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Protein

Rho-related GTP-binding protein RhoV

Gene

RHOV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.By similarity

Cofactori

Mg2+By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45GTPBy similarity8
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi143 – 146GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoV
Alternative name(s):
CDC42-like GTPase 2
GTP-binding protein-like 2
Rho GTPase-like protein ARHV
Wnt-1 responsive Cdc42 homolog 2
Short name:
WRCH-2
Gene namesi
Name:RHOVImported
Synonyms:ARHVImported, WRCH2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104140.6
HGNCiHGNC:18313 RHOV
neXtProtiNX_Q96L33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi171177
OpenTargetsiENSG00000104140
PharmGKBiPA38313

Polymorphism and mutation databases

BioMutaiRHOV
DMDMi74724228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264381 – 236Rho-related GTP-binding protein RhoVAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Lipidationi234S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ96L33
MaxQBiQ96L33
PaxDbiQ96L33
PeptideAtlasiQ96L33
PRIDEiQ96L33
ProteomicsDBi77144

PTM databases

iPTMnetiQ96L33
PhosphoSitePlusiQ96L33

Expressioni

Tissue specificityi

Highly expressed in pancreas, placenta, and fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000104140 Expressed in 154 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_RHOV
ExpressionAtlasiQ96L33 baseline and differential
GenevisibleiQ96L33 HS

Organism-specific databases

HPAiHPA053343

Interactioni

Subunit structurei

Interacts with PAK2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK2O436394EBI-8538631,EBI-713635

Protein-protein interaction databases

BioGridi128110, 1 interactor
IntActiQ96L33, 2 interactors
MINTiQ96L33
STRINGi9606.ENSP00000220507

Structurei

3D structure databases

ProteinModelPortaliQ96L33
SMRiQ96L33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.By similarity

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ96L33
KOiK07866
OMAiPPQMDYF
OrthoDBiEOG091G0E4F
PhylomeDBiQ96L33
TreeFamiTF321839

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Q96L33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS
60 70 80 90 100
YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY
110 120 130 140 150
PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD
160 170 180 190 200
VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS
210 220 230
AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
Length:236
Mass (Da):26,217
Last modified:December 1, 2001 - v1
Checksum:i334CEEF501107B91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177K → R in BAB86363 (PubMed:11956592).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079131 mRNA Translation: BAB86363.1
AY059636 mRNA Translation: AAL17966.1
CH471125 Genomic DNA Translation: EAW92459.1
BC105020 mRNA Translation: AAI05021.1
BC105022 mRNA Translation: AAI05023.1
BC112945 mRNA Translation: AAI12946.2
CCDSiCCDS10068.1
RefSeqiNP_598378.3, NM_133639.3
UniGeneiHs.447901

Genome annotation databases

EnsembliENST00000220507; ENSP00000220507; ENSG00000104140
GeneIDi171177
KEGGihsa:171177
UCSCiuc001znd.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079131 mRNA Translation: BAB86363.1
AY059636 mRNA Translation: AAL17966.1
CH471125 Genomic DNA Translation: EAW92459.1
BC105020 mRNA Translation: AAI05021.1
BC105022 mRNA Translation: AAI05023.1
BC112945 mRNA Translation: AAI12946.2
CCDSiCCDS10068.1
RefSeqiNP_598378.3, NM_133639.3
UniGeneiHs.447901

3D structure databases

ProteinModelPortaliQ96L33
SMRiQ96L33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128110, 1 interactor
IntActiQ96L33, 2 interactors
MINTiQ96L33
STRINGi9606.ENSP00000220507

PTM databases

iPTMnetiQ96L33
PhosphoSitePlusiQ96L33

Polymorphism and mutation databases

BioMutaiRHOV
DMDMi74724228

Proteomic databases

EPDiQ96L33
MaxQBiQ96L33
PaxDbiQ96L33
PeptideAtlasiQ96L33
PRIDEiQ96L33
ProteomicsDBi77144

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220507; ENSP00000220507; ENSG00000104140
GeneIDi171177
KEGGihsa:171177
UCSCiuc001znd.3 human

Organism-specific databases

CTDi171177
DisGeNETi171177
EuPathDBiHostDB:ENSG00000104140.6
GeneCardsiRHOV
HGNCiHGNC:18313 RHOV
HPAiHPA053343
neXtProtiNX_Q96L33
OpenTargetsiENSG00000104140
PharmGKBiPA38313
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ96L33
KOiK07866
OMAiPPQMDYF
OrthoDBiEOG091G0E4F
PhylomeDBiQ96L33
TreeFamiTF321839

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

GenomeRNAii171177
PROiPR:Q96L33

Gene expression databases

BgeeiENSG00000104140 Expressed in 154 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_RHOV
ExpressionAtlasiQ96L33 baseline and differential
GenevisibleiQ96L33 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHOV_HUMAN
AccessioniPrimary (citable) accession number: Q96L33
Secondary accession number(s): Q2KHQ5, Q8TDW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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