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Entry version 180 (16 Oct 2019)
Sequence version 4 (11 Jan 2011)
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Protein

E1A-binding protein p400

Gene

EP400

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1116 – 1123ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.6.4.11 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-3214847 HATs acetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E1A-binding protein p400 (EC:3.6.4.-)
Alternative name(s):
CAG repeat protein 32
Domino homolog
Short name:
hDomino
Trinucleotide repeat-containing gene 12 protein
p400 kDa SWI2/SNF2-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EP400
Synonyms:CAGH32, KIAA1498, KIAA1818, TNRC12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:11958 EP400

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606265 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96L91

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57634

Open Targets

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OpenTargetsi
ENSG00000183495

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27808

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96L91

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
EP400

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373565

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743121 – 3159E1A-binding protein p400Add BLAST3159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei315PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei736PhosphoserineCombined sources1
Modified residuei755PhosphoserineBy similarity1
Modified residuei928PhosphoserineBy similarity1
Modified residuei941PhosphoserineCombined sources1
Modified residuei945PhosphothreonineCombined sources1
Modified residuei1011PhosphoserineBy similarity1
Modified residuei1472N6-acetyllysineCombined sources1
Modified residuei1547PhosphoserineCombined sources1
Modified residuei1728PhosphoserineCombined sources1
Modified residuei1732PhosphoserineCombined sources1
Modified residuei2349N6-acetyllysineCombined sources1
Modified residuei2356N6-acetyllysineCombined sources1
Modified residuei2686PhosphoserineCombined sources1
Modified residuei2813PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96L91

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96L91

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96L91

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96L91

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96L91

PeptideAtlas

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PeptideAtlasi
Q96L91

PRoteomics IDEntifications database

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PRIDEi
Q96L91

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
77156 [Q96L91-1]
77157 [Q96L91-2]
77158 [Q96L91-3]
77159 [Q96L91-4]
77160 [Q96L91-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96L91

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96L91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000183495 Expressed in 228 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96L91 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96L91 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA016704
HPA049013

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. May also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. The NuA4 complex interacts with MYC and the adenovirus E1A protein. EP400 interacts with TRRAP, RUVBL1 and RUVBL2.

Component of a SWR1-like complex.

Interacts with ZNF42.

Interacts with PHF5A.

Interacts with human cytomegalovirus UL27.

Interacts with human adenovirus 5 E1A protein; this interaction stabilizes MYC (PubMed:18413597).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121676, 74 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-978 NuA4 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96L91

Database of interacting proteins

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DIPi
DIP-29915N

Protein interaction database and analysis system

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IntActi
Q96L91, 42 interactors

Molecular INTeraction database

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MINTi
Q96L91

STRING: functional protein association networks

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STRINGi
9606.ENSP00000374213

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96L91

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini799 – 871HSAPROSITE-ProRule annotationAdd BLAST73
Domaini1103 – 1268Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1899 – 2056Helicase C-terminalPROSITE-ProRule annotationAdd BLAST158
Domaini2360 – 2429Myb-likePROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni951 – 1365Interactions with RUVBL1 and RUVBL2Add BLAST415
Regioni2524 – 2789Interaction with ZNF42By similarityAdd BLAST266

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1219 – 1222DEAH box-like4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi278 – 281Poly-Gln4
Compositional biasi316 – 319Poly-Pro4
Compositional biasi426 – 437Poly-GluAdd BLAST12
Compositional biasi1517 – 1522Poly-Ala6
Compositional biasi2543 – 2554Poly-ProAdd BLAST12
Compositional biasi2557 – 2564Poly-Pro8
Compositional biasi2756 – 2784Poly-GlnAdd BLAST29
Compositional biasi2828 – 2834Poly-Pro7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0391 Eukaryota
COG0553 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154764

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96L91

KEGG Orthology (KO)

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KOi
K11320

Identification of Orthologs from Complete Genome Data

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OMAi
GQEGIWG

Database of Orthologous Groups

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OrthoDBi
188211at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96L91

