UniProtKB - Q96KQ4 (ASPP1_HUMAN)

BLAST

>sp|Q96KQ4|ASPP1_HUMAN Apoptosis-stimulating of p53 protein 1 OS=Homo sapiens OX=9606 GN=PPP1R13B PE=1 SV=3
MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDH
MMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVG
NPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLK
ERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQ
QLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRN
MEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPV
LGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVK
QGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLE
RRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPA
GDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSA
LNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADG
STVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGP
NIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP
LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEA
PSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGE
FDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHC
AASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMN
KGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYP
RIKPRQRTLA

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History
Entry version 144 (07 Nov 2018)
Sequence version 3 (18 May 2010)
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Protein

Apoptosis-stimulating of p53 protein 1

Gene

PPP1R13B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.1 Publication

Miscellaneous

In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.

GO - Molecular functionⁱ

p53 binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intrinsic apoptotic signaling pathway by p53 class mediator
Source: UniProtKB
Inferred from direct assayⁱ
- 11684014
negative regulation of cell cycle
Source: UniProtKB
Traceable author statementⁱ
- 14729977
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
regulation of apoptotic process Source: Reactome
regulation of signal transduction by p53 class mediator Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-139915 Activation of PUMA and translocation to mitochondria R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Reactomeⁱ

R-HSA-139915 Activation of PUMA and translocation to mitochondria
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apoptosis-stimulating of p53 protein 1 Alternative name(s): Protein phosphatase 1 regulatory subunit 13B
Gene namesⁱ	Name:PPP1R13B Synonyms:ASPP1, KIAA0771
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000088808.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14950 PPP1R13B
MIMⁱ	606455 gene
neXtProtⁱ	NX_Q96KQ4

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23368
Open Targets More...OpenTargetsⁱ	ENSG00000088808
PharmGKBⁱ	PA33622

Polymorphism and mutation databases

BioMutaⁱ	PPP1R13B
DMDMⁱ	296439434

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066962	1 – 1090	Apoptosis-stimulating of p53 protein 1Add BLAST		1090

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	332	PhosphoserineCombined sources	1
Modified residueⁱ	335	PhosphoserineCombined sources	1
Modified residueⁱ	554	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	681	PhosphoserineCombined sources	1
Modified residueⁱ	710	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q96KQ4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96KQ4
PaxDbⁱ	Q96KQ4
PeptideAtlas More...PeptideAtlasⁱ	Q96KQ4
PRIDEⁱ	Q96KQ4
ProteomicsDBⁱ	77101

PTM databases

CarbonylDBⁱ	Q96KQ4
iPTMnetⁱ	Q96KQ4
PhosphoSitePlusⁱ	Q96KQ4

Expressionⁱ

Tissue specificityⁱ

Reduced expression in breast carcinomas expressing a wild-type TP53 protein.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000088808 Expressed in 217 organ(s), highest expression level in testis
CleanExⁱ	HS_PPP1R13B
ExpressionAtlasⁱ	Q96KQ4 baseline and differential
Genevisibleⁱ	Q96KQ4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB015454 HPA006394

HPAⁱ

CAB015454
HPA006394

Interactionⁱ

Subunit structureⁱ

Interacts with TP53.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCDC184	Q52MB2	3	EBI-1105153,EBI-10179526
CDC5L	Q99459	3	EBI-1105153,EBI-374880
EP300	Q09472	2	EBI-1105153,EBI-447295
MIPOL1	Q8TD10	3	EBI-1105153,EBI-2548751
PPP1CA	P62136	9	EBI-1105153,EBI-357253
TRAF1	Q13077	3	EBI-1105153,EBI-359224

GO - Molecular functionⁱ

p53 binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116948, 52 interactors
CORUMⁱ	Q96KQ4
ELMⁱ	Q96KQ4
IntActⁱ	Q96KQ4, 88 interactors
Molecular INTeraction database More...MINTⁱ	Q96KQ4
STRINGⁱ	9606.ENSP00000202556

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96KQ4
SMRⁱ	Q96KQ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	920 – 952	ANK 1Add BLAST	33
Repeatⁱ	953 – 985	ANK 2Add BLAST	33
Domainⁱ	1019 – 1081	SH3PROSITE-ProRule annotationAdd BLAST	63

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	132 – 292	Gln-richAdd BLAST		161
Compositional biasⁱ	428 – 860	Pro-richAdd BLAST		433

Domainⁱ

The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.

