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Protein

Sorting nexin-22

Gene

SNX22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43Phosphatidylinositol 3-phosphate1
Binding sitei45Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen1
Binding sitei66Phosphatidylinositol 3-phosphate1
Binding sitei79Phosphatidylinositol 3-phosphate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-22
Gene namesi
Name:SNX22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000157734.13
HGNCiHGNC:16315 SNX22
neXtProtiNX_Q96L94

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157734
PharmGKBiPA134897329

Polymorphism and mutation databases

BioMutaiSNX22
DMDMi20140142

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138711 – 193Sorting nexin-22Add BLAST193

Proteomic databases

MaxQBiQ96L94
PaxDbiQ96L94
PeptideAtlasiQ96L94
PRIDEiQ96L94
ProteomicsDBi77170

PTM databases

iPTMnetiQ96L94
PhosphoSitePlusiQ96L94

Expressioni

Gene expression databases

BgeeiENSG00000157734 Expressed in 177 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SNX22
ExpressionAtlasiQ96L94 baseline and differential
GenevisibleiQ96L94 HS

Organism-specific databases

HPAiHPA038470

Interactioni

Protein-protein interaction databases

BioGridi122945, 8 interactors
IntActiQ96L94, 5 interactors
MINTiQ96L94
STRINGi9606.ENSP00000323435

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96L94
SMRiQ96L94
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96L94

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 118PXPROSITE-ProRule annotationAdd BLAST118

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiENOG410IMHS Eukaryota
ENOG4111RIF LUCA
GeneTreeiENSGT00390000001280
HOGENOMiHOG000253944
HOVERGENiHBG064936
InParanoidiQ96L94
KOiK17941
OMAiGVLQGFY
OrthoDBiEOG091G0U2N
PhylomeDBiQ96L94
TreeFamiTF332414

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96L94-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLEVHIPSVG PEAEGPRQSP EKSHMVFRVE VLCSGRRHTV PRRYSEFHAL
60 70 80 90 100
HKRIKKLYKV PDFPSKRLPN WRTRGLEQRR QGLEAYIQGI LYLNQEVPKE
110 120 130 140 150
LLEFLRLRHF PTDPKASNWG TLREFLPGDS SSQQHQRPVL SFHVDPYVCN
160 170 180 190
PSPESLPNVV VNGVLQGLYS FSISPDKAQP KAACHPAPLP PMP
Length:193
Mass (Da):22,068
Last modified:December 1, 2001 - v1
Checksum:iB57D8F8B737F429E
GO
Isoform 2 (identifier: Q96L94-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-193: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):14,194
Checksum:iB97221C3546F468B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191P → L in BAB14776 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056595121 – 193Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044653 mRNA Translation: AAK98767.1
AK024014 mRNA Translation: BAB14776.1
AC100840 Genomic DNA No translation available.
BC019655 mRNA Translation: AAH19655.1
CCDSiCCDS10190.1 [Q96L94-1]
RefSeqiNP_079074.2, NM_024798.2 [Q96L94-1]
UniGeneiHs.744250

Genome annotation databases

EnsembliENST00000325881; ENSP00000323435; ENSG00000157734 [Q96L94-1]
ENST00000558466; ENSP00000452692; ENSG00000157734 [Q96L94-2]
GeneIDi79856
KEGGihsa:79856
UCSCiuc002anc.1 human [Q96L94-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044653 mRNA Translation: AAK98767.1
AK024014 mRNA Translation: BAB14776.1
AC100840 Genomic DNA No translation available.
BC019655 mRNA Translation: AAH19655.1
CCDSiCCDS10190.1 [Q96L94-1]
RefSeqiNP_079074.2, NM_024798.2 [Q96L94-1]
UniGeneiHs.744250

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ETTNMR-A2-120[»]
ProteinModelPortaliQ96L94
SMRiQ96L94
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122945, 8 interactors
IntActiQ96L94, 5 interactors
MINTiQ96L94
STRINGi9606.ENSP00000323435

PTM databases

iPTMnetiQ96L94
PhosphoSitePlusiQ96L94

Polymorphism and mutation databases

BioMutaiSNX22
DMDMi20140142

Proteomic databases

MaxQBiQ96L94
PaxDbiQ96L94
PeptideAtlasiQ96L94
PRIDEiQ96L94
ProteomicsDBi77170

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325881; ENSP00000323435; ENSG00000157734 [Q96L94-1]
ENST00000558466; ENSP00000452692; ENSG00000157734 [Q96L94-2]
GeneIDi79856
KEGGihsa:79856
UCSCiuc002anc.1 human [Q96L94-1]

Organism-specific databases

CTDi79856
EuPathDBiHostDB:ENSG00000157734.13
GeneCardsiSNX22
HGNCiHGNC:16315 SNX22
HPAiHPA038470
neXtProtiNX_Q96L94
OpenTargetsiENSG00000157734
PharmGKBiPA134897329
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMHS Eukaryota
ENOG4111RIF LUCA
GeneTreeiENSGT00390000001280
HOGENOMiHOG000253944
HOVERGENiHBG064936
InParanoidiQ96L94
KOiK17941
OMAiGVLQGFY
OrthoDBiEOG091G0U2N
PhylomeDBiQ96L94
TreeFamiTF332414

Miscellaneous databases

ChiTaRSiSNX22 human
EvolutionaryTraceiQ96L94
GenomeRNAii79856
PROiPR:Q96L94

Gene expression databases

BgeeiENSG00000157734 Expressed in 177 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SNX22
ExpressionAtlasiQ96L94 baseline and differential
GenevisibleiQ96L94 HS

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX22_HUMAN
AccessioniPrimary (citable) accession number: Q96L94
Secondary accession number(s): Q8WUS9, Q9H844
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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