TreeFam database of animal gene trees

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TreeFami
TF106424

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031575 EP400_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR017877 Myb-like_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15790 EP400_N, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS50090 MYB_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96L91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHHGTGPQNV QHQLQRSRAC PGSEGEEQPA HPNPPPSPAA PFAPSASPSA
60 70 80 90 100
PQSPSYQIQQ LMNRSPATGQ NVNITLQSVG PVVGGNQQIT LAPLPLPSPT
110 120 130 140 150
SPGFQFSAQP RRFEHGSPSY IQVTSPLSQQ VQTQSPTQPS PGPGQALQNV
160 170 180 190 200
RAGAPGPGLG LCSSSPTGGF VDASVLVRQI SLSPSSGGHF VFQDGSGLTQ
210 220 230 240 250
IAQGAQVQLQ HPGTPITVRE RRPSQPHTQS GGTIHHLGPQ SPAAAGGAGL
260 270 280 290 300
QPLASPSHIT TANLPPQISS IIQGQLVQQQ QVLQGPPLPR PLGFERTPGV
310 320 330 340 350
LLPGAGGAAG FGMTSPPPPT SPSRTAVPPG LSSLPLTSVG NTGMKKVPKK
360 370 380 390 400
LEEIPPASPE MAQMRKQCLD YHYQEMQALK EVFKEYLIEL FFLQHFQGNM
410 420 430 440 450
MDFLAFKKKH YAPLQAYLRQ NDLDIEEEEE EEEEEEEKSE VINDEVKVVT
460 470 480 490 500
GKDGQTGTPV AIATQLPPKV SAAFSSQQQP FQQALAGSLV AGAGSTVETD
510 520 530 540 550
LFKRQQAMPS TGMAEQSKRP RLEVGHQGVV FQHPGADAGV PLQQLMPTAQ
560 570 580 590 600
GGMPPTPQAA QLAGQRQSQQ QYDPSTGPPV QNAASLHTPL PQLPGRLPPA
610 620 630 640 650
GVPTAALSSA LQFAQQPQVV EAQTQLQIPV KTQQPNVPIP APPSSQLPIP
660 670 680 690 700
PSQPAQLALH VPTPGKVQVQ ASQLSSLPQM VASTRLPVDP APPCPRPLPT
710 720 730 740 750
SSTSSLAPVS GSGPGPSPAR SSPVNRPSSA TNKALSPVTS RTPGVVASAP
760 770 780 790 800
TKPQSPAQNA TSSQDSSQDT LTEQITLENQ VHQRIAELRK AGLWSQRRLP
810 820 830 840 850
KLQEAPRPKS HWDYLLEEMQ WMATDFAQER RWKVAAAKKL VRTVVRHHEE
860 870 880 890 900
KQLREERGKK EEQSRLRRIA ASTAREIECF WSNIEQVVEI KLRVELEEKR
910 920 930 940 950
KKALNLQKVS RRGKELRPKG FDALQESSLD SGMSGRKRKA SISLTDDEVD
960 970 980 990 1000
DEEETIEEEE ANEGVVDHQT ELSNLAKEAE LPLLDLMKLY EGAFLPSSQW
1010 1020 1030 1040 1050
PRPKPDGEDT SGEEDADDCP GDRESRKDLV LIDSLFIMDQ FKAAERMNIG
1060 1070 1080 1090 1100
KPNAKDIADV TAVAEAILPK GSARVTTSVK FNAPSLLYGA LRDYQKIGLD
1110 1120 1130 1140 1150
WLAKLYRKNL NGILADEAGL GKTVQIIAFF AHLACNEGNW GPHLVVVRSC
1160 1170 1180 1190 1200
NILKWELELK RWCPGLKILS YIGSHRELKA KRQEWAEPNS FHVCITSYTQ
1210 1220 1230 1240 1250
FFRGLTAFTR VRWKCLVIDE MQRVKGMTER HWEAVFTLQS QQRLLLIDSP
1260 1270 1280 1290 1300
LHNTFLELWT MVHFLVPGIS RPYLSSPLRA PSEESQDYYH KVVIRLHRVT
1310 1320 1330 1340 1350
QPFILRRTKR DVEKQLTKKY EHVLKCRLSN RQKALYEDVI LQPGTQEALK
1360 1370 1380 1390 1400
SGHFVNVLSI LVRLQRICNH PGLVEPRHPG SSYVAGPLEY PSASLILKAL
1410 1420 1430 1440 1450
ERDFWKEADL SMFDLIGLEN KITRHEAELL SKKKIPRKLM EEISTSAAPA
1460 1470 1480 1490 1500
