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UniProtKB - Q96KN3 (PKNX2_HUMAN)
Protein
Homeobox protein PKNOX2
Gene
PKNOX2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 291 – 350 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- actin filament binding Source: Ensembl
- actin monomer binding Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96KN3 |
SignaLinki | Q96KN3 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein PKNOX2Alternative name(s): Homeobox protein PREP-2 PBX/knotted homeobox 2 |
Gene namesi | Name:PKNOX2 Synonyms:PREP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16714, PKNOX2 |
MIMi | 613066, gene |
neXtProti | NX_Q96KN3 |
VEuPathDBi | HostDB:ENSG00000165495 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Cytoskeleton
- actin cytoskeleton Source: Ensembl
- microtubule cytoskeleton Source: Ensembl
Extracellular region or secreted
- intercellular bridge Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 63876 |
OpenTargetsi | ENSG00000165495 |
PharmGKBi | PA33355 |
Miscellaneous databases
Pharosi | Q96KN3, Tbio |
Genetic variation databases
BioMutai | PKNOX2 |
DMDMi | 115311621 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049250 | 1 – 472 | Homeobox protein PKNOX2Add BLAST | 472 |
Proteomic databases
MassIVEi | Q96KN3 |
MaxQBi | Q96KN3 |
PaxDbi | Q96KN3 |
PeptideAtlasi | Q96KN3 |
PRIDEi | Q96KN3 |
ProteomicsDBi | 24907 77086 [Q96KN3-1] |
PTM databases
GlyGeni | Q96KN3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96KN3 |
PhosphoSitePlusi | Q96KN3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165495, Expressed in quadriceps femoris and 199 other tissues |
ExpressionAtlasi | Q96KN3, baseline and differential |
Genevisiblei | Q96KN3, HS |
Organism-specific databases
HPAi | ENSG00000165495, Tissue enhanced (tongue) |
Interactioni
Binary interactionsi
Q96KN3
GO - Molecular functioni
- actin filament binding Source: Ensembl
- actin monomer binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 121969, 43 interactors |
IntActi | Q96KN3, 38 interactors |
STRINGi | 9606.ENSP00000298282 |
Miscellaneous databases
RNActi | Q96KN3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 351 – 371 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 386 – 405 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 422 – 472 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 53 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 429 – 456 | Acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the TALE/MEIS homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0773, Eukaryota |
GeneTreei | ENSGT00940000158793 |
HOGENOMi | CLU_023139_0_2_1 |
InParanoidi | Q96KN3 |
OMAi | MMATQTV |
OrthoDBi | 1221551at2759 |
PhylomeDBi | Q96KN3 |
TreeFami | TF318093 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain IPR032453, PKNOX/Meis_N |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit PF16493, Meis_PKNOX_N, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96KN3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMQHASPAPA LTMMATQNVP PPPYQDSPQM TATAQPPSKA QAVHISAPSA
60 70 80 90 100
AASTPVPSAP IDPQAQLEAD KRAVYRHPLF PLLTLLFEKC EQATQGSECI
110 120 130 140 150
TSASFDVDIE NFVHQQEQEH KPFFSDDPEL DNLMVKAIQV LRIHLLELEK
160 170 180 190 200
VNELCKDFCN RYITCLKTKM HSDNLLRNDL GGPYSPNQPS INLHSQDLLQ
210 220 230 240 250
NSPNSMSGVS NNPQGIVVPA SALQQGNIAM TTVNSQVVSG GALYQPVTMV
260 270 280 290 300
TSQGQVVTQA IPQGAIQIQN TQVNLDLTSL LDNEDKKSKN KRGVLPKHAT
310 320 330 340 350
NIMRSWLFQH LMHPYPTEDE KRQIAAQTNL TLLQVNNWFI NARRRILQPM
360 370 380 390 400
LDASNPDPAP KAKKIKSQHR PTQRFWPNSI AAGVLQQQGG APGTNPDGSI
410 420 430 440 450
NLDNLQSLSS DSATMAMQQA MMAAHDDSLD GTEEEDEDEM EEEEEEELEE
460 470
EVDELQTTNV SDLGLEHSDS LE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YLX0 | H0YLX0_HUMAN | Homeobox protein PKNOX2 | PKNOX2 | 98 | Annotation score: | ||
E9PKL2 | E9PKL2_HUMAN | Homeobox protein PKNOX2 | PKNOX2 | 39 | Annotation score: | ||
E9PQS4 | E9PQS4_HUMAN | Homeobox protein PKNOX2 | PKNOX2 | 40 | Annotation score: | ||
E9PRB6 | E9PRB6_HUMAN | Homeobox protein PKNOX2 | PKNOX2 | 40 | Annotation score: |
Sequence cautioni
The sequence BAB83665 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 427 | D → G in BAH12921 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049590 | 110 | E → K. Corresponds to variant dbSNP:rs34936365Ensembl. | 1 | |
Natural variantiVAR_027500 | 447 | Missing 1 PublicationCorresponds to variant dbSNP:rs3832749Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054306 | 1 – 75 | MMQHA…KRAVY → MSRPHPTRTAH in isoform 2. 1 PublicationAdd BLAST | 75 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK298999 mRNA Translation: BAH12921.1 BX648615 mRNA Translation: CAH56146.1 AP000708 Genomic DNA No translation available. AP001007 Genomic DNA No translation available. AP003061 Genomic DNA No translation available. AP003069 Genomic DNA No translation available. BC045626 mRNA Translation: AAH45626.3 AB065001 mRNA Translation: BAB83665.1 Different initiation. AJ417081 mRNA Translation: CAD01142.1 |
CCDSi | CCDS41730.1 [Q96KN3-1] |
PIRi | JC7766 |
RefSeqi | NP_071345.2, NM_022062.2 XP_005271699.1, XM_005271642.2 XP_011541246.1, XM_011542944.2 XP_011541247.1, XM_011542945.2 XP_016873599.1, XM_017018110.1 |
Genome annotation databases
Ensembli | ENST00000298282; ENSP00000298282; ENSG00000165495 |
GeneIDi | 63876 |
MANE-Selecti | ENST00000298282.14; ENSP00000298282.8; NM_001382323.2; NP_001369252.1 |
UCSCi | uc001qbu.4, human [Q96KN3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK298999 mRNA Translation: BAH12921.1 BX648615 mRNA Translation: CAH56146.1 AP000708 Genomic DNA No translation available. AP001007 Genomic DNA No translation available. AP003061 Genomic DNA No translation available. AP003069 Genomic DNA No translation available. BC045626 mRNA Translation: AAH45626.3 AB065001 mRNA Translation: BAB83665.1 Different initiation. AJ417081 mRNA Translation: CAD01142.1 |
CCDSi | CCDS41730.1 [Q96KN3-1] |
PIRi | JC7766 |
RefSeqi | NP_071345.2, NM_022062.2 XP_005271699.1, XM_005271642.2 XP_011541246.1, XM_011542944.2 XP_011541247.1, XM_011542945.2 XP_016873599.1, XM_017018110.1 |
3D structure databases
SMRi | Q96KN3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121969, 43 interactors |
IntActi | Q96KN3, 38 interactors |
STRINGi | 9606.ENSP00000298282 |
PTM databases
GlyGeni | Q96KN3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96KN3 |
PhosphoSitePlusi | Q96KN3 |
Genetic variation databases
BioMutai | PKNOX2 |
DMDMi | 115311621 |
Proteomic databases
MassIVEi | Q96KN3 |
MaxQBi | Q96KN3 |
PaxDbi | Q96KN3 |
PeptideAtlasi | Q96KN3 |
PRIDEi | Q96KN3 |
ProteomicsDBi | 24907 77086 [Q96KN3-1] |
Protocols and materials databases
Antibodypediai | 9279, 200 antibodies from 28 providers |
DNASUi | 63876 |
Genome annotation databases
Ensembli | ENST00000298282; ENSP00000298282; ENSG00000165495 |
GeneIDi | 63876 |
MANE-Selecti | ENST00000298282.14; ENSP00000298282.8; NM_001382323.2; NP_001369252.1 |
UCSCi | uc001qbu.4, human [Q96KN3-1] |
Organism-specific databases
CTDi | 63876 |
DisGeNETi | 63876 |
GeneCardsi | PKNOX2 |
HGNCi | HGNC:16714, PKNOX2 |
HPAi | ENSG00000165495, Tissue enhanced (tongue) |
MIMi | 613066, gene |
neXtProti | NX_Q96KN3 |
OpenTargetsi | ENSG00000165495 |
PharmGKBi | PA33355 |
VEuPathDBi | HostDB:ENSG00000165495 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0773, Eukaryota |
GeneTreei | ENSGT00940000158793 |
HOGENOMi | CLU_023139_0_2_1 |
InParanoidi | Q96KN3 |
OMAi | MMATQTV |
OrthoDBi | 1221551at2759 |
PhylomeDBi | Q96KN3 |
TreeFami | TF318093 |
Enzyme and pathway databases
PathwayCommonsi | Q96KN3 |
SignaLinki | Q96KN3 |
Miscellaneous databases
BioGRID-ORCSi | 63876, 4 hits in 1059 CRISPR screens |
ChiTaRSi | PKNOX2, human |
GenomeRNAii | 63876 |
Pharosi | Q96KN3, Tbio |
PROi | PR:Q96KN3 |
RNActi | Q96KN3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165495, Expressed in quadriceps femoris and 199 other tissues |
ExpressionAtlasi | Q96KN3, baseline and differential |
Genevisiblei | Q96KN3, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain IPR032453, PKNOX/Meis_N |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit PF16493, Meis_PKNOX_N, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKNX2_HUMAN | |
Accessioni | Q96KN3Primary (citable) accession number: Q96KN3 Secondary accession number(s): B7Z5I5 Q86XD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | September 19, 2006 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families