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Entry version 157 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Apoptosis-stimulating of p53 protein 1

Gene

PPP1R13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.2 Publications

Miscellaneous

In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96KQ4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-139915, Activation of PUMA and translocation to mitochondria
R-HSA-6803204, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apoptosis-stimulating of p53 protein 1
Alternative name(s):
Protein phosphatase 1 regulatory subunit 13B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R13B
Synonyms:ASPP1, KIAA0771
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000088808.16

Human Gene Nomenclature Database

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HGNCi
HGNC:14950, PPP1R13B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606455, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96KQ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23368

Open Targets

More...
OpenTargetsi
ENSG00000088808

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33622

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96KQ4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R13B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439434

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669621 – 1090Apoptosis-stimulating of p53 protein 1Add BLAST1090

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei332PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei554Asymmetric dimethylarginineBy similarity1
Modified residuei681PhosphoserineCombined sources1
Modified residuei710PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96KQ4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96KQ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96KQ4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96KQ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96KQ4

PeptideAtlas

More...
PeptideAtlasi
Q96KQ4

PRoteomics IDEntifications database

More...
PRIDEi
Q96KQ4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
77101

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q96KQ4

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96KQ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96KQ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Reduced expression in breast carcinomas expressing a wild-type TP53 protein.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000088808, Expressed in testis and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96KQ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96KQ4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000088808, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with P53/TP53; the interaction promotes pro-apoptotic activity.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96KQ4
With#Exp.IntAct
ACSF3 [Q4G176]3EBI-1105153,EBI-10714818
ARHGAP45 [Q92619]3EBI-1105153,EBI-2825900
BFSP2 [Q13515]3EBI-1105153,EBI-10229433
C2orf42 [Q9NWW7]3EBI-1105153,EBI-2812028
CAPN7 [Q9Y6W3]3EBI-1105153,EBI-1765641
CBY2 - isoform 2 [Q8NA61-2]3EBI-1105153,EBI-11524851
CCDC102B [Q68D86]3EBI-1105153,EBI-10171570
CCDC184 [Q52MB2]3EBI-1105153,EBI-10179526
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-1105153,EBI-10175300
CDC5L [Q99459]5EBI-1105153,EBI-374880
CEP57 - isoform 3 [Q86XR8-3]3EBI-1105153,EBI-11752486
CGN [B9EK46]3EBI-1105153,EBI-14314072
CKS1B [P61024]3EBI-1105153,EBI-456371
DEUP1 [Q05D60]3EBI-1105153,EBI-748597
DGCR6L [Q9BY27]3EBI-1105153,EBI-742953
DIRAS1 [O95057]3EBI-1105153,EBI-11993172
DTNB - isoform 5 [O60941-5]3EBI-1105153,EBI-11984733
EP300 [Q09472]2EBI-1105153,EBI-447295
FAM184A [Q8NB25]3EBI-1105153,EBI-9917523
FAM90A1 [Q86YD7]3EBI-1105153,EBI-6658203
GAS2L2 [Q8NHY3]3EBI-1105153,EBI-7960826
GINS4 [Q9BRT9]3EBI-1105153,EBI-747500
GOLGA1 [Q92805]3EBI-1105153,EBI-6164177
HMG20B [Q9P0W2]3EBI-1105153,EBI-713401
HNRNPUL1 [Q9BUJ2]3EBI-1105153,EBI-1018153
KIF9 [Q9HAQ2]3EBI-1105153,EBI-8472129
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-1105153,EBI-14069005
KRT20 [P35900]3EBI-1105153,EBI-742094
KRT4 [P19013]3EBI-1105153,EBI-2371606
LMNB1 [P20700]3EBI-1105153,EBI-968218
LMNB2 [Q03252]3EBI-1105153,EBI-2830427
LMO1 [P25800]3EBI-1105153,EBI-8639312
LMO3 - isoform 4 [Q8TAP4-4]3EBI-1105153,EBI-11742507
LNX1 [Q8TBB1]3EBI-1105153,EBI-739832
MATN4 - isoform 2 [O95460-2]3EBI-1105153,EBI-12072296
MCRS1 [Q96EZ8]3EBI-1105153,EBI-348259
MIPOL1 [Q8TD10]3EBI-1105153,EBI-2548751
MIS18A [Q9NYP9]3EBI-1105153,EBI-1104552
MLH1 [P40692]3EBI-1105153,EBI-744248
NAP1L2 [Q9ULW6]3EBI-1105153,EBI-3911716
NDC80 [O14777]3EBI-1105153,EBI-715849
NHSL2 [Q5HYW2]3EBI-1105153,EBI-2859639
PPFIA3 [O75145]3EBI-1105153,EBI-1763225
PPP1CA [P62136]11EBI-1105153,EBI-357253
PPP1R18 [Q6NYC8]3EBI-1105153,EBI-2557469
PRKAB2 [O43741]3EBI-1105153,EBI-1053424
PRPH [P41219]3EBI-1105153,EBI-752074
PRR35 [P0CG20]3EBI-1105153,EBI-11986293
RALBP1 [Q15311]3EBI-1105153,EBI-749285
RASAL3 [Q86YV0]3EBI-1105153,EBI-3437896
RASSF8 - isoform 2 [Q8NHQ8-2]6EBI-1105153,EBI-10976415
SALL1 [Q9NSC2]3EBI-1105153,EBI-11317266
SOGA1 - isoform 4 [O94964-4]3EBI-1105153,EBI-14083835
TCL1A [P56279]3EBI-1105153,EBI-749995
TEKT4 [Q8WW24]3EBI-1105153,EBI-750487
TEX12 [Q9BXU0]3EBI-1105153,EBI-12090309
TEX9 [Q8N6V9]3EBI-1105153,EBI-746341
TRAF1 [Q13077]3EBI-1105153,EBI-359224
TSG101 [Q99816]3EBI-1105153,EBI-346882
TSGA10 [Q9BZW7]3EBI-1105153,EBI-744794
TXLNA [P40222]3EBI-1105153,EBI-359793
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-1105153,EBI-10183064
ZZZ3 [Q8IYH5]3EBI-1105153,EBI-2795524

