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UniProtKB - Q96LA9 (MRGX4_HUMAN)

Entry version 125 (13 Feb 2019)
Sequence version 2 (08 Feb 2011)
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Protein

Mas-related G-protein coupled receptor member X4

Gene

MRGPRX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X4
Alternative name(s):
Sensory neuron-specific G-protein coupled receptor 5/6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRGPRX4
Synonyms:MRGX4, SNSR5, SNSR6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000179817.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:17617 MRGPRX4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607230 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96LA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 96ExtracellularSequence analysisAdd BLAST15
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 137CytoplasmicSequence analysisAdd BLAST20
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 177ExtracellularSequence analysisAdd BLAST19
Transmembranei178 – 198Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini199 – 218CytoplasmicSequence analysisAdd BLAST20
Transmembranei219 – 239Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini240 – 254ExtracellularSequence analysisAdd BLAST15
Transmembranei255 – 275Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini276 – 322CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		117196

Open Targets

More...OpenTargetsi		ENSG00000179817

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671337

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MRGPRX4

Domain mapping of disease mutations (DMDM)

More...DMDMi		322510048

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000697831 – 322Mas-related G-protein coupled receptor member X4Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96LA9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96LA9

PeptideAtlas

More...PeptideAtlasi		Q96LA9

PRoteomics IDEntifications database

More...PRIDEi		Q96LA9

ProteomicsDB human proteome resource

More...ProteomicsDBi		77183

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000179817 Expressed in 17 organ(s), highest expression level in middle temporal gyrus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96LA9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000314042

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q96LA9

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J9NM Eukaryota
ENOG4111AUB LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153553

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000015412

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG003592

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96LA9

KEGG Orthology (KO)

More...KOi		K08396

Identification of Orthologs from Complete Genome Data

More...OMAi		VYLVCMS

Database of Orthologous Groups

More...OrthoDBi		1123658at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96LA9

TreeFam database of animal gene trees

More...TreeFami		TF336336

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR026234 MRGPCRFAMILY

The PANTHER Classification System

More...PANTHERi		PTHR11334 PTHR11334, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237 GPCRRHODOPSN
PR02108 MRGPCRFAMILY

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96LA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPTVPVFGT KLTPINGREE TPCYNQTLSF TVLTCIISLV GLTGNAVVLW 
        60         70         80         90        100
LLGYRMRRNA VSIYILNLAA ADFLFLSFQI IRLPLRLINI SHLIRKILVS 
       110        120        130        140        150
VMTFPYFTGL SMLSAISTER CLSVLWPIWY RCRRPTHLSA VVCVLLWGLS 
       160        170        180        190        200
LLFSMLEWRF CDFLFSGADS SWCETSDFIP VAWLIFLCVV LCVSSLVLLV 
       210        220        230        240        250
RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGILGALIY RMHLNLEVLY 
       260        270        280        290        300
CHVYLVCMSL SSLNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDKPE 
       310        320 
VDKGEGQLPE ESLELSGSRL GP
Length:322
Mass (Da):36,461
Last modified:February 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0D7B1ECD08FD15A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti318S → R in AAL86882 (PubMed:11850634).Curated1
Sequence conflicti319R → K in AAL86883 (PubMed:11850634).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0194358F → L1 PublicationCorresponds to variant dbSNP:rs2468774Ensembl.1
Natural variantiVAR_01943625N → K1 PublicationCorresponds to variant dbSNP:rs2445180Ensembl.1
Natural variantiVAR_01943754Y → C1 PublicationCorresponds to variant dbSNP:rs1869788Ensembl.1
Natural variantiVAR_01943883L → S3 PublicationsCorresponds to variant dbSNP:rs2445179Ensembl.1
Natural variantiVAR_025506182A → V2 PublicationsCorresponds to variant dbSNP:rs11024532Ensembl.1
Natural variantiVAR_049419245N → S. Corresponds to variant dbSNP:rs7102322Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY042216 Genomic DNA Translation: AAK91807.1
AF474991 Genomic DNA Translation: AAL86882.1
AF474992 Genomic DNA Translation: AAL86883.1
AC090099 Genomic DNA No translation available.
BC095509 mRNA Translation: AAH95509.1
BC107099 mRNA Translation: AAI07100.1
BC107100 mRNA Translation: AAI07101.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7831.1

NCBI Reference Sequences

More...RefSeqi		NP_473373.2, NM_054032.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.632138

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000314254; ENSP00000314042; ENSG00000179817

Database of genes from NCBI RefSeq genomes

More...GeneIDi		117196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:117196

UCSC genome browser

More...UCSCi		uc001mnv.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042216 Genomic DNA Translation: AAK91807.1
AF474991 Genomic DNA Translation: AAL86882.1
AF474992 Genomic DNA Translation: AAL86883.1
AC090099 Genomic DNA No translation available.
BC095509 mRNA Translation: AAH95509.1
BC107099 mRNA Translation: AAI07100.1
BC107100 mRNA Translation: AAI07101.1
CCDSiCCDS7831.1
RefSeqiNP_473373.2, NM_054032.3
UniGeneiHs.632138

3D structure databases

ProteinModelPortaliQ96LA9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000314042

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

Polymorphism and mutation databases

BioMutaiMRGPRX4
DMDMi322510048

Proteomic databases

jPOSTiQ96LA9
PaxDbiQ96LA9
PeptideAtlasiQ96LA9
PRIDEiQ96LA9
ProteomicsDBi77183

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314254; ENSP00000314042; ENSG00000179817
GeneIDi117196
KEGGihsa:117196
UCSCiuc001mnv.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		117196
DisGeNETi117196
EuPathDBiHostDB:ENSG00000179817.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		MRGPRX4

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0036111
HGNCiHGNC:17617 MRGPRX4
MIMi607230 gene
neXtProtiNX_Q96LA9
OpenTargetsiENSG00000179817
PharmGKBiPA142671337

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J9NM Eukaryota
ENOG4111AUB LUCA
GeneTreeiENSGT00940000153553
HOGENOMiHOG000015412
HOVERGENiHBG003592
InParanoidiQ96LA9
KOiK08396
OMAiVYLVCMS
OrthoDBi1123658at2759
PhylomeDBiQ96LA9
TreeFamiTF336336

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MRGPRX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		117196

Protein Ontology

More...PROi		PR:Q96LA9

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000179817 Expressed in 17 organ(s), highest expression level in middle temporal gyrus
GenevisibleiQ96LA9 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR026234 MRGPCRFAMILY
PANTHERiPTHR11334 PTHR11334, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR02108 MRGPCRFAMILY
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRGX4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LA9
Secondary accession number(s): Q3KNU3
, Q3KNU4, Q502W0, Q8TDD6, Q8TDD7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: February 8, 2011
Last modified: February 13, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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