UniProtKB - Q96KN4 (LRAT1_HUMAN)
Protein
Protein LRATD1
Gene
LRATD1
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in cell morphology and motility.1 Publication
GO - Biological processi
- cell morphogenesis Source: UniProtKB
- cell motility Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q96KN4 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein LRATD1CuratedAlternative name(s): LRAT domain-containing 1Imported Neurologic sensory protein 1 Short name: NSE1 Protein FAM84A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20743, LRATD1 |
MIMi | 611234, gene |
neXtProti | NX_Q96KN4 |
VEuPathDBi | HostDB:ENSG00000162981.13 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | S → A: Abolishes phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 67 | S → A: No effect on phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 151354 |
OpenTargetsi | ENSG00000162981 |
PharmGKBi | PA142671854 |
Miscellaneous databases
Pharosi | Q96KN4, Tdark |
Genetic variation databases
BioMutai | FAM84A |
DMDMi | 97049335 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234425 | 1 – 292 | Protein LRATD1Add BLAST | 292 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q96KN4 |
MassIVEi | Q96KN4 |
MaxQBi | Q96KN4 |
PaxDbi | Q96KN4 |
PeptideAtlasi | Q96KN4 |
PRIDEi | Q96KN4 |
ProteomicsDBi | 77087 [Q96KN4-1] 77088 [Q96KN4-2] |
PTM databases
iPTMneti | Q96KN4 |
PhosphoSitePlusi | Q96KN4 |
Expressioni
Tissue specificityi
Only detected in testis. Highly expressed in colon cancer cells.1 Publication
Gene expression databases
Bgeei | ENSG00000162981, Expressed in caput epididymis and 187 other tissues |
Genevisiblei | Q96KN4, HS |
Organism-specific databases
HPAi | ENSG00000162981, Tissue enhanced (intestine) |
Interactioni
Binary interactionsi
Hide detailsQ96KN4
With | #Exp. | IntAct |
---|---|---|
ARHGEF5 [Q12774] | 5 | EBI-11477916,EBI-602199 |
ATXN10 [Q9UBB4] | 3 | EBI-11477916,EBI-702390 |
CYGB [Q8WWM9] | 3 | EBI-11477916,EBI-6309037 |
Protein-protein interaction databases
BioGRIDi | 127371, 3 interactors |
IntActi | Q96KN4, 4 interactors |
MINTi | Q96KN4 |
STRINGi | 9606.ENSP00000295092 |
Miscellaneous databases
RNActi | Q96KN4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 228 | LRATPROSITE-ProRule annotationAdd BLAST | 96 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 71 – 74 | Poly-His | 4 |
Sequence similaritiesi
Belongs to the LRATD family.Curated
Phylogenomic databases
eggNOGi | ENOG502QPSG, Eukaryota |
GeneTreei | ENSGT00940000161165 |
HOGENOMi | CLU_082142_0_0_1 |
InParanoidi | Q96KN4 |
OMAi | DQVIHLH |
OrthoDBi | 953643at2759 |
PhylomeDBi | Q96KN4 |
TreeFami | TF330836 |
Family and domain databases
InterProi | View protein in InterPro IPR007053, LRAT_dom IPR043299, LRATD1_LRATD2 |
PANTHERi | PTHR46341, PTHR46341, 1 hit |
Pfami | View protein in Pfam PF04970, LRAT, 1 hit |
PROSITEi | View protein in PROSITE PS51934, LRAT, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96KN4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP
60 70 80 90 100
DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS
110 120 130 140 150
GGPQGADLSV YAVTALPALC EPGDLLELLW LQPAPEPPAP APHWAVYVGG
160 170 180 190 200
GQIIHLHQGE IRQDSLYEAG AANVGRVVNS WYRYRPLVAE LVVQNACGHL
210 220 230 240 250
GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ QQYYLKVHLG
260 270 280 290
ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | H → Q in CAD10038 (Ref. 1) Curated | 1 | |
