ALPK3

Functionⁱ

Involved in cardiomyocyte differentiation.4 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.By similarity

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac muscle cell development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
heart development Source: HGNC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Molecular function

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-protein kinase 3Curated (EC:2.7.11.1By similarity) Alternative name(s): Muscle alpha-protein kinase1 Publication
Gene namesⁱ	Name:ALPK3Imported Synonyms:KIAA13301 Publication, MAK1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136383.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17574 ALPK3
MIMⁱ	617608 gene
neXtProtⁱ	NX_Q96L96

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cardiomyopathy, familial hypertrophic 27 (CMH27)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of hypertrophic cardiomyopathy, a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH27 is a severe, early-onset form with features of hypertrophic and dilated cardiomyopathy.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_079142	1261 – 1907	Missing in CMH27. 1 PublicationAdd BLAST	647
Natural variantⁱVAR_079143	1264 – 1907	Missing in CMH27. 1 PublicationAdd BLAST	644
Natural variantⁱVAR_079144	1765 – 1907	Missing in CMH27. 1 PublicationAdd BLAST	143

Keywords - Diseaseⁱ

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57538
MIMⁱ	618052 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000136383
PharmGKBⁱ	PA134921552

Polymorphism and mutation databases

BioMutaⁱ	ALPK3
DMDMⁱ	296434393

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000260031	1 – 1907	Alpha-protein kinase 3Add BLAST		1907

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	430	PhosphoserineBy similarity	1
Modified residueⁱ	1424	PhosphoserineBy similarity	1
Disulfide bondⁱ	1498 ↔ 1548	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	Q96L96
PaxDbⁱ	Q96L96
PeptideAtlas More...PeptideAtlasⁱ	Q96L96
PRIDEⁱ	Q96L96
ProteomicsDBⁱ	77171

PTM databases

iPTMnetⁱ	Q96L96
PhosphoSitePlusⁱ	Q96L96

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136383 Expressed in 135 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_ALPK3 HS_MAK
Genevisibleⁱ	Q96L96 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026558

HPAⁱ

HPA026558

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q96L96, 1 interactor
STRINGⁱ	9606.ENSP00000258888

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96L96
SMRⁱ	Q96L96
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	279 – 370	Ig-like 1Add BLAST	92
Domainⁱ	1476 – 1564	Ig-like 2Add BLAST	89
Domainⁱ	1592 – 1827	Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST	236

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	170 – 175	Poly-Ala	6
Compositional biasⁱ	517 – 521	Poly-Lys	5
Compositional biasⁱ	766 – 771	Poly-Ser	6
Compositional biasⁱ	1166 – 1172	Poly-Leu	7

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IHFU Eukaryota ENOG410Y8B3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063799
HOGENOMⁱ	HOG000169775
HOVERGENⁱ	HBG074162
InParanoidⁱ	Q96L96
KEGG Orthology (KO) More...KOⁱ	K08868
OMAⁱ	TQEDRRM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01T6
PhylomeDBⁱ	Q96L96
TreeFamⁱ	TF332629