Sequence similaritiesⁱ

Belongs to the ASPP family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG0515 Eukaryota ENOG410Y17W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119141
HOGENOMⁱ	HOG000034106
HOVERGENⁱ	HBG050596
InParanoidⁱ	Q96KQ4
KEGG Orthology (KO) More...KOⁱ	K17554
OMAⁱ	NYQPAAH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R1R
PhylomeDBⁱ	Q96KQ4
TreeFamⁱ	TF105545

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR028319 ASPP_1 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR24131:SF5 PTHR24131:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00326 SH3, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF50044 SSF50044, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits PS50002 SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q96KQ4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR 
        60         70         80         90        100
GNERPIPFDH MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ 
       110        120        130        140        150
RTQRNVINVP GEKRTENGVG NPRVELTLSE LQDMAARQQQ QIENQQQMLV 
       160        170        180        190        200
AKEQRLHFLK QQERRQQQSI SENEKLQKLK ERVEAQENKL KKIRAMRGQV 
       210        220        230        240        250
DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ QLEDLKKGKL 
       260        270        280        290        300
NGFQSYNGKL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN 
       310        320        330        340        350
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI 
       360        370        380        390        400
QVPSAGSFPV LGDPIKPQSL SIASNAAHGR SKSANDGNWP TLKQNSSSSV 
       410        420        430        440        450
KPVQVAGADW KDPSVEGSVK QGTVSSQPVP FSALGPTEKP GIEIGKVPPP 
       460        470        480        490        500
IPGVGKQLPP SYGTYPSPTP LGPGSTSSLE RRKEGSLPRP SAGLPSRQRP 
       510        520        530        540        550
TLLPATGSTP QPGSSQQIQQ RISVPPSPTY PPAGPPAFPA GDSKPELPLT 
       560        570        580        590        600
VAIRPFLADK GSRPQSPRKG PQTVNSSSIY SMYLQQATPP KNYQPAAHSA 
       610        620        630        640        650
LNKSVKAVYG KPVLPSGSTS PSPLPFLHGS LSTGTPQPQP PSESTEKEPE 
       660        670        680        690        700
QDGPAAPADG STVESLPRPL SPTKLTPIVH SPLRYQSDAD LEALRRKLAN 
       710        720        730        740        750
APRPLKKRSS ITEPEGPGGP NIQKLLYQRF NTLAGGMEGT PFYQPSPSQD 
       760        770        780        790        800
FMGTLADVDN GNTNANGNLE ELPPAQPTAP LPAEPAPSSD ANDNELPSPE 
       810        820        830        840        850
PEELICPQTT HQTAEPAEDN NNNVATVPTT EQIPSPVAEA PSPGEEQVPP 
       860        870        880        890        900
APLPPASHPP ATSTNKRTNL KKPNSERTGH GLRVRFNPLA LLLDASLEGE 
       910        920        930        940        950
FDLVQRIIYE VEDPSKPNDE GITPLHNAVC AGHHHIVKFL LDFGVNVNAA 
       960        970        980        990       1000
DSDGWTPLHC AASCNSVHLC KQLVESGAAI FASTISDIET AADKCEEMEE 
      1010       1020       1030       1040       1050
GYIQCSQFLY GVQEKLGVMN KGVAYALWDY EAQNSDELSF HEGDALTILR 
      1060       1070       1080       1090
RKDESETEWW WARLGDREGY VPKNLLGLYP RIKPRQRTLA

Length:1,090

Mass (Da):119,565

Last modified:May 18, 2010 - v3

Checksum:ⁱ0026F07D7AB33295

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YJL1	H0YJL1_HUMAN	Apoptosis-stimulating of p53 protei... Apoptosis-stimulating of p53 protein 1	PPP1R13B	635	Annotation score:
G3V5J1	G3V5J1_HUMAN	Apoptosis-stimulating of p53 protei... Apoptosis-stimulating of p53 protein 1	PPP1R13B	149	Annotation score:
G3V3S2	G3V3S2_HUMAN	Apoptosis-stimulating of p53 protei... Apoptosis-stimulating of p53 protein 1	PPP1R13B	122	Annotation score:
G3V2L3	G3V2L3_HUMAN	Apoptosis-stimulating of p53 protei... Apoptosis-stimulating of p53 protein 1	PPP1R13B	143	Annotation score:
H0YJG1	H0YJG1_HUMAN	Apoptosis-stimulating of p53 protei... Apoptosis-stimulating of p53 protein 1	PPP1R13B	106	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	68	K → I in CAC83011 (PubMed:11684014).Curated	1
Sequence conflictⁱ	112	E → D in CAC83011 (PubMed:11684014).Curated	1
Sequence conflictⁱ	117	N → Y in CAC83011 (PubMed:11684014).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ318887 mRNA Translation: CAC83011.2 AL049840 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81847.1 BC136527 mRNA Translation: AAI36528.1 AB018314 mRNA Translation: BAA34491.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41997.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056131.2, NM_015316.2
UniGeneⁱ	Hs.709297

