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UniProtKB - Q96KR7 (PHAR3_HUMAN)

Entry version 165 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Phosphatase and actin regulator 3

Gene

PHACTR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Protein phosphatase inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96KR7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatase and actin regulator 3
Alternative name(s):
Scaffold-associated PP1-inhibiting protein
Short name:
Scapinin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHACTR3
Synonyms:C20orf101, SCAPIN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000087495.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:15833, PHACTR3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608725, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96KR7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		116154

Open Targets

More...OpenTargetsi		ENSG00000087495

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394750

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96KR7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PHACTR3

Domain mapping of disease mutations (DMDM)

More...DMDMi		38605426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001266381 – 559Phosphatase and actin regulator 3Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei70PhosphothreonineCombined sources1
Modified residuei230PhosphoserineBy similarity1
Modified residuei236PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96KR7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96KR7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96KR7

PeptideAtlas

More...PeptideAtlasi		Q96KR7

PRoteomics IDEntifications database

More...PRIDEi		Q96KR7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3118
77109 [Q96KR7-1]
77110 [Q96KR7-2]
77111 [Q96KR7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96KR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96KR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL-60 leukemia cells.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in HL-60 leukemia cells by RA, PMA and dimethyl sulfoxide.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000087495, Expressed in frontal cortex and 154 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96KR7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96KR7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000087495, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125483, 34 interactors

Protein interaction database and analysis system

More...IntActi		Q96KR7, 34 interactors

Molecular INTeraction database

More...MINTi		Q96KR7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360054

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96KR7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96KR7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati93 – 118RPEL 1Add BLAST26
Repeati401 – 426RPEL 2Add BLAST26
Repeati439 – 464RPEL 3Add BLAST26
Repeati477 – 502RPEL 4Add BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni438 – 518Required for PP1CA binding and inhibition of PP1 activityAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili346 – 369Sequence analysisAdd BLAST24
Coiled coili450 – 486Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi217 – 239Pro-richAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphatase and actin regulator family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4339, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157562

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015753_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96KR7

Identification of Orthologs from Complete Genome Data

More...OMAi		EDCVLQR

Database of Orthologous Groups

More...OrthoDBi		1205245at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96KR7

TreeFam database of animal gene trees

More...TreeFami		TF316316

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029990, Phactr3
IPR004018, RPEL_repeat

The PANTHER Classification System

More...PANTHERi		PTHR12751:SF7, PTHR12751:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02755, RPEL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00707, RPEL, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51073, RPEL, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96KR7-1) [UniParc]FASTAAdd to basket
Also known as: Scapinin 1B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASEDGSGC LVSRGRSQSD PSVLTDSSAT SSADAGENPD EMDQTPPARP 
        60         70         80         90        100
EYLVSGIRTP PVRRNSKLAT LGRIFKPWKW RKKKNEKLKQ TTSALEKKMA 
       110        120        130        140        150
GRQGREELIK KGLLEMMEQD AESKTCNPDG GPRSVQSEPP TPKSETLTSE 
       160        170        180        190        200
DAQPGSPLAT GTDQVSLDKP LSSAAHLDDA AKMPSASSGE EADAGSLLPT 
       210        220        230        240        250
TNELSQALAG ADSLDSPPRP LERSVGQLPS PPLLPTPPPK ASSKTTKNVT 
       260        270        280        290        300
GQATLFQASS MKSADPSLRG QLSTPTGSPH LTTVHRPLPP SRVIEELHRA 
       310        320        330        340        350
LATKHRQDSF QGRESKGSPK KRLDVRLSRT SSVERGKERE EAWSFDGALE 
       360        370        380        390        400
NKRTAAKESE ENKENLIINS ELKDDLLLYQ DEEALNDSII SGTLPRKCKK 
       410        420        430        440        450
ELLAVKLRNR PSKQELEDRN IFPRRTDEER QEIRQQIEMK LSKRLSQRPA 
       460        470        480        490        500
VEELERRNIL KQRNDQTEQE ERREIKQRLT RKLNQRPTVD ELRDRKILIR 
       510        520        530        540        550
FSDYVEVAKA QDYDRRADKP WTRLSAADKA AIRKELNEYK SNEMEVHASS 

KHLTRFHRP
Length:559
Mass (Da):62,552
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE98182FBE3D25D37
GO
Isoform 2 (identifier: Q96KR7-2) [UniParc]FASTAAdd to basket
Also known as: Scapinin-L, Scapinin 1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:518
Mass (Da):58,525
Checksum:i9DE458851866A690
GO
Isoform 3 (identifier: Q96KR7-3) [UniParc]FASTAAdd to basket
Also known as: Scapinin-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     181-250: Missing.

Show »
Length:448
Mass (Da):51,479
Checksum:i2F9803B04D14228F
GO
Isoform 4 (identifier: Q96KR7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MAASEDGSGCLVSRGRSQSDPSVLTDSSATSSADAGENP → MRGRGGGRARCPAPLRSLLGAFGARDAAAAARDPAQ

Show »
Length:556
Mass (Da):62,373
Checksum:i347BA6104D0920FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F9ZHM5A0A5F9ZHM5_HUMAN
Phosphatase and actin regulator
PHACTR3
128Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RP66F6RP66_HUMAN
Phosphatase and actin regulator 3
PHACTR3
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC67489 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62V → M in AK098788 (PubMed:14702039).Curated1
Sequence conflicti118E → G in AK098788 (PubMed:14702039).Curated1
Sequence conflicti321K → R in CAF04087 (Ref. 2) Curated1
Sequence conflicti399K → R in CAF04087 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021969154P → L. Corresponds to variant dbSNP:rs2277759Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0090911 – 41Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST41
Alternative sequenceiVSP_0445461 – 39MAASE…AGENP → MRGRGGGRARCPAPLRSLLG AFGARDAAAAARDPAQ in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_009092181 – 250Missing in isoform 3. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB098521 mRNA Translation: BAC82348.1
AB098522 mRNA Translation: BAC82349.1
AJ311122 mRNA Translation: CAC67489.2 Different initiation.
AJ617581 mRNA Translation: CAF04087.1
AK098788 mRNA No translation available.
AK314493 mRNA Translation: BAG37093.1
AK316047 mRNA Translation: BAH14418.1
AL121908 Genomic DNA No translation available.
AL357503 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75428.1
CH471077 Genomic DNA Translation: EAW75429.1
CH471077 Genomic DNA Translation: EAW75430.1
BC108303 mRNA Translation: AAI08304.1
BC117362 mRNA Translation: AAI17363.1
BC117364 mRNA Translation: AAI17365.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13480.1 [Q96KR7-1]
CCDS13481.1 [Q96KR7-3]
CCDS42895.1 [Q96KR7-2]
CCDS56202.1 [Q96KR7-4]

NCBI Reference Sequences

More...RefSeqi		NP_001186434.1, NM_001199505.1 [Q96KR7-4]
NP_001186435.1, NM_001199506.1 [Q96KR7-2]
NP_001268436.1, NM_001281507.1 [Q96KR7-2]
NP_542403.1, NM_080672.4 [Q96KR7-1]
NP_899067.1, NM_183244.1 [Q96KR7-2]
NP_899069.1, NM_183246.1 [Q96KR7-3]
XP_011526827.1, XM_011528525.2 [Q96KR7-2]
XP_016883115.1, XM_017027626.1 [Q96KR7-2]
XP_016883116.1, XM_017027627.1 [Q96KR7-2]
XP_016883118.1, XM_017027629.1 [Q96KR7-3]
XP_016883119.1, XM_017027630.1 [Q96KR7-3]
XP_016883120.1, XM_017027631.1 [Q96KR7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355648; ENSP00000347866; ENSG00000087495 [Q96KR7-2]
ENST00000359926; ENSP00000353002; ENSG00000087495 [Q96KR7-4]
ENST00000361300; ENSP00000354555; ENSG00000087495 [Q96KR7-3]
ENST00000371015; ENSP00000360054; ENSG00000087495 [Q96KR7-1]
ENST00000395636; ENSP00000378998; ENSG00000087495 [Q96KR7-2]
ENST00000541461; ENSP00000442483; ENSG00000087495 [Q96KR7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:116154

UCSC genome browser

More...UCSCi		uc002yat.3, human [Q96KR7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098521 mRNA Translation: BAC82348.1
AB098522 mRNA Translation: BAC82349.1
AJ311122 mRNA Translation: CAC67489.2 Different initiation.
AJ617581 mRNA Translation: CAF04087.1
AK098788 mRNA No translation available.
AK314493 mRNA Translation: BAG37093.1
AK316047 mRNA Translation: BAH14418.1
AL121908 Genomic DNA No translation available.
AL357503 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75428.1
CH471077 Genomic DNA Translation: EAW75429.1
CH471077 Genomic DNA Translation: EAW75430.1
BC108303 mRNA Translation: AAI08304.1
BC117362 mRNA Translation: AAI17363.1
BC117364 mRNA Translation: AAI17365.1
CCDSiCCDS13480.1 [Q96KR7-1]
CCDS13481.1 [Q96KR7-3]
CCDS42895.1 [Q96KR7-2]
CCDS56202.1 [Q96KR7-4]
RefSeqiNP_001186434.1, NM_001199505.1 [Q96KR7-4]
NP_001186435.1, NM_001199506.1 [Q96KR7-2]
NP_001268436.1, NM_001281507.1 [Q96KR7-2]
NP_542403.1, NM_080672.4 [Q96KR7-1]
NP_899067.1, NM_183244.1 [Q96KR7-2]
NP_899069.1, NM_183246.1 [Q96KR7-3]
XP_011526827.1, XM_011528525.2 [Q96KR7-2]
XP_016883115.1, XM_017027626.1 [Q96KR7-2]
XP_016883116.1, XM_017027627.1 [Q96KR7-2]
XP_016883118.1, XM_017027629.1 [Q96KR7-3]
XP_016883119.1, XM_017027630.1 [Q96KR7-3]
XP_016883120.1, XM_017027631.1 [Q96KR7-2]

3D structure databases

SMRiQ96KR7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125483, 34 interactors
IntActiQ96KR7, 34 interactors
MINTiQ96KR7
STRINGi9606.ENSP00000360054

PTM databases

iPTMnetiQ96KR7
PhosphoSitePlusiQ96KR7

Polymorphism and mutation databases

BioMutaiPHACTR3
DMDMi38605426

Proteomic databases

EPDiQ96KR7
MassIVEiQ96KR7
PaxDbiQ96KR7
PeptideAtlasiQ96KR7
PRIDEiQ96KR7
ProteomicsDBi3118
77109 [Q96KR7-1]
77110 [Q96KR7-2]
77111 [Q96KR7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29289, 111 antibodies

The DNASU plasmid repository

More...DNASUi		116154

Genome annotation databases

EnsembliENST00000355648; ENSP00000347866; ENSG00000087495 [Q96KR7-2]
ENST00000359926; ENSP00000353002; ENSG00000087495 [Q96KR7-4]
ENST00000361300; ENSP00000354555; ENSG00000087495 [Q96KR7-3]
ENST00000371015; ENSP00000360054; ENSG00000087495 [Q96KR7-1]
ENST00000395636; ENSP00000378998; ENSG00000087495 [Q96KR7-2]
ENST00000541461; ENSP00000442483; ENSG00000087495 [Q96KR7-2]
GeneIDi116154
KEGGihsa:116154
UCSCiuc002yat.3, human [Q96KR7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		116154
DisGeNETi116154
EuPathDBiHostDB:ENSG00000087495.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		PHACTR3
HGNCiHGNC:15833, PHACTR3
HPAiENSG00000087495, Tissue enriched (brain)
MIMi608725, gene
neXtProtiNX_Q96KR7
OpenTargetsiENSG00000087495
PharmGKBiPA128394750

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4339, Eukaryota
GeneTreeiENSGT00940000157562
HOGENOMiCLU_015753_3_1_1
InParanoidiQ96KR7
OMAiEDCVLQR
OrthoDBi1205245at2759
PhylomeDBiQ96KR7
TreeFamiTF316316

Enzyme and pathway databases

PathwayCommonsiQ96KR7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		116154, 3 hits in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PHACTR3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PHACTR3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		116154
PharosiQ96KR7, Tbio

Protein Ontology

More...PROi		PR:Q96KR7
RNActiQ96KR7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000087495, Expressed in frontal cortex and 154 other tissues
ExpressionAtlasiQ96KR7, baseline and differential
GenevisibleiQ96KR7, HS

Family and domain databases

InterProiView protein in InterPro
IPR029990, Phactr3
IPR004018, RPEL_repeat
PANTHERiPTHR12751:SF7, PTHR12751:SF7, 1 hit
PfamiView protein in Pfam
PF02755, RPEL, 1 hit
SMARTiView protein in SMART
SM00707, RPEL, 4 hits
PROSITEiView protein in PROSITE
PS51073, RPEL, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHAR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KR7
Secondary accession number(s): B1AKX0
, B1AN68, B1AN69, B2RB46, Q32P33, Q707P6, Q9H4T4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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