FAM84A

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM84A Alternative name(s): Neurologic sensory protein 1 Short name: NSE1
Gene namesⁱ	Name:FAM84A Synonyms:NSE1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162981.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20743 FAM84A
MIMⁱ	611234 gene
neXtProtⁱ	NX_Q96KN4

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	151354
Open Targets More...OpenTargetsⁱ	ENSG00000162981
PharmGKBⁱ	PA142671854

Polymorphism and mutation databases

BioMutaⁱ	FAM84A
DMDMⁱ	97049335

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000234425	1 – 292	Protein FAM84AAdd BLAST		292

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96KN4
PaxDbⁱ	Q96KN4
PeptideAtlas More...PeptideAtlasⁱ	Q96KN4
PRIDEⁱ	Q96KN4
ProteomicsDBⁱ	77087 77088 [Q96KN4-2]

PTM databases

iPTMnetⁱ	Q96KN4
PhosphoSitePlusⁱ	Q96KN4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162981
CleanExⁱ	HS_FAM84A
Genevisibleⁱ	Q96KN4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047703

HPAⁱ

HPA047703

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127371, 1 interactor
IntActⁱ	Q96KN4, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q96KN4
STRINGⁱ	9606.ENSP00000295092

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96KN4
SMRⁱ	Q96KN4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	71 – 74	Poly-His		4

Sequence similaritiesⁱ

Belongs to the FAM84 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IJCX Eukaryota ENOG4111FA5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013755
HOGENOMⁱ	HOG000293400
HOVERGENⁱ	HBG054465
InParanoidⁱ	Q96KN4
OMAⁱ	CIFSKLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CP2
PhylomeDBⁱ	Q96KN4
TreeFamⁱ	TF330836

Family and domain databases

InterProⁱ	View protein in InterPro IPR007053 LRAT-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04970 LRAT, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q96KN4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP 
        60         70         80         90        100
DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS 
       110        120        130        140        150
GGPQGADLSV YAVTALPALC EPGDLLELLW LQPAPEPPAP APHWAVYVGG 
       160        170        180        190        200
GQIIHLHQGE IRQDSLYEAG AANVGRVVNS WYRYRPLVAE LVVQNACGHL 
       210        220        230        240        250
GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ QQYYLKVHLG 
       260        270        280        290 
ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE

Length:292

Mass (Da):32,491

Last modified:May 16, 2006 - v2

Checksum:ⁱ652F11029F517626

GO

Isoform 2 (identifier: Q96KN4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
146-292: VYVGGGQIIH...ELADLVDDKE → SRARRSAGRT...TWPSPRVHGQ

« Hide

        10         20         30         40         50
MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP 
        60         70         80         90        100
DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS 
       110        120        130        140        150
GGPQGADLSV YAVTALPALC EPGDLLELLW LQPAPEPPAP APHWASRARR 
       160        170        180        190        200
SAGRTRRASP PGAALASGSS RREGRCRQAR SPRSSSTISR CTWERTRSTP 
       210        220        230        240        250
PGFTAWKTSS ARSAVSTPAA ACECSRSSPT SWTTRSSRLG AAGPSASPAP 
       260        270        280        290        300
RSLPFPAPGL RSQRFSTSAP PRHARPPPVA RARAAPPHPQ ASGRKSQELP 
       310        320        330        340        350
QGRKGAAASA WLTATAVVTV LGDPACAFPL RCKPGTGKGL RGERTWPSPR 

VHGQ

Show »

Length:354

Mass (Da):37,751

Checksum:ⁱDF510D1FEEF93C1D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	72	H → Q in CAD10038 (Ref. 1) Curated		1
Sequence conflictⁱ	133	P → H in AAH26346 (PubMed:15815621).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018314	146 – 292	VYVGG…VDDKE → SRARRSAGRTRRASPPGAAL ASGSSRREGRCRQARSPRSS STISRCTWERTRSTPPGFTA WKTSSARSAVSTPAAACECS RSSPTSWTTRSSRLGAAGPS ASPAPRSLPFPAPGLRSQRF STSAPPRHARPPPVARARAA PPHPQASGRKSQELPQGRKG AAASAWLTATAVVTVLGDPA CAFPLRCKPGTGKGLRGERT WPSPRVHGQ in isoform 2. 1 PublicationAdd BLAST		147

