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UniProtKB - Q96LA8 (ANM6_HUMAN)

Entry version 184 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Protein arginine N-methyltransferase 6

Gene

PRMT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520).

Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910).

Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460).

H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460).

Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293).

Repression of TP53 blocks cellular senescence (By similarity).

Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869).

Methylates HMGA1 (PubMed:16157300, PubMed:16159886).

Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity).

May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505).

Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity).

Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520).

By similarity12 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18.6 µM for AdoMet1 Publication
  2. KM=501 µM for WGGYSRGGYGGW peptide1 Publication
  3. KM=183.7 µM for WGGYSR(MMA)GGYGGW monomethylated peptide1 Publication
  1. Vmax=3.3 nmol/min/mg enzyme with AdoMet as substrate1 Publication
  2. Vmax=1.8 nmol/min/mg enzyme with WGGYSRGGYGGW peptide as substrate1 Publication
  3. Vmax=3.2 nmol/min/mg enzyme with WGGYSR(MMA)GGYGGW monomethylated peptide as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei57S-adenosyl-L-methionineBy similarity1
Binding sitei66S-adenosyl-L-methionine1
Binding sitei90S-adenosyl-L-methionine; via carbonyl oxygen1
Binding sitei112S-adenosyl-L-methionine1
Binding sitei141S-adenosyl-L-methionine1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei155By similarity1
Active sitei164By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processDNA damage, DNA repair, Host-virus interaction, Transcription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.319, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96LA8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214858, RMTs methylate histone arginines
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q96LA8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96LA8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein arginine N-methyltransferase 6 (EC:2.1.1.3195 Publications)
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
Histone-arginine N-methyltransferase PRMT6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRMT6
Synonyms:HRMT1L6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18241, PRMT6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608274, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96LA8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198890

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35R → A: Inhibits automethylation but does not affect methylation of other proteins. Reduces protein stability. 1 Publication1
Mutagenesisi86 – 88VLD → KLA in PRMT6dn; abolishes histone methyltransferase H3R2me2a and transcriptional coactivator activities and reduces protein stability. This mutation abolishes automethylation. 4 Publications3

Organism-specific databases

DisGeNET

More...DisGeNETi		55170

Open Targets

More...OpenTargetsi		ENSG00000198890

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134992775

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96LA8, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1275221

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1257

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRMT6

Domain mapping of disease mutations (DMDM)

More...DMDMi		20137409

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002123321 – 375Protein arginine N-methyltransferase 6Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphothreonineCombined sources1
Modified residuei29Asymmetric dimethylarginine; by autocatalysis1 Publication1
Modified residuei35Asymmetric dimethylarginine; by autocatalysis1 Publication1
Modified residuei37Asymmetric dimethylarginine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Automethylation enhances its stability and antiretroviral activity.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96LA8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96LA8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96LA8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96LA8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96LA8

PeptideAtlas

More...PeptideAtlasi		Q96LA8

PRoteomics IDEntifications database

More...PRIDEi		Q96LA8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77181 [Q96LA8-1]
77182 [Q96LA8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96LA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96LA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198890, Expressed in metanephros and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96LA8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96LA8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198890, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EPB41L3 and NCOA1.

6 Publications

(Microbial infection) Interacts with (and methylates) HIV-1 Tat, Rev and Nucleocapsid protein p7 (NC).

4 Publications

(Microbial infection) Interacts with human cytomegalovirus protein UL69.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120469, 164 interactors

Protein interaction database and analysis system

More...IntActi		Q96LA8, 105 interactors

Molecular INTeraction database

More...MINTi		Q96LA8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359095

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q96LA8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96LA8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96LA8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96LA8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 374SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST331

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1499, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017375_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96LA8

Identification of Orthologs from Complete Genome Data

More...OMAi		SARHICI

Database of Orthologous Groups

More...OrthoDBi		840669at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96LA8

TreeFam database of animal gene trees

More...TreeFami		TF328817

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025799, Arg_MeTrfase
IPR041698, Methyltransf_25
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR11006, PTHR11006, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13649, Methyltransf_25, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51678, SAM_MT_PRMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96LA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQPKKRKLE SGGGGEGGEG TEEEDGAERE AALERPRRTK RERDQLYYEC 
        60         70         80         90        100
YSDVSVHEEM IADRVRTDAY RLGILRNWAA LRGKTVLDVG AGTGILSIFC 
       110        120        130        140        150
AQAGARRVYA VEASAIWQQA REVVRFNGLE DRVHVLPGPV ETVELPEQVD 
       160        170        180        190        200
AIVSEWMGYG LLHESMLSSV LHARTKWLKE GGLLLPASAE LFIAPISDQM 
       210        220        230        240        250
LEWRLGFWSQ VKQHYGVDMS CLEGFATRCL MGHSEIVVQG LSGEDVLARP 
       260        270        280        290        300
QRFAQLELSR AGLEQELEAG VGGRFRCSCY GSAPMHGFAI WFQVTFPGGE 
       310        320        330        340        350
SEKPLVLSTS PFHPATHWKQ ALLYLNEPVQ VEQDTDVSGE ITLLPSRDNP 
       360        370 
RRLRVLLRYK VGDQEEKTKD FAMED
Length:375
Mass (Da):41,938
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40AAEC7342C08A38
GO
Isoform 2 (identifier: Q96LA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-109: GAEREAALER...CAQAGARRVY → D

