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UniProtKB - Q96L96 (ALPK3_HUMAN)

Entry version 133 (17 Jun 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Alpha-protein kinase 3

Gene

ALPK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cardiomyocyte differentiation.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-protein kinase 3Curated (EC:2.7.11.1By similarity)
Alternative name(s):
Muscle alpha-protein kinase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALPK3Imported
Synonyms:KIAA13301 Publication, MAK1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000136383.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:17574 ALPK3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617608 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96L96

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, familial hypertrophic 27 (CMH27)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hypertrophic cardiomyopathy, a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH27 is a severe, early-onset form with features of hypertrophic and dilated cardiomyopathy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0791421261 – 1907Missing in CMH27. 1 PublicationAdd BLAST647
Natural variantiVAR_0791431264 – 1907Missing in CMH27. 1 PublicationAdd BLAST644
Natural variantiVAR_0791441765 – 1907Missing in CMH27. 1 PublicationAdd BLAST143

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		57538

MalaCards human disease database

More...MalaCardsi		ALPK3
MIMi618052 phenotype

Open Targets

More...OpenTargetsi		ENSG00000136383

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134921552

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96L96 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ALPK3

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002600311 – 1907Alpha-protein kinase 3Add BLAST1907

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei430PhosphoserineBy similarity1
Modified residuei1424PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1498 ↔ 1548PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96L96

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96L96

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96L96

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96L96

PeptideAtlas

More...PeptideAtlasi		Q96L96

PRoteomics IDEntifications database

More...PRIDEi		Q96L96

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77171

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96L96

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96L96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136383 Expressed in gastrocnemius and 134 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96L96 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136383 Tissue enhanced (heart muscle, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q96L96, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000258888

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96L96 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini279 – 370Ig-like 1Add BLAST92
Domaini1476 – 1564Ig-like 2Add BLAST89
Domaini1592 – 1827Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST236

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi170 – 175Poly-Ala6
Compositional biasi517 – 521Poly-Lys5
Compositional biasi766 – 771Poly-Ser6
Compositional biasi1166 – 1172Poly-Leu7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IHFU Eukaryota
ENOG410Y8B3 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158534

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003270_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96L96

KEGG Orthology (KO)

More...KOi		K08868

Identification of Orthologs from Complete Genome Data

More...OMAi		MGNGGEN

Database of Orthologous Groups

More...OrthoDBi		32441at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96L96

TreeFam database of animal gene trees

More...TreeFami		TF332629

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF07679 I-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00811 Alpha_kinase, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit
PS50835 IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96L96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVAWLVYVL GQQPLARQGE GQSRLVPGRG LVLWLPGLPR SSPSWPAVDL 
        60         70         80         90        100
APLAPARPRG PLICHTGHEQ AGREPGPGSS TKGPVLHDQD TRCAFLPRPP 
       110        120        130        140        150
GPLQTRRYCR HQGRQGSGLG AGPGAGTWAP APPGVSKPRC PGRARPGEGQ 
       160        170        180        190        200
QQVTTARPPA INRGARQPRA GAAAAGRGPG AGAWRTGEAA ASAGPAVGEG 
       210        220        230        240        250
GAMGSRRAPS RGWGAGGRSG AGGDGEDDGP VWIPSPASRS YLLSVRPETS 
       260        270        280        290        300
LSSNRLSHPS SGRSTFCSII AQLTEETQPL FETTLKSRSV SEDSDVRFTC 
       310        320        330        340        350
IVTGYPEPEV TWYKDDTELD RYCGLPKYEI THQGNRHTLQ LYRCREEDAA 
       360        370        380        390        400
IYQASAQNSK GIVSCSGVLE VGTMTEYKIH QRWFAKLKRK AAAKLREIEQ 
       410        420        430        440        450
SWKHEKAVPG EVDTLRKLSP DRFQRKRRLS GAQAPGPSVP TREPEGGTLA 
       460        470        480        490        500
AWQEGETETA QHSGLGLINS FASGEVTTNG EAAPENGEDG EHGLLTYICD 
       510        520        530        540        550
AMELGPQRAL KEESGAKKKK KDEESKQGLR KPELEKAAQS RRSSENCIPS 
       560        570        580        590        600
SDEPDSCGTQ GPVGVEQVQT QPRGRAARGP GSSGTDSTRK PASAVGTPDK 
       610        620        630        640        650
AQKAPGPGPG QEVYFSLKDM YLENTQAVRP LGEEGPQTLS VRAPGESPKG 
       660        670        680        690        700
KAPLRARSEG VPGAPGQPTH SLTPQPTRPF NRKRFAPPKP KGEATTDSKP 
       710        720        730        740        750
ISSLSQAPEC GAQSLGKAPP QASVQVPTPP ARRRHGTRDS TLQGQAGHRT 
       760        770        780        790        800
PGEVLECQTT TAPTMSASSS SDVASIGVST SGSQGIIEPM DMETQEDGRT 
       810        820        830        840        850
SANQRTGSKK NVQADGKIQV DGRTRGDGTQ TAQRTRADRK TQVDAGTQES 
       860        870        880        890        900
KRPQSDRSAQ KGMMTQGRAE TQLETTQAGE KIQEDRKAQA DKGTQEDRRM 
       910        920        930        940        950
QGEKGMQGEK GTQSEGSAPT AMEGQSEQEV ATSLGPPSRT PKLPPTAGPR 
       960        970        980        990       1000
APLNIECFVQ TPEGSCFPKK PGCLPRSEEA VVTASRNHEQ TVLGPLSGNL 
      1010       1020       1030       1040       1050
MLPAQPPHEG SVEQVGGERC RGPQSSGPVE AKQEDSPFQC PKEERPGGVP 
      1060       1070       1080       1090       1100
CMDQGGCPLA GLSQEVPTMP SLPGTGLTAS PKAGPCSTPT SQHGSTATFL 
      1110       1120       1130       1140       1150
PSEDQVLMSS APTLHLGLGT PTQSHPPETM ATSSEGACAQ VPDVEGRTPG 
      1160       1170       1180       1190       1200
PRSCDPGLID SLKNYLLLLL KLSSTETSGA GGESQVGAAT GGLVPSATLT 
      1210       1220       1230       1240       1250
PTVEVAGLSP RTSRRILERV ENNHLVQSAQ TLLLSPCTSR RLTGLLDREV 
      1260       1270       1280       1290       1300
QAGRQALAAA RGSWGPGPSS LTVPAIVVDE EDPGLASEGA SEGEGEVSPE 
      1310       1320       1330       1340       1350
GPGLLGASQE SSMAGRLGEA GGQAAPGQGP SAESIAQEPS QEEKFPGEAL 
      1360       1370       1380       1390       1400
TGLPAATPEE LALGARRKRF LPKVRAAGDG EATTPEERES PTVSPRGPRK 
      1410       1420       1430       1440       1450
SLVPGSPGTP GRERRSPTQG RKASMLEVPR AEEELAAGDL GPSPKAGGLD 
      1460       1470       1480       1490       1500
TEVALDEGKQ ETLAKPRKAK DLLKAPQVIR KIRVEQFPDA SGSLKLWCQF 
      1510       1520       1530       1540       1550
FNILSDSVLT WAKDQRPVGE VGRSAGDEGP AALAIVQASP VDCGVYRCTI 
      1560       1570       1580       1590       1600
HNEHGSASTD FCLSPEVLSG FISREEGEVG EEIEMTPMVF AKGLADSGCW 
      1610       1620       1630       1640       1650
GDKLFGRLVS EELRGGGYGC GLRKASQAKV IYGLEPIFES GRTCIIKVSS 
      1660       1670       1680       1690       1700
LLVFGPSSET SLVGRNYDVT IQGCKIQNMS REYCKIFAAE ARAAPGFGEV 
      1710       1720       1730       1740       1750
PEIIPLYLIY RPANNIPYAT LEEDLGKPLE SYCSREWGCA EAPTASGSSE 
      1760       1770       1780       1790       1800
AMQKCQTFQH WLYQWTNGSF LVTDLAGVDW KMTDVQIATK LRGYQGLKES 
      1810       1820       1830       1840       1850
CFPALLDRFA SSHQCNAYCE LLGLTPLKGP EAAHPQAKAK GSKSPSAGRK 
      1860       1870       1880       1890       1900
GSQLSPQPQK KGLPSPQGTR KSAPSSKATP QASEPVTTQL LGQPPTQEEG 

