RHOV

Functionⁱ

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.By similarity

Cofactorⁱ

Mg²⁺By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	38 – 45	GTPBy similarity	8
Nucleotide bindingⁱ	85 – 89	GTPBy similarity	5
Nucleotide bindingⁱ	143 – 146	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of small GTPase mediated signal transduction Source: Reactome
small GTPase mediated signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Ligand

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-194840 Rho GTPase cycle

Reactomeⁱ

R-HSA-194840 Rho GTPase cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Rho-related GTP-binding protein RhoV Alternative name(s): CDC42-like GTPase 2 GTP-binding protein-like 2 Rho GTPase-like protein ARHV Wnt-1 responsive Cdc42 homolog 2 Short name: WRCH-2
Gene namesⁱ	Name:RHOVImported Synonyms:ARHVImported, WRCH2Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104140.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18313 RHOV
neXtProtⁱ	NX_Q96L33

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	171177
Open Targets More...OpenTargetsⁱ	ENSG00000104140
PharmGKBⁱ	PA38313

Polymorphism and mutation databases

BioMutaⁱ	RHOV
DMDMⁱ	74724228

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000326438	1 – 236	Rho-related GTP-binding protein RhoVAdd BLAST		236

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	25	PhosphoserineCombined sources		1
Lipidationⁱ	234	S-palmitoyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	Q96L33
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96L33
PaxDbⁱ	Q96L33
PeptideAtlas More...PeptideAtlasⁱ	Q96L33
PRIDEⁱ	Q96L33
ProteomicsDBⁱ	77144

PTM databases

iPTMnetⁱ	Q96L33
PhosphoSitePlusⁱ	Q96L33

Expressionⁱ

Tissue specificityⁱ

Highly expressed in pancreas, placenta, and fetal brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000104140 Expressed in 154 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_RHOV
ExpressionAtlasⁱ	Q96L33 baseline and differential
Genevisibleⁱ	Q96L33 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053343

HPAⁱ

HPA053343

Interactionⁱ

Subunit structureⁱ

Interacts with PAK2.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NCK2	O43639	4	EBI-8538631,EBI-713635

With

Entry

#Exp.

IntAct

Notes

NCK2

O43639

4

EBI-8538631,EBI-713635

Protein-protein interaction databases

BioGridⁱ	128110, 1 interactor
IntActⁱ	Q96L33, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q96L33
STRINGⁱ	9606.ENSP00000220507

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96L33
SMRⁱ	Q96L33
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rho family.By similarity

Phylogenomic databases

eggNOGⁱ	KOG0393 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118978
HOGENOMⁱ	HOG000233974
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q96L33
KEGG Orthology (KO) More...KOⁱ	K07866
OMAⁱ	PPQMDYF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E4F
PhylomeDBⁱ	Q96L33
TreeFamⁱ	TF321839

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR003578 Small_GTPase_Rho
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51420 RHO, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96L33-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS 
        60         70         80         90        100
YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY 
       110        120        130        140        150
PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD 
       160        170        180        190        200
VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS 
       210        220        230 
AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV

Length:236

Mass (Da):26,217

Last modified:December 1, 2001 - v1

Checksum:ⁱ334CEEF501107B91

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	177	K → R in BAB86363 (PubMed:11956592).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB079131 mRNA Translation: BAB86363.1 AY059636 mRNA Translation: AAL17966.1 CH471125 Genomic DNA Translation: EAW92459.1 BC105020 mRNA Translation: AAI05021.1 BC105022 mRNA Translation: AAI05023.1 BC112945 mRNA Translation: AAI12946.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10068.1
NCBI Reference Sequences More...RefSeqⁱ	NP_598378.3, NM_133639.3
UniGeneⁱ	Hs.447901

Genome annotation databases

Ensemblⁱ	ENST00000220507; ENSP00000220507; ENSG00000104140
GeneIDⁱ	171177
KEGGⁱ	hsa:171177
UCSC genome browser More...UCSCⁱ	uc001znd.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96L33	Ras homolog gene family, member V, isoform CRA_a		HUMAN		236	UniRef100_Q96L33
RHOV isoform 1		PANTR		236
Ras homolog family member V		CALJA		236
RHOV isoform 1		PONAB		236
Uncharacterized protein		PANPA		236

Protein	Similar proteins		Species	Score	Length	Source
Q96L33	Rho-related GTP-binding protein RhoV		RAT		236	UniRef90_Q9Z1Y0
Rho-related GTP-binding protein RhoV		MOUSE		236
Rho-related GTP-binding protein RhoV		BOVIN		236
Uncharacterized protein		NEOLE		278
RHOV protein (Fragment)		HUMAN		254
+90

Protein	Similar proteins		Species	Score	Length	Source
Q96L33	Rho-related GTP-binding protein RhoV		RAT		236	UniRef50_Q9Z1Y0
Rho-related GTP-binding protein RhoV		BOVIN		236
Rho-related GTP-binding protein RhoV		MOUSE		236
Uncharacterized protein		NEOLE		278
RHOV protein (Fragment)		HUMAN		254
+94

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB079131 mRNA Translation: BAB86363.1 AY059636 mRNA Translation: AAL17966.1 CH471125 Genomic DNA Translation: EAW92459.1 BC105020 mRNA Translation: AAI05021.1 BC105022 mRNA Translation: AAI05023.1 BC112945 mRNA Translation: AAI12946.2
CCDSⁱ	CCDS10068.1
RefSeqⁱ	NP_598378.3, NM_133639.3
UniGeneⁱ	Hs.447901

3D structure databases

ProteinModelPortalⁱ	Q96L33
SMRⁱ	Q96L33
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128110, 1 interactor
IntActⁱ	Q96L33, 2 interactors
MINTⁱ	Q96L33
STRINGⁱ	9606.ENSP00000220507

PTM databases

iPTMnetⁱ	Q96L33
PhosphoSitePlusⁱ	Q96L33

Polymorphism and mutation databases

BioMutaⁱ	RHOV
DMDMⁱ	74724228

Proteomic databases

EPDⁱ	Q96L33
MaxQBⁱ	Q96L33
PaxDbⁱ	Q96L33
PeptideAtlasⁱ	Q96L33
PRIDEⁱ	Q96L33
ProteomicsDBⁱ	77144

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000220507; ENSP00000220507; ENSG00000104140
GeneIDⁱ	171177
KEGGⁱ	hsa:171177
UCSCⁱ	uc001znd.3 human

Organism-specific databases

CTDⁱ	171177
DisGeNETⁱ	171177
EuPathDBⁱ	HostDB:ENSG00000104140.6
GeneCardsⁱ	RHOV
HGNCⁱ	HGNC:18313 RHOV
HPAⁱ	HPA053343
neXtProtⁱ	NX_Q96L33
OpenTargetsⁱ	ENSG00000104140
PharmGKBⁱ	PA38313
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0393 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00760000118978
HOGENOMⁱ	HOG000233974
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q96L33
KOⁱ	K07866
OMAⁱ	PPQMDYF
OrthoDBⁱ	EOG091G0E4F
PhylomeDBⁱ	Q96L33
TreeFamⁱ	TF321839

Enzyme and pathway databases

Reactomeⁱ	R-HSA-194840 Rho GTPase cycle

Reactomeⁱ

R-HSA-194840 Rho GTPase cycle

Miscellaneous databases

GenomeRNAiⁱ	171177
Protein Ontology More...PROⁱ	PR:Q96L33

Gene expression databases

Bgeeⁱ	ENSG00000104140 Expressed in 154 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_RHOV
ExpressionAtlasⁱ	Q96L33 baseline and differential
Genevisibleⁱ	Q96L33 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR003578 Small_GTPase_Rho
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51420 RHO, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RHOV_HUMAN
Accessionⁱ	Q96L33Primary (citable) accession number: Q96L33 Secondary accession number(s): Q2KHQ5, Q8TDW6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96L33 (RHOV_HUMAN)

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Rho-related GTP-binding protein RhoV

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Cytosol

Endosome

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