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Protein

60S ribosomal protein L10-like

Gene

RPL10L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in compensating for the inactivated X-linked gene during spermatogenesis.1 Publication

Miscellaneous

This gene has no introns in its coding regions, and therefore was most likely produced by retrotransposition of the original X-linked gene during evolution.

GO - Molecular functioni

GO - Biological processi

  • ribosomal large subunit assembly Source: GO_Central
  • spermatogenesis Source: UniProtKB
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L10-like
Alternative name(s):
Large ribosomal subunit protein uL16-like
Gene namesi
Name:RPL10L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165496.4
HGNCiHGNC:17976 RPL10L
neXtProtiNX_Q96L21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165496
PharmGKBiPA34662

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

Polymorphism and mutation databases

BioMutaiRPL10L
DMDMi57013008

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001471061 – 21460S ribosomal protein L10-likeAdd BLAST214

Proteomic databases

EPDiQ96L21
MaxQBiQ96L21
PaxDbiQ96L21
PeptideAtlasiQ96L21
PRIDEiQ96L21
ProteomicsDBi77142

PTM databases

iPTMnetiQ96L21
PhosphoSitePlusiQ96L21
SwissPalmiQ96L21

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000165496
CleanExiHS_RPL10L
GenevisibleiQ96L21 HS

Organism-specific databases

HPAiHPA011311

Interactioni

Protein-protein interaction databases

BioGridi126711, 82 interactors
IntActiQ96L21, 7 interactors
MINTiQ96L21
STRINGi9606.ENSP00000298283

Structurei

3D structure databases

ProteinModelPortaliQ96L21
SMRiQ96L21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0857 Eukaryota
COG0197 LUCA
GeneTreeiENSGT00390000003897
HOGENOMiHOG000223754
HOVERGENiHBG002287
InParanoidiQ96L21
KOiK02866
OMAiGRRPACC
OrthoDBiEOG091G0H9M
PhylomeDBiQ96L21
TreeFamiTF300082

Family and domain databases

CDDicd01433 Ribosomal_L16_L10e, 1 hit
Gene3Di3.90.1170.10, 1 hit
InterProiView protein in InterPro
IPR001197 Ribosomal_L10e
IPR016180 Ribosomal_L10e/L16
IPR036920 Ribosomal_L10e/L16_sf
IPR018255 Ribosomal_L10e_CS
PANTHERiPTHR11726 PTHR11726, 1 hit
PfamiView protein in Pfam
PF00252 Ribosomal_L16, 1 hit
PIRSFiPIRSF005590 Ribosomal_L10, 1 hit
SUPFAMiSSF54686 SSF54686, 1 hit
TIGRFAMsiTIGR00279 uL16_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS01257 RIBOSOMAL_L10E, 1 hit

Sequencei

Sequence statusi: Complete.

Q96L21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLGG
60 70 80 90 100
HMVSDEYEQL SSEALEAARI CANKYMVKSC GRDGFHMRVR LHPFHVIRIN
110 120 130 140 150
KMLSCAGADR LQTGMRGAFG KPQGTVARVH IGQVIMSIRT KLQNEEHVIE
160 170 180 190 200
ALRRAKFKFP GRQKIHISKK WGFTKFNADE FEDMVAKKCL IPDGCGVKYV
210
PSHGPLDKWR VLHS
Length:214
Mass (Da):24,519
Last modified:January 23, 2007 - v3
Checksum:i9119E2F8C40C2E37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063605 Genomic DNA Translation: BAC19833.1
AB063608 mRNA Translation: BAC19835.1
BC014310 mRNA Translation: AAH14310.1
BC066312 mRNA Translation: AAH66312.1
CCDSiCCDS32071.1
RefSeqiNP_542784.1, NM_080746.2
UniGeneiHs.308332

Genome annotation databases

EnsembliENST00000298283; ENSP00000298283; ENSG00000165496
GeneIDi140801
KEGGihsa:140801
UCSCiuc001wwg.5 human

Similar proteinsi

Entry informationi

Entry nameiRL10L_HUMAN
AccessioniPrimary (citable) accession number: Q96L21
Secondary accession number(s): Q8IUD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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