SKAQGMR
Length:1,907
Mass (Da):201,272
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3896A1EC187BF5C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti210S → T in AAK95951 (PubMed:10021370).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041524336R → H1 PublicationCorresponds to variant dbSNP:rs34407151EnsemblClinVar.1
Natural variantiVAR_041525338T → I1 PublicationCorresponds to variant dbSNP:rs56015306EnsemblClinVar.1
Natural variantiVAR_028989414T → S1 PublicationCorresponds to variant dbSNP:rs3803403EnsemblClinVar.1
Natural variantiVAR_041526433Q → E in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_028990579G → E1 PublicationCorresponds to variant dbSNP:rs3803405EnsemblClinVar.1
Natural variantiVAR_041527602Q → R1 PublicationCorresponds to variant dbSNP:rs55702300EnsemblClinVar.1
Natural variantiVAR_041528663G → D1 PublicationCorresponds to variant dbSNP:rs34409363Ensembl.1
Natural variantiVAR_028991761T → M1 PublicationCorresponds to variant dbSNP:rs16974569EnsemblClinVar.1
Natural variantiVAR_041529836R → L1 PublicationCorresponds to variant dbSNP:rs34906636Ensembl.1
Natural variantiVAR_041530929E → D1 PublicationCorresponds to variant dbSNP:rs56191073EnsemblClinVar.1
Natural variantiVAR_0577431013E → K. Corresponds to variant dbSNP:rs35633849EnsemblClinVar.1
Natural variantiVAR_0577441137A → G. Corresponds to variant dbSNP:rs34173528Ensembl.1
Natural variantiVAR_0791421261 – 1907Missing in CMH27. 1 PublicationAdd BLAST647
Natural variantiVAR_0791431264 – 1907Missing in CMH27. 1 PublicationAdd BLAST644
Natural variantiVAR_0289921299P → L3 PublicationsCorresponds to variant dbSNP:rs306197EnsemblClinVar.1
Natural variantiVAR_0415311364G → E in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0415321412R → W1 PublicationCorresponds to variant dbSNP:rs55752937EnsemblClinVar.1
Natural variantiVAR_0415331557A → D1 PublicationCorresponds to variant dbSNP:rs34775428EnsemblClinVar.1
Natural variantiVAR_0289931622L → P1 PublicationCorresponds to variant dbSNP:rs187316EnsemblClinVar.1
Natural variantiVAR_0791441765 – 1907Missing in CMH27. 1 PublicationAdd BLAST143
Natural variantiVAR_0577451873A → V. Corresponds to variant dbSNP:rs36002219EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY044449 mRNA Translation: AAK95951.1
AB037751 mRNA Translation: BAA92568.1
AC012291 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_065829.3, NM_020778.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258888; ENSP00000258888; ENSG00000136383

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57538

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57538

UCSC genome browser

More...UCSCi		uc002ble.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044449 mRNA Translation: AAK95951.1
AB037751 mRNA Translation: BAA92568.1
AC012291 Genomic DNA No translation available.
RefSeqiNP_065829.3, NM_020778.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ96L96, 7 interactors
STRINGi9606.ENSP00000258888

PTM databases

iPTMnetiQ96L96
PhosphoSitePlusiQ96L96

Polymorphism and mutation databases

BioMutaiALPK3
DMDMi296434393

Proteomic databases

EPDiQ96L96
jPOSTiQ96L96
MassIVEiQ96L96
PaxDbiQ96L96
PeptideAtlasiQ96L96
PRIDEiQ96L96
ProteomicsDBi77171

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15507 52 antibodies

Genome annotation databases

EnsembliENST00000258888; ENSP00000258888; ENSG00000136383
GeneIDi57538
KEGGihsa:57538
UCSCiuc002ble.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57538
DisGeNETi57538
EuPathDBiHostDB:ENSG00000136383.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		ALPK3
HGNCiHGNC:17574 ALPK3
HPAiENSG00000136383 Tissue enhanced (heart muscle, skeletal muscle)
MalaCardsiALPK3
MIMi617608 gene
618052 phenotype
neXtProtiNX_Q96L96
OpenTargetsiENSG00000136383
PharmGKBiPA134921552

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IHFU Eukaryota
ENOG410Y8B3 LUCA
GeneTreeiENSGT00940000158534
HOGENOMiCLU_003270_1_0_1
InParanoidiQ96L96
KOiK08868
OMAiMGNGGEN
OrthoDBi32441at2759
PhylomeDBiQ96L96
TreeFamiTF332629

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57538 7 hits in 791 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ALPK3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57538
PharosiQ96L96 Tdark

Protein Ontology

More...PROi		PR:Q96L96
RNActiQ96L96 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136383 Expressed in gastrocnemius and 134 other tissues
GenevisibleiQ96L96 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
PfamiView protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00811 Alpha_kinase, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit
PS50835 IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALPK3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96L96
Secondary accession number(s): Q9P2L6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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