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Entry version 104 (13 Feb 2019)
Sequence version 2 (16 May 2006)
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Protein

Protein FAM84A

Gene

FAM84A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM84A
Alternative name(s):
Neurologic sensory protein 1
Short name:
NSE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM84A
Synonyms:NSE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162981.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20743 FAM84A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611234 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96KN4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
151354

Open Targets

More...
OpenTargetsi
ENSG00000162981

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671854

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM84A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97049335

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002344251 – 292Protein FAM84AAdd BLAST292

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96KN4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96KN4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96KN4

PeptideAtlas

More...
PeptideAtlasi
Q96KN4

PRoteomics IDEntifications database

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PRIDEi
Q96KN4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77087
77088 [Q96KN4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96KN4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96KN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162981 Expressed in 173 organ(s), highest expression level in caput epididymis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96KN4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047703

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127371, 1 interactor

Protein interaction database and analysis system

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IntActi
Q96KN4, 3 interactors

Molecular INTeraction database

More...
MINTi
Q96KN4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295092

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96KN4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96KN4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 74Poly-His4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM84 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJCX Eukaryota
ENOG4111FA5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161165

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293400

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054465

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96KN4

KEGG Orthology (KO)

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KOi
K22805

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIFSKLR

Database of Orthologous Groups

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OrthoDBi
953643at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96KN4

TreeFam database of animal gene trees

More...
TreeFami
TF330836

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007053 LRAT-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04970 LRAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96KN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP
60 70 80 90 100
DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS
110 120 130 140 150
GGPQGADLSV YAVTALPALC EPGDLLELLW LQPAPEPPAP APHWAVYVGG
160 170 180 190 200
GQIIHLHQGE IRQDSLYEAG AANVGRVVNS WYRYRPLVAE LVVQNACGHL
210 220 230 240 250
GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ QQYYLKVHLG
260 270 280 290
ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE
Length:292
Mass (Da):32,491
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i652F11029F517626
GO
Isoform 2 (identifier: Q96KN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-292: VYVGGGQIIH...ELADLVDDKE → SRARRSAGRT...TWPSPRVHGQ

Show »
Length:354
Mass (Da):37,751
Checksum:iDF510D1FEEF93C1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72H → Q in CAD10038 (Ref. 1) Curated1
Sequence conflicti133P → H in AAH26346 (PubMed:15815621).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018314146 – 292VYVGG…VDDKE → SRARRSAGRTRRASPPGAAL ASGSSRREGRCRQARSPRSS STISRCTWERTRSTPPGFTA WKTSSARSAVSTPAAACECS RSSPTSWTTRSSRLGAAGPS ASPAPRSLPFPAPGLRSQRF STSAPPRHARPPPVARARAA PPHPQASGRKSQELPQGRKG AAASAWLTATAVVTVLGDPA CAFPLRCKPGTGKGLRGERT WPSPRVHGQ in isoform 2. 1 PublicationAdd BLAST147

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ417080 mRNA Translation: CAD10038.1
AK092654 mRNA Translation: BAC03938.1
AC011897 Genomic DNA Translation: AAY15041.1
CH471053 Genomic DNA Translation: EAX00905.1
BC026346 mRNA Translation: AAH26346.1
BC052284 mRNA Translation: AAH52284.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1684.1 [Q96KN4-1]

NCBI Reference Sequences

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RefSeqi
NP_660158.2, NM_145175.3 [Q96KN4-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.260855
Hs.657296

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295092; ENSP00000295092; ENSG00000162981 [Q96KN4-1]
ENST00000331243; ENSP00000330681; ENSG00000162981 [Q96KN4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
151354

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:151354

UCSC genome browser

More...
UCSCi
uc002rbz.3 human [Q96KN4-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417080 mRNA Translation: CAD10038.1
AK092654 mRNA Translation: BAC03938.1
AC011897 Genomic DNA Translation: AAY15041.1
CH471053 Genomic DNA Translation: EAX00905.1
BC026346 mRNA Translation: AAH26346.1
BC052284 mRNA Translation: AAH52284.1
CCDSiCCDS1684.1 [Q96KN4-1]
RefSeqiNP_660158.2, NM_145175.3 [Q96KN4-1]
UniGeneiHs.260855
Hs.657296

3D structure databases

ProteinModelPortaliQ96KN4
SMRiQ96KN4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127371, 1 interactor
IntActiQ96KN4, 3 interactors
MINTiQ96KN4
STRINGi9606.ENSP00000295092

PTM databases

iPTMnetiQ96KN4
PhosphoSitePlusiQ96KN4

Polymorphism and mutation databases

BioMutaiFAM84A
DMDMi97049335

Proteomic databases

jPOSTiQ96KN4
MaxQBiQ96KN4
PaxDbiQ96KN4
PeptideAtlasiQ96KN4
PRIDEiQ96KN4
ProteomicsDBi77087
77088 [Q96KN4-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
151354
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295092; ENSP00000295092; ENSG00000162981 [Q96KN4-1]
ENST00000331243; ENSP00000330681; ENSG00000162981 [Q96KN4-1]
GeneIDi151354
KEGGihsa:151354
UCSCiuc002rbz.3 human [Q96KN4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
151354
DisGeNETi151354
EuPathDBiHostDB:ENSG00000162981.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM84A

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0001836
HGNCiHGNC:20743 FAM84A
HPAiHPA047703
MIMi611234 gene
neXtProtiNX_Q96KN4
OpenTargetsiENSG00000162981
PharmGKBiPA142671854

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJCX Eukaryota
ENOG4111FA5 LUCA
GeneTreeiENSGT00940000161165
HOGENOMiHOG000293400
HOVERGENiHBG054465
InParanoidiQ96KN4
KOiK22805
OMAiCIFSKLR
OrthoDBi953643at2759
PhylomeDBiQ96KN4
TreeFamiTF330836

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM84A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
151354

Protein Ontology

More...
PROi
PR:Q96KN4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162981 Expressed in 173 organ(s), highest expression level in caput epididymis
GenevisibleiQ96KN4 HS

Family and domain databases

InterProiView protein in InterPro
IPR007053 LRAT-like_dom
PfamiView protein in Pfam
PF04970 LRAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA84A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KN4
Secondary accession number(s): A6NP76
, Q86UZ2, Q8NAH7, Q8TAM5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: February 13, 2019
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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