BTN2A3P

Functionⁱ

Caution

Could be the product of a pseudogene.Curated

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative butyrophilin subfamily 2 member A3
Gene namesⁱ	Name:BTN2A3P Synonyms:BTN2A3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13229 BTN2A3P
MIMⁱ	613592 gene
neXtProtⁱ	NX_Q96KV6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	28 – 246	ExtracellularSequence analysisAdd BLAST	219
Transmembraneⁱ	247 – 267	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	268 – 586	CytoplasmicSequence analysisAdd BLAST	319

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Polymorphism and mutation databases

DMDMⁱ	152031567

DMDMⁱ

152031567

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	Sequence analysisAdd BLAST		27
ChainⁱPRO_0000014531	28 – 586	Putative butyrophilin subfamily 2 member A3Add BLAST		559

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	45	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	50 ↔ 123	PROSITE-ProRule annotation
Glycosylationⁱ	112	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	214	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	220	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q96KV6
PRIDEⁱ	Q96KV6
ProteomicsDBⁱ	77119

PTM databases

iPTMnetⁱ	Q96KV6
PhosphoSitePlusⁱ	Q96KV6

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_BTN2A3

CleanExⁱ

HS_BTN2A3

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q96KV6, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q96KV6

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96KV6
SMRⁱ	Q96KV6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 139	Ig-like V-typeAdd BLAST		112
Domainⁱ	281 – 474	B30.2/SPRYPROSITE-ProRule annotationAdd BLAST		194

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. BTN/MOG family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENⁱ	HBG050747
InParanoidⁱ	Q96KV6
PhylomeDBⁱ	Q96KV6

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15819 SPRY_PRY_BTN1_2, 1 hit
Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR006574 PRY IPR037958 SPRY/PRY_BTN1/2 IPR003877 SPRY_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF00622 SPRY, 1 hit PF07686 V-set, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit SM00589 PRY, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50835 IG_LIKE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q96KV6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPAAALHFS RPASLLLLLS LCALVSAQVT VVGPTDPILA MVGENTTLRC 
        60         70         80         90        100
CLSPEENAED MEVRWFQSQF SPAVFVYKGG RERTEEQKEE YRGRTTFVSK 
       110        120        130        140        150
DSRGSVALII HNVTAEDNGI YQCYFQEGRS CNEAILHLVV AGLDSEPVIE 
       160        170        180        190        200
MRDHEDGGIQ LECISGGWYP KPLTVWRDPY GEVVPALKEV STPDADSLFM 
       210        220        230        240        250
VTTAVIIRDK SVRNVSCSIN DTLLGQKKES VIFIPESFMP SRSPCVVILP 
       260        270        280        290        300
VIMIILMIPI AICIYWINNL QKEKKDSHLM TFNLCLSLAG WRRTFLHAAN 
       310        320        330        340        350
VVLDQDTGHP YLFVSEDKRS VTLDPSRESI PGNPERFDSQ LCVLGQESFA 
       360        370        380        390        400
SGKHYLEVDV ENVIEWTVGI CRDNVERKWE VPLLPQNGFW TLEMHKRKYW 
       410        420        430        440        450
ALTSLKWILS LEEPLCQVGI FLDYEAGDVS FYNMRDRSHI YTFPHSAFSV 
       460        470        480        490        500
PVRPFFSLGS YDSQILICSA FTGASGVTVP EEGWTLHRAG THHSPQNQFP 
       510        520        530        540        550
SLTAMETSPG HLSSHCTMPL VEDTPSSPLV TQENIFQLPL SHPLQTSAPV 
       560        570        580 
HLLIRCGFSS SFGCNYGMES RHRELVVPQL PARKKV

Length:586

Mass (Da):65,713

Last modified:July 10, 2007 - v2

Checksum:ⁱE320F80CAD074448

GO

Sequence cautionⁱ

The sequence CAC69644 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049830	79	G → D. Corresponds to variant dbSNP:rs7745238Ensembl.	1
Natural variantⁱVAR_049831	148	V → I. Corresponds to variant dbSNP:rs10946829Ensembl.	1
Natural variantⁱVAR_049832	300	N → S. Corresponds to variant dbSNP:rs2893848Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL021917 Genomic DNA Translation: CAC69644.2 Sequence problems. CH471087 Genomic DNA Translation: EAW55569.1
UniGeneⁱ	Hs.729655

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length
Q96KV6	Butyrophilin subfamily 2 member A2		MOUSE		514
Butyrophilin, subfamily 2, member A2		RAT		523
UPI000A31A2C8		MUSCR		514
UPI000719FDD1		EQUAS		560
UPI0004BD65FD		EQUPR		560
+267

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL021917 Genomic DNA Translation: CAC69644.2 Sequence problems. CH471087 Genomic DNA Translation: EAW55569.1
UniGeneⁱ	Hs.729655

3D structure databases

ProteinModelPortalⁱ	Q96KV6
SMRⁱ	Q96KV6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q96KV6, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q96KV6

PTM databases

iPTMnetⁱ	Q96KV6
PhosphoSitePlusⁱ	Q96KV6

Polymorphism and mutation databases

DMDMⁱ	152031567

DMDMⁱ

152031567

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q96KV6
PRIDEⁱ	Q96KV6
ProteomicsDBⁱ	77119

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

GeneCardsⁱ	BTN2A3P
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13229 BTN2A3P
MIMⁱ	613592 gene
neXtProtⁱ	NX_Q96KV6
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

HOVERGENⁱ	HBG050747
InParanoidⁱ	Q96KV6
PhylomeDBⁱ	Q96KV6

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

CleanExⁱ	HS_BTN2A3

CleanExⁱ

HS_BTN2A3

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15819 SPRY_PRY_BTN1_2, 1 hit
Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR006574 PRY IPR037958 SPRY/PRY_BTN1/2 IPR003877 SPRY_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF00622 SPRY, 1 hit PF07686 V-set, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit SM00589 PRY, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BT2A3_HUMAN
Accessionⁱ	Q96KV6Primary (citable) accession number: Q96KV6 Secondary accession number(s): A6NEF4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
	Last sequence update:	July 10, 2007
	Last modified:	June 20, 2018
	This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96KV6 (BT2A3_HUMAN)

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Putative butyrophilin subfamily 2 member A3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