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Entry version 164 (12 Aug 2020)
Sequence version 2 (19 Sep 2002)
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Protein

Cytosolic non-specific dipeptidase

Gene

CNDP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).4 Publications

Miscellaneous

The reverse proteolysis is not negligible in vivo as long as the substrates are present in considerable concentrations, such as upon physical exercice. N-lac-Phe plasma levels are increased in patients with PKU with increased plasma Phe levels. N-lactoyl-amino acids are present in many tissues.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by p-hydroxymercurybenzoate. The inhibitory concentration 50% (IC50) is 13 µM. Inhibited by bestatin. The inhibitory concentration 50% (IC50) is 7 nM at pH 9.5.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.04 mM for Ser-Gln (at pH 7.5 and in the presence of 0.1 mM manganese ions)2 Publications
  2. KM=0.6 mM for Cys-Gly (at pH 8.0 and in the presence of 50 µM manganese ions)2 Publications
  3. KM=15 mM for carnosine (at pH 9.5 and in the presence of 0.1 mM manganese ions)2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi99Manganese 2By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei101By similarity1
    Metal bindingi132Manganese 1By similarity1
    Metal bindingi132Manganese 2By similarity1
    Active sitei166Proton acceptorBy similarity1
    Metal bindingi167Manganese 1By similarity1
    Metal bindingi195Manganese 2By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei195Substrate; via carbonyl oxygenBy similarity1
    Binding sitei228Substrate; shared with homodimeric partnerBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei228Important for catalytic activityBy similarity1
    Binding sitei330Substrate; shared with homodimeric partnerBy similarity1
    Binding sitei343SubstrateBy similarity1
    Binding sitei417Substrate; via amide nitrogen and carbonyl oxygenBy similarity1
    Metal bindingi445Manganese 1By similarity1
    Binding sitei445SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
    LigandManganese, Metal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.13.18, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q96KP4

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-174403, Glutathione synthesis and recycling

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q96KP4

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M20.005

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytosolic non-specific dipeptidase (EC:3.4.13.18)
    Alternative name(s):
    CNDP dipeptidase 2
    Carnosine dipeptidase II1 Publication
    Epididymis secretory protein Li 13Imported
    Glutamate carboxypeptidase-like protein 1
    Peptidase A
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CNDP2
    Synonyms:CN2, CPGL, HEL-S-13Imported, PEPA
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000133313.14

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:24437, CNDP2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    169800, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q96KP4

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    55748

    Open Targets

    More...
    OpenTargetsi
    ENSG00000133313

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134975242

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q96KP4, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CNDP2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    23396498

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852722 – 475Cytosolic non-specific dipeptidaseAdd BLAST474

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
    Modified residuei9N6-acetyllysineCombined sources1
    Modified residuei58PhosphoserineBy similarity1
    Modified residuei299PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    CPTAC-47
    CPTAC-48

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q96KP4

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q96KP4

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q96KP4

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q96KP4

    PeptideAtlas

    More...
    PeptideAtlasi
    Q96KP4

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q96KP4

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    77098 [Q96KP4-1]
    77099 [Q96KP4-2]

    2D gel databases

    USC-OGP 2-DE database

    More...
    OGPi
    Q96KP4

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q96KP4

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    Q96KP4

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q96KP4

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q96KP4

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568).3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000133313, Expressed in adult mammalian kidney and 239 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q96KP4, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q96KP4, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000133313, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    120866, 55 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q96KP4, 9 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000325548

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q96KP4, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1475
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q96KP4

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni166 – 167Substrate bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M20A family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2276, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156500

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_029469_3_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q96KP4

    KEGG Orthology (KO)

    More...
    KOi
    K08660

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HITIPGF

    Database of Orthologous Groups

    More...
    OrthoDBi
    733473at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q96KP4

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300633

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001261, ArgE/DapE_CS
    IPR017153, CNDP/DUG1
    IPR002933, Peptidase_M20
    IPR011650, Peptidase_M20_dimer

