UniProtKB - Q96L33 (RHOV_HUMAN)
Protein
Rho-related GTP-binding protein RhoV
Gene
RHOV
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.By similarity
Cofactori
Mg2+By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 45 | GTPBy similarity | 8 | |
Nucleotide bindingi | 85 – 89 | GTPBy similarity | 5 | |
Nucleotide bindingi | 143 – 146 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- Cdc42 protein signal transduction Source: GO_Central
- cell migration Source: GO_Central
- cell projection assembly Source: GO_Central
- endocytosis Source: GO_Central
- regulation of small GTPase mediated signal transduction Source: Reactome
Keywordsi
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96L33 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Rho-related GTP-binding protein RhoVAlternative name(s): CDC42-like GTPase 2 GTP-binding protein-like 2 Rho GTPase-like protein ARHV Wnt-1 responsive Cdc42 homolog 2 Short name: WRCH-2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104140.6 |
HGNCi | HGNC:18313, RHOV |
neXtProti | NX_Q96L33 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Endosome
- Endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Treatment with TNF activates endosomal but not plasma membrane RHOV.By similarity
Cytosol
- cytosol Source: Reactome
Endosome
- endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 171177 |
OpenTargetsi | ENSG00000104140 |
PharmGKBi | PA38313 |
Miscellaneous databases
Pharosi | Q96L33, Tbio |
Polymorphism and mutation databases
BioMutai | RHOV |
DMDMi | 74724228 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326438 | 1 – 236 | Rho-related GTP-binding protein RhoVAdd BLAST | 236 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Lipidationi | 234 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | Q96L33 |
MassIVEi | Q96L33 |
MaxQBi | Q96L33 |
PaxDbi | Q96L33 |
PeptideAtlasi | Q96L33 |
PRIDEi | Q96L33 |
ProteomicsDBi | 77144 |
PTM databases
iPTMneti | Q96L33 |
PhosphoSitePlusi | Q96L33 |
Expressioni
Tissue specificityi
Highly expressed in pancreas, placenta, and fetal brain.1 Publication
Gene expression databases
Bgeei | ENSG00000104140, Expressed in lower esophagus mucosa and 165 other tissues |
ExpressionAtlasi | Q96L33, baseline and differential |
Genevisiblei | Q96L33, HS |
Organism-specific databases
HPAi | ENSG00000104140, Tissue enhanced (esophagus, skin, tongue) |
Interactioni
Subunit structurei
Interacts with PAK2.
By similarityBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 128110, 2 interactors |
IntActi | Q96L33, 2 interactors |
MINTi | Q96L33 |
STRINGi | 9606.ENSP00000220507 |
Miscellaneous databases
RNActi | Q96L33, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
GeneTreei | ENSGT00940000157624 |
HOGENOMi | CLU_041217_21_7_1 |
InParanoidi | Q96L33 |
OMAi | PPQMDYF |
OrthoDBi | 1091615at2759 |
PhylomeDBi | Q96L33 |
TreeFami | TF321839 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96L33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS
60 70 80 90 100
YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY
110 120 130 140 150
PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD
160 170 180 190 200
VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS
210 220 230
AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 177 | K → R in BAB86363 (PubMed:11956592).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB079131 mRNA Translation: BAB86363.1 AY059636 mRNA Translation: AAL17966.1 CH471125 Genomic DNA Translation: EAW92459.1 BC105020 mRNA Translation: AAI05021.1 BC105022 mRNA Translation: AAI05023.1 BC112945 mRNA Translation: AAI12946.2 |
CCDSi | CCDS10068.1 |
RefSeqi | NP_598378.3, NM_133639.3 |
Genome annotation databases
Ensembli | ENST00000220507; ENSP00000220507; ENSG00000104140 |
GeneIDi | 171177 |
KEGGi | hsa:171177 |
UCSCi | uc001znd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB079131 mRNA Translation: BAB86363.1 AY059636 mRNA Translation: AAL17966.1 CH471125 Genomic DNA Translation: EAW92459.1 BC105020 mRNA Translation: AAI05021.1 BC105022 mRNA Translation: AAI05023.1 BC112945 mRNA Translation: AAI12946.2 |
CCDSi | CCDS10068.1 |
RefSeqi | NP_598378.3, NM_133639.3 |
3D structure databases
SMRi | Q96L33 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128110, 2 interactors |
IntActi | Q96L33, 2 interactors |
MINTi | Q96L33 |
STRINGi | 9606.ENSP00000220507 |
PTM databases
iPTMneti | Q96L33 |
PhosphoSitePlusi | Q96L33 |
Polymorphism and mutation databases
BioMutai | RHOV |
DMDMi | 74724228 |
Proteomic databases
EPDi | Q96L33 |
MassIVEi | Q96L33 |
MaxQBi | Q96L33 |
PaxDbi | Q96L33 |
PeptideAtlasi | Q96L33 |
PRIDEi | Q96L33 |
ProteomicsDBi | 77144 |
Protocols and materials databases
Antibodypediai | 23194, 18 antibodies |
Genome annotation databases
Ensembli | ENST00000220507; ENSP00000220507; ENSG00000104140 |
GeneIDi | 171177 |
KEGGi | hsa:171177 |
UCSCi | uc001znd.3, human |
Organism-specific databases
CTDi | 171177 |
DisGeNETi | 171177 |
EuPathDBi | HostDB:ENSG00000104140.6 |
GeneCardsi | RHOV |
HGNCi | HGNC:18313, RHOV |
HPAi | ENSG00000104140, Tissue enhanced (esophagus, skin, tongue) |
neXtProti | NX_Q96L33 |
OpenTargetsi | ENSG00000104140 |
PharmGKBi | PA38313 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
GeneTreei | ENSGT00940000157624 |
HOGENOMi | CLU_041217_21_7_1 |
InParanoidi | Q96L33 |
OMAi | PPQMDYF |
OrthoDBi | 1091615at2759 |
PhylomeDBi | Q96L33 |
TreeFami | TF321839 |
Enzyme and pathway databases
PathwayCommonsi | Q96L33 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
Miscellaneous databases
BioGRID-ORCSi | 171177, 6 hits in 843 CRISPR screens |
ChiTaRSi | RHOV, human |
GenomeRNAii | 171177 |
Pharosi | Q96L33, Tbio |
PROi | PR:Q96L33 |
RNActi | Q96L33, protein |
Gene expression databases
Bgeei | ENSG00000104140, Expressed in lower esophagus mucosa and 165 other tissues |
ExpressionAtlasi | Q96L33, baseline and differential |
Genevisiblei | Q96L33, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHOV_HUMAN | |
Accessioni | Q96L33Primary (citable) accession number: Q96L33 Secondary accession number(s): Q2KHQ5, Q8TDW6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM