UniProtKB - Q96KN8 (HRSL5_HUMAN)

BLAST

>sp|Q96KN8|HRSL5_HUMAN Ca(2+)-independent N-acyltransferase OS=Homo sapiens OX=9606 GN=HRASLS5 PE=1 SV=2
MGLSPGAEGEYALRLPRIPPPLPKPASRTASTGPKDQPPALRRSAVPHSGLNSISPLELE
ESVGFAALVQLPAKQPPPGTLEQGRSIQQGEKAVVSLETTPSQKADWSSIPKPENEGKLI
KQAAEGKPRPRPGDLIEIFRIGYEHWAIYVEDDCVVHLAPPSEEFEVGSITSIFSNRAVV
KYSRLEDVLHGCSWKVNNKLDGTYLPLPVDKIIQRTKKMVNKIVQYSLIEGNCEHFVNGL
RYGVPRSQQVEHALMEGAKAAGAVISAVVDSIKPKPITA

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History
Entry version 111 (07 Nov 2018)
Sequence version 2 (18 May 2010)
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Protein

Ca(2+)-independent N-acyltransferase

Gene

HRASLS5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide.1 Publication

GO - Molecular functionⁱ

N-acyltransferase activity
Source: MGI
Inferred from direct assayⁱ
- 19000777

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

N-acylphosphatidylethanolamine metabolic process
Source: MGI
Inferred from direct assayⁱ
- 19000777

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase

Molecular function

Acyltransferase, Transferase

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1482839 Acyl chain remodelling of PE

Reactomeⁱ

R-HSA-1482839 Acyl chain remodelling of PE

Chemistry databases

SwissLipidsⁱ	SLP:000001126

SwissLipidsⁱ

SLP:000001126

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ca(2+)-independent N-acyltransferase (EC:2.3.1.-) Short name: iNAT Alternative name(s): H-rev107-like protein 5 HRAS-like suppressor 5 Short name: HRSL5
Gene namesⁱ	Name:HRASLS5 Synonyms:HRLP5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168004.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24978 HRASLS5
MIMⁱ	611474 gene
neXtProtⁱ	NX_Q96KN8

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000168004
PharmGKBⁱ	PA142671672

Polymorphism and mutation databases

BioMutaⁱ	HRASLS5
DMDMⁱ	296434533

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000152488	1 – 279	Ca(2+)-independent N-acyltransferaseAdd BLAST		279

Proteomic databases

PaxDbⁱ	Q96KN8
PeptideAtlas More...PeptideAtlasⁱ	Q96KN8
PRIDEⁱ	Q96KN8
ProteomicsDBⁱ	77095

PTM databases

iPTMnetⁱ	Q96KN8

iPTMnetⁱ

Q96KN8

Expressionⁱ

Tissue specificityⁱ

Highest expression level in testis and pancreas.

Gene expression databases

Bgeeⁱ	ENSG00000168004 Expressed in 134 organ(s), highest expression level in testis
CleanExⁱ	HS_HRASLS5
ExpressionAtlasⁱ	Q96KN8 baseline and differential
Genevisibleⁱ	Q96KN8 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GGACT	Q9BVM4	7	EBI-10290304,EBI-10299852
GOLGA2	Q08379	5	EBI-10290304,EBI-618309
ZNF783	Q6ZMS7	5	EBI-10290304,EBI-10254978

Protein-protein interaction databases

BioGridⁱ	125580, 6 interactors
IntActⁱ	Q96KN8, 4 interactors
STRINGⁱ	9606.ENSP00000301790

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96KN8
SMRⁱ	Q96KN8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the H-rev107 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410J8WF Eukaryota ENOG4111DRT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013327
HOGENOMⁱ	HOG000134692
HOVERGENⁱ	HBG051926
InParanoidⁱ	Q96KN8
OMAⁱ	TKKMVNK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08MK
PhylomeDBⁱ	Q96KN8
TreeFamⁱ	TF330836

Family and domain databases

InterProⁱ	View protein in InterPro IPR007053 LRAT-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04970 LRAT, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96KN8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLSPGAEGE YALRLPRIPP PLPKPASRTA STGPKDQPPA LRRSAVPHSG 
        60         70         80         90        100
LNSISPLELE ESVGFAALVQ LPAKQPPPGT LEQGRSIQQG EKAVVSLETT 
       110        120        130        140        150
PSQKADWSSI PKPENEGKLI KQAAEGKPRP RPGDLIEIFR IGYEHWAIYV 
       160        170        180        190        200
EDDCVVHLAP PSEEFEVGSI TSIFSNRAVV KYSRLEDVLH GCSWKVNNKL 
       210        220        230        240        250
DGTYLPLPVD KIIQRTKKMV NKIVQYSLIE GNCEHFVNGL RYGVPRSQQV 
       260        270 
EHALMEGAKA AGAVISAVVD SIKPKPITA

Length:279

Mass (Da):30,312

Last modified:May 18, 2010 - v2

Checksum:ⁱF388449962CA8E3D

Isoform 2 (identifier: Q96KN8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
234-279: EHFVNGLRYGVPRSQQVEHALMEGAKAAGAVISAVVDSIKPKPITA → RARPDGRSEGCWSSYFSCSG

« Hide

        10         20         30         40         50
MGLSPGAEGE YALRLPRIPP PLPKPASRTA STGPKDQPPA LRRSAVPHSG 
        60         70         80         90        100
LNSISPLELE ESVGFAALVQ LPAKQPPPGT LEQGRSIQQG EKAVVSLETT 
       110        120        130        140        150
PSQKADWSSI PKPENEGKLI KQAAEGKPRP RPGDLIEIFR IGYEHWAIYV 
       160        170        180        190        200
EDDCVVHLAP PSEEFEVGSI TSIFSNRAVV KYSRLEDVLH GCSWKVNNKL 
       210        220        230        240        250
DGTYLPLPVD KIIQRTKKMV NKIVQYSLIE GNCRARPDGR SEGCWSSYFS 

CSG

Note: No experimental confirmation available.

Show »

Length:253

Mass (Da):27,677

Checksum:ⁱ2605CF3AFEA24C34

Isoform 3 (identifier: Q96KN8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
50-59: Missing.

« Hide

        10         20         30         40         50
MGLSPGAEGE YALRLPRIPP PLPKPASRTA STGPKDQPPA LRRSAVPHSE 
        60         70         80         90        100
ESVGFAALVQ LPAKQPPPGT LEQGRSIQQG EKAVVSLETT PSQKADWSSI 
       110        120        130        140        150
PKPENEGKLI KQAAEGKPRP RPGDLIEIFR IGYEHWAIYV EDDCVVHLAP 
       160        170        180        190        200
PSEEFEVGSI TSIFSNRAVV KYSRLEDVLH GCSWKVNNKL DGTYLPLPVD 
       210        220        230        240        250
KIIQRTKKMV NKIVQYSLIE GNCEHFVNGL RYGVPRSQQV EHALMEGAKA 
       260 
AGAVISAVVD SIKPKPITA

Note: No experimental confirmation available.

Show »

Length:269

Mass (Da):29,288

Checksum:ⁱD6C3D0D8AF0917D7

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YGT7	H0YGT7_HUMAN	Ca(2+)-independent N-acyltransferas... Ca(2+)-independent N-acyltransferase	HRASLS5	49	Annotation score:
F5H4Q3	F5H4Q3_HUMAN	Ca(2+)-independent N-acyltransferas... Ca(2+)-independent N-acyltransferase	HRASLS5	19	Annotation score:
H7BYL7	H7BYL7_HUMAN	Ca(2+)-independent N-acyltransferas... Ca(2+)-independent N-acyltransferase	HRASLS5	37	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049477	31	S → G3 PublicationsCorresponds to variant dbSNP:rs10897424Ensembl.	1
Natural variantⁱVAR_024486	93	A → P. Corresponds to variant dbSNP:rs940611Ensembl.	1
Natural variantⁱVAR_049478	214	Q → R. Corresponds to variant dbSNP:rs35735923Ensembl.	1
Natural variantⁱVAR_049479	258	A → V. Corresponds to variant dbSNP:rs35375575Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045825	50 – 59	Missing in isoform 3. Curated		10
Alternative sequenceⁱVSP_045826	234 – 279	EHFVN…KPITA → RARPDGRSEGCWSSYFSCSG in isoform 2. CuratedAdd BLAST		46

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB298804 mRNA Translation: BAH08633.1 AJ416558 mRNA Translation: CAC94942.1 AP000484 Genomic DNA No translation available. AP001591 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74150.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53646.1 [Q96KN8-3] CCDS53647.1 [Q96KN8-2] CCDS8044.1 [Q96KN8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_473449.1, NM_054108.3
UniGeneⁱ	Hs.410316

Genome annotation databases

Ensemblⁱ	ENST00000301790; ENSP00000301790; ENSG00000168004 [Q96KN8-1] ENST00000539221; ENSP00000443873; ENSG00000168004 [Q96KN8-2] ENST00000540857; ENSP00000444809; ENSG00000168004 [Q96KN8-3]
GeneIDⁱ	117245
KEGGⁱ	hsa:117245
UCSC genome browser More...UCSCⁱ	uc001nwy.3 human [Q96KN8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96KN8	Uncharacterized protein		AOTNA		286	UniRef90_Q96KN8
HRASLS5 isoform 4		PANTR		279
Uncharacterized protein		PANPA		279
HRAS like suppressor family member 5		GORGO		279
Uncharacterized protein		COLAP		278
+7
Q96KN8-2	Isoform 3 of Ca(2+)-independent N-acyltransferase		HUMAN		269	UniRef90_Q96KN8-3
H-rev107-like protein 5		MACFA		279
H-rev107-like protein 5		MACMU		279
Uncharacterized protein		MACNE		279
HRASLS5 isoform 4		PONAB		279
+33
Q96KN8-3	H-rev107-like protein 5		MACFA		279	UniRef90_Q96KN8-3
H-rev107-like protein 5		MACMU		279
Uncharacterized protein		MACNE		279
HRASLS5 isoform 4		PONAB		279
Uncharacterized protein		CERAT		279
+33

Protein	Similar proteins		Species	Score	Length	Source
Q96KN8	Uncharacterized protein		AOTNA		286	UniRef50_Q96KN8
Uncharacterized protein		PANPA		279
HRASLS5 isoform 4		PANTR		279
HRAS like suppressor family member 5		GORGO		279
Uncharacterized protein		COLAP		278
+108

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB298804 mRNA Translation: BAH08633.1 AJ416558 mRNA Translation: CAC94942.1 AP000484 Genomic DNA No translation available. AP001591 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74150.1
CCDSⁱ	CCDS53646.1 [Q96KN8-3] CCDS53647.1 [Q96KN8-2] CCDS8044.1 [Q96KN8-1]
RefSeqⁱ	NP_473449.1, NM_054108.3
UniGeneⁱ	Hs.410316

3D structure databases

ProteinModelPortalⁱ	Q96KN8
SMRⁱ	Q96KN8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125580, 6 interactors
IntActⁱ	Q96KN8, 4 interactors
STRINGⁱ	9606.ENSP00000301790

Chemistry databases

SwissLipidsⁱ	SLP:000001126

SwissLipidsⁱ

SLP:000001126

PTM databases

iPTMnetⁱ	Q96KN8

iPTMnetⁱ

Q96KN8

Polymorphism and mutation databases

BioMutaⁱ	HRASLS5
DMDMⁱ	296434533

Proteomic databases

PaxDbⁱ	Q96KN8
PeptideAtlasⁱ	Q96KN8
PRIDEⁱ	Q96KN8
ProteomicsDBⁱ	77095

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	117245
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000301790; ENSP00000301790; ENSG00000168004 [Q96KN8-1] ENST00000539221; ENSP00000443873; ENSG00000168004 [Q96KN8-2] ENST00000540857; ENSP00000444809; ENSG00000168004 [Q96KN8-3]
GeneIDⁱ	117245
KEGGⁱ	hsa:117245
UCSCⁱ	uc001nwy.3 human [Q96KN8-1]

Organism-specific databases

CTDⁱ	117245
EuPathDBⁱ	HostDB:ENSG00000168004.9
GeneCardsⁱ	HRASLS5
HGNCⁱ	HGNC:24978 HRASLS5
MIMⁱ	611474 gene
neXtProtⁱ	NX_Q96KN8
OpenTargetsⁱ	ENSG00000168004
PharmGKBⁱ	PA142671672
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J8WF Eukaryota ENOG4111DRT LUCA
GeneTreeⁱ	ENSGT00390000013327
HOGENOMⁱ	HOG000134692
HOVERGENⁱ	HBG051926
InParanoidⁱ	Q96KN8
OMAⁱ	TKKMVNK
OrthoDBⁱ	EOG091G08MK
PhylomeDBⁱ	Q96KN8
TreeFamⁱ	TF330836

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1482839 Acyl chain remodelling of PE

Reactomeⁱ

R-HSA-1482839 Acyl chain remodelling of PE

Miscellaneous databases

ChiTaRSⁱ	HRASLS5 human
GenomeRNAiⁱ	117245
Protein Ontology More...PROⁱ	PR:Q96KN8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168004 Expressed in 134 organ(s), highest expression level in testis
CleanExⁱ	HS_HRASLS5
ExpressionAtlasⁱ	Q96KN8 baseline and differential
Genevisibleⁱ	Q96KN8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007053 LRAT-like_dom
Pfamⁱ	View protein in Pfam PF04970 LRAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HRSL5_HUMAN
Accessionⁱ	Q96KN8Primary (citable) accession number: Q96KN8 Secondary accession number(s): B7X6T1, F5GZ87, F5H4Y9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q96KN8 (HRSL5_HUMAN)

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Ca(2+)-independent N-acyltransferase

HRASLS5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