Show »
Length:292
Mass (Da):32,509
Checksum:i9E6341283024795C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITK4A0A3B3ITK4_HUMAN
Protein arginine N-methyltransferas...
PRMT6
313Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02729 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH63446 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA91681 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057150194A → V1 PublicationCorresponds to variant dbSNP:rs2232016Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03746526 – 109GAERE…ARRVY → D in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY043278 mRNA Translation: AAK85733.1
AK001421 mRNA Translation: BAA91681.1 Different initiation.
AK295541 mRNA Translation: BAG58450.1
AL355539 Genomic DNA No translation available.
CH471156 Genomic DNA Translation: EAW51248.1
BC002729 mRNA Translation: AAH02729.3 Different initiation.
BC063446 mRNA Translation: AAH63446.2 Different initiation.
BC073866 mRNA Translation: AAH73866.1
BX475300 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41360.2 [Q96LA8-1]

NCBI Reference Sequences

More...RefSeqi		NP_060607.2, NM_018137.2 [Q96LA8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370078.2; ENSP00000359095.1; ENSG00000198890.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55170

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000370078.2; ENSP00000359095.1; NM_018137.3; NP_060607.2

UCSC genome browser

More...UCSCi		uc010ous.4, human [Q96LA8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043278 mRNA Translation: AAK85733.1
AK001421 mRNA Translation: BAA91681.1 Different initiation.
AK295541 mRNA Translation: BAG58450.1
AL355539 Genomic DNA No translation available.
CH471156 Genomic DNA Translation: EAW51248.1
BC002729 mRNA Translation: AAH02729.3 Different initiation.
BC063446 mRNA Translation: AAH63446.2 Different initiation.
BC073866 mRNA Translation: AAH73866.1
BX475300 mRNA No translation available.
CCDSiCCDS41360.2 [Q96LA8-1]
RefSeqiNP_060607.2, NM_018137.2 [Q96LA8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HC4X-ray1.97A1-375[»]
4QPPX-ray2.52A/B/C1-375[»]
4QQKX-ray1.88A1-375[»]
4Y2HX-ray2.37A/B27-375[»]
4Y30X-ray2.10A/B25-375[»]
5E8RX-ray2.55A/B1-375[»]
5EGSX-ray2.15A/B/C/D1-375[»]
5HZMX-ray2.02A1-375[»]
5WCFX-ray1.98A1-375[»]
6P7IX-ray2.00A/B/C/D1-375[»]
6W6DX-ray1.91A1-375[»]
6WADX-ray2.45A1-375[»]
7NR4X-ray2.03A/B/C/D1-375[»]
AlphaFoldDBiQ96LA8
SMRiQ96LA8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120469, 164 interactors
IntActiQ96LA8, 105 interactors
MINTiQ96LA8
STRINGi9606.ENSP00000359095

Chemistry databases

BindingDBiQ96LA8
ChEMBLiCHEMBL1275221
GuidetoPHARMACOLOGYi1257

PTM databases

iPTMnetiQ96LA8
PhosphoSitePlusiQ96LA8

Genetic variation databases

BioMutaiPRMT6
DMDMi20137409

Proteomic databases

EPDiQ96LA8
jPOSTiQ96LA8
MassIVEiQ96LA8
MaxQBiQ96LA8
PaxDbiQ96LA8
PeptideAtlasiQ96LA8
PRIDEiQ96LA8
ProteomicsDBi77181 [Q96LA8-1]
77182 [Q96LA8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		21010, 417 antibodies from 42 providers

The DNASU plasmid repository

More...DNASUi		55170

Genome annotation databases

EnsembliENST00000370078.2; ENSP00000359095.1; ENSG00000198890.9
GeneIDi55170
KEGGihsa:55170
MANE-SelectiENST00000370078.2; ENSP00000359095.1; NM_018137.3; NP_060607.2
UCSCiuc010ous.4, human [Q96LA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55170
DisGeNETi55170

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRMT6
HGNCiHGNC:18241, PRMT6
HPAiENSG00000198890, Low tissue specificity
MIMi608274, gene
neXtProtiNX_Q96LA8
OpenTargetsiENSG00000198890
PharmGKBiPA134992775
VEuPathDBiHostDB:ENSG00000198890

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1499, Eukaryota
GeneTreeiENSGT00940000160961
HOGENOMiCLU_017375_1_2_1
InParanoidiQ96LA8
OMAiSARHICI
OrthoDBi840669at2759
PhylomeDBiQ96LA8
TreeFamiTF328817

Enzyme and pathway databases

BRENDAi2.1.1.319, 2681
PathwayCommonsiQ96LA8
ReactomeiR-HSA-3214858, RMTs methylate histone arginines
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
SABIO-RKiQ96LA8
SignaLinkiQ96LA8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55170, 16 hits in 1084 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRMT6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRMT6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55170
PharosiQ96LA8, Tchem

Protein Ontology

More...PROi		PR:Q96LA8
RNActiQ96LA8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198890, Expressed in metanephros and 206 other tissues
ExpressionAtlasiQ96LA8, baseline and differential
GenevisibleiQ96LA8, HS

Family and domain databases

Gene3Di3.40.50.150, 1 hit
InterProiView protein in InterPro
IPR025799, Arg_MeTrfase
IPR041698, Methyltransf_25
IPR029063, SAM-dependent_MTases
PANTHERiPTHR11006, PTHR11006, 1 hit
PfamiView protein in Pfam
PF13649, Methyltransf_25, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51678, SAM_MT_PRMT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANM6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96LA8
Secondary accession number(s): A3KME1
, B4DID8, Q5T5Y5, Q6DKI4, Q9NVR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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