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ417080 mRNA Translation: CAD10038.1 AK092654 mRNA Translation: BAC03938.1 AC011897 Genomic DNA Translation: AAY15041.1 CH471053 Genomic DNA Translation: EAX00905.1 BC026346 mRNA Translation: AAH26346.1 BC052284 mRNA Translation: AAH52284.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1684.1 [Q96KN4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_660158.2, NM_145175.3 [Q96KN4-1]
UniGeneⁱ	Hs.260855 Hs.657296

Genome annotation databases

Ensemblⁱ	ENST00000295092; ENSP00000295092; ENSG00000162981 [Q96KN4-1] ENST00000331243; ENSP00000330681; ENSG00000162981 [Q96KN4-1]
GeneIDⁱ	151354
KEGGⁱ	hsa:151354
UCSC genome browser More...UCSCⁱ	uc002rbz.3 human [Q96KN4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length
Q96KN4	FAM84A isoform 3		PANTR		292
Family with sequence similarity 84 member A		PANPA		292

Protein	Similar proteins		Species	Score	Length
Q96KN4	FAM84A isoform 3		PANTR		292
Family with sequence similarity 84 member A		PANPA		292
Protein FAM84A		CRIGR		339
Protein FAM84A (Fragment)		MOUSE		63
Uncharacterized protein		NEOLE		316
+78

Protein	Similar proteins		Species	Score	Length
Q96KN4	FAM84A isoform 3		PANTR		292
Family with sequence similarity 84 member A		PANPA		292
Protein FAM84A		CRIGR		339
Protein FAM84A (Fragment)		MOUSE		63
Uncharacterized protein		NEOLE		316
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ417080 mRNA Translation: CAD10038.1 AK092654 mRNA Translation: BAC03938.1 AC011897 Genomic DNA Translation: AAY15041.1 CH471053 Genomic DNA Translation: EAX00905.1 BC026346 mRNA Translation: AAH26346.1 BC052284 mRNA Translation: AAH52284.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1684.1 [Q96KN4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_660158.2, NM_145175.3 [Q96KN4-1]
UniGeneⁱ	Hs.260855 Hs.657296

3D structure databases

ProteinModelPortalⁱ	Q96KN4
SMRⁱ	Q96KN4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127371, 1 interactor
IntActⁱ	Q96KN4, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q96KN4
STRINGⁱ	9606.ENSP00000295092

PTM databases

iPTMnetⁱ	Q96KN4
PhosphoSitePlusⁱ	Q96KN4

Polymorphism and mutation databases

BioMutaⁱ	FAM84A
DMDMⁱ	97049335

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96KN4
PaxDbⁱ	Q96KN4
PeptideAtlas More...PeptideAtlasⁱ	Q96KN4
PRIDEⁱ	Q96KN4
ProteomicsDBⁱ	77087 77088 [Q96KN4-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	151354
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295092; ENSP00000295092; ENSG00000162981 [Q96KN4-1] ENST00000331243; ENSP00000330681; ENSG00000162981 [Q96KN4-1]
GeneIDⁱ	151354
KEGGⁱ	hsa:151354
UCSC genome browser More...UCSCⁱ	uc002rbz.3 human [Q96KN4-1]

Organism-specific databases

CTDⁱ	151354
DisGeNET More...DisGeNETⁱ	151354
EuPathDBⁱ	HostDB:ENSG00000162981.13
GeneCardsⁱ	FAM84A
H-InvDBⁱ	HIX0001836
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20743 FAM84A
Human Protein Atlas More...HPAⁱ	HPA047703
MIMⁱ	611234 gene
neXtProtⁱ	NX_Q96KN4
Open Targets More...OpenTargetsⁱ	ENSG00000162981
PharmGKBⁱ	PA142671854
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJCX Eukaryota ENOG4111FA5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013755
HOGENOMⁱ	HOG000293400
HOVERGENⁱ	HBG054465
InParanoidⁱ	Q96KN4
OMAⁱ	CIFSKLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CP2
PhylomeDBⁱ	Q96KN4
TreeFamⁱ	TF330836

Miscellaneous databases

ChiTaRSⁱ	FAM84A human
GenomeRNAiⁱ	151354
Protein Ontology More...PROⁱ	PR:Q96KN4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000162981
CleanExⁱ	HS_FAM84A
Genevisibleⁱ	Q96KN4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007053 LRAT-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04970 LRAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FA84A_HUMAN
Accessionⁱ	Q96KN4Primary (citable) accession number: Q96KN4 Secondary accession number(s): A6NP76 , Q86UZ2, Q8NAH7, Q8TAM5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	May 16, 2006
	Last modified:	June 20, 2018
	This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q96KN4 (FA84A_HUMAN)

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Protein FAM84A

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