Sequence conflicti | 133 | P → H in AAH26346 (PubMed:15815621).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018314 | 146 – 292 | VYVGG…VDDKE → SRARRSAGRTRRASPPGAAL ASGSSRREGRCRQARSPRSS STISRCTWERTRSTPPGFTA WKTSSARSAVSTPAAACECS RSSPTSWTTRSSRLGAAGPS ASPAPRSLPFPAPGLRSQRF STSAPPRHARPPPVARARAA PPHPQASGRKSQELPQGRKG AAASAWLTATAVVTVLGDPA CAFPLRCKPGTGKGLRGERT WPSPRVHGQ in isoform 2. 1 PublicationAdd BLAST | 147 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ417080 mRNA Translation: CAD10038.1 AK092654 mRNA Translation: BAC03938.1 AC011897 Genomic DNA Translation: AAY15041.1 CH471053 Genomic DNA Translation: EAX00905.1 BC026346 mRNA Translation: AAH26346.1 BC052284 mRNA Translation: AAH52284.1 |
CCDSi | CCDS1684.1 [Q96KN4-1] |
RefSeqi | NP_660158.2, NM_145175.3 [Q96KN4-1] |
Genome annotation databases
Ensembli | ENST00000295092; ENSP00000295092; ENSG00000162981 [Q96KN4-1] ENST00000331243; ENSP00000330681; ENSG00000162981 [Q96KN4-1] |
GeneIDi | 151354 |
KEGGi | hsa:151354 |
UCSCi | uc002rbz.3, human [Q96KN4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ417080 mRNA Translation: CAD10038.1 AK092654 mRNA Translation: BAC03938.1 AC011897 Genomic DNA Translation: AAY15041.1 CH471053 Genomic DNA Translation: EAX00905.1 BC026346 mRNA Translation: AAH26346.1 BC052284 mRNA Translation: AAH52284.1 |
CCDSi | CCDS1684.1 [Q96KN4-1] |
RefSeqi | NP_660158.2, NM_145175.3 [Q96KN4-1] |
3D structure databases
SMRi | Q96KN4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127371, 3 interactors |
IntActi | Q96KN4, 4 interactors |
MINTi | Q96KN4 |
STRINGi | 9606.ENSP00000295092 |
PTM databases
iPTMneti | Q96KN4 |
PhosphoSitePlusi | Q96KN4 |
Genetic variation databases
BioMutai | FAM84A |
DMDMi | 97049335 |
Proteomic databases
jPOSTi | Q96KN4 |
MassIVEi | Q96KN4 |
MaxQBi | Q96KN4 |
PaxDbi | Q96KN4 |
PeptideAtlasi | Q96KN4 |
PRIDEi | Q96KN4 |
ProteomicsDBi | 77087 [Q96KN4-1] 77088 [Q96KN4-2] |
Protocols and materials databases
Antibodypediai | 26913, 88 antibodies |
DNASUi | 151354 |
Genome annotation databases
Ensembli | ENST00000295092; ENSP00000295092; ENSG00000162981 [Q96KN4-1] ENST00000331243; ENSP00000330681; ENSG00000162981 [Q96KN4-1] |
GeneIDi | 151354 |
KEGGi | hsa:151354 |
UCSCi | uc002rbz.3, human [Q96KN4-1] |
Organism-specific databases
CTDi | 151354 |
DisGeNETi | 151354 |
GeneCardsi | LRATD1 |
HGNCi | HGNC:20743, LRATD1 |
HPAi | ENSG00000162981, Tissue enhanced (intestine) |
MIMi | 611234, gene |
neXtProti | NX_Q96KN4 |
OpenTargetsi | ENSG00000162981 |
PharmGKBi | PA142671854 |
VEuPathDBi | HostDB:ENSG00000162981.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPSG, Eukaryota |
GeneTreei | ENSGT00940000161165 |
HOGENOMi | CLU_082142_0_0_1 |
InParanoidi | Q96KN4 |
OMAi | DQVIHLH |
OrthoDBi | 953643at2759 |
PhylomeDBi | Q96KN4 |
TreeFami | TF330836 |
Enzyme and pathway databases
PathwayCommonsi | Q96KN4 |
Miscellaneous databases
BioGRID-ORCSi | 151354, 4 hits in 867 CRISPR screens |
ChiTaRSi | FAM84A, human |
GenomeRNAii | 151354 |
Pharosi | Q96KN4, Tdark |
PROi | PR:Q96KN4 |
RNActi | Q96KN4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162981, Expressed in caput epididymis and 187 other tissues |
Genevisiblei | Q96KN4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007053, LRAT_dom IPR043299, LRATD1_LRATD2 |
PANTHERi | PTHR46341, PTHR46341, 1 hit |
Pfami | View protein in Pfam PF04970, LRAT, 1 hit |
PROSITEi | View protein in PROSITE PS51934, LRAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRAT1_HUMAN | |
Accessioni | Q96KN4Primary (citable) accession number: Q96KN4 Secondary accession number(s): A6NP76 Q8TAM5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | May 16, 2006 | |
Last modified: | February 10, 2021 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM