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Entry version 100 (16 Oct 2019)
Sequence version 2 (16 Apr 2014)
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Protein

POM121-like protein 2

Gene

POM121L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

This sequence lacks full-length transcript support.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POM121-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POM121L2
Synonyms:POM121L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13973 POM121L2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96KW2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
94026

Open Targets

More...
OpenTargetsi
ENSG00000158553

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33524

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96KW2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POM121L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002920391 – 1035POM121-like protein 2Add BLAST1035

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96KW2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96KW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96KW2

PeptideAtlas

More...
PeptideAtlasi
Q96KW2

PRoteomics IDEntifications database

More...
PRIDEi
Q96KW2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77125
8090

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96KW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96KW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158553 Expressed in 16 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96KW2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96KW2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046150

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000392726

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96KW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi434 – 502Pro-richAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POM121 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKW8 Eukaryota
ENOG41116VW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015364

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96KW2

KEGG Orthology (KO)

More...
KOi
K14316

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIWSLRH

Database of Orthologous Groups

More...
OrthoDBi
355024at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96KW2

TreeFam database of animal gene trees

More...
TreeFami
TF350673

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026054 Nucleoporin

The PANTHER Classification System

More...
PANTHERi
PTHR23193 PTHR23193, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96KW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSFLSKLEL SPSSPAQVRT DLPERPTKRR PPQPLHQVHR VQFVHRAHPA
60 70 80 90 100
PRYRPVRRRP NLDPANPTTW LANEAWRRFP MKKSQNSPLG PLPSDWWESY
110 120 130 140 150
LKRTIWSLRH PRPIWSPVTI RITPPDQRVP PSTSPEDVIA LAGLPPSEEL
160 170 180 190 200
ADPCSKETVL RALRECRKGK GRLEEPLFPE SLDSKRRSPE TRPSAFKPLM
210 220 230 240 250
KNGTLTSFVP RPGPLKRSLH SWGSDHSLTK RPNCSSMSSL ASIYRGGTLS
260 270 280 290 300
SKRNAIGSSY SSCRNFSDPW KRSVPSVSFE TPEWPIKKEK SCHRPSSPVP
310 320 330 340 350
LVSDFESLGG SESSGQQNQK IPQLPSSPEN LVSEIPPPQL GYAVSDENLT
360 370 380 390 400
LGKKAELQVS NNAGEDTTEV NTDPFPETWL AIQPSLSLAL PSSETDLTQG
410 420 430 440 450
ANPQLENLRK MQKSLGPLAS PQSTGEATSV AHSPLKTPSL PTPPGCSQSE
460 470 480 490 500
LLPGTSPDSK PTATFILLTP TSPTLPVTDT TWPPSTSQAD RSPMPPDPPA
510 520 530 540 550
PPTIQSTLLG MVSSPTSHLS ASAPPDATSA HLMLKPILGP LHNSEIGSSS
560 570 580 590 600
YSRISVTAAA SSISSLSTIQ GTLTPTFKPI FGSIDPLKTT PMIAPFSSKQ
610 620 630 640 650
TPPPFTHAST HHFHGLVKAT SVVMSTTLAS TSKDSVFKPP LDFGVVNVTS
660 670 680 690 700
AVGNTYSVPS TCDTFLLGTA QAFRADFTPA TGFIFPPHHH PTIPTVHTVT
710 720 730 740 750
MFTQVLSSVV QISPRSSTAN FRGMGSPLPA SALVSTNWLA STPSISNLTP
760 770 780 790 800
AITSPLGSSS RPPFPLSQGA NPQPAFGATN GQKQGPSQPA LMPSVSSSFL
810 820 830 840 850
FGSSAVALPT PMPTPAQPAF ISTTQSALGC LTPSASTSQT PASTWSGIGG
860 870 880 890 900
IPAGFPISQA STTGFRIVIQ THQSGAFGSV FGSRAPQPFT FGGFVTPMDC
910 920 930 940 950
DESGIIMTGP DMSPTSGAFS IGALPSGTTN TMIPFGKGWS QNTEGLPSHR
960 970 980 990 1000
TAFSLGRGSI SARKTMAPIA QNTPVPGQAK AGSSVGFGMP FPPAQGSVGR
1010 1020 1030
GPFRSSASSF SIGAKSKTPK NREKGHSRRH HAYKK
Length:1,035
Mass (Da):109,912
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31DC5E1160B21E5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C418H7C418_HUMAN
POM121-like protein 2
POM121L2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL021808 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59497.1

NCBI Reference Sequences

More...
RefSeqi
NP_258443.2, NM_033482.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000444565; ENSP00000392726; ENSG00000158553

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94026

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:94026

UCSC genome browser

More...
UCSCi
uc011dku.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021808 Genomic DNA No translation available.
CCDSiCCDS59497.1
RefSeqiNP_258443.2, NM_033482.3

3D structure databases

SMRiQ96KW2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000392726

PTM databases

iPTMnetiQ96KW2
PhosphoSitePlusiQ96KW2

Polymorphism and mutation databases

BioMutaiPOM121L2
DMDMi74751990

Proteomic databases

EPDiQ96KW2
jPOSTiQ96KW2
PaxDbiQ96KW2
PeptideAtlasiQ96KW2
PRIDEiQ96KW2
ProteomicsDBi77125
8090

Genome annotation databases

EnsembliENST00000444565; ENSP00000392726; ENSG00000158553
GeneIDi94026
KEGGihsa:94026
UCSCiuc011dku.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94026
DisGeNETi94026

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POM121L2
HGNCiHGNC:13973 POM121L2
HPAiHPA046150
neXtProtiNX_Q96KW2
OpenTargetsiENSG00000158553
PharmGKBiPA33524

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKW8 Eukaryota
ENOG41116VW LUCA
GeneTreeiENSGT00940000153253
HOGENOMiHOG000015364
InParanoidiQ96KW2
KOiK14316
OMAiTIWSLRH
OrthoDBi355024at2759
PhylomeDBiQ96KW2
TreeFamiTF350673

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
POM121L2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
94026
PharosiQ96KW2

Protein Ontology

More...
PROi
PR:Q96KW2

Gene expression databases

BgeeiENSG00000158553 Expressed in 16 organ(s), highest expression level in right testis
ExpressionAtlasiQ96KW2 baseline and differential
GenevisibleiQ96KW2 HS

Family and domain databases

InterProiView protein in InterPro
IPR026054 Nucleoporin
PANTHERiPTHR23193 PTHR23193, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP12L2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KW2
Secondary accession number(s): C9J1I7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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