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116948, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96KQ4

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q96KQ4

Protein interaction database and analysis system

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IntActi
Q96KQ4, 94 interactors

Molecular INTeraction database

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MINTi
Q96KQ4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000202556

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96KQ4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96KQ4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati920 – 952ANK 1Add BLAST33
Repeati953 – 985ANK 2Add BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1019 – 1081SH3PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi132 – 292Gln-richAdd BLAST161
Compositional biasi428 – 860Pro-richAdd BLAST433

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ASPP family.Curated

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0515, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008234_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96KQ4

KEGG Orthology (KO)

More...
KOi
K17554

Identification of Orthologs from Complete Genome Data

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OMAi
EGLICPP

Database of Orthologous Groups

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OrthoDBi
1041229at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96KQ4

TreeFam database of animal gene trees

More...
TreeFami
TF105545

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR028319, ASPP_1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

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PANTHERi
PTHR24131:SF5, PTHR24131:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q96KQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR
60 70 80 90 100
GNERPIPFDH MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ
110 120 130 140 150
RTQRNVINVP GEKRTENGVG NPRVELTLSE LQDMAARQQQ QIENQQQMLV
160 170 180 190 200
AKEQRLHFLK QQERRQQQSI SENEKLQKLK ERVEAQENKL KKIRAMRGQV
210 220 230 240 250
DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ QLEDLKKGKL
260 270 280 290 300
NGFQSYNGKL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN
310 320 330 340 350
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI
360 370 380 390 400
QVPSAGSFPV LGDPIKPQSL SIASNAAHGR SKSANDGNWP TLKQNSSSSV
410 420 430 440 450
KPVQVAGADW KDPSVEGSVK QGTVSSQPVP FSALGPTEKP GIEIGKVPPP
460 470 480 490 500
IPGVGKQLPP SYGTYPSPTP LGPGSTSSLE RRKEGSLPRP SAGLPSRQRP
510 520 530 540 550
TLLPATGSTP QPGSSQQIQQ RISVPPSPTY PPAGPPAFPA GDSKPELPLT
560 570 580 590 600
VAIRPFLADK GSRPQSPRKG PQTVNSSSIY SMYLQQATPP KNYQPAAHSA
610 620 630 640 650
LNKSVKAVYG KPVLPSGSTS PSPLPFLHGS LSTGTPQPQP PSESTEKEPE
660 670 680 690 700
QDGPAAPADG STVESLPRPL SPTKLTPIVH SPLRYQSDAD LEALRRKLAN
710 720 730 740 750
APRPLKKRSS ITEPEGPGGP NIQKLLYQRF NTLAGGMEGT PFYQPSPSQD
760 770 780 790 800
FMGTLADVDN GNTNANGNLE ELPPAQPTAP LPAEPAPSSD ANDNELPSPE
810 820 830 840 850
PEELICPQTT HQTAEPAEDN NNNVATVPTT EQIPSPVAEA PSPGEEQVPP
860 870 880 890 900
APLPPASHPP ATSTNKRTNL KKPNSERTGH GLRVRFNPLA LLLDASLEGE
910 920 930 940 950
FDLVQRIIYE VEDPSKPNDE GITPLHNAVC AGHHHIVKFL LDFGVNVNAA
960 970 980 990 1000
DSDGWTPLHC AASCNSVHLC KQLVESGAAI FASTISDIET AADKCEEMEE
1010 1020 1030 1040 1050
GYIQCSQFLY GVQEKLGVMN KGVAYALWDY EAQNSDELSF HEGDALTILR
1060 1070 1080 1090
RKDESETEWW WARLGDREGY VPKNLLGLYP RIKPRQRTLA
Length:1,090
Mass (Da):119,565
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0026F07D7AB33295
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISJ2A0A3B3ISJ2_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
1,075Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJL1H0YJL1_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5J1G3V5J1_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2L3G3V2L3_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3S2G3V3S2_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJG1H0YJG1_HUMAN
Apoptosis-stimulating of p53 protei...
PPP1R13B
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68K → I in CAC83011 (PubMed:11684014).Curated1
Sequence conflicti112E → D in CAC83011 (PubMed:11684014).Curated1
Sequence conflicti117N → Y in CAC83011 (PubMed:11684014).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ318887 mRNA Translation: CAC83011.2
AL049840 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81847.1
BC136527 mRNA Translation: AAI36528.1
AB018314 mRNA Translation: BAA34491.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41997.1

NCBI Reference Sequences

More...
RefSeqi
NP_056131.2, NM_015316.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000202556; ENSP00000202556; ENSG00000088808

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23368

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23368

UCSC genome browser

More...
UCSCi
uc001yof.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318887 mRNA Translation: CAC83011.2
AL049840 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81847.1
BC136527 mRNA Translation: AAI36528.1
AB018314 mRNA Translation: BAA34491.1
CCDSiCCDS41997.1
RefSeqiNP_056131.2, NM_015316.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6HL5X-ray1.98S932-954[»]
SMRiQ96KQ4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116948, 54 interactors
CORUMiQ96KQ4
ELMiQ96KQ4
IntActiQ96KQ4, 94 interactors
MINTiQ96KQ4
STRINGi9606.ENSP00000202556

PTM databases

CarbonylDBiQ96KQ4
iPTMnetiQ96KQ4
PhosphoSitePlusiQ96KQ4

Polymorphism and mutation databases

BioMutaiPPP1R13B
DMDMi296439434

Proteomic databases

EPDiQ96KQ4
jPOSTiQ96KQ4
MassIVEiQ96KQ4
MaxQBiQ96KQ4
PaxDbiQ96KQ4
PeptideAtlasiQ96KQ4
PRIDEiQ96KQ4
ProteomicsDBi77101

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
87, 218 antibodies

Genome annotation databases

EnsembliENST00000202556; ENSP00000202556; ENSG00000088808
GeneIDi23368
KEGGihsa:23368
UCSCiuc001yof.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23368
DisGeNETi23368
EuPathDBiHostDB:ENSG00000088808.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP1R13B
HGNCiHGNC:14950, PPP1R13B
HPAiENSG00000088808, Low tissue specificity
MIMi606455, gene
neXtProtiNX_Q96KQ4
OpenTargetsiENSG00000088808
PharmGKBiPA33622

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0515, Eukaryota
GeneTreeiENSGT00940000153463
HOGENOMiCLU_008234_0_0_1
InParanoidiQ96KQ4
KOiK17554
OMAiEGLICPP
OrthoDBi1041229at2759
PhylomeDBiQ96KQ4
TreeFamiTF105545

Enzyme and pathway databases

PathwayCommonsiQ96KQ4
ReactomeiR-HSA-139915, Activation of PUMA and translocation to mitochondria
R-HSA-6803204, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23368, 10 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP1R13B, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPP1R13B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23368
PharosiQ96KQ4, Tbio

Protein Ontology

More...
PROi
PR:Q96KQ4
RNActiQ96KQ4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088808, Expressed in testis and 229 other tissues
ExpressionAtlasiQ96KQ4, baseline and differential
GenevisibleiQ96KQ4, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR028319, ASPP_1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR24131:SF5, PTHR24131:SF5, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASPP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KQ4
Secondary accession number(s): B2RMX5, O94870
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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