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Entry version 127 (26 Feb 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Protein FAM167A

Gene

FAM167A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM167A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM167A
Synonyms:C8orf13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15549 FAM167A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610085 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96KS9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83648

Open Targets

More...
OpenTargetsi
ENSG00000154319

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387057

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96KS9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM167A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
27923752

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002214331 – 214Protein FAM167AAdd BLAST214

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96KS9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96KS9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96KS9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96KS9

PeptideAtlas

More...
PeptideAtlasi
Q96KS9

PRoteomics IDEntifications database

More...
PRIDEi
Q96KS9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77114

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96KS9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96KS9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skin, including primary keratinocytes, spleen, kidney, leukocytes, testis, lung, small intestine and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154319 Expressed in thyroid gland and 150 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96KS9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96KS9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023915
HPA030426

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123710, 49 interactors

Protein interaction database and analysis system

More...
IntActi
Q96KS9, 52 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000284486

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96KS9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96KS9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili118 – 156Sequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM167 (SEC) family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIXX Eukaryota
ENOG4111HGN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_111170_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96KS9

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTCDLHR

Database of Orthologous Groups

More...
OrthoDBi
1249197at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96KS9

TreeFam database of animal gene trees

More...
TreeFami
TF330468

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024280 FAM167

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11652 FAM167, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96KS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVPQIHVEE VGAEEGAGAA APPDDHLRSL KALTEKLRLE TRRPSYLEWQ
60 70 80 90 100
ARLEEHTWPF PRPAAEPQAS LEEGERGGQE PLLPLREAGQ HPPSARSASQ
110 120 130 140 150
GARPLSTGKL EGFQSIDEAI AWLRKELTEM RLQDQQLARQ LMRLRGDINK
160 170 180 190 200
LKIEHTCRLH RRMLNDATYE LEERDELADL FCDSPLASSF SLSTPLKLIG
210
VTKMNINSRR FSLC
Length:214
Mass (Da):24,182
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14216A4E58987284
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIY0E9PIY0_HUMAN
Protein FAM167A
FAM167A
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU03A0A3B3IU03_HUMAN
Protein FAM167A
FAM167A
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130M → L in CAD38843 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06220556H → Q3 PublicationsCorresponds to variant dbSNP:rs3021513Ensembl.1
Natural variantiVAR_062206107T → S2 PublicationsCorresponds to variant dbSNP:rs3021512Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ301564 mRNA Translation: CAC82740.1
AK290704 mRNA Translation: BAF83393.1
AL834122 mRNA Translation: CAD38843.1
AL157475 mRNA Translation: CAB75670.1
BC104041 mRNA Translation: AAI04042.1
BC104042 mRNA Translation: AAI04043.1
BC104043 mRNA Translation: AAI04044.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5981.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T46905

NCBI Reference Sequences

More...
RefSeqi
NP_444509.2, NM_053279.2
XP_005272455.1, XM_005272398.4
XP_011542139.1, XM_011543837.1
XP_011542140.1, XM_011543838.2
XP_011542142.1, XM_011543840.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000284486; ENSP00000284486; ENSG00000154319
ENST00000528897; ENSP00000436655; ENSG00000154319
ENST00000534308; ENSP00000432232; ENSG00000154319

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83648

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83648

UCSC genome browser

More...
UCSCi
uc003wtw.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ301564 mRNA Translation: CAC82740.1
AK290704 mRNA Translation: BAF83393.1
AL834122 mRNA Translation: CAD38843.1
AL157475 mRNA Translation: CAB75670.1
BC104041 mRNA Translation: AAI04042.1
BC104042 mRNA Translation: AAI04043.1
BC104043 mRNA Translation: AAI04044.1
CCDSiCCDS5981.1
PIRiT46905
RefSeqiNP_444509.2, NM_053279.2
XP_005272455.1, XM_005272398.4
XP_011542139.1, XM_011543837.1
XP_011542140.1, XM_011543838.2
XP_011542142.1, XM_011543840.2

3D structure databases

SMRiQ96KS9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123710, 49 interactors
IntActiQ96KS9, 52 interactors
STRINGi9606.ENSP00000284486

PTM databases

iPTMnetiQ96KS9
PhosphoSitePlusiQ96KS9

Polymorphism and mutation databases

BioMutaiFAM167A
DMDMi27923752

Proteomic databases

EPDiQ96KS9
jPOSTiQ96KS9
MassIVEiQ96KS9
PaxDbiQ96KS9
PeptideAtlasiQ96KS9
PRIDEiQ96KS9
ProteomicsDBi77114

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83648

Genome annotation databases

EnsembliENST00000284486; ENSP00000284486; ENSG00000154319
ENST00000528897; ENSP00000436655; ENSG00000154319
ENST00000534308; ENSP00000432232; ENSG00000154319
GeneIDi83648
KEGGihsa:83648
UCSCiuc003wtw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83648
DisGeNETi83648

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM167A
HGNCiHGNC:15549 FAM167A
HPAiHPA023915
HPA030426
MIMi610085 gene
neXtProtiNX_Q96KS9
OpenTargetsiENSG00000154319
PharmGKBiPA162387057

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIXX Eukaryota
ENOG4111HGN LUCA
GeneTreeiENSGT00940000159097
HOGENOMiCLU_111170_0_0_1
InParanoidiQ96KS9
OMAiQTCDLHR
OrthoDBi1249197at2759
PhylomeDBiQ96KS9
TreeFamiTF330468

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM167A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83648
PharosiQ96KS9 Tbio

Protein Ontology

More...
PROi
PR:Q96KS9
RNActiQ96KS9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154319 Expressed in thyroid gland and 150 other tissues
ExpressionAtlasiQ96KS9 baseline and differential
GenevisibleiQ96KS9 HS

Family and domain databases

InterProiView protein in InterPro
IPR024280 FAM167
PfamiView protein in Pfam
PF11652 FAM167, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF167A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KS9
Secondary accession number(s): A8K3T9
, Q3SXY1, Q3SXY3, Q8N3M3, Q9NSR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: December 1, 2001
Last modified: February 26, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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