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR011009 Kinase-like_dom_sf IPR004166 MHCK_EF2_kinase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02816 Alpha_kinase, 1 hit PF07679 I-set, 1 hit
SMARTⁱ	View protein in SMART SM00811 Alpha_kinase, 1 hit SM00409 IG, 2 hits SM00408 IGc2, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51158 ALPHA_KINASE, 1 hit PS50835 IG_LIKE, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96L96-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVAWLVYVL GQQPLARQGE GQSRLVPGRG LVLWLPGLPR SSPSWPAVDL 
        60         70         80         90        100
APLAPARPRG PLICHTGHEQ AGREPGPGSS TKGPVLHDQD TRCAFLPRPP 
       110        120        130        140        150
GPLQTRRYCR HQGRQGSGLG AGPGAGTWAP APPGVSKPRC PGRARPGEGQ 
       160        170        180        190        200
QQVTTARPPA INRGARQPRA GAAAAGRGPG AGAWRTGEAA ASAGPAVGEG 
       210        220        230        240        250
GAMGSRRAPS RGWGAGGRSG AGGDGEDDGP VWIPSPASRS YLLSVRPETS 
       260        270        280        290        300
LSSNRLSHPS SGRSTFCSII AQLTEETQPL FETTLKSRSV SEDSDVRFTC 
       310        320        330        340        350
IVTGYPEPEV TWYKDDTELD RYCGLPKYEI THQGNRHTLQ LYRCREEDAA 
       360        370        380        390        400
IYQASAQNSK GIVSCSGVLE VGTMTEYKIH QRWFAKLKRK AAAKLREIEQ 
       410        420        430        440        450
SWKHEKAVPG EVDTLRKLSP DRFQRKRRLS GAQAPGPSVP TREPEGGTLA 
       460        470        480        490        500
AWQEGETETA QHSGLGLINS FASGEVTTNG EAAPENGEDG EHGLLTYICD 
       510        520        530        540        550
AMELGPQRAL KEESGAKKKK KDEESKQGLR KPELEKAAQS RRSSENCIPS 
       560        570        580        590        600
SDEPDSCGTQ GPVGVEQVQT QPRGRAARGP GSSGTDSTRK PASAVGTPDK 
       610        620        630        640        650
AQKAPGPGPG QEVYFSLKDM YLENTQAVRP LGEEGPQTLS VRAPGESPKG 
       660        670        680        690        700
KAPLRARSEG VPGAPGQPTH SLTPQPTRPF NRKRFAPPKP KGEATTDSKP 
       710        720        730        740        750
ISSLSQAPEC GAQSLGKAPP QASVQVPTPP ARRRHGTRDS TLQGQAGHRT 
       760        770        780        790        800
PGEVLECQTT TAPTMSASSS SDVASIGVST SGSQGIIEPM DMETQEDGRT 
       810        820        830        840        850
SANQRTGSKK NVQADGKIQV DGRTRGDGTQ TAQRTRADRK TQVDAGTQES 
       860        870        880        890        900
KRPQSDRSAQ KGMMTQGRAE TQLETTQAGE KIQEDRKAQA DKGTQEDRRM 
       910        920        930        940        950
QGEKGMQGEK GTQSEGSAPT AMEGQSEQEV ATSLGPPSRT PKLPPTAGPR 
       960        970        980        990       1000
APLNIECFVQ TPEGSCFPKK PGCLPRSEEA VVTASRNHEQ TVLGPLSGNL 
      1010       1020       1030       1040       1050
MLPAQPPHEG SVEQVGGERC RGPQSSGPVE AKQEDSPFQC PKEERPGGVP 
      1060       1070       1080       1090       1100
CMDQGGCPLA GLSQEVPTMP SLPGTGLTAS PKAGPCSTPT SQHGSTATFL 
      1110       1120       1130       1140       1150
PSEDQVLMSS APTLHLGLGT PTQSHPPETM ATSSEGACAQ VPDVEGRTPG 
      1160       1170       1180       1190       1200
PRSCDPGLID SLKNYLLLLL KLSSTETSGA GGESQVGAAT GGLVPSATLT 
      1210       1220       1230       1240       1250
PTVEVAGLSP RTSRRILERV ENNHLVQSAQ TLLLSPCTSR RLTGLLDREV 
      1260       1270       1280       1290       1300
QAGRQALAAA RGSWGPGPSS LTVPAIVVDE EDPGLASEGA SEGEGEVSPE 
      1310       1320       1330       1340       1350
GPGLLGASQE SSMAGRLGEA GGQAAPGQGP SAESIAQEPS QEEKFPGEAL 
      1360       1370       1380       1390       1400
TGLPAATPEE LALGARRKRF LPKVRAAGDG EATTPEERES PTVSPRGPRK 
      1410       1420       1430       1440       1450
SLVPGSPGTP GRERRSPTQG RKASMLEVPR AEEELAAGDL GPSPKAGGLD 
      1460       1470       1480       1490       1500
TEVALDEGKQ ETLAKPRKAK DLLKAPQVIR KIRVEQFPDA SGSLKLWCQF 
      1510       1520       1530       1540       1550
FNILSDSVLT WAKDQRPVGE VGRSAGDEGP AALAIVQASP VDCGVYRCTI 
      1560       1570       1580       1590       1600
HNEHGSASTD FCLSPEVLSG FISREEGEVG EEIEMTPMVF AKGLADSGCW 
      1610       1620       1630       1640       1650
GDKLFGRLVS EELRGGGYGC GLRKASQAKV IYGLEPIFES GRTCIIKVSS 
      1660       1670       1680       1690       1700
LLVFGPSSET SLVGRNYDVT IQGCKIQNMS REYCKIFAAE ARAAPGFGEV 
      1710       1720       1730       1740       1750
PEIIPLYLIY RPANNIPYAT LEEDLGKPLE SYCSREWGCA EAPTASGSSE 
      1760       1770       1780       1790       1800
AMQKCQTFQH WLYQWTNGSF LVTDLAGVDW KMTDVQIATK LRGYQGLKES 
      1810       1820       1830       1840       1850
CFPALLDRFA SSHQCNAYCE LLGLTPLKGP EAAHPQAKAK GSKSPSAGRK 
      1860       1870       1880       1890       1900
GSQLSPQPQK KGLPSPQGTR KSAPSSKATP QASEPVTTQL LGQPPTQEEG 

