UniProtKB - Q96KV6 (BT2A3_HUMAN)
Protein
Putative butyrophilin subfamily 2 member A3
Gene
BTN2A3P
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Could be the product of a pseudogene.Curated
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
GO - Biological processi
- regulation of cytokine production Source: GO_Central
- regulation of immune response Source: GO_Central
- T cell receptor signaling pathway Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96KV6 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative butyrophilin subfamily 2 member A3 |
Gene namesi | Name:BTN2A3P Synonyms:BTN2A3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13229, BTN2A3P |
MIMi | 613592, gene |
neXtProti | NX_Q96KV6 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 246 | ExtracellularSequence analysisAdd BLAST | 219 | |
Transmembranei | 247 – 267 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 268 – 586 | CytoplasmicSequence analysisAdd BLAST | 319 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Miscellaneous databases
Pharosi | Q96KV6, Tdark |
Genetic variation databases
BioMutai | HGNC:13229 |
DMDMi | 152031567 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000014531 | 28 – 586 | Putative butyrophilin subfamily 2 member A3Add BLAST | 559 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 45 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 50 ↔ 123 | PROSITE-ProRule annotation | ||
Glycosylationi | 112 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 214 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q96KV6 |
MassIVEi | Q96KV6 |
PeptideAtlasi | Q96KV6 |
PRIDEi | Q96KV6 |
ProteomicsDBi | 77119 |
PTM databases
GlyGeni | Q96KV6, 4 sites |
iPTMneti | Q96KV6 |
PhosphoSitePlusi | Q96KV6 |
Interactioni
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
IntActi | Q96KV6, 1 interactor |
MINTi | Q96KV6 |
Miscellaneous databases
RNActi | Q96KV6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 139 | Ig-like V-typeAdd BLAST | 112 | |
Domaini | 281 – 474 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 194 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | Q96KV6 |
PhylomeDBi | Q96KV6 |
Family and domain databases
CDDi | cd15819, SPRY_PRY_BTN1_2, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR006574, PRY IPR037958, SPRY/PRY_BTN1/2 IPR003877, SPRY_dom |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF07686, V-set, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00589, PRY, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q96KV6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPAAALHFS RPASLLLLLS LCALVSAQVT VVGPTDPILA MVGENTTLRC
60 70 80 90 100
CLSPEENAED MEVRWFQSQF SPAVFVYKGG RERTEEQKEE YRGRTTFVSK
110 120 130 140 150
DSRGSVALII HNVTAEDNGI YQCYFQEGRS CNEAILHLVV AGLDSEPVIE
160 170 180 190 200
MRDHEDGGIQ LECISGGWYP KPLTVWRDPY GEVVPALKEV STPDADSLFM
210 220 230 240 250
VTTAVIIRDK SVRNVSCSIN DTLLGQKKES VIFIPESFMP SRSPCVVILP
260 270 280 290 300
VIMIILMIPI AICIYWINNL QKEKKDSHLM TFNLCLSLAG WRRTFLHAAN
310 320 330 340 350
VVLDQDTGHP YLFVSEDKRS VTLDPSRESI PGNPERFDSQ LCVLGQESFA
360 370 380 390 400
SGKHYLEVDV ENVIEWTVGI CRDNVERKWE VPLLPQNGFW TLEMHKRKYW
410 420 430 440 450
ALTSLKWILS LEEPLCQVGI FLDYEAGDVS FYNMRDRSHI YTFPHSAFSV
460 470 480 490 500
PVRPFFSLGS YDSQILICSA FTGASGVTVP EEGWTLHRAG THHSPQNQFP
510 520 530 540 550
SLTAMETSPG HLSSHCTMPL VEDTPSSPLV TQENIFQLPL SHPLQTSAPV
560 570 580
HLLIRCGFSS SFGCNYGMES RHRELVVPQL PARKKV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049830 | 79 | G → D. Corresponds to variant dbSNP:rs7745238Ensembl. | 1 | |
Natural variantiVAR_049831 | 148 | V → I. Corresponds to variant dbSNP:rs10946829Ensembl. | 1 | |
Natural variantiVAR_049832 | 300 | N → S. Corresponds to variant dbSNP:rs2893848Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL021917 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55569.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL021917 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55569.1 |
3D structure databases
SMRi | Q96KV6 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q96KV6, 1 interactor |
MINTi | Q96KV6 |
PTM databases
GlyGeni | Q96KV6, 4 sites |
iPTMneti | Q96KV6 |
PhosphoSitePlusi | Q96KV6 |
Genetic variation databases
BioMutai | HGNC:13229 |
DMDMi | 152031567 |
Proteomic databases
jPOSTi | Q96KV6 |
MassIVEi | Q96KV6 |
PeptideAtlasi | Q96KV6 |
PRIDEi | Q96KV6 |
ProteomicsDBi | 77119 |
Organism-specific databases
GeneCardsi | BTN2A3P |
HGNCi | HGNC:13229, BTN2A3P |
MIMi | 613592, gene |
neXtProti | NX_Q96KV6 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | Q96KV6 |
PhylomeDBi | Q96KV6 |
Enzyme and pathway databases
PathwayCommonsi | Q96KV6 |
Miscellaneous databases
Pharosi | Q96KV6, Tdark |
RNActi | Q96KV6, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd15819, SPRY_PRY_BTN1_2, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR006574, PRY IPR037958, SPRY/PRY_BTN1/2 IPR003877, SPRY_dom |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF07686, V-set, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00589, PRY, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BT2A3_HUMAN | |
Accessioni | Q96KV6Primary (citable) accession number: Q96KV6 Secondary accession number(s): A6NEF4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | July 10, 2007 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families