ARPAAAKLKA SRLFQPVQYG QKPEGRTVAF PSTHPPRTAA PTTASAAPQG
1510 1520 1530 1540 1550
PLRGRPPIAT FSANPEAKAA AAPFQTSQAS ASAPRHQPAS ASSTAASPAH
1560 1570 1580 1590 1600
PAKLRAQTTA QASTPGQPPP QPQAPSHAAG QSALPQRLVL PSQAQARLPS
1610 1620 1630 1640 1650
GEVVKIAQLA SITGPQSRVA QPETPVTLQF QGSKFTLSHS QLRQLTAGQP
1660 1670 1680 1690 1700
LQLQGSVLQI VSAPGQPYLR APGPVVMQTV SQAGAVHGAL GSKPPAGGPS
1710 1720 1730 1740 1750
PAPLTPQVGV PGRVAVNALA VGEPGTASKP ASPIGGPTQE EKTRLLKERL
1760 1770 1780 1790 1800
DQIYLVNERR CSQAPVYGRD LLRICALPSH GRVQWRGSLD GRRGKEAGPA
1810 1820 1830 1840 1850
HSYTSSSESP SELMLTLCRC GESLQDVIDR VAFVIPPVVA APPSLRVPRP
1860 1870 1880 1890 1900
PPLYSHRMRI LRQGLREHAA PYFQQLRQTT APRLLQFPEL RLVQFDSGKL
1910 1920 1930 1940 1950
EALAILLQKL KSEGRRVLIL SQMILMLDIL EMFLNFHYLT YVRIDENASS
1960 1970 1980 1990 2000
EQRQELMRSF NRDRRIFCAI LSTHSRTTGI NLVEADTVVF YDNDLNPVMD
2010 2020 2030 2040 2050
AKAQEWCDRI GRCKDIHIYR LVSGNSIEEK LLKNGTKDLI REVAAQGNDY
2060 2070 2080 2090 2100
SMAFLTQRTI QELFEVYSPM DDAGFPVKAE EFVVLSQEPS VTETIAPKIA
2110 2120 2130 2140 2150
RPFIEALKSI EYLEEDAQKS AQEGVLGPHT DALSSDSENM PCDEEPSQLE
2160 2170 2180 2190 2200
ELADFMEQLT PIEKYALNYL ELFHTSIEQE KERNSEDAVM TAVRAWEFWN
2210 2220 2230 2240 2250
LKTLQEREAR LRLEQEEAEL LTYTREDAYS MEYVYEDVDG QTEVMPLWTP
2260 2270 2280 2290 2300
PTPPQDDSDI YLDSVMCLMY EATPIPEAKL PPVYVRKERK RHKTDPSAAG
2310 2320 2330 2340 2350
RKKKQRHGEA VVPPRSLFDR ATPGLLKIRR EGKEQKKNIL LKQQVPFAKP
2360 2370 2380 2390 2400
LPTFAKPTAE PGQDNPEWLI SEDWALLQAV KQLLELPLNL TIVSPAHTPN
2410 2420 2430 2440 2450
WDLVSDVVNS CSRIYRSSKQ CRNRYENVII PREEGKSKNN RPLRTSQIYA
2460 2470 2480 2490 2500
QDENATHTQL YTSHFDLMKM TAGKRSPPIK PLLGMNPFQK NPKHASVLAE
2510 2520 2530 2540 2550
SGINYDKPLP PIQVASLRAE RIAKEKKALA DQQKAQQPAV AQPPPPQPQP
2560 2570 2580 2590 2600
PPPPQQPPPP LPQPQAAGSQ PPAGPPAVQP QPQPQPQTQP QPVQAPAKAQ
2610 2620 2630 2640 2650
PAITTGGSAA VLAGTIKTSV TGTSMPTGAV SGNVIVNTIA GVPAATFQSI
2660 2670 2680 2690 2700
NKRLASPVAP GALTTPGGSA PAQVVHTQPP PRAVGSPATA TPDLVSMATT
2710 2720 2730 2740 2750
QGVRAVTSVT ASAVVTTNLT PVQTPARSLV PQVSQATGVQ LPGKTITPAH
2760 2770 2780 2790 2800
FQLLRQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQTTTTSQ VQVPQIQGQA
2810 2820 2830 2840 2850
QSPAQIKAVG KLTPEHLIKM QKQKLQMPPQ PPPPQAQSAP PQPTAQVQVQ
2860 2870 2880 2890 2900
TSQPPQQQSP QLTTVTAPRP GALLTGTTVA NLQVARLTRV PTSQLQAQGQ
2910 2920 2930 2940 2950
MQTQAPQPAQ VALAKPPVVS VPAAVVSSPG VTTLPMNVAG ISVAIGQPQK
2960 2970 2980 2990 3000
AAGQTVVAQP VHMQQLLKLK QQAVQQQKAI QPQAAQGPAA VQQKITAQQI
3010 3020 3030 3040 3050
TTPGAQQKVA YAAQPALKTQ FLTTPISQAQ KLAGAQQVQT QIQVAKLPQV
3060 3070 3080 3090 3100
VQQQTPVASI QQVASASQQA SPQTVALTQA TAAGQQVQMI PAVTATAQVV
3110 3120 3130 3140 3150
QQKLIQQQVV TTASAPLQTP GAPNPAQVPA SSDSPSQQPK LQMRVPAVRL

