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Protein

Fc receptor-like protein 2

Gene

FCRL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have an regulatory role in normal and neoplastic B cell development.1 Publication

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: UniProtKB

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 2
Short name:
FcR-like protein 2
Short name:
FcRL2
Alternative name(s):
Fc receptor homolog 2
Short name:
FcRH2
IFGP family protein 4
Immunoglobulin receptor translocation-associated protein 4
SH2 domain-containing phosphatase anchor protein 1
CD_antigen: CD307b
Gene namesi
Name:FCRL2
Synonyms:FCRH2, IFGP4, IRTA4, SPAP1
ORF Names:UNQ9236/PRO31998
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132704.15
HGNCiHGNC:14875 FCRL2
MIMi606509 gene
neXtProtiNX_Q96LA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 401ExtracellularSequence analysisAdd BLAST382
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 508CytoplasmicSequence analysisAdd BLAST86

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79368
OpenTargetsiENSG00000132704
PharmGKBiPA37913

Polymorphism and mutation databases

BioMutaiFCRL2
DMDMi68052374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001476120 – 508Fc receptor-like protein 2Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi128 ↔ 177PROSITE-ProRule annotation
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi226 ↔ 275PROSITE-ProRule annotation
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi321 ↔ 368PROSITE-ProRule annotation
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Isoform 2 is N- and O-glycosylated, and phosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96LA5
PeptideAtlasiQ96LA5
PRIDEiQ96LA5
ProteomicsDBi77172
77173 [Q96LA5-2]
77174 [Q96LA5-3]
77175 [Q96LA5-4]
77176 [Q96LA5-5]
TopDownProteomicsiQ96LA5-1 [Q96LA5-1]

PTM databases

iPTMnetiQ96LA5
PhosphoSitePlusiQ96LA5

Expressioni

Tissue specificityi

Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).4 Publications

Gene expression databases

BgeeiENSG00000132704 Expressed in 81 organ(s), highest expression level in spleen
CleanExiHS_FCRL2
GenevisibleiQ96LA5 HS

Interactioni

Subunit structurei

The tyrosine-phosphorylated isoform 2 interacts with PTPN6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK2O436393EBI-10185081,EBI-713635

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122656, 2 interactors
IntActiQ96LA5, 4 interactors
STRINGi9606.ENSP00000355157

Structurei

3D structure databases

ProteinModelPortaliQ96LA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 98Ig-like C2-type 1Add BLAST79
Domaini109 – 187Ig-like C2-type 2Add BLAST79
Domaini201 – 290Ig-like C2-type 3Add BLAST90
Domaini300 – 387Ig-like C2-type 4Add BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi446 – 451ITIM motif 16
Motifi460 – 465ITIM motif 26
Motifi472 – 477ITIM motif 36
Motifi500 – 505ITIM motif 46

Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5T Eukaryota
ENOG410YF57 LUCA
GeneTreeiENSGT00760000119130
HOVERGENiHBG074073
InParanoidiQ96LA5
KOiK06727
OMAiTHRIRKQ
OrthoDBiEOG091G03OP
PhylomeDBiQ96LA5
TreeFamiTF351107

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 3 hits
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96LA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLWSLLVIF DAVTEQADSL TLVAPSSVFE GDSIVLKCQG EQNWKIQKMA
60 70 80 90 100
YHKDNKELSV FKKFSDFLIQ SAVLSDSGNY FCSTKGQLFL WDKTSNIVKI
110 120 130 140 150
KVQELFQRPV LTASSFQPIE GGPVSLKCET RLSPQRLDVQ LQFCFFRENQ
160 170 180 190 200
VLGSGWSSSP ELQISAVWSE DTGSYWCKAE TVTHRIRKQS LQSQIHVQRI
210 220 230 240 250
PISNVSLEIR APGGQVTEGQ KLILLCSVAG GTGNVTFSWY REATGTSMGK
260 270 280 290 300
KTQRSLSAEL EIPAVKESDA GKYYCRADNG HVPIQSKVVN IPVRIPVSRP
310 320 330 340 350
VLTLRSPGAQ AAVGDLLELH CEALRGSPPI LYQFYHEDVT LGNSSAPSGG
360 370 380 390 400
GASFNLSLTA EHSGNYSCEA NNGLGAQCSE AVPVSISGPD GYRRDLMTAG
410 420 430 440 450
VLWGLFGVLG FTGVALLLYA LFHKISGESS ATNEPRGASR PNPQEFTYSS
460 470 480 490 500
PTPDMEELQP VYVNVGSVDV DVVYSQVWSM QQPESSANIR TLLENKDSQV

IYSSVKKS
Length:508
Mass (Da):55,542
Last modified:December 1, 2001 - v1
Checksum:i9AB30E0411B41EDC
GO
Isoform 2 (identifier: Q96LA5-2) [UniParc]FASTAAdd to basket
Also known as: SPAP1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.
     254-295: RSLSAELEIP...SKVVNIPVRI → MWEWKICNSH...FLIAPLCLSV

Show »
Length:255
Mass (Da):27,546
Checksum:i826E6447FB6BAB14
GO
Isoform 3 (identifier: Q96LA5-3) [UniParc]FASTAAdd to basket
Also known as: SPAP1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.
     254-295: RSLSAELEIP...SKVVNIPVRI → MWEWKICNSH...FLIAPLCLSV
     428-445: ESSATNEPRGASRPNPQE → CIYHLDSPYFAMTFPLLI
     446-508: Missing.

Show »
Length:192
Mass (Da):20,680
Checksum:iC9962BBB4B15B08D
GO
Isoform 4 (identifier: Q96LA5-4) [UniParc]FASTAAdd to basket
Also known as: SPAP1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.
     254-295: RSLSAELEIP...SKVVNIPVRI → MWEWKICNSH...FLIAPLCLSV
     389-397: PDGYRRDLM → GWVLPGYRV
     398-508: Missing.