Genome annotation databases

Ensemblⁱ	ENST00000202556; ENSP00000202556; ENSG00000088808
GeneIDⁱ	23368
KEGGⁱ	hsa:23368
UCSC genome browser More...UCSCⁱ	uc001yof.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96KQ4	Apoptosis-stimulating of p53 protein 1		MOUSE		1087	UniRef90_Q96KQ4
Apoptosis-stimulating of protein 1		CRIGR		1196
Uncharacterized protein		MACMU		1094
Uncharacterized protein		MACNE		1092
Uncharacterized protein		COLAP		1092
+75

Protein	Similar proteins		Species	Score	Length	Source
Q96KQ4	Apoptosis-stimulating of p53 protein 1		MOUSE		1087	UniRef50_Q96KQ4
Apoptosis-stimulating of protein 1		CRIGR		1196
Uncharacterized protein		MACMU		1094
Uncharacterized protein		MACNE		1092
Uncharacterized protein		COLAP		1092
+591

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ318887 mRNA Translation: CAC83011.2 AL049840 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81847.1 BC136527 mRNA Translation: AAI36528.1 AB018314 mRNA Translation: BAA34491.1
CCDSⁱ	CCDS41997.1
RefSeqⁱ	NP_056131.2, NM_015316.2
UniGeneⁱ	Hs.709297

3D structure databases

ProteinModelPortalⁱ	Q96KQ4
SMRⁱ	Q96KQ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116948, 52 interactors
CORUMⁱ	Q96KQ4
ELMⁱ	Q96KQ4
IntActⁱ	Q96KQ4, 88 interactors
MINTⁱ	Q96KQ4
STRINGⁱ	9606.ENSP00000202556

PTM databases

CarbonylDBⁱ	Q96KQ4
iPTMnetⁱ	Q96KQ4
PhosphoSitePlusⁱ	Q96KQ4

Polymorphism and mutation databases

BioMutaⁱ	PPP1R13B
DMDMⁱ	296439434

Proteomic databases

EPDⁱ	Q96KQ4
MaxQBⁱ	Q96KQ4
PaxDbⁱ	Q96KQ4
PeptideAtlasⁱ	Q96KQ4
PRIDEⁱ	Q96KQ4
ProteomicsDBⁱ	77101

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000202556; ENSP00000202556; ENSG00000088808
GeneIDⁱ	23368
KEGGⁱ	hsa:23368
UCSCⁱ	uc001yof.2 human

Organism-specific databases

CTDⁱ	23368
DisGeNETⁱ	23368
EuPathDBⁱ	HostDB:ENSG00000088808.16
GeneCardsⁱ	PPP1R13B
H-InvDBⁱ	HIX0012009
HGNCⁱ	HGNC:14950 PPP1R13B
HPAⁱ	CAB015454 HPA006394
MIMⁱ	606455 gene
neXtProtⁱ	NX_Q96KQ4
OpenTargetsⁱ	ENSG00000088808
PharmGKBⁱ	PA33622
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0515 Eukaryota ENOG410Y17W LUCA
GeneTreeⁱ	ENSGT00760000119141
HOGENOMⁱ	HOG000034106
HOVERGENⁱ	HBG050596
InParanoidⁱ	Q96KQ4
KOⁱ	K17554
OMAⁱ	NYQPAAH
OrthoDBⁱ	EOG091G0R1R
PhylomeDBⁱ	Q96KQ4
TreeFamⁱ	TF105545

Enzyme and pathway databases

Reactomeⁱ	R-HSA-139915 Activation of PUMA and translocation to mitochondria R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Reactomeⁱ

Miscellaneous databases

ChiTaRSⁱ	PPP1R13B human
GeneWikiⁱ	PPP1R13B
GenomeRNAiⁱ	23368
Protein Ontology More...PROⁱ	PR:Q96KQ4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000088808 Expressed in 217 organ(s), highest expression level in testis
CleanExⁱ	HS_PPP1R13B
ExpressionAtlasⁱ	Q96KQ4 baseline and differential
Genevisibleⁱ	Q96KQ4 HS

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR028319 ASPP_1 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR24131:SF5 PTHR24131:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00326 SH3, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF50044 SSF50044, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ASPP1_HUMAN
Accessionⁱ	Q96KQ4Primary (citable) accession number: Q96KQ4 Secondary accession number(s): B2RMX5, O94870
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q96KQ4 (ASPP1_HUMAN)

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Apoptosis-stimulating of p53 protein 1

PPP1R13B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