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Protein

Protein FAM84A

Gene

FAM84A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM84A
Alternative name(s):
Neurologic sensory protein 1
Short name:
NSE1
Gene namesi
Name:FAM84A
Synonyms:NSE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000162981.13
HGNCiHGNC:20743 FAM84A
MIMi611234 gene
neXtProtiNX_Q96KN4

Pathology & Biotechi

Organism-specific databases

DisGeNETi151354
OpenTargetsiENSG00000162981
PharmGKBiPA142671854

Polymorphism and mutation databases

BioMutaiFAM84A
DMDMi97049335

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002344251 – 292Protein FAM84AAdd BLAST292

Proteomic databases

MaxQBiQ96KN4
PaxDbiQ96KN4
PeptideAtlasiQ96KN4
PRIDEiQ96KN4
ProteomicsDBi77087
77088 [Q96KN4-2]

PTM databases

iPTMnetiQ96KN4
PhosphoSitePlusiQ96KN4

Expressioni

Gene expression databases

BgeeiENSG00000162981
CleanExiHS_FAM84A
GenevisibleiQ96KN4 HS

Organism-specific databases

HPAiHPA047703

Interactioni

Protein-protein interaction databases

BioGridi127371, 1 interactor
IntActiQ96KN4, 3 interactors
MINTiQ96KN4
STRINGi9606.ENSP00000295092

Structurei

3D structure databases

ProteinModelPortaliQ96KN4
SMRiQ96KN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 74Poly-His4

Sequence similaritiesi

Belongs to the FAM84 family.Curated

Phylogenomic databases

eggNOGiENOG410IJCX Eukaryota
ENOG4111FA5 LUCA
GeneTreeiENSGT00390000013755
HOGENOMiHOG000293400
HOVERGENiHBG054465
InParanoidiQ96KN4
OMAiCIFSKLR
OrthoDBiEOG091G0CP2
PhylomeDBiQ96KN4
TreeFamiTF330836

Family and domain databases

InterProiView protein in InterPro
IPR007053 LRAT-like_dom
PfamiView protein in Pfam
PF04970 LRAT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96KN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP
60 70 80 90 100
DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS
110 120 130 140 150
GGPQGADLSV YAVTALPALC EPGDLLELLW LQPAPEPPAP APHWAVYVGG
160 170 180 190 200
GQIIHLHQGE IRQDSLYEAG AANVGRVVNS WYRYRPLVAE LVVQNACGHL
210 220 230 240 250
GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ QQYYLKVHLG
260 270 280 290
ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE
Length:292
Mass (Da):32,491
Last modified:May 16, 2006 - v2
Checksum:i652F11029F517626
GO
Isoform 2 (identifier: Q96KN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-292: VYVGGGQIIH...ELADLVDDKE → SRARRSAGRT...TWPSPRVHGQ

Show »
Length:354
Mass (Da):37,751
Checksum:iDF510D1FEEF93C1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72H → Q in CAD10038 (Ref. 1) Curated1
Sequence conflicti133P → H in AAH26346 (PubMed:15815621).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018314146 – 292VYVGG…VDDKE → SRARRSAGRTRRASPPGAAL ASGSSRREGRCRQARSPRSS STISRCTWERTRSTPPGFTA WKTSSARSAVSTPAAACECS RSSPTSWTTRSSRLGAAGPS ASPAPRSLPFPAPGLRSQRF STSAPPRHARPPPVARARAA PPHPQASGRKSQELPQGRKG AAASAWLTATAVVTVLGDPA CAFPLRCKPGTGKGLRGERT WPSPRVHGQ in isoform 2. 1 PublicationAdd BLAST147

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417080 mRNA Translation: CAD10038.1
AK092654 mRNA Translation: BAC03938.1
AC011897 Genomic DNA Translation: AAY15041.1
CH471053 Genomic DNA Translation: EAX00905.1
BC026346 mRNA Translation: AAH26346.1
BC052284 mRNA Translation: AAH52284.1
CCDSiCCDS1684.1 [Q96KN4-1]
RefSeqiNP_660158.2, NM_145175.3 [Q96KN4-1]
UniGeneiHs.260855
Hs.657296

Genome annotation databases

EnsembliENST00000295092; ENSP00000295092; ENSG00000162981 [Q96KN4-1]
ENST00000331243; ENSP00000330681; ENSG00000162981 [Q96KN4-1]
GeneIDi151354
KEGGihsa:151354
UCSCiuc002rbz.3 human [Q96KN4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFA84A_HUMAN
AccessioniPrimary (citable) accession number: Q96KN4
Secondary accession number(s): A6NP76
, Q86UZ2, Q8NAH7, Q8TAM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: June 20, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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