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Protein

Apoptosis-stimulating of p53 protein 1

Gene

PPP1R13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.1 Publication

Miscellaneous

In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.

GO - Molecular functioni

  • p53 binding Source: GO_Central
  • transcription factor binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-139915 Activation of PUMA and translocation to mitochondria
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-stimulating of p53 protein 1
Alternative name(s):
Protein phosphatase 1 regulatory subunit 13B
Gene namesi
Name:PPP1R13B
Synonyms:ASPP1, KIAA0771
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000088808.16
HGNCiHGNC:14950 PPP1R13B
MIMi606455 gene
neXtProtiNX_Q96KQ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23368
OpenTargetsiENSG00000088808
PharmGKBiPA33622

Polymorphism and mutation databases

BioMutaiPPP1R13B
DMDMi296439434

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669621 – 1090Apoptosis-stimulating of p53 protein 1Add BLAST1090

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei554Asymmetric dimethylarginineBy similarity1
Modified residuei681PhosphoserineCombined sources1
Modified residuei710PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ96KQ4
MaxQBiQ96KQ4
PaxDbiQ96KQ4
PeptideAtlasiQ96KQ4
PRIDEiQ96KQ4
ProteomicsDBi77101

PTM databases

CarbonylDBiQ96KQ4
iPTMnetiQ96KQ4
PhosphoSitePlusiQ96KQ4

Expressioni

Tissue specificityi

Reduced expression in breast carcinomas expressing a wild-type TP53 protein.1 Publication

Gene expression databases

BgeeiENSG00000088808 Expressed in 217 organ(s), highest expression level in testis
CleanExiHS_PPP1R13B
ExpressionAtlasiQ96KQ4 baseline and differential
GenevisibleiQ96KQ4 HS

Organism-specific databases

HPAiCAB015454
HPA006394

Interactioni

Subunit structurei

Interacts with TP53.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116948, 52 interactors
CORUMiQ96KQ4
ELMiQ96KQ4
IntActiQ96KQ4, 88 interactors
MINTiQ96KQ4
STRINGi9606.ENSP00000202556

Structurei

3D structure databases

ProteinModelPortaliQ96KQ4
SMRiQ96KQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati920 – 952ANK 1Add BLAST33
Repeati953 – 985ANK 2Add BLAST33
Domaini1019 – 1081SH3PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 292Gln-richAdd BLAST161
Compositional biasi428 – 860Pro-richAdd BLAST433

Domaini

The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.

Sequence similaritiesi

Belongs to the ASPP family.Curated

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0515 Eukaryota
ENOG410Y17W LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000034106
HOVERGENiHBG050596
InParanoidiQ96KQ4
KOiK17554
OMAiNYQPAAH
OrthoDBiEOG091G0R1R
PhylomeDBiQ96KQ4
TreeFamiTF105545

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR028319 ASPP_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR24131:SF5 PTHR24131:SF5, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q96KQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR
60 70 80 90 100
GNERPIPFDH MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ
110 120 130 140 150
RTQRNVINVP GEKRTENGVG NPRVELTLSE LQDMAARQQQ QIENQQQMLV
160 170 180 190 200
AKEQRLHFLK QQERRQQQSI SENEKLQKLK ERVEAQENKL KKIRAMRGQV
210 220 230 240 250
DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ QLEDLKKGKL
260 270 280 290 300
NGFQSYNGKL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN
310 320 330 340 350
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI
360 370 380 390 400
QVPSAGSFPV LGDPIKPQSL SIASNAAHGR SKSANDGNWP TLKQNSSSSV
410 420 430 440 450
KPVQVAGADW KDPSVEGSVK QGTVSSQPVP FSALGPTEKP GIEIGKVPPP
460 470 480 490 500
IPGVGKQLPP SYGTYPSPTP LGPGSTSSLE RRKEGSLPRP SAGLPSRQRP
510 520 530 540 550
TLLPATGSTP QPGSSQQIQQ RISVPPSPTY PPAGPPAFPA GDSKPELPLT
560 570 580 590 600
VAIRPFLADK GSRPQSPRKG PQTVNSSSIY SMYLQQATPP KNYQPAAHSA
610 620 630 640 650
LNKSVKAVYG KPVLPSGSTS PSPLPFLHGS LSTGTPQPQP PSESTEKEPE
660 670 680 690 700
QDGPAAPADG STVESLPRPL SPTKLTPIVH SPLRYQSDAD LEALRRKLAN
710 720 730 740 750
APRPLKKRSS ITEPEGPGGP NIQKLLYQRF NTLAGGMEGT PFYQPSPSQD
760 770 780 790 800
FMGTLADVDN GNTNANGNLE ELPPAQPTAP LPAEPAPSSD ANDNELPSPE
810 820 830 840 850
PEELICPQTT HQTAEPAEDN NNNVATVPTT EQIPSPVAEA PSPGEEQVPP
860 870 880 890 900
APLPPASHPP ATSTNKRTNL KKPNSERTGH GLRVRFNPLA LLLDASLEGE
910 920 930 940 950
FDLVQRIIYE VEDPSKPNDE GITPLHNAVC AGHHHIVKFL LDFGVNVNAA
960 970 980 990 1000
DSDGWTPLHC AASCNSVHLC KQLVESGAAI FASTISDIET AADKCEEMEE
1010 1020 1030 1040 1050
GYIQCSQFLY GVQEKLGVMN KGVAYALWDY EAQNSDELSF HEGDALTILR
1060 1070 1080 1090
RKDESETEWW WARLGDREGY VPKNLLGLYP RIKPRQRTLA
Length:1,090
Mass (Da):119,565
Last modified:May 18, 2010 - v3
Checksum:i0026F07D7AB33295
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJL1H0YJL1_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
635Annotation score:
G3V5J1G3V5J1_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
149Annotation score:
G3V3S2G3V3S2_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
122Annotation score:
G3V2L3G3V2L3_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
143Annotation score:
H0YJG1H0YJG1_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
106Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68K → I in CAC83011 (PubMed:11684014).Curated1
Sequence conflicti112E → D in CAC83011 (PubMed:11684014).Curated1
Sequence conflicti117N → Y in CAC83011 (PubMed:11684014).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318887 mRNA Translation: CAC83011.2
AL049840 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81847.1
BC136527 mRNA Translation: AAI36528.1
AB018314 mRNA Translation: BAA34491.1
CCDSiCCDS41997.1
RefSeqiNP_056131.2, NM_015316.2
UniGeneiHs.709297

Genome annotation databases

EnsembliENST00000202556; ENSP00000202556; ENSG00000088808
GeneIDi23368
KEGGihsa:23368
UCSCiuc001yof.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318887 mRNA Translation: CAC83011.2
AL049840 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81847.1
BC136527 mRNA Translation: AAI36528.1
AB018314 mRNA Translation: BAA34491.1
CCDSiCCDS41997.1
RefSeqiNP_056131.2, NM_015316.2
UniGeneiHs.709297

3D structure databases

ProteinModelPortaliQ96KQ4
SMRiQ96KQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116948, 52 interactors
CORUMiQ96KQ4
ELMiQ96KQ4
IntActiQ96KQ4, 88 interactors
MINTiQ96KQ4
STRINGi9606.ENSP00000202556

PTM databases

CarbonylDBiQ96KQ4
iPTMnetiQ96KQ4
PhosphoSitePlusiQ96KQ4

Polymorphism and mutation databases

BioMutaiPPP1R13B
DMDMi296439434

Proteomic databases

EPDiQ96KQ4
MaxQBiQ96KQ4
PaxDbiQ96KQ4
PeptideAtlasiQ96KQ4
PRIDEiQ96KQ4
ProteomicsDBi77101

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000202556; ENSP00000202556; ENSG00000088808
GeneIDi23368
KEGGihsa:23368
UCSCiuc001yof.2 human

Organism-specific databases

CTDi23368
DisGeNETi23368
EuPathDBiHostDB:ENSG00000088808.16
GeneCardsiPPP1R13B
H-InvDBiHIX0012009
HGNCiHGNC:14950 PPP1R13B
HPAiCAB015454
HPA006394
MIMi606455 gene
neXtProtiNX_Q96KQ4
OpenTargetsiENSG00000088808
PharmGKBiPA33622
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0515 Eukaryota
ENOG410Y17W LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000034106
HOVERGENiHBG050596
InParanoidiQ96KQ4
KOiK17554
OMAiNYQPAAH
OrthoDBiEOG091G0R1R
PhylomeDBiQ96KQ4
TreeFamiTF105545

Enzyme and pathway databases

ReactomeiR-HSA-139915 Activation of PUMA and translocation to mitochondria
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Miscellaneous databases

ChiTaRSiPPP1R13B human
GeneWikiiPPP1R13B
GenomeRNAii23368
PROiPR:Q96KQ4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088808 Expressed in 217 organ(s), highest expression level in testis
CleanExiHS_PPP1R13B
ExpressionAtlasiQ96KQ4 baseline and differential
GenevisibleiQ96KQ4 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR028319 ASPP_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR24131:SF5 PTHR24131:SF5, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASPP1_HUMAN
AccessioniPrimary (citable) accession number: Q96KQ4
Secondary accession number(s): B2RMX5, O94870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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