SKAQGMR

Length:1,907

Mass (Da):201,272

Last modified:May 18, 2010 - v2

Checksum:ⁱ3896A1EC187BF5C7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	210	S → T in AAK95951 (PubMed:10021370).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041524	336	R → H1 PublicationCorresponds to variant dbSNP:rs34407151EnsemblClinVar.	1
Natural variantⁱVAR_041525	338	T → I1 PublicationCorresponds to variant dbSNP:rs56015306EnsemblClinVar.	1
Natural variantⁱVAR_028989	414	T → S1 PublicationCorresponds to variant dbSNP:rs3803403EnsemblClinVar.	1
Natural variantⁱVAR_041526	433	Q → E in a lung large cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_028990	579	G → E1 PublicationCorresponds to variant dbSNP:rs3803405EnsemblClinVar.	1
Natural variantⁱVAR_041527	602	Q → R1 PublicationCorresponds to variant dbSNP:rs55702300EnsemblClinVar.	1
Natural variantⁱVAR_041528	663	G → D1 PublicationCorresponds to variant dbSNP:rs34409363Ensembl.	1
Natural variantⁱVAR_028991	761	T → M1 PublicationCorresponds to variant dbSNP:rs16974569EnsemblClinVar.	1
Natural variantⁱVAR_041529	836	R → L1 PublicationCorresponds to variant dbSNP:rs34906636Ensembl.	1
Natural variantⁱVAR_041530	929	E → D1 PublicationCorresponds to variant dbSNP:rs56191073EnsemblClinVar.	1
Natural variantⁱVAR_057743	1013	E → K. Corresponds to variant dbSNP:rs35633849EnsemblClinVar.	1
Natural variantⁱVAR_057744	1137	A → G. Corresponds to variant dbSNP:rs34173528Ensembl.	1
Natural variantⁱVAR_079142	1261 – 1907	Missing in CMH27. 1 PublicationAdd BLAST	647
Natural variantⁱVAR_079143	1264 – 1907	Missing in CMH27. 1 PublicationAdd BLAST	644
Natural variantⁱVAR_028992	1299	P → L3 PublicationsCorresponds to variant dbSNP:rs306197EnsemblClinVar.	1
Natural variantⁱVAR_041531	1364	G → E in a metastatic melanoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041532	1412	R → W1 PublicationCorresponds to variant dbSNP:rs55752937EnsemblClinVar.	1
Natural variantⁱVAR_041533	1557	A → D1 PublicationCorresponds to variant dbSNP:rs34775428EnsemblClinVar.	1
Natural variantⁱVAR_028993	1622	L → P1 PublicationCorresponds to variant dbSNP:rs187316EnsemblClinVar.	1
Natural variantⁱVAR_079144	1765 – 1907	Missing in CMH27. 1 PublicationAdd BLAST	143
Natural variantⁱVAR_057745	1873	A → V. Corresponds to variant dbSNP:rs36002219EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY044449 mRNA Translation: AAK95951.1 AB037751 mRNA Translation: BAA92568.1 AC012291 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10333.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065829.3, NM_020778.4
UniGeneⁱ	Hs.459183