KTPTKPPCQ
Length:3,159
Mass (Da):343,489
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E502CE1BE9CFAC1
GO
Isoform 2 (identifier: Q96L91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-481: Missing.

Show »
Length:3,123
Mass (Da):339,823
Checksum:i846B71A59CE2B201
GO
Isoform 3 (identifier: Q96L91-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-481: Missing.
     482-482: Missing.
     515-550: Missing.

Note: No experimental confirmation available.
Show »
Length:3,086
Mass (Da):335,805
Checksum:i706B650493BC8580
GO
Isoform 4 (identifier: Q96L91-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-481: Missing.
     1519-1600: AAAAPFQTSQ...PSQAQARLPS → G

Note: No experimental confirmation available.
Show »
Length:3,042
Mass (Da):331,778
Checksum:i6D57F7F463C74FE1
GO
Isoform 5 (identifier: Q96L91-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-481: Missing.
     482-482: Missing.

Note: No experimental confirmation available.
Show »
Length:3,122
Mass (Da):339,695
Checksum:i0F04797ACF402088
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR80A0A0A0MR80_HUMAN
E1A-binding protein p400
EP400
985Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR72A0A0A0MR72_HUMAN
E1A-binding protein p400
EP400
826Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR70A0A0A0MR70_HUMAN
E1A-binding protein p400
EP400
374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB91441 differs from that shown. Reason: Frameshift.Curated
The sequence AAH37208 differs from that shown. Intron retention.Curated
The sequence AAH64554 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA96022 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti537D → G in AAH37208 (PubMed:15489334).Curated1
Sequence conflicti810S → P in AAH37208 (PubMed:15489334).Curated1
Sequence conflicti1563S → F in AAK97789 (PubMed:11509179).Curated1
Sequence conflicti1642L → F in AAK97789 (PubMed:11509179).Curated1
Sequence conflicti1645L → F in AAK97789 (PubMed:11509179).Curated1
Sequence conflicti2756Q → QQ in AAK97789 (PubMed:11509179).Curated1
Sequence conflicti2756Q → QQ in BAB47447 (PubMed:11347906).Curated1
Sequence conflicti2756Q → QQ in AAB91441 (PubMed:9225980).Curated1
Sequence conflicti2844T → A in AAK97789 (PubMed:11509179).Curated1
Sequence conflicti2844T → A in AAB91441 (PubMed:9225980).Curated1
Sequence conflicti2897A → S in AAK97789 (PubMed:11509179).Curated1
Sequence conflicti2897A → S in AAB91441 (PubMed:9225980).Curated1
Sequence conflicti2912 – 2914ALA → PLP in AAK97789 (PubMed:11509179).Curated3
Sequence conflicti2912 – 2914ALA → PLP in AAB91441 (PubMed:9225980).Curated3
Sequence conflicti2990A → T in AAK97789 (PubMed:11509179).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0469571308T → I. Corresponds to variant dbSNP:rs13377636Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011992446 – 481Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST36
Alternative sequenceiVSP_011993482Missing in isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_011994515 – 550Missing in isoform 3. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_0119951519 – 1600AAAAP…ARLPS → G in isoform 4. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY044869 mRNA Translation: AAK97789.1
AC137590 Genomic DNA No translation available.
AC137632 Genomic DNA No translation available.
AB040931 mRNA Translation: BAA96022.1 Different initiation.
AK096311 mRNA Translation: BAC04759.1
BC037208 mRNA Translation: AAH37208.1 Sequence problems.
BC064554 mRNA Translation: AAH64554.1 Sequence problems.
AB058721 mRNA Translation: BAB47447.1
U80743 mRNA Translation: AAB91441.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31929.2 [Q96L91-2]