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07687, M20_dimer, 1 hit
    PF01546, Peptidase_M20, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF037242, CNDP_dipeptidase, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00759, ARGE_DAPE_CPG2_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q96KP4-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAALTTLFKY IDENQDRYIK KLAKWVAIQS VSAWPEKRGE IRRMMEVAAA
    60 70 80 90 100
    DVKQLGGSVE LVDIGKQKLP DGSEIPLPPI LLGRLGSDPQ KKTVCIYGHL
    110 120 130 140 150
    DVQPAALEDG WDSEPFTLVE RDGKLYGRGS TDDKGPVAGW INALEAYQKT
    160 170 180 190 200
    GQEIPVNVRF CLEGMEESGS EGLDELIFAR KDTFFKDVDY VCISDNYWLG
    210 220 230 240 250
    KKKPCITYGL RGICYFFIEV ECSNKDLHSG VYGGSVHEAM TDLILLMGSL
    260 270 280 290 300
    VDKRGNILIP GINEAVAAVT EEEHKLYDDI DFDIEEFAKD VGAQILLHSH
    310 320 330 340 350
    KKDILMHRWR YPSLSLHGIE GAFSGSGAKT VIPRKVVGKF SIRLVPNMTP
    360 370 380 390 400
    EVVGEQVTSY LTKKFAELRS PNEFKVYMGH GGKPWVSDFS HPHYLAGRRA
    410 420 430 440 450
    MKTVFGVEPD LTREGGSIPV TLTFQEATGK NVMLLPVGSA DDGAHSQNEK
    460 470
    LNRYNYIEGT KMLAAYLYEV SQLKD
    Length:475
    Mass (Da):52,878
    Last modified:September 19, 2002 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43FA0668B0587A39
    GO
    Isoform 2 (identifier: Q96KP4-2) [UniParc]FASTAAdd to basket
    Also known as: CPGL-B

    The sequence of this isoform differs from the canonical sequence as follows:
         69-152: Missing.

    Note: Lacks a part of the catalytic domain.Curated
    Show »
    Length:391
    Mass (Da):43,833
    Checksum:i07E5F4464C8FC179
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    J3QKT2J3QKT2_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    249Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QRD0J3QRD0_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    134Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3KSV5J3KSV5_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    149Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QKQ0J3QKQ0_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    128Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WYZ1A0A087WYZ1_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    157Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QL02J3QL02_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    138Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QLU1J3QLU1_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    123Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QQN6J3QQN6_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    89Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QR27J3QR27_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    122Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QRH4J3QRH4_HUMAN
    Cytosolic non-specific dipeptidase
    CNDP2
    204Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128R → G in BAA91840 (PubMed:14702039).Curated1
    Sequence conflicti348M → T in BAG53426 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057154126Y → H1 PublicationCorresponds to variant dbSNP:rs2278161Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03820369 – 152Missing in isoform 2. 1 PublicationAdd BLAST84

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AX523938 Unassigned DNA Translation: CAD56843.1
    AJ347717 mRNA Translation: CAC69883.1
    AK001692 mRNA Translation: BAA91840.1
    AK097155 mRNA Translation: BAG53426.1
    AF258592 mRNA Translation: AAG23795.1
    EU794600 mRNA Translation: ACJ13654.1
    AC009704 Genomic DNA No translation available.
    CH471117 Genomic DNA Translation: EAW66551.1
    CH471117 Genomic DNA Translation: EAW66552.1
    CH471117 Genomic DNA Translation: EAW66554.1
    BC001375 mRNA Translation: AAH01375.1
    BC003176 mRNA Translation: AAH03176.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12006.1 [Q96KP4-1]
    CCDS54190.1 [Q96KP4-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001161971.1, NM_001168499.1 [Q96KP4-2]
    NP_060705.2, NM_018235.2 [Q96KP4-1]
    XP_005266785.1, XM_005266728.2
    XP_006722566.1, XM_006722503.2
    XP_011524373.1, XM_011526071.2
    XP_011524374.1, XM_011526072.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000324262; ENSP00000325548; ENSG00000133313 [Q96KP4-1]
    ENST00000324301; ENSP00000325756; ENSG00000133313 [Q96KP4-2]
    ENST00000579847; ENSP00000462311; ENSG00000133313 [Q96KP4-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    55748

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:55748

    UCSC genome browser

    More...
    UCSCi
    uc002llm.3, human
    uc002lln.3, human [Q96KP4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AX523938 Unassigned DNA Translation: CAD56843.1
    AJ347717 mRNA Translation: CAC69883.1
    AK001692 mRNA Translation: BAA91840.1
    AK097155 mRNA Translation: BAG53426.1
    AF258592 mRNA Translation: AAG23795.1
    EU794600 mRNA Translation: ACJ13654.1
    AC009704 Genomic DNA No translation available.
    CH471117 Genomic DNA Translation: EAW66551.1
    CH471117 Genomic DNA Translation: EAW66552.1
    CH471117 Genomic DNA Translation: EAW66554.1
    BC001375 mRNA Translation: AAH01375.1
    BC003176 mRNA Translation: AAH03176.1
    CCDSiCCDS12006.1 [Q96KP4-1]
    CCDS54190.1 [Q96KP4-2]
    RefSeqiNP_001161971.1, NM_001168499.1 [Q96KP4-2]
    NP_060705.2, NM_018235.2 [Q96KP4-1]
    XP_005266785.1, XM_005266728.2
    XP_006722566.1, XM_006722503.2
    XP_011524373.1, XM_011526071.2
    XP_011524374.1, XM_011526072.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4RUHX-ray2.25A/B1-475[»]
    SMRiQ96KP4
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi120866, 55 interactors
    IntActiQ96KP4, 9 interactors
    STRINGi9606.ENSP00000325548

    Protein family/group databases

    MEROPSiM20.005

    PTM databases

    iPTMnetiQ96KP4
    MetOSiteiQ96KP4
    PhosphoSitePlusiQ96KP4
    SwissPalmiQ96KP4

    Polymorphism and mutation databases

    BioMutaiCNDP2
    DMDMi23396498

    2D gel databases

    OGPiQ96KP4

    Proteomic databases

    CPTACiCPTAC-47
    CPTAC-48
    EPDiQ96KP4
    jPOSTiQ96KP4
    MassIVEiQ96KP4
    PaxDbiQ96KP4
    PeptideAtlasiQ96KP4
    PRIDEiQ96KP4
    ProteomicsDBi77098 [Q96KP4-1]
    77099 [Q96KP4-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    23332, 398 antibodies

    Genome annotation databases

    EnsembliENST00000324262; ENSP00000325548; ENSG00000133313 [Q96KP4-1]
    ENST00000324301; ENSP00000325756; ENSG00000133313 [Q96KP4-2]
    ENST00000579847; ENSP00000462311; ENSG00000133313 [Q96KP4-1]
    GeneIDi55748
    KEGGihsa:55748
    UCSCiuc002llm.3, human
    uc002lln.3, human [Q96KP4-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    55748
    DisGeNETi55748
    EuPathDBiHostDB:ENSG00000133313.14

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CNDP2
    HGNCiHGNC:24437, CNDP2
    HPAiENSG00000133313, Low tissue specificity
    MIMi169800, gene
    neXtProtiNX_Q96KP4
    OpenTargetsiENSG00000133313
    PharmGKBiPA134975242

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2276, Eukaryota
    GeneTreeiENSGT00940000156500
    HOGENOMiCLU_029469_3_1_1
    InParanoidiQ96KP4
    KOiK08660
    OMAiHITIPGF
    OrthoDBi733473at2759
    PhylomeDBiQ96KP4
    TreeFamiTF300633

    Enzyme and pathway databases

    BRENDAi3.4.13.18, 2681
    PathwayCommonsiQ96KP4
    ReactomeiR-HSA-174403, Glutathione synthesis and recycling
    SABIO-RKiQ96KP4

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    55748, 2 hits in 872 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    CNDP2, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    55748
    PharosiQ96KP4, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q96KP4
    RNActiQ96KP4, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000133313, Expressed in adult mammalian kidney and 239 other tissues
    ExpressionAtlasiQ96KP4, baseline and differential
    GenevisibleiQ96KP4, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR001261, ArgE/DapE_CS
    IPR017153, CNDP/DUG1
    IPR002933, Peptidase_M20
    IPR011650, Peptidase_M20_dimer
    PfamiView protein in Pfam
    PF07687, M20_dimer, 1 hit
    PF01546, Peptidase_M20, 1 hit
    PIRSFiPIRSF037242, CNDP_dipeptidase, 1 hit
    PROSITEiView protein in PROSITE
    PS00759, ARGE_DAPE_CPG2_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNDP2_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KP4
    Secondary accession number(s): B3KUG4
    , Q8WY59, Q9BQ94, Q9NVB4, V9HWE5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: August 12, 2020
    This is version 164 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families
    7. Peptidase families
      Classification of peptidase families and list of entries
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