Genome annotation databases

Ensemblⁱ	ENST00000258888; ENSP00000258888; ENSG00000136383
GeneIDⁱ	57538
KEGGⁱ	hsa:57538
UCSC genome browser More...UCSCⁱ	uc002ble.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96L96	ALPK3 isoform 1		PONAB		1910	UniRef90_Q96L96
ALPK3 isoform 1		PANTR		1901
Uncharacterized protein		CERAT		1878
Uncharacterized protein		MACMU		1861
Uncharacterized protein		PAPAN		1838
+36

Protein	Similar proteins		Species	Score	Length	Source
Q96L96	ALPK3 isoform 1		PONAB		1910	UniRef50_Q96L96
ALPK3 isoform 1		PANTR		1901
Uncharacterized protein		CERAT		1878
Uncharacterized protein		MACMU		1861
Uncharacterized protein		PAPAN		1838
+90

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY044449 mRNA Translation: AAK95951.1 AB037751 mRNA Translation: BAA92568.1 AC012291 Genomic DNA No translation available.
CCDSⁱ	CCDS10333.1
RefSeqⁱ	NP_065829.3, NM_020778.4
UniGeneⁱ	Hs.459183

3D structure databases

ProteinModelPortalⁱ	Q96L96
SMRⁱ	Q96L96
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q96L96, 1 interactor
STRINGⁱ	9606.ENSP00000258888

PTM databases

iPTMnetⁱ	Q96L96
PhosphoSitePlusⁱ	Q96L96

Polymorphism and mutation databases

BioMutaⁱ	ALPK3
DMDMⁱ	296434393

Proteomic databases

EPDⁱ	Q96L96
PaxDbⁱ	Q96L96
PeptideAtlasⁱ	Q96L96
PRIDEⁱ	Q96L96
ProteomicsDBⁱ	77171

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000258888; ENSP00000258888; ENSG00000136383
GeneIDⁱ	57538
KEGGⁱ	hsa:57538
UCSCⁱ	uc002ble.3 human

Organism-specific databases

CTDⁱ	57538
DisGeNETⁱ	57538
EuPathDBⁱ	HostDB:ENSG00000136383.6
GeneCardsⁱ	ALPK3
H-InvDBⁱ	HIX0012537
HGNCⁱ	HGNC:17574 ALPK3
HPAⁱ	HPA026558
MIMⁱ	617608 gene 618052 phenotype
neXtProtⁱ	NX_Q96L96
OpenTargetsⁱ	ENSG00000136383
PharmGKBⁱ	PA134921552
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHFU Eukaryota ENOG410Y8B3 LUCA
GeneTreeⁱ	ENSGT00530000063799
HOGENOMⁱ	HOG000169775
HOVERGENⁱ	HBG074162
InParanoidⁱ	Q96L96
KOⁱ	K08868
OMAⁱ	TQEDRRM
OrthoDBⁱ	EOG091G01T6
PhylomeDBⁱ	Q96L96
TreeFamⁱ	TF332629

Miscellaneous databases

ChiTaRSⁱ	ALPK3 human
GenomeRNAiⁱ	57538
Protein Ontology More...PROⁱ	PR:Q96L96
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136383 Expressed in 135 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_ALPK3 HS_MAK
Genevisibleⁱ	Q96L96 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR011009 Kinase-like_dom_sf IPR004166 MHCK_EF2_kinase
Pfamⁱ	View protein in Pfam PF02816 Alpha_kinase, 1 hit PF07679 I-set, 1 hit
SMARTⁱ	View protein in SMART SM00811 Alpha_kinase, 1 hit SM00409 IG, 2 hits SM00408 IGc2, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51158 ALPHA_KINASE, 1 hit PS50835 IG_LIKE, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ALPK3_HUMAN
Accessionⁱ	Q96L96Primary (citable) accession number: Q96L96 Secondary accession number(s): Q9P2L6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96L96 (ALPK3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Alpha-protein kinase 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