Show »
Length:144
Mass (Da):15,373
Checksum:iD03F859338237CA5
GO
Isoform 5 (identifier: Q96LA5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-387: Missing.
     465-486: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,533
Checksum:i9D6C578B6E136E6E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049873202I → N. Corresponds to variant dbSNP:rs16839100Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0141111 – 253Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST253
Alternative sequenceiVSP_014113104 – 387Missing in isoform 5. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_014112254 – 295RSLSA…IPVRI → MWEWKICNSHGARPFAEPAG WEFVNLLRHHKSFLIAPLCL SV in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST42
Alternative sequenceiVSP_014114389 – 397PDGYRRDLM → GWVLPGYRV in isoform 4. 1 Publication9
Alternative sequenceiVSP_014115398 – 508Missing in isoform 4. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_014116428 – 445ESSAT…PNPQE → CIYHLDSPYFAMTFPLLI in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_014117446 – 508Missing in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_014118465 – 486Missing in isoform 5. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043465 mRNA Translation: AAK91778.1
AF319438 mRNA Translation: AAK01402.1
AF319439 mRNA Translation: AAK01403.1
AF319440 mRNA Translation: AAK01404.1
AF459633 mRNA Translation: AAL60249.1
AF390037 mRNA Translation: AAM12152.1
EF064733 Genomic DNA Translation: ABK41916.1
AY358130 mRNA Translation: AAQ88497.1
AL356276 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52864.1
CH471121 Genomic DNA Translation: EAW52867.1
CH471121 Genomic DNA Translation: EAW52869.1
BC069185 mRNA Translation: AAH69185.1
BC129836 mRNA Translation: AAI29837.1
CCDSiCCDS1168.1 [Q96LA5-1]
PIRiJC7593
RefSeqiNP_001152960.1, NM_001159488.1
NP_110391.2, NM_030764.3 [Q96LA5-1]
UniGeneiHs.437393

Genome annotation databases

EnsembliENST00000361516; ENSP00000355157; ENSG00000132704 [Q96LA5-1]
ENST00000368181; ENSP00000357163; ENSG00000132704 [Q96LA5-5]
ENST00000469986; ENSP00000417393; ENSG00000132704 [Q96LA5-3]
GeneIDi79368
KEGGihsa:79368
UCSCiuc001fre.3 human [Q96LA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043465 mRNA Translation: AAK91778.1
AF319438 mRNA Translation: AAK01402.1
AF319439 mRNA Translation: AAK01403.1
AF319440 mRNA Translation: AAK01404.1
AF459633 mRNA Translation: AAL60249.1
AF390037 mRNA Translation: AAM12152.1
EF064733 Genomic DNA Translation: ABK41916.1
AY358130 mRNA Translation: AAQ88497.1
AL356276 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52864.1
CH471121 Genomic DNA Translation: EAW52867.1
CH471121 Genomic DNA Translation: EAW52869.1
BC069185 mRNA Translation: AAH69185.1
BC129836 mRNA Translation: AAI29837.1
CCDSiCCDS1168.1 [Q96LA5-1]
PIRiJC7593
RefSeqiNP_001152960.1, NM_001159488.1
NP_110391.2, NM_030764.3 [Q96LA5-1]
UniGeneiHs.437393

3D structure databases

ProteinModelPortaliQ96LA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122656, 2 interactors
IntActiQ96LA5, 4 interactors
STRINGi9606.ENSP00000355157

PTM databases

iPTMnetiQ96LA5
PhosphoSitePlusiQ96LA5

Polymorphism and mutation databases

BioMutaiFCRL2
DMDMi68052374

Proteomic databases

PaxDbiQ96LA5
PeptideAtlasiQ96LA5
PRIDEiQ96LA5
ProteomicsDBi77172
77173 [Q96LA5-2]
77174 [Q96LA5-3]
77175 [Q96LA5-4]
77176 [Q96LA5-5]
TopDownProteomicsiQ96LA5-1 [Q96LA5-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361516; ENSP00000355157; ENSG00000132704 [Q96LA5-1]
ENST00000368181; ENSP00000357163; ENSG00000132704 [Q96LA5-5]
ENST00000469986; ENSP00000417393; ENSG00000132704 [Q96LA5-3]
GeneIDi79368
KEGGihsa:79368
UCSCiuc001fre.3 human [Q96LA5-1]

Organism-specific databases

CTDi79368
DisGeNETi79368
EuPathDBiHostDB:ENSG00000132704.15
GeneCardsiFCRL2
HGNCiHGNC:14875 FCRL2
MIMi606509 gene
neXtProtiNX_Q96LA5
OpenTargetsiENSG00000132704
PharmGKBiPA37913
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5T Eukaryota
ENOG410YF57 LUCA
GeneTreeiENSGT00760000119130
HOVERGENiHBG074073
InParanoidiQ96LA5
KOiK06727
OMAiTHRIRKQ
OrthoDBiEOG091G03OP
PhylomeDBiQ96LA5
TreeFamiTF351107

Miscellaneous databases

ChiTaRSiFCRL2 human
GeneWikiiFCRL2
GenomeRNAii79368
PROiPR:Q96LA5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132704 Expressed in 81 organ(s), highest expression level in spleen
CleanExiHS_FCRL2
GenevisibleiQ96LA5 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 3 hits
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCRL2_HUMAN
AccessioniPrimary (citable) accession number: Q96LA5
Secondary accession number(s): A0N0M5
, A1L307, A6NMS0, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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