NCBI Reference Sequences

More...
RefSeqi
NP_056224.3, NM_015409.4 [Q96L91-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389561; ENSP00000374212; ENSG00000183495 [Q96L91-2]
ENST00000389562; ENSP00000374213; ENSG00000183495 [Q96L91-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57634

UCSC genome browser

More...
UCSCi
uc001ujn.3 human [Q96L91-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044869 mRNA Translation: AAK97789.1
AC137590 Genomic DNA No translation available.
AC137632 Genomic DNA No translation available.
AB040931 mRNA Translation: BAA96022.1 Different initiation.
AK096311 mRNA Translation: BAC04759.1
BC037208 mRNA Translation: AAH37208.1 Sequence problems.
BC064554 mRNA Translation: AAH64554.1 Sequence problems.
AB058721 mRNA Translation: BAB47447.1
U80743 mRNA Translation: AAB91441.1 Frameshift.
CCDSiCCDS31929.2 [Q96L91-2]
RefSeqiNP_056224.3, NM_015409.4 [Q96L91-2]

3D structure databases

SMRiQ96L91
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121676, 74 interactors
ComplexPortaliCPX-978 NuA4 histone acetyltransferase complex
CORUMiQ96L91
DIPiDIP-29915N
IntActiQ96L91, 42 interactors
MINTiQ96L91
STRINGi9606.ENSP00000374213

PTM databases

iPTMnetiQ96L91
PhosphoSitePlusiQ96L91

Polymorphism and mutation databases

BioMutaiEP400
DMDMi317373565

Proteomic databases

EPDiQ96L91
jPOSTiQ96L91
MassIVEiQ96L91
MaxQBiQ96L91
PaxDbiQ96L91
PeptideAtlasiQ96L91
PRIDEiQ96L91
ProteomicsDBi77156 [Q96L91-1]
77157 [Q96L91-2]
77158 [Q96L91-3]
77159 [Q96L91-4]
77160 [Q96L91-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57634

Genome annotation databases

EnsembliENST00000389561; ENSP00000374212; ENSG00000183495 [Q96L91-2]
ENST00000389562; ENSP00000374213; ENSG00000183495 [Q96L91-2]
GeneIDi57634
KEGGihsa:57634
UCSCiuc001ujn.3 human [Q96L91-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57634
DisGeNETi57634

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EP400
HGNCiHGNC:11958 EP400
HPAiHPA016704
HPA049013
MIMi606265 gene
neXtProtiNX_Q96L91
OpenTargetsiENSG00000183495
PharmGKBiPA27808

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0391 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000154764
InParanoidiQ96L91
KOiK11320
OMAiGQEGIWG
OrthoDBi188211at2759
PhylomeDBiQ96L91
TreeFamiTF106424

Enzyme and pathway databases

BRENDAi3.6.4.11 2681
ReactomeiR-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-3214847 HATs acetylate histones

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EP400 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EP400

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57634
PharosiQ96L91

Protein Ontology

More...
PROi
PR:Q96L91

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183495 Expressed in 228 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ96L91 baseline and differential
GenevisibleiQ96L91 HS

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR031575 EP400_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR017877 Myb-like_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF15790 EP400_N, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS50090 MYB_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEP400_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96L91
Secondary accession number(s): O15411
, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 11, 2011
Last modified: October 16, 2019
This is version 180 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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