMi | 607230, gene |
neXtProti | NX_Q96LA9 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 32 – 52 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 53 – 60 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 61 – 81 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 82 – 96 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 97 – 117 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 137 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 138 – 158 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 177 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 178 – 198 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 199 – 218 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 219 – 239 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 240 – 254 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 255 – 275 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 276 – 322 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 117196 |
OpenTargetsi | ENSG00000179817 |
PharmGKBi | PA142671337 |
Miscellaneous databases
Pharosi | Q96LA9, Tdark |
Polymorphism and mutation databases
BioMutai | MRGPRX4 |
DMDMi | 322510048 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069783 | 1 – 322 | Mas-related G-protein coupled receptor member X4Add BLAST | 322 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q96LA9 |
PeptideAtlasi | Q96LA9 |
PRIDEi | Q96LA9 |
ProteomicsDBi | 77183 |
PTM databases
GlyGeni | Q96LA9, 2 sites |
Expressioni
Tissue specificityi
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.1 Publication
Gene expression databases
Bgeei | ENSG00000179817, Expressed in middle temporal gyrus and 19 other tissues |
Genevisiblei | Q96LA9, HS |
Organism-specific databases
HPAi | ENSG00000179817, Not detected |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000314042 |
Miscellaneous databases
RNActi | Q96LA9, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RTWA, Eukaryota |
GeneTreei | ENSGT01010000222446 |
InParanoidi | Q96LA9 |
OMAi | VYLVCMS |
OrthoDBi | 1123658at2759 |
PhylomeDBi | Q96LA9 |
TreeFami | TF336336 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026234, MRGPCRFAMILY |
PANTHERi | PTHR11334, PTHR11334, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96LA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPTVPVFGT KLTPINGREE TPCYNQTLSF TVLTCIISLV GLTGNAVVLW
60 70 80 90 100
LLGYRMRRNA VSIYILNLAA ADFLFLSFQI IRLPLRLINI SHLIRKILVS
110 120 130 140 150
VMTFPYFTGL SMLSAISTER CLSVLWPIWY RCRRPTHLSA VVCVLLWGLS
160 170 180 190 200
LLFSMLEWRF CDFLFSGADS SWCETSDFIP VAWLIFLCVV LCVSSLVLLV
210 220 230 240 250
RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGILGALIY RMHLNLEVLY
260 270 280 290 300
CHVYLVCMSL SSLNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDKPE
310 320
VDKGEGQLPE ESLELSGSRL GP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 318 | S → R in AAL86882 (PubMed:11850634).Curated | 1 | |
Sequence conflicti | 319 | R → K in AAL86883 (PubMed:11850634).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019435 | 8 | F → L1 PublicationCorresponds to variant dbSNP:rs2468774Ensembl. | 1 | |
Natural variantiVAR_019436 | 25 | N → K1 PublicationCorresponds to variant dbSNP:rs2445180Ensembl. | 1 | |
Natural variantiVAR_019437 | 54 | Y → C1 PublicationCorresponds to variant dbSNP:rs1869788Ensembl. | 1 | |
Natural variantiVAR_019438 | 83 | L → S3 PublicationsCorresponds to variant dbSNP:rs2445179Ensembl. | 1 | |
Natural variantiVAR_025506 | 182 | A → V2 PublicationsCorresponds to variant dbSNP:rs11024532Ensembl. | 1 | |
Natural variantiVAR_049419 | 245 | N → S. Corresponds to variant dbSNP:rs7102322Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY042216 Genomic DNA Translation: AAK91807.1 AF474991 Genomic DNA Translation: AAL86882.1 AF474992 Genomic DNA Translation: AAL86883.1 AC090099 Genomic DNA No translation available. BC095509 mRNA Translation: AAH95509.1 BC107099 mRNA Translation: AAI07100.1 BC107100 mRNA Translation: AAI07101.1 |
CCDSi | CCDS7831.1 |
RefSeqi | NP_473373.2, NM_054032.3 |
Genome annotation databases
Ensembli | ENST00000314254; ENSP00000314042; ENSG00000179817 |
GeneIDi | 117196 |
KEGGi | hsa:117196 |
UCSCi | uc001mnv.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY042216 Genomic DNA Translation: AAK91807.1 AF474991 Genomic DNA Translation: AAL86882.1 AF474992 Genomic DNA Translation: AAL86883.1 AC090099 Genomic DNA No translation available. BC095509 mRNA Translation: AAH95509.1 BC107099 mRNA Translation: AAI07100.1 BC107100 mRNA Translation: AAI07101.1 |
CCDSi | CCDS7831.1 |
RefSeqi | NP_473373.2, NM_054032.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000314042 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q96LA9, 2 sites |
Polymorphism and mutation databases
BioMutai | MRGPRX4 |
DMDMi | 322510048 |
Proteomic databases
PaxDbi | Q96LA9 |
PeptideAtlasi | Q96LA9 |
PRIDEi | Q96LA9 |
ProteomicsDBi | 77183 |
Protocols and materials databases
Antibodypediai | 24983, 113 antibodies |
Genome annotation databases
Ensembli | ENST00000314254; ENSP00000314042; ENSG00000179817 |
GeneIDi | 117196 |
KEGGi | hsa:117196 |
UCSCi | uc001mnv.1, human |
Organism-specific databases
CTDi | 117196 |
DisGeNETi | 117196 |
EuPathDBi | HostDB:ENSG00000179817.4 |
GeneCardsi | MRGPRX4 |
HGNCi | HGNC:17617, MRGPRX4 |
HPAi | ENSG00000179817, Not detected |
MIMi | 607230, gene |
neXtProti | NX_Q96LA9 |
OpenTargetsi | ENSG00000179817 |
PharmGKBi | PA142671337 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RTWA, Eukaryota |
GeneTreei | ENSGT01010000222446 |
InParanoidi | Q96LA9 |
OMAi | VYLVCMS |
OrthoDBi | 1123658at2759 |
PhylomeDBi | Q96LA9 |
TreeFami | TF336336 |
Enzyme and pathway databases
PathwayCommonsi | Q96LA9 |
Miscellaneous databases
BioGRID-ORCSi | 117196, 3 hits in 815 CRISPR screens |
ChiTaRSi | MRGPRX4, human |
GeneWikii | MRGPRX4 |
GenomeRNAii | 117196 |
Pharosi | Q96LA9, Tdark |
PROi | PR:Q96LA9 |
RNActi | Q96LA9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179817, Expressed in middle temporal gyrus and 19 other tissues |
Genevisiblei | Q96LA9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026234, MRGPCRFAMILY |
PANTHERi | PTHR11334, PTHR11334, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MRGX4_HUMAN | |
Accessioni | Q96LA9Primary (citable) accession number: Q96LA9 Secondary accession number(s): Q3KNU3 Q8TDD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries