UniProtKB - Q96KP1 (EXOC2_HUMAN)
Protein
Exocyst complex component 2
Gene
EXOC2
Organism
Homo sapiens (Human)
Status
Functioni
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- protein N-terminus binding Source: Ensembl
- small GTPase binding Source: UniProtKB
GO - Biological processi
- cilium assembly Source: Reactome
- exocytosis Source: GO_Central
- Golgi to plasma membrane transport Source: GO_Central
- protein transport Source: UniProtKB-KW
- regulation of entry of bacterium into host cell Source: AgBase
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96KP1 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-264876, Insulin processing R-HSA-5620916, VxPx cargo-targeting to cilium |
SignaLinki | Q96KP1 |
Protein family/group databases
TCDBi | 1.F.2.1.2, the octameric exocyst (exocyst) family |
Names & Taxonomyi
Protein namesi | Recommended name: Exocyst complex component 2Alternative name(s): Exocyst complex component Sec5 |
Gene namesi | Name:EXOC2 Synonyms:SEC5, SEC5L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24968, EXOC2 |
MIMi | 615329, gene |
neXtProti | NX_Q96KP1 |
VEuPathDBi | HostDB:ENSG00000112685.13 |
Subcellular locationi
Other locations
- Midbody ring 2 Publications
Note: Recruitment to the midbody does not require RALA, nor RALB (PubMed:18756269). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214).2 Publications
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- exocyst Source: UniProtKB
- Flemming body Source: UniProtKB-SubCell
- membrane Source: UniProtKB
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 11 | T → A: Impaired cytokinesis. Loss of RALA-binding. No change in localization to the midbody during cytokinesis. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 55770 |
OpenTargetsi | ENSG00000112685 |
PharmGKBi | PA134862170 |
Miscellaneous databases
Pharosi | Q96KP1, Tbio |
Genetic variation databases
BioMutai | EXOC2 |
DMDMi | 24638219 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118918 | 1 – 924 | Exocyst complex component 2Add BLAST | 924 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 431 | PhosphoserineCombined sources | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Modified residuei | 435 | PhosphoserineCombined sources | 1 | |
Modified residuei | 440 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 454 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 888 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96KP1 |
jPOSTi | Q96KP1 |
MassIVEi | Q96KP1 |
MaxQBi | Q96KP1 |
PaxDbi | Q96KP1 |
PeptideAtlasi | Q96KP1 |
PRIDEi | Q96KP1 |
ProteomicsDBi | 77097 |
PTM databases
iPTMneti | Q96KP1 |
PhosphoSitePlusi | Q96KP1 |
Expressioni
Tissue specificityi
Widely expressed with highest levels in brain and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000112685, Expressed in middle temporal gyrus and 214 other tissues |
ExpressionAtlasi | Q96KP1, baseline and differential |
Genevisiblei | Q96KP1, HS |
Organism-specific databases
HPAi | ENSG00000112685, Low tissue specificity |
Interactioni
Subunit structurei
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity).
Interacts with EXOC3L1 (By similarity).
Interacts with GNEFR/DELGEF; this interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (PubMed:12459492).
Interacts with RALA and RALB (PubMed:18756269, PubMed:19166349).
By similarity3 PublicationsBinary interactionsi
Q96KP1
With | #Exp. | IntAct |
---|---|---|
EXOC1 [Q9NV70] | 6 | EBI-465715,EBI-1045313 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- protein N-terminus binding Source: Ensembl
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120887, 64 interactors |
ComplexPortali | CPX-4943, Exocyst, EXOC6 variant CPX-4944, Exocyst, EXOC6B variant |
CORUMi | Q96KP1 |
DIPi | DIP-31795N |
IntActi | Q96KP1, 26 interactors |
MINTi | Q96KP1 |
STRINGi | 9606.ENSP00000230449 |
Miscellaneous databases
RNActi | Q96KP1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 93 | IPT/TIGAdd BLAST | 86 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 240 – 260 | Sequence analysisAdd BLAST | 21 |
Domaini
Interacts with RALA through the TIG domain.By similarity
Sequence similaritiesi
Belongs to the SEC5 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2347, Eukaryota |
GeneTreei | ENSGT00390000010872 |
HOGENOMi | CLU_005811_0_0_1 |
InParanoidi | Q96KP1 |
OMAi | WEKLAFW |
OrthoDBi | 97000at2759 |
PhylomeDBi | Q96KP1 |
TreeFami | TF105891 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR029175, EXOC2/Sec5 IPR039481, EXOC2/Sec5_N_dom IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom |
PANTHERi | PTHR13043, PTHR13043, 1 hit |
Pfami | View protein in Pfam PF15469, Sec5, 1 hit PF01833, TIG, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96KP1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPTDLIG LTICGHNCLL
60 70 80 90 100
TAEWMSASKI VCRVGQAKND KGDIIVTTKS GGRGTSTVSF KLLKPEKIGI
110 120 130 140 150
LDQSAVWVDE MNYYDMRTDR NKGIPPLSLR PANPLGIEIE KSKFSQKDLE
160 170 180 190 200
MLFHGMSADF TSENFSAAWY LIENHSNTSF EQLKMAVTNL KRQANKKSEG
210 220 230 240 250
SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ KLENVLNRAS
260 270 280 290 300
NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI ERNIQKGDYD
310 320 330 340 350
VVINDYEKAK SLFGKTEVQV FKKYYAEVET RIEALRELLL DKLLETPSTL
360 370 380 390 400
HDQKRYIRYL SDLHASGDPA WQCIGAQHKW ILQLMHSCKE GYVKDLKGNP
410 420 430 440 450
GLHSPMLDLD NDTRPSVLGH LSQTASLKRG SSFQSGRDDT WRYKTPHRVA
460 470 480 490 500
FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS ETAEKSGQIE RSKNVRQRQN
510 520 530 540 550
DFKKMIQEVM HSLVKLTRGA LLPLSIRDGE AKQYGGWEVK CELSGQWLAH
560 570 580 590 600
AIQTVRLTHE SLTALEIPND LLQTIQDLIL DLRVRCVMAT LQHTAEEIKR
610 620 630 640 650
LAEKEDWIVD NEGLTSLPCQ FEQCIVCSLQ SLKGVLECKP GEASVFQQPK
660 670 680 690 700
TQEEVCQLSI NIMQVFIYCL EQLSTKPDAD IDTTHLSVDV SSPDLFGSIH
710 720 730 740 750
EDFSLTSEQR LLIVLSNCCY LERHTFLNIA EHFEKHNFQG IEKITQVSMA
760 770 780 790 800
SLKELDQRLF ENYIELKADP IVGSLEPGIY AGYFDWKDCL PPTGVRNYLK
810 820 830 840 850
EALVNIIAVH AEVFTISKEL VPRVLSKVIE AVSEELSRLM QCVSSFSKNG
860 870 880 890 900
ALQARLEICA LRDTVAVYLT PESKSSFKQA LEALPQLSSG ADKKLLEELL
910 920
NKFKSSMHLQ LTCFQAASST MMKT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ2MDF5 | Q2MDF5_HUMAN | Exocyst complex component 2 | EXOC2 | 140 | Annotation score: |
Sequence cautioni
The sequence BAA91963 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | I → K in BAG37193 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 522 | L → H in BAA91963 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048956 | 195 | N → T. Corresponds to variant dbSNP:rs35600069Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ414403 mRNA Translation: CAC92092.1 AK001888 mRNA Translation: BAA91963.1 Different initiation. AK314628 mRNA Translation: BAG37193.1 AL833213 mRNA Translation: CAI46189.1 AL031770 Genomic DNA No translation available. AL512308 Genomic DNA No translation available. BC016918 mRNA Translation: AAH16918.2 BC080542 mRNA Translation: AAH80542.1 |
CCDSi | CCDS34327.1 |
RefSeqi | NP_060773.3, NM_018303.5 XP_016866507.1, XM_017011018.1 XP_016866508.1, XM_017011019.1 XP_016866509.1, XM_017011020.1 XP_016866510.1, XM_017011021.1 XP_016866511.1, XM_017011022.1 XP_016866512.1, XM_017011023.1 XP_016866513.1, XM_017011024.1 |
Genome annotation databases
Ensembli | ENST00000230449; ENSP00000230449; ENSG00000112685 |
GeneIDi | 55770 |
KEGGi | hsa:55770 |
UCSCi | uc003mtd.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ414403 mRNA Translation: CAC92092.1 AK001888 mRNA Translation: BAA91963.1 Different initiation. AK314628 mRNA Translation: BAG37193.1 AL833213 mRNA Translation: CAI46189.1 AL031770 Genomic DNA No translation available. AL512308 Genomic DNA No translation available. BC016918 mRNA Translation: AAH16918.2 BC080542 mRNA Translation: AAH80542.1 |
CCDSi | CCDS34327.1 |
RefSeqi | NP_060773.3, NM_018303.5 XP_016866507.1, XM_017011018.1 XP_016866508.1, XM_017011019.1 XP_016866509.1, XM_017011020.1 XP_016866510.1, XM_017011021.1 XP_016866511.1, XM_017011022.1 XP_016866512.1, XM_017011023.1 XP_016866513.1, XM_017011024.1 |
3D structure databases
SMRi | Q96KP1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120887, 64 interactors |
ComplexPortali | CPX-4943, Exocyst, EXOC6 variant CPX-4944, Exocyst, EXOC6B variant |
CORUMi | Q96KP1 |
DIPi | DIP-31795N |
IntActi | Q96KP1, 26 interactors |
MINTi | Q96KP1 |
STRINGi | 9606.ENSP00000230449 |
Protein family/group databases
TCDBi | 1.F.2.1.2, the octameric exocyst (exocyst) family |
PTM databases
iPTMneti | Q96KP1 |
PhosphoSitePlusi | Q96KP1 |
Genetic variation databases
BioMutai | EXOC2 |
DMDMi | 24638219 |
Proteomic databases
EPDi | Q96KP1 |
jPOSTi | Q96KP1 |
MassIVEi | Q96KP1 |
MaxQBi | Q96KP1 |
PaxDbi | Q96KP1 |
PeptideAtlasi | Q96KP1 |
PRIDEi | Q96KP1 |
ProteomicsDBi | 77097 |
Protocols and materials databases
Antibodypediai | 24190, 138 antibodies |
Genome annotation databases
Ensembli | ENST00000230449; ENSP00000230449; ENSG00000112685 |
GeneIDi | 55770 |
KEGGi | hsa:55770 |
UCSCi | uc003mtd.5, human |
Organism-specific databases
CTDi | 55770 |
DisGeNETi | 55770 |
GeneCardsi | EXOC2 |
HGNCi | HGNC:24968, EXOC2 |
HPAi | ENSG00000112685, Low tissue specificity |
MIMi | 615329, gene |
neXtProti | NX_Q96KP1 |
OpenTargetsi | ENSG00000112685 |
PharmGKBi | PA134862170 |
VEuPathDBi | HostDB:ENSG00000112685.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2347, Eukaryota |
GeneTreei | ENSGT00390000010872 |
HOGENOMi | CLU_005811_0_0_1 |
InParanoidi | Q96KP1 |
OMAi | WEKLAFW |
OrthoDBi | 97000at2759 |
PhylomeDBi | Q96KP1 |
TreeFami | TF105891 |
Enzyme and pathway databases
PathwayCommonsi | Q96KP1 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-264876, Insulin processing R-HSA-5620916, VxPx cargo-targeting to cilium |
SignaLinki | Q96KP1 |
Miscellaneous databases
BioGRID-ORCSi | 55770, 246 hits in 1001 CRISPR screens |
ChiTaRSi | EXOC2, human |
GeneWikii | EXOC2 |
GenomeRNAii | 55770 |
Pharosi | Q96KP1, Tbio |
PROi | PR:Q96KP1 |
RNActi | Q96KP1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112685, Expressed in middle temporal gyrus and 214 other tissues |
ExpressionAtlasi | Q96KP1, baseline and differential |
Genevisiblei | Q96KP1, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR029175, EXOC2/Sec5 IPR039481, EXOC2/Sec5_N_dom IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom |
PANTHERi | PTHR13043, PTHR13043, 1 hit |
Pfami | View protein in Pfam PF15469, Sec5, 1 hit PF01833, TIG, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EXOC2_HUMAN | |
Accessioni | Q96KP1Primary (citable) accession number: Q96KP1 Secondary accession number(s): B2RBE6 Q